• Korean Institute of Interior Design Journal
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• v.15 no.6 s.59
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• pp.68-76
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• 2006

Founding himself on 'The Principle of Self-making' that is the instrument of 'the natural construction' and accomplishing the various interdisciplinary researches, Frei Otto could explicate the fundamental structure of life that is able to make visible the self-making processes in the nature, the technique and the architecture. It is the flexible pneumatic construction that is grounded on the fibrous organization. This was a milestone not only for him who wanted to put the idea of the new architectural form into practice, but also for the contemporary architecture that faces on the style-pluralistic disorientedness. The architectural form of the natural construction includes in itself three constitutional sub-ideas. One of them is 'the adaptable architecture', which is inclined to the architecture similar to the organization of human body, and the other 'the light architecture' that is in the pursuit of the optimal form through the minimal material. The last one is 'the ecological architecture' that aims to realize the optimal dwelling environment based on the effective energy consumption by accumulating knowledges of the always fluid and unstable nature. With these architectural ideas Frei Otto could develop a new architectural form language 'the light architecture of the natural construction'. This study is purposed to explain the various experiments that were made by his team and the basic principles of the structural dynamics of 'the architecture of the natural construction' and then to analyze the structures that were built on the ground of those principles.

• Journal of architectural history
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• v.7 no.4 s.17
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• pp.29-47
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• 1998

The aim of this study is to understand the original methods of architectural composition in F. L. Wright's works, For this purpose, the principal thoughts based on his organic architecture was examined over all others, and the results of this study are as follows. 1. F. L. Wright knew Taoist Philosophy, especially Lao-tzu's thought about space based on traditional oriental arts included traditional japanese arts by his superior intuition. this is similar to Froebel Thought in the principal theory, that is, his own unique field of abstract architectural education with three-dimensional geometry learned through Froebel Gifts. 2. Space is reality ; such Lao-tzu's thought, reversed the sense of values, influenced F. L. Wright's way to accomplish his own continuous space. that is to say, he attempted taking precedence of spatial organization by the unit of three-dimensional module made the substance, Froebel Blocks (3, 4, 5, 6 Gifts) into non-substance, and trying to do the methods of continuous liberal composition in architecture. which is his original accomplishment, namely his mentioned 'democratic' because of judging the space and the mold of architecture as individualities. 3. F. L. Wright treated the space as a positive entity, so that he created his own architecture organically combined with spaces and forms. : This was the result that he comprehended both formative, physical worth in West and spatial, non-physical worth in East as equivalence. It is understood that F. L. Wright's works combined with East and West are the significance of his architecture and the progress of true internationalities and modernization in modern architecture. 4. From the analyses of his works, we knew the fact that F. L. Wright's architecture, especially in the spatial organization were performed by the reasonable methods with geometric system of Froebel Gifts. In the observation of our fundamental way of thinking on his architecture, this study shows the necessity to let us get out of preconceptions and conclusions that the organic architecture is mysterious and difficult, but to systematize and put his organic methods to practical use.

• Journal of Information Technology and Architecture
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• v.9 no.2
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• pp.133-142
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• 2012

Gartner predicts that by 2012, 40% of EA programs will be stopped due to poor execution and the failure of delivering business value. An organization needs a practical solution to achieve an EA vision. The EA essential approach should be that of business service and process orientation than systems and IT orientation. We propose an Actionable Enterprise Architecture (AEA) which is based on BPM (Business Process Management) and SOA (Service Oriented Architecture), and connected to service & process orientation and engineering. The architecture proposed provides traceability between service-oriented enterprise architecture and its solution. The proposed architecture can transform enterprise architecture from conceptual to physical levels (solutions) with a service and business process paradigm.

• Journal of the Korean Society for information Management
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• v.33 no.1
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• pp.181-196
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• 2016

The objective of this study is to evaluate the organization system and the labeling system of information architecture of a website for the elderly. To achieve this aims, we selected a representative website, i.e., Naver, and the participants were conducted given three types of search tasks using their own information literacy skills and they were answered to the questionnaire and an additional interview, if necessary. A total of 74 valid data were collected through the experiment, and we analyzed the data using SPSS Ver. 20. It revealed that Naver received a positive evaluation in the organization system aspect, particularly its systematic subject categorization and chronological browsing mechanisms. Old adults were preferred the icon-based labeling than the text-based labeling system, and showed a significant difference among their academic backgrounds.

• Journal of The Korea Institute of Healthcare Architecture
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• v.23 no.4
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• pp.37-53
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• 2017

Purpose: As the structure of the disease has been changed and the infectious disease has been increased, the demand for diagnostic examination has been increasing. So, the department of laboratory medicine in hospital has playing the important role accounting for about nineteen percent of total medical expenses in korea. This study is to investigate the laboratory function and spatial composition of the department and figure out the space area and space organization. Methods: Explore the literature review to identify the laboratory function. Limit to five cases of tertiary level general hospital having about a thousand bed and analyze the space layout and floor area to confirm the spatial composition. Classify the exam function and check the spatial composition and spatial organization. Results: This study allows 5 conclusions to be summarized. Laboratory medicine divided into nine part in regulation, but in space allocated into core lab, emergency lab and six part lab. Total laboratory area is $2,036m^2$ in average, and is composited with 60% for lab, 17% for office and 20% for public. Lab area per a bed presents $1.88m^2$. Microbiolgy and molecular lab area are getting large. Laboratory space organized into the four zone, like an entrance zone, core zone, rear zone and peripheral zone. Emergency and transfusion lab are allocated in entrance zone, hematology chemistry and immunology in core lab, microbiology and molecular lab in rear, support offices in peripheral zone. The most important point was to check the spatial composition of the Laboratory Medicine according to the inspection function. Implications: This study can be used as a useful data in planning and designing a Laboratory Medicine Department.

• Genomics & Informatics
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• v.21 no.2
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• pp.19.1-19.13
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• 2023

Liver cancer, particularly hepatocellular carcinoma (HCC), poses a significant global threat to human lives. To advance the development of innovative diagnostic and treatment approaches, it is essential to examine the hidden features of HCC, particularly its 3D genome architecture, which is not well understood. In this study, we investigated the 3D genome organization of four HCC cell lines-Hep3B, Huh1, Huh7, and SNU449-using in situ Hi-C and assay for transposase-accessible chromatin sequencing. Our findings revealed that HCC cell lines had more long-range interactions, both intra-and interchromosomal, compared to human mammary epithelial cells (HMECs). Unexpectedly, HCC cell lines displayed cell line-specific compartmental modifications at the megabase (Mb) scale, which could potentially be leveraged in determining HCC subtypes. At the sub-Mb scale, we observed decreases in intra-TAD (topologically associated domain) interactions and chromatin loops in HCC cell lines compared to HMECs. Lastly, we discovered a correlation between gene expression and the 3D chromatin architecture of SLC8A1, which encodes a sodium-calcium antiporter whose modulation is known to induce apoptosis by comparison between HCC cell lines and HMECs. Our findings suggest that HCC cell lines have a distinct 3D genome organization that is different from those of normal and other cancer cells based on the analysis of compartments, TADs, and chromatin loops. Overall, we take this as evidence that genome organization plays a crucial role in cancer phenotype determination. Further exploration of epigenetics in HCC will help us to better understand specific gene regulation mechanisms and uncover novel targets for cancer treatment.

• Korean Architects
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• s.625
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• pp.94-97
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• 2021

• Korean Architects
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• s.619
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• pp.18-19
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• 2020

• Korean Architects
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• s.626
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• pp.94-97
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• 2021

• Journal of the Korean Society for information Management
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• v.18 no.3
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• pp.115-138
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• 2001

The purpose of this study is to provide general principles to be used in designing university websites from the perspective of information architecture. Quantitative and qualitative evaluation criteria of web sites were developed based on information architecture principles. The students taking IA class were directly involved in constructing the evaluation criteria and they can be classified into four categories: 1) information organization; 2) navigation system; 3) labeling system; and searching system. These criteria were employed in evaluating twenty randomly selected university websites in Korea. General principles to be used in designing university websites were developed based on the findings of the study. They are composed of four major components in designing: 1) systematic information organization; 2) flexible navigation system; 3) consistent labeling system; and 4) efficient searching system.