• Title/Summary/Keyword: Antitumor

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Antitumor Activity of Chitosan Oligosaccharides Produced in Ultrafiltration Membrane Reactor System

  • Jeon, You-Jin;Kim, Se-Kwon
    • Journal of Microbiology and Biotechnology
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    • v.12 no.3
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    • pp.503-507
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    • 2002
  • Chitosan oligosaccharides (COSs) were prepared and fractionated into three groups of COS [a high molecular weight COS (HMWCOS), medium molecular weight COS (LMWCOS), and low molecular weight COS (LMWCOS)] according to their molecular weight, using an ultrafiltration membrane enzymatic bioreactor designed earlier [8]. Antitumor activity of these COSs was then examined against Sarcoma 180 solid (S180) or Uterine cervix carcinoma No. 14 (Ul4) tumor cell-bearing mice. Among these COSs, MMWCOS with molecular weight range from 1.5 to 5.5 kDa effectively inhibited the growth of both tumor cells in the mice. In addition, the administration of MMWCOS resulted in increased thymus weight among lymphoid organs. The mice treated with MMWCOS showed improved survival rate and larger number of survivors after 40 days of feeding. The most effective of MMWCOS far antitumor activity in the S180- or U14-bearing mice was 20 mg/kg/day or more.

Antitumor activity of 2(S)-5,$2^{I}$,$5^{I}$-trihydroxy-7,8-dimenthoxyflavanone and its analogues

  • Min, Byung-Sun;Chung, Kyeong-Soo;Bae, Ki-Hwan
    • Archives of Pharmacal Research
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    • v.20 no.4
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    • pp.368-371
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    • 1997
  • In an effort to increase of the antitumor activity of 2(S)-$2^{I}$,$5^{I}$-trihydroxy-7, 8-dimethoxyflavanone isolated from Scutellaria indica, we synthesized its analogues, II, III and IV. They showed potent cytotoxicity in vitro against cancer cell lines, L1210, K562 and A549. On the basis of $ED_50$ values against the cancer cell lines, III exhibited about 2-7 times stronger activity than I against various cell lines. We tested the antitumor activity of the analogues against Sarcoma 180 cells in vivo and evaluated the structure-activity relationship. The antitumor activity appeared to be related to the hydrogen bond between carbonyl group at C-4 and hydroxyl group at C-5, in contrast to cytotoxic action.

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Studies on Antitumor Components of Wild Pholiota squarrosa (Fr.) Quel. (야생 비늘 버섯의 항암 성분에 관한 연구)

  • 박완희
    • YAKHAK HOEJI
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    • v.26 no.3
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    • pp.185-188
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    • 1982
  • In order to investigate the antitumor components of Korean wild higher fungi, the carpo-phores of Pholiota squarrosa collected in Kaung Nung area were extracted with water by refluxing for eight hours at 80-90.deg. C. The extracts were dialized for six days against distilled water and lyophilized to produce crude polysaccharide powders. They were found to have the antitumor activity against sarcoma 180 implanted in mice. Especially, the inhibition ratio of the extract of Pholiota squarrosa was 78.7% in the dose of 20mg/kg/day for the period of ten days. The tumor in two of the ten mice was completely regressed. The components of these aqueous extracts were found to be polysaccharide and protein. The total polysaccharide was 42% by Anthrone method and the protein was 55% by Lowry-Folin method in the antitumor component of Pholiota squarrosa.

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Synthesis and Structure-Activity Relationship Studies of Substituted Isoquinoline Analogs Antitumor Agent

  • Cheon, Seung-Hoon;Park, Joon-Suck;Chung, Byung-Ho;Choi, Bo-Gil;Cho, Won-Jae;Choi, Sang-Un;Lee, Chong-Ock
    • Archives of Pharmacal Research
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    • v.21 no.2
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    • pp.193-197
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    • 1998
  • A number of substituted isoquinolin-1-ones, possible bioisosteres of the 5-aryl substituted 2,3-dihydroimidazo[2,$1-a$]isoquinolines, were synthesized and tested for their antitumor activity against five different human tumor cell lines. O-(3-hydroxyporpyl) substituted compound (15) exhibited the best antitumor activity which is 3-5 times better than 5-[$4^1$-(piperidinomethyl)phenyl]-2,3-dihydroimidazo[2,$1-a$]isoquinoline (1).

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Naphthazarin Derivatives (Ⅶ): Antitumor Action against ICR Mice Bearing Ascitic S-180 Cells

  • Song, Gyu-Yong;Kim, Yong;You, Young-Jae;Gho, Hoon;Ahn, Byung-Zun
    • Archives of Pharmacal Research
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    • v.24 no.1
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    • pp.35-38
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    • 2001
  • Various analogues of 5,8-dimethoxy-1,4-naphthoquinone (DMNQ) such as 2- or 6-(1-hydro-xyiminoalkyl)-DMNQs were prepared and evaluated for the antitumor action. (1-Hydroxyiminoalkyl)-DMNQ derivatives expressed greater antitumor action than (1 -hydroxyalkyl)- or acyl-DMNQ derivatives. Moreover, 6-(1-hydroxyiminoalkyl)-DMNQ derivatives expressed higher anti-tumor action than 2-sudstituted ones, suggestive of a steric effect. Some of 6-(1-propyloxyalkyl)-DMNQ derivatives with an alkyl group of butyl to octyl moiety showed T/C values of > 400 %.

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Studies on the Components of Pholiota squarrosa(II) (비늘버섯의 성분(成分)에 관한 연구(硏究)(제 2 보))

  • Park, Wan-Hee;Kim, Byong-Kak;Ro, Ihl-Hyeob
    • The Korean Journal of Mycology
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    • v.11 no.1
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    • pp.35-37
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    • 1983
  • To investigate antitumor components in Korean higher fungi, the carpophores of Pholiota squarrosa belonging to the family Strophariaceae were collected and extracted with hot water. A protein-bound polysaccharide fraction was obtained by adding ethanol to the extract and by dialyzing through Visking tube. The fraction was examined for antitumor activity against sarcoma 180 implanted in mice. It showed an inhibition ratio of 78.7% at the dose of 20mg/kg/day. The tumor in two of the ten mice was completely regressed. The chemical analysis of the antitumor fraction by Anthrone and Lowry-Folin methods showed that it consisted of 42% polysaccharide and 55% protein. The enzyme fraction of the carpophores showed no proteolytic activity on casein.

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Antitumor Activity of Lactobacillus casei against Sarcoma 180 and Lewis Lung Carcinoma in Mice (생쥐에서 Sarcoma 180 및 Lewis Lung Carcinoma에 대한 Lactobacillus casei의 항암 효과)

  • 배형석;백영진;윤영호
    • Microbiology and Biotechnology Letters
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    • v.21 no.3
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    • pp.247-255
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    • 1993
  • Antitumor activity of Lactobacillus casei YIP 9018(LC9018) was studied in mice by using sarcoma 180(S-180) and Lewis lung carcinoma (3LL). Following the eatablishment of in vivo tumor models such as ascites form S-180, solid form S-180 and 3LL for estimating antitumor activity of Lactobacilli, optimal dose and injection route of heat-killed LC9018 for supperssion of local tumor were examined. Administration of 100ng/mouse of LC9018 significantly inhibited the growth of ascites form S-180, solid form S-180 and 3LL.

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The Effect of Salvia plebeia on Murine Macrophage-mediated Cytotoxicity

  • Um, Sung-Hee;Lee, Kang-Ro;Zee, Ok-Pyo;Pyo, SuhKneung
    • Natural Product Sciences
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    • v.2 no.1
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    • pp.43-47
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    • 1996
  • Macrophages play an important role in host defense against tumors by killing tumor cells. Our work is directed toward studying the effect of the extracts of Salvia plebeia on induction of antitumor activity in macrophages, since it has been usezd as a folk-medicine for the treatment of hepatitis and tumors. The ability of macrophage treated with the plant extracts to inhibit the growth of tumor cells was assessed. The Extracts of the plant induced antitumor activity and could enhance the tumoricidal activity of macrophages when used in combination with $IFN-{\gamma}$. These results suggest that Salvia plebeia extract contain immunomodulatory factors responsible for the induction of the antitumor activity.

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In vivo Antitumor Activity of Mansonone E isolated from Ulmus davidiana var. japonica NAKAI (느릅나무의 근피로부터 분리한 Mansonone E의 항암효과)

  • Cho, Choa-Hyung;Yoon, Won-Ho;Lee, Keyong-Ho
    • Korean Journal of Pharmacognosy
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    • v.35 no.3 s.138
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    • pp.199-202
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    • 2004
  • A highly potent antitumor sesquiterpene O-naphthoquionone has been isolated from Ulmus davidiana, which has been traditionally used as the folk medicine. The structure of this compound was established on the basis of spectral data obtained from UV, IR, MS, and NMR spectrometry, and determined as mansonone E. This compound showed potent antitumor activity on in vivo assay, hollow fiber and xenograft assay.

Use of cccDNA Breakage Assay and Sulforhodamine B Assay for the Prescreening of Antitumor Agents from Microbial Sources (미생물 배양액으로부터 항암제의 예비선별을 위한 cccDNA Breakage 활성검정과 Assay Sulforhodamine B 활성검정의 이용)

  • Lee, Sang-Han;Lee, Dong-Sun;Kim, Jong-Guk;Hong, Soon-Duck
    • Journal of Life Science
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    • v.8 no.1
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    • pp.67-71
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    • 1998
  • In order to develop new antitumor agents from fermentation broths, we used cccDNA breakage assay abd sulforhodamine B assay for prescreening. As a result, it was shown that sample reach 3.3% when using cccDNA breakage assay. In sulforhodamine B assay, we obtained 4 acive fraction against A549 (a cell line of human lung carcinoma) and SK-OV-3 (a cell line of human adenocarcinoma). These results suggest that these assay would be a promising method for antitumor prescreening from microbial sources.

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