Browse > Article

Antitumor Activity of Chitosan Oligosaccharides Produced in Ultrafiltration Membrane Reactor System  

Jeon, You-Jin (Faculty of Applied Marine Science, Cheju National University)
Kim, Se-Kwon (Faculty of Applied Marine Science, Cheju National University)
Publication Information
Journal of Microbiology and Biotechnology / v.12, no.3, 2002 , pp. 503-507 More about this Journal
Abstract
Chitosan oligosaccharides (COSs) were prepared and fractionated into three groups of COS [a high molecular weight COS (HMWCOS), medium molecular weight COS (LMWCOS), and low molecular weight COS (LMWCOS)] according to their molecular weight, using an ultrafiltration membrane enzymatic bioreactor designed earlier [8]. Antitumor activity of these COSs was then examined against Sarcoma 180 solid (S180) or Uterine cervix carcinoma No. 14 (Ul4) tumor cell-bearing mice. Among these COSs, MMWCOS with molecular weight range from 1.5 to 5.5 kDa effectively inhibited the growth of both tumor cells in the mice. In addition, the administration of MMWCOS resulted in increased thymus weight among lymphoid organs. The mice treated with MMWCOS showed improved survival rate and larger number of survivors after 40 days of feeding. The most effective of MMWCOS far antitumor activity in the S180- or U14-bearing mice was 20 mg/kg/day or more.
Keywords
Chitosan; oligosaccharide; antitumor; ultrafiltration; membrane;
Citations & Related Records
Times Cited By KSCI : 11  (Citation Analysis)
Times Cited By Web Of Science : 62  (Related Records In Web of Science)
연도 인용수 순위
1 Purification and characterization of extracellular chitinase produced by marine bacterium /
[ Lee, J.-S. D.-S. Joo;S.-Y. Cho;J.-H. Ha;E. -H. Lee ] / Bacillus sp. LJ-25. J. Microbiol. Biotechnol.   과학기술학회마을
2 Antimetastatic and growth-inhibitory effects of N-acetylchitohexaose in mice bearing Lewis lung carcinoma /
[ Tsukada, K.;T. Matsumoto;K. Aizawa;A. Tokoro;R.-S. Naruse;S. Suzuki;M. Suzuki ] / Jpn. J. Cancer Res.   DOI
3 Effect of antimicrobial activity by chitosan oligosaccharides N-conjugated with asparagine /
[ Jeon, Y.-J;S.-K. Kim ] / J. Microbiol. Biotechnol.   과학기술학회마을
4 Protective effect of N-acetyl chitohexaose on Listeria monocytogenes infection in mice /
[ Tokoro, A.;M. Kobayashi;N. Tatewaki;K. Suzuki;Y. Okawa;T. Mikami;T. S. Suzuki;M. Suzuki ] / Microbiol. Immunol.   DOI
5 Isolation and characterization of chitosanase-producing microorganism, Aureohactrium sp. YL, from crab shells /
[ Lee, D.;E. L. Lee;K. M. Lee ] / J. Microbiol. Biotechnol.   과학기술학회마을
6 Antitumor effect of hexa-N-acetylchitohexaose and chitohexaose /
[ Suzuki, K.;T. Mikami;Y. Okawa;A. Tokoro;S. Suzuki;M. Suzuki ] / Carbohydr. Res.   DOI   ScienceOn
7 Production of chitooligosaccharides using an ultrafiltration membrane reactor and their antibacterial activity /
[ Jeon, Y.-J;S.-K. Kim ] / Carbohydr. Polym.   DOI   ScienceOn
8 Preparation of chitin and chitosan oligomers and their applications in chitin and chitosan oligomers and their applications in physiological functional foods /
[ Jeon, Y.-J;F. Shahidi;S.-K.Kim ] / Food Rev. Int.   DOI   ScienceOn
9 The fungicidal effect of chitosan on fungi of varying cell wall composition /
[ Allan, C. R.;L. A. Hadwiger ] / Exp. Mycol.   DOI
10 Antibacterial action of chitosan /
[ Sudharshan, N. R.;D. G. Hoover;D. Knorr ] / Food Biotechnol.   DOI
11 Growth-inhibitory effect of hexa-N-acetylchitohexaose and chitohexaose against Meth-A solid tumor /
[ Tokoro, A.;N. Tatewaki;K. Suzuki;K. Mikami;S. Suzuki;M. Suzuki ] / Chem, Pharm. Bull.   DOI
12 Pythium aphanidermatum: Culture, cell wall composition, and isolation and structure of antitumor storage and solubilized cell-wall (1/leftrightharpoons3),(11/leftrightharpoons6)-β-D-glucans /
[ Blaschek, W.;J. Kasbauer;J. Kraus;G. Franz ] / Carbohydr. Res.
13 Bactericidal effects of chitosan from squid pens on oral Streptococci /
[ Shimojoh, M.;K. Masaki;K. Kurita;L. Fukoshima ] / Nippon Nogeikagaku Kaishi   DOI
14 Chitosan and gelatin based edible films: State diagrams, mechanical and permeation properties /
[ Arvanitoyannis, I. S.;A. Nakayama;S. Aiba ] / Carbohydr. Polym.   DOI   ScienceOn
15 Chemotactic response of human neutrophils to N-acetylchitohexaose in vitro /
[ Tokoro, A.;K. Suzuki;T. Matsumoto;T. Mikami;S. Suzuki;M. Suzuki ] / Microbiol. Immunol.   DOI
16 Chitosan oligomers from Fusarium solani/pea interactions, chitinase/-glucanase digestion of sporelings and from fungal wall chitin actively inhibit fungal growth and enhance disease resistance /
[ Kendra, D. F.;D. Christinan;L. A. Hadwiger ] / Physiol. Mol. Plant Path.   DOI
17 Antimicrogial effect of chitooligosaccharides produced by bioreactor /
[ Jeon, Y.-J.;P.-J. Park;S.-K. Kim ] / carbohydr. Polym.   DOI   ScienceOn
18 Purification and characterization of a chitinase from Cytophage sp. H.J. isolated from sea sand /
[ Lee, D.;H.-J. Noh;K. M. Lee ] / J. Microbiol. Biotechnol.   과학기술학회마을
19 (1/leftrightharpoons3)-β-D-glucans as biological response modifiers: A review of structure functional activity relationships /
[ Bohn, J. A.;J. N. BeMiller ] / Carbolhydr. Polym.   DOI   ScienceOn
20 Effect of N-acetylchitohexaose against Candida dlbicans infection of tumor-bearing mice /
[ Kobayashi, M.;T. Watanabe;S. Suzuki;M. Suzuki ] / Microbiol. Immunol.   DOI
21 Continuous production of chitooligosaccharides using a dual reactor system /
[ Jeon, Y.-J.;P.-J. Park;S.-K. Kim ] / Process Biochemistry   DOI
22 Antibacterial activity of shrimp chitosan against Escherichea coli /
[ Tsai, G. J.;W. H. Su ] / J. Food Protect.   DOI
23 Bioactive chitin derivatives. Activation of mouse-peritoneal macrophages by O-(carboxymethyl) chitins /
[ Nishimura, S.;N. Nishi;S. Tokura, K.;Nishimura;I. Azuma ] / Carbohydr. Res.   DOI   ScienceOn