Browse > Article

In vivo Antitumor Activity of Mansonone E isolated from Ulmus davidiana var. japonica NAKAI  

Cho, Choa-Hyung (Department of Food Engineering Iksan National College)
Yoon, Won-Ho (Department of Food Science & Technology Seoill College)
Lee, Keyong-Ho (Kolon Central Research Park)
Publication Information
Korean Journal of Pharmacognosy / v.35, no.3, 2004 , pp. 199-202 More about this Journal
Abstract
A highly potent antitumor sesquiterpene O-naphthoquionone has been isolated from Ulmus davidiana, which has been traditionally used as the folk medicine. The structure of this compound was established on the basis of spectral data obtained from UV, IR, MS, and NMR spectrometry, and determined as mansonone E. This compound showed potent antitumor activity on in vivo assay, hollow fiber and xenograft assay.
Keywords
Ulmus davidiana; hollow fiber assay; antitumor activity; mansonone E;
Citations & Related Records
Times Cited By KSCI : 1  (Citation Analysis)
연도 인용수 순위
1 은재순, 송원영(1994) 암세포주에 대한 유근피 n-BuOH 분획과 항암제의 병용효과. 생약학회지 25(20): 144-152
2 조승길, 이순교, 김창종(1996) 참느릅나무 근피수침엑스의 소염 진통작용. 생약학회지 27(3): 274-281
3 Mamo, K., Ueyama, Y, Inaba, M., Emura, R., Ohnishi, Y, Nakamura, O. Sato, O., and Nomura, T. (1990) Responsiveness of subcutaneous human glioma xenografts to various antitumor agents. Anticancer Res. 10(1): 209-212
4 Villamil, S. F., Dubin, M., Galeffi, C., and Stoppani, A. O. (1990) Effects of mansonones on lipid peroxidation, P450 monooxygenase activity, and superoxide anion generation by rat liver microsomes. Biochem. Pharmacol. 40(10): 23432351   DOI   ScienceOn
5 Lee, K. H., Lee, J. H., Cho, C. H., Noh, M. J., and Kim, Y. B. (2001) Radiosensitizing and topoisomerase I inhibitory effects of Aloe vera, Fonnitella fraxinea and Ulmus davidainas extracts. Natural Product Sciences 7(2): 60-62
6 홍남두, 노영수, 김남재, 김진식(1900) 유백피의 성분에 관한 연구. 생약학회지 12(3): 201-204
7 Chen, G. M., Chen, Z. T., and Hong, Y. L. (1990) A mansonone from Helicteres angustifolia. Phytochemistry 29(3): 980-982   DOI   ScienceOn
8 Nambiar, M. P., Muragesan, R., and Wu, H. C. (1998) Inhibition of the cytotoxicity of protein toxins by a novel plant metabolite, mansonone-D. Cell Physiol. 176(1): 40-49   DOI   ScienceOn
9 Tiew, P., Ioset, J. R., Kokpol, U., Chavasiri, W., and Hostettmann, K. (2003) Antifungal, antioxidant and larvicidal activities of compounds isolated from the heartwood of Mansonia gagei. Phytother Res. 17(2): 190193   DOI   ScienceOn
10 Lee, M. K., Sung, S. H., Lee, H. S., Cho, J. H., and Kim, Y. C. (2001) Lignan and neolignan glycosides from Ulmus davidiana Var. japonica. Arch. Pharm. Res. 24: 198-201   DOI   ScienceOn
11 문영희, 임기룡(1995) 참느릅나무의 성분에 관한 연구. 생약학회지 26(1): 1-7
12 Hollingshead, M. G., Alley, M. C., Camalier, R. F., Abbott, B. J., Mayo, J. G., Malspeis, L., and Grever, M. R. (1995) In vivo cultivation of tumor cells in hollow fibers. Life Science 57(2): 131-141   DOI   ScienceOn
13 Shin, D. Y, Kim, H. S., Min, K. H., Hyun, S. S., Kim, S. A., Huh, H., Choi, E. C., Choi, Y H., Kim, J. W., Choi, S. H., Kim, W. B., and Suh, Y G. (2000) Isolation of a potent anti-MRSA sesquiterpenoid quinone from Ulmus davidiana var. japonica. Chem. Pham. Bull. 48(11): 1805-1806   DOI   ScienceOn
14 Kim, J. P., Kim, W. G., Koshino, H., Park, J. H., Jung, J., and Yoo, I. D. (1996) Isolation and identification of sesquiterpene O-naphthoquinones, mansonone E, F and H, from the root bark of Ulmus davidiana Planch. 한국농화학회지 39(1): 89-94
15 이경화, 조좌형, 윤원호(2003) Hollow fiber 검색법과 Xenograft assah를 이용한 생약재의 암세포 저해활성 비교. 생약학회지 34(4): 288-292
16 Johnson, I. J., Gandhidasan, R., and Murugesan, R. (1999) Cytotoxicity and superoxid anion generation by some naturally occurring quinones. Free Radic. BioI. Med. 26(910): 1072-1078   DOI
17 Son, B. W., Park, J. H., and Zee, O. P (1989) Catechin glycoside from Ulmus davidiana. Arch. Pharm. Res. 12: 219222   DOI   ScienceOn
18 이은방, 정기화, 정춘식, 김옥경(1995) 느릅나무 수피 엑스가 흰쥐의 위염, 위궤양 및 발부종에 미치는 영향. 생약학회지 39(6): 671-675
19 Milbrodt, M., Konig, W. A., and Hausen, B. M. (1997) 7Hydorxy-2,3,5,6-tetrahydro-3,6,9-trimethyInaphtho[1,8B,C]pyran-4,8-dione from Thespesia populnea. Phytochemistry 45(7): 1523-1525   DOI   ScienceOn
20 김성환, 황금택, 박종철(1992) 참느릅나무 잎에서 flavonoid 성분의 분리 및 HPLC에 의한 정량. 생약학회지 23(4): 229-234
21 Kim, J. P., Kim, W. G., Koshino, H., Jung, J., and Yoo, I. D. (1996) Sesquiterpene O-naphthoquinones from the root bark of Ulmus davidiana. Phytochemistry 43(2): 425-430   DOI   ScienceOn
22 Tanaka, N., Yasue, M. and Imamura, H. (1967) The chemistry of wood extractives. X VII. Constituents of Mansonia altissima (Ill). 木林 學會誌 13(1): 16-20
23 Letcher, R. M. and Shirley, I. M. (1992) O-naphthoquinones from the heartwood of Azanza garckeana. Phytochemistry 31(12): 4171-4172   DOI   ScienceOn