• Journal of Mechanical Science and Technology
• /
• 제19권2호
• /
• pp.505-519
• /
• 2005

In this paper, we develop an anti-sway control in proposed techniques for an ATC system. The developed algorithm is to build the optimal path of container motion and to calculate an anti-collision path for collision avoidance in its movement to the finial coordinate. Moreover, in order to show the effectiveness in this research, we compared NNP PID controller to be tuning parameters of controller using NN with 2 DOF PID controller. The simulation and experimental results show that the proposed control scheme guarantees performances, trolley position, sway angle and settling time in NNP PID controller than other controller. As the results in this paper, the application of NNP PID controller is analyzed to have robustness about disturbance which is wind of fixed pattern in the yard. Accordingly, the proposed algorithm in this study can be readily used for industrial applications.

• Asian Pacific Journal of Cancer Prevention
• /
• 제16권3호
• /
• pp.863-868
• /
• 2015

Background: Artemisia species are important medicinal plants throughout the world. The present in vitro study, using a sesquiterpene lactone-bearing fraction prepared from Artemisia khorassanica (SLAK), sought to investigate anti-cancer properties of this plant and elucidate potential underlying mechanisms for the effects. Materials and Methods: Anti-cancer potential was evaluated by toxicity against human melanoma and fibroblast cell lines. To explore the involved pathways, pattern of any cell death was determined using annexin-V/PI staining and also the expression of Bax and cytochrome c was investigated by Western blotting. Results: The results showed that SLAK selectively caused a concentration-related inhibition of proliferation of melanoma cells that was associated with remarkable increase in early events and over-expression of both Bax and cytochrome c. Conclusions: The current experiment indicates that Artemisia may have anti-cancer activity. We anticipate that the ingredients may be employed as therapeutic candidates for melanoma.

• Biomolecules & Therapeutics
• /
• 제7권1호
• /
• pp.22-28
• /
• 1999

Induction of apoptosis is considered to be the underlying mechanism that accounts for the efficiency of chemotherapeutic drugs. It has recently been proposed that doxorubicin (DOX) can induce apoptosis in human leukemic cells via the Fas/Fas Ligand (FasL) system. Comparison of Fas and FasL mRNA expression between drug- and anti-Fas antibody(Fas-Ab)- induced apoptosis was analyzed for examining the role of Fas/FasL system in the mediation of drug-induced apoptosis. After HL-60 cells were routinely cultured, MTT assay was performed for cytotoxicity test. Giemsa staining was carried out to monitor the apoptosis morphologically. By semiquantitative RT-PCR analysis, the expression of Fas and FasL at 4, 10, 24 hours was determined after DOX and Fas-Ab treatment. Dose-dependent cytotoxicity was induced by DOX-treatment, while Fas-Ab treatment showed the similar dose-dependent pattern but the cytotoxicity is not reached at LD$_{50}$ at 100 ng/ml concentration of Fas-Ab. In the 10ng/m1 DOX and 10ng/m1 Fas-Ab treated group, typical apoptotic cell morphology was shown such as fragmented nuclei and cell membrane budding in the Giemsa-stained slide. Fas mRNA expression was not changed significantly in the both groups. But, FasL mRNA expression was induced significantly at initial period of apoptosis. In this study, Fas/FasL interaction assumed to be involved in drug-induced apoptosis.s.

• 한국컴퓨터정보학회논문지
• /
• 제11권4호
• /
• pp.291-297
• /
• 2006

본 논문에서는 하드카피 문서에 대한 새로운 재생산 방지 기법을 제안한다. 일반 프린터로 일반 용지에 출력한 원본 하드카피를 칼라 복사기로 복사하거나 스캐너로 스캔하여 다시 출력할 경우 원본 하드카피에 포함된 복사방지 패턴에 특별한 문구 패턴이 나타나 복사본임을 육안으로 구분할 수 있는 기술이다. 이를 위하여 본 논문에서는 제안하는 기법은 인간시각시스템(HVS: Human Visual System)의 칼라 인지특성을 이용 우선 배경과 칼라 복사기로 복사하거나 스캐너로 스캔하여 다시 출력할 경우 보일 이진 패턴 맵을 구현하고 원본을 출력하려는 프린너의 도트 게인과 하프토닝 특성을 테스트하는 단계, 하프톤 셀과 스폿을 생성하여 만들어진 하프톤 셀과 스폿을 사용하여 병치 감법혼합으로 농도가 잘 조절된 칼라패턴을 생성한다. 본 논문에서 제안한 하드카피 복사 방지 기법은 기존의 방법에 비해 고해상도 복사 방지 기법으로 유용한 방법이다.

• 대한의생명과학회지
• /
• 제29권4호
• /
• pp.280-286
• /
• 2023

In humic substances, fulvic acid (FA) is a subclass of diverse compounds known as humic substances, which are by-products of organic degradation from microorganisms. FA can suppress the proliferation of tumor cells. Despite numerous studies, the exact mechanism for the various effects of FA is not clearly understood. Based on results demonstrating anti-proliferation effects on human cancer, we investigated whether FA has similar effects on lung cancer in this study. Firstly, the anti-cancer effect of FA in pulmonary epithelial tumor cell lines (TC-1 cells) was examined by confirming its inhibitory effect on the cell proliferation of TC-1 cells. TC-1 cell proliferation was reduced by FA on a dose-dependent and time-dependent manner. After 24 hours of FA treatment, cell morphological changes such as cell volume decrease, non-adherence and increased number of apoptotic cells were clearly observed. In addition, FA induced a DNA ladder pattern by increased of DNA fragments in TC-1 cells. In the intracellular regulatory pathway by FA, we confirmed that FA induced the reduction of the anti-apoptotic protein, Bcl-2 protein levels. These results indicate that FA has anticancer effect by inducing intracellular apoptotic pathway. Further research on the mechanism of anticancer effects will be basic data for the development of potential anticancer drugs.

• 한국실내디자인학회논문집
• /
• 제40호
• /
• pp.34-41
• /
• 2003

A purpose of this study is to comprehend a concept of 'Open Space', realization of a deconstruction, presented in his works, based on a deconstruction and surrealism Coop Himmelblau's philosophical contemplation and to look into how this concept is interpreted in spaces. A concept of 'Open Space' is functioned as not a singular meaning but a multiple meaning accompanied with other formative ingredient and contemplation, scientific paradigm and a realation with a surroundings. The concept of 'Open Space' in their architentural space is applied. First, the space openness that represents to the extreme a concept 'Open Space', as a 3D designing ways that demolishes a structure and outgrows an ex siting thinking pattern, represents multiple grade spaces and an anti-gravity space. In a material, using glass and iron provides a spacial transparency and through this, visibly liberal sense that an interior and exterior is felt as an unification. Second, an non-expressive box pattern repulses to a spatial rank nature, outgrowing an uniform geometrical system, through demolishing a geometrical system, an edge and fold pattern. This is, as an anti-gravity, dynamic a typical structure, outgrowing an orthogonal system, interpreted as a composite meaning without division in spatial area. Third, the collage is used to represent a complexity and pluralism in representing 'Open space'. The collage that forms a image through combining a fragmentary elements into being a space change, composite constitution and spatial amusement. Thus, It is worthwhile to study how the collage that forms a diverse shape will be developed making what impact as an age and surroundings changed. As we contemplate in former part, Coop Himmelblou has deployed 'deconstruction beyond deconstruction' realm as just their midterm concept in their works like the words 'The architecture must climb', the deconstructive architect. A studying for their works reflecting the 'Open Space' concept based on deconstruction must be lasted and this enables us to comprehend space concept containing an architecture and interior design.

• 한국잡초학회지
• /
• 제16권4호
• /
• pp.346-353
• /
• 1996

중금속(Cd, Cu, Zn, Al) 처리하에서 생육시켰을때 봄여뀌(persicaria vulgaris Webb. et Moq)의 부위별 항산화효소활성 및 동위효소 pattern을 조사해 본 결과는 다음과 같다. 1. 잎과 줄기의 SOD활성은 감소되었으나, 뿌리에서는 증가되었다. 특히 Al처리하에서 자란 뿌리는 높은 SOD활성을 나타내었다. 2. Cd, Cu처리하에서 POD 활성은 중금속 및 농도간에 일정한 경향을 나타내지 않았고, Zn, Al 처리하에서는 억제되었으나, Zn 5000ppm, Al 500ppm 하에서 생육시킨 뿌리에서는 높은 활성을 나타내었다. 3 중금속처리시 CAT 활성은 잎에서 감소되었고, 뿌리에서는 농도가 증가할수록 활성이 뚜렷이 높아졌다. 특히, Al처리하에서 자란 뿌리가 가장 높은 활성을 나타내었다. 4 중금속처리에 따른 동위효소 pattern은 POD의 경우 한 개 band에서 동위효소의 출현없이 강도의 크기 변화만 나타났고, SOD의 동위효소 pattern 변화는 다양하였다.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
• /
• 제35권6호
• /
• pp.426-430
• /
• 2009

Purpose: Many patients in anti-platelet therapy have been consulted for bleeding risks before minor oral surgery. However, there has not been an established pretreatment protocol for treating these patients. The purpose of this study is to make a protocol for the preoperative management for patients in anti-platelet therapy. Patients and Methods: The existed consultation pattern of patients was examined in the Department of Oral and Maxillofacial Surgery, Yonsei Dental Hospital. Based on the observation, a protocol including classification of medical status of patients and the type of oral surgery in need was introduced. This protocol had been performed for 6 months. Result: Following this protocol, the frequency of consultation for bleeding risk was decreased. The number of minor oral surgeries with concurrent anti-platelet therapy was increased. There was no severe bleeding event observed among minor oral surgeries that were performed while maintaining anti-platelet therapy. Conclusion: This protocol can be used as a guideline for clinical practice of patients in anti-platelet therapy requiring minor oral surgery.

• 한국전자통신학회논문지
• /
• 제6권6호
• /
• pp.881-887
• /
• 2011

미국을 비롯한 선진국들은 배치 운용중인 개발 무기체계의 야전 운용자료를 수집 분석하여 신뢰도 유지여부를 확인하고 설계 재반영, 군수지원 요소 최적화를 위한 기초 경험자료 등으로 잘 활용하고 있으나 국내에서는 적용이 미흡한 실정이다. 따라서 본 논문에서는 국내 연구개발후 함정에 배치 운용 중인 ${\bigcirc}{\bigcirc}$대함유도탄을 대상으로 최근 6년간 ${\bigcirc}{\bigcirc}{\bigcirc}$발에 대한 구성품별 고장현황 등이 포함된 야전 운용자료를 수집하여 Weibull++ v7 소프트웨어에 입력후 모수적 추정방법을 이용하여 신뢰도를 분석하였다. 분석결과를 개발단계에서 분석된 유도탄과 구성품별 MTBF와 비교하여 초기신뢰도 유지여부를 분석하였고, 고장패턴과 검사주기 적절성도 확인하였다. 도출결과를 개발기관 및 품질보증기관, 제작사에 환류하여 RCM 분석을 통한 초기 신뢰도 회복 조치 및 총수명주기간 유지보수비가 절감되도록 정비정책에 대한 개선방안을 제시하였다.

• 한국자원식물학회:학술대회논문집
• /
• 한국자원식물학회 2018년도 춘계학술발표회
• /
• pp.91-91
• /
• 2018

Poncirus Fructus (PF) is obtained by drying the trifoliate orange fruit belonging to the Rutaceae family. In our country of medicine, PF has been used as a treatment of indigestion, allergy and inflammation. But Mechanism and medical data for PF is insignificant. Recently, the effect of the study PF of biological activity was reported, such as anti- thrombosis, anti-bacteria, anti-virus, anti- allergic. We investigated that the effect of PF on anti-inflammatory in murine macrophage-like cell line Raw264.7 cells. Our results show that the expression level of Nitric Oxide (NO) and Matrix-metallopeptidase-9 (MMP-9) significantly decreased. Moreover, to determine the expression level of pro-inflammatory cytokines such as Tumor Necrosis Factor ($TNF-{\alpha}$) and Interleukin-6 (IL-6) and the phosphorylation pattern of signaling molecules of mitogen-activated protein kinase (MAPK) family, we performed ELISA and westren blot in Raw264.7 cells. In addition, nuclear factor-kappa B ($NF-{\kappa}B$) pathway was confirmed. PF extract inhibited the production of $TNF-{\alpha}$ and IL-6. The extract suppressed the phosphorylation of ERK1/2, JNK, and p38 MAPK, and the nuclear translocation of $NF-{\kappa}B$ p65 in activated cells. Our results suggest that PF can be used as a potential therapeutic agent or functional food to relieve inflammation.