• 제목/요약/키워드: Anterograde

검색결과 37건 처리시간 0.027초

Isoflurane Induces Transient Anterograde Amnesia through Suppression of Brain-Derived Neurotrophic Factor in Hippocampus

  • Cho, Han-Jin;Sung, Yun-Hee;Lee, Seung-Hwan;Chung, Jun-Young;Kang, Jong-Man;Yi, Jae-Woo
    • Journal of Korean Neurosurgical Society
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    • 제53권3호
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    • pp.139-144
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    • 2013
  • Objective : Transient anterograde amnesia is occasionally observed in a number of conditions, including migraine, focal ischemia, venous flow abnormalities, and after general anesthesia. The inhalation anesthetic, isoflurane, is known to induce transient anterograde amnesia. We examined the involvement of brain-derived neurotrophic factor (BDNF) and its receptor tyrosine kinase B (TrkB) in the underlying mechanisms of the isoflurane-induced transient anterograde amnesia. Methods : Adult male Sprague-Dawley rats were divided into three groups : the control group, the 10 minutes after recovery from isoflurane anesthesia group, and the 2 hours after recovery from isoflurane anesthesia group (n=8 in each group). The rats in the isoflurane-exposed groups were anesthetized with 1.2% isoflurane in 75% nitrous oxide and 25% oxygen for 2 hours in a Plexiglas anesthetizing chamber. Short-term memory was determined using the step-down avoidance task. BDNF and TrkB expressions in the hippocampus were evaluated by immunofluorescence staining and western blot analysis. Results : Latency in the step-down avoidance task was decreased 10 minutes after recovery from isoflurane anesthesia, whereas it recovered to the control level 2 hours after isoflurane anesthesia. The expressions of BDNF and TrkB in the hippocampus were decreased immediately after isoflurane anesthesia but were increased 2 hours after isoflurane anesthesia. Conclusion : In this study, isoflurane anesthesia induced transient anterograde amnesia, and the expressions of BDNF and TrkB in the hippocampus might be involved in the underlying mechanisms of this transient anterograde amnesia.

Interconnections between the Rat Dorsal Raphe and the Locus Coeruleus Nuclei Demonstrated by Anterograde Tracing with Phaseolus Vulgaris Leucoagglutinin

  • Lee, Hyun S.
    • Animal cells and systems
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    • 제8권3호
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    • pp.221-229
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    • 2004
  • The projections from the dorsal raphe (DR) to the locus coeruleus (LC) or vice versa were analyzed in the rat using an anterograde tracer, Phaseolus vulgaris leucoagglutinin (PHA-L) combined with serotonin (5-hydroxytryptamine, 5-HT) or dopamine-beta-hydroxylase (DBH) immunostaining. Following the injection of PHA-L into the middle DR, DR-originating fibers with varicosities have contacted DBH-immunolabeled cells in the rostral, middle, and caudal LC. Axon terminals were also observed in the subcoeruleus nucleus. When the PHA-L injection was confined within the caudal DR, axonal fibers with varicosities were observed mainly at the rostral pole of the LC. Following the injection of PHA-L into the caudal, principal LC, labeled fibers with varicosities have contacted 5-HT-immunolabeled neurons at dorsomedial, ventromedial, lateral wing, and caudal sub-divisions of the DR. The present anterograde study suggests that the DR or the LC nuclei communicate with each other in order to perform a variety of functions including vigilance, analgesia, and stress responses.

Intramedullary Screw Fixation for Clavicle Shaft Fractures: Comparison of the Anterograde versus the Retrograde Technique

  • Rhee, Yong Girl;Cho, Nam Su;Cho, Sung Whan;Song, Jong Hoon
    • Clinics in Shoulder and Elbow
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    • 제19권1호
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    • pp.8-14
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    • 2016
  • Background: The purpose of this study was to investigate the difference between two nailing approaches of intramedullary screw fixation, the retrograde nailing versus the anterograde nailing, on the radiological and clinical outcomes in patients with clavicle shaft fractures. Methods: From April 2002 to August 2014, we enrolled a total of 22 patients with clavicle shaft fractures to participate in this study. Twelve patients received retrograde intramedullary nailing and 10 received anterograde nailing. The average duration of follow-up was 12 months. In all the patients, we took follow-up radiographs of the anteroposterior and the axial views to assess the postoperative radiological outcomes. We measured the visual analogue scale (VAS) score, American Shoulder and Elbow Surgeons (ASES) score, and the range of motion (ROM). Results: Clinically, we did not find a statistically significant difference in the retrograde group and the anterograde group in terms of the duration to bone union, the VAS score the ASES score and the ROMs. Radiologically, we found that the difference in the clavicle shortening of the affected arm and the unaffected arm did not show a statistically significant difference at the immediate postoperative assessment. we found that the difference in the clavicle shortening of the affected arm between the immediate postoperative and the final follow-up value did not show a statistically significant difference. Conclusions: We found that both the retrograde nailing and the anterograde nailing gave a favorable outcome for clavicle shaft fractures. Although we saw evidence of clavicle shortening after intramedullary screw fixation, this was not a factor that influenced clinical outcome.

Midazolam 투여시 선행성 건망증 발현에 관한 연구 (ANTEROGRADE AMNESIC EFFECT OF MIDAZOLAM)

  • 이정하;김미라;이난영;이상호
    • 대한소아치과학회지
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    • 제31권3호
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    • pp.412-420
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    • 2004
  • 최근 의식하 진정요법에 많이 이용되고 있는 Midazolam의 임상적 효과로는 항불안, 진정, 수면, 항경련, 근이완, 기억상실 등이 있는데, 이중 기억상실효과는 주로 선행성 건망증(anterograde amnesia)으로 약물투여 후 약물의 작용이 지속되는 동안에 경험한 일들을 기억하지 못하는 현상이다. 이는 시술 중환자의 협조를 얻을 수 있으면서도 시술 후 환자는 시술중의 불편한 과정을 기억하지 못하는 효과를 얻을 수 있다는 임상적 장점이 있다. 본 연구는 Midazolam 투여 시 선행성 건망증의 발현 양상을 평가할 목적으로 약물에 대한 기왕력이 없으며 미국 마취학회 전신상태 평가기준에 따라 1등급으로 판정된 조선대학교 치과대학에 재학중인 학생 15명을 대상으로 위약, 경구용 Midazolam투여 주사용 Midazolam의 비강내 투여 후 Snograss와 Vanderwart에 의해 표준화된 260개 그림 시리즈를 이용하여 선행성 건망증의 발현정도를 평가한 결과 다음과 같은 결론을 얻었다. 1. Midazolam의 경구투여와 비강내 투여 시 선행성 건망증의 정도가 위약에 비해 유의하게 높았다(P<0.01). 2. Midazolam의 비강내 투여시 선행성 건망증의 정도가 경구투여보다 높았으나 유의한 차이는 없었다(P>0.01). 3. Midazolam의 경구투여와 비강내 투여 모두 약물투여 15분 후부터 선행성 건망증을 보이기 시작하여 경구투여시는 45분, 비강내 투여시는 30분에 가장 높은 효과를 보였다. 4. 약물투여 30분이 지나면서 비강내 투여보다 경구투여에서 선행성 건망증의 정도와 진정정도가 더 높았으나 유의한 차이는 없었다(P>0.01). 본 결과로 미루어 보아Midazolam을 투여한 후 선행성 건망증은 경구투여와 비강내 투여 모두 약물투여 15분 후부터 나타났으며 30분전까지는 비강내 투여에서, 30분이 지나면 경구투여에서 더 높은 효과를 보이는 경향이 관찰된 바, 치과치료 시 Midazolam의 경구투여와 비강내 투여를 이용한 의식진정요법을 시행함에 있어 국소마취 등의 고통스러운 과정은 최소 약물투여 15분 후 시행하는 것이 향후 치과진료에 대한 환자의 긍정적 자세를 유도하는데 도움이 되리라 사료된다.

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미다졸람 근주요법을 이용한 자폐증 환자의 우식치료 : 증례보고 (INTRAMUSCULAR MIDAZOLAM SEDATON IN AUTISM PATIENT FOR CARIES TREATMENT : CASE REPORT)

  • 배영은;노태환;김보미;정태성
    • 대한장애인치과학회지
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    • 제11권1호
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    • pp.17-20
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    • 2015
  • Autism is a life-long neurodevelopmental disorder characterized by qualitative abnormalities in reciprocal social interactions and patterns of communication. Patients with autism are difficult to manage during dental treatment. Thus they need special consideration like physical restraint, conscious sedation or general anesthesia. A 5-year-old male dental patient with autism was reffered to dental treatment under conscious sedation using intramuscular midazolam that creats anterograde amnesia. Dental procedure using midazolm which cause anterograde amnesia can be effective treatment strategy in autism patient.

급성 글루포시네이트 암모니움 중독 후 양측성 해마 병변과 전향적 기억상실증을 보인 증례 1례 보고 (A Case of Anterograde Amnesia with Bilateral Hippocampus Involvement After Acute Glufosinate Ammonium Intoxication)

  • 윤성원;김호균;이희중
    • Investigative Magnetic Resonance Imaging
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    • 제18권4호
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    • pp.352-356
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    • 2014
  • 본 증례의 51세 남자 환자는 글루포시네이트 암모니움을 과다 섭취한 후에 전향적 기억상실증이 발생하였다. 뇌 자기공명영상에서 양측 해마와 해마옆이랑, 오른쪽 후두엽에서 고신호강도 병변을 관찰할 수 있었다. 급성 글루포시네이트 암모니움 중독이 해마에 병변을 만드는 기전과, 양측성 해마에서 생길 수 있는 질환들의 감별진단에 대하여 논하고자 한다.

Sacral Nerve Stimulation Through the Sacral Hiatus

  • Park, Chan-Hong;Kim, Bong-Il
    • The Korean Journal of Pain
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    • 제25권3호
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    • pp.195-197
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    • 2012
  • Sacral nerve stimulation through the retrograde approach has been used for peroneal or irritable bowel syndrome through the retrograde approach. However, several reasons, lead could not be advanced down ward. In this case, anterograde sacral nerve stimulation through the sacral hiatus could be used. The aim of this report is to present of technique of sacral nerve root stimulation through the sacral hiatus approach.

Glufosinate ammonium 중독 후에 발생한 해마 손상에 의한 선행성 기억상실 1례 (A Case of anterograde amnesia with hippocampal lesions following glufosinate intoxication)

  • 설승환;박현수;안정환;박희영;이필휴;김기운
    • 대한임상독성학회지
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    • 제4권1호
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    • pp.61-64
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    • 2006
  • Glufosinate ammonium (GLA), a phosphinic acid derivate of glutamate, is a broad-spectrum contact herbicide. It structurally resembles glutamate, a typical excitatory amino acid in the central nervous system. In korea, the ingestion of GLA for suicidal attempt or accidental event has increased. The neurological complication of GLA intoxication are characterized by loss of consciousness, convulsion, or memory impairment. But, the exact mechanism of GLA toxicity is yet unknown. This report is about a patient with GLA intoxication who showed anterograde amnesia with selective bilateral hip-pocampal lesions supported GLA intoxication with literature reviews supported.

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Projections from the Prefrontal Cortex to the Dorsal Raphe Nucleus of the Rat

  • Lee, Hyun S.;Kim, Myung-A
    • Animal cells and systems
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    • 제6권2호
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    • pp.159-165
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    • 2002
  • Projections from the prefrontal cortex to subdivisions of the dorsal raphe nucleus were investigated in the rat using retrograde and anterograde tracing methods. A retrograde tracer, gold-conjugated horseradish peroxidase (WGA-apo-HRP-gold), was injected into each subdivision of the dorsal raphe including lateral wing, dorsomedial, and ventromedial areas. The majority of retrogradely labeled cells were located in the prelimbic, infralim-bic, and dorsal peduncular areas of the medial prefrontal cortex. A few cells were also identified in the cingulate, various regions of the orbital, and agranular insular cortices. Secondly, an anterograde tracer, Phaseolus vulgaris leucoagglutinin (PHA-L), was injected into the medial prefrontal cortex involving the prelimbic or infralimbic areas. Axonal fibers with varicosities were identified in all subdivisions of the DR including the lateral wing, dorsomedial, and ventromedial areas. Projections were bilateral, with ipsilateral predominance. Axonal fibers were observed at the lateral border of medial longitudinal fasciculus or in the interfascicular region at the midline. The present findings demonstrate that both the midline and lateral wing regions of the dorsal raphe nucleus receive excitatory input from cognitive and emotional centers of the cerebral cortex.

Midazolam을 이용한 의식하진정법을 시행한 환자에서 나타난 선행성 및 후행성 기억상실 (Retro- and Ante-grade Amnesia after Conscious Sedation using Midazolam)

  • 김영욱;금윤선;모동엽;이장렬;김현철;이상철
    • 대한치과마취과학회지
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    • 제11권2호
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    • pp.153-158
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    • 2011
  • Midazolam is known to produce sedation as well as amnesia. Many articles reported about anterograde amnesia, but it is rare that articles about retrograde amnesia. The 61-year-old female patient (64 kg, 154 cm, ASA physical status I) was administered 3.02 mg (0.047 mg/kg) of midazolam during 2 hours. The patient's Modified Observer's Assesment of Alertness/Sedation Scale was 4. The patient who had been consciously sedated with midazolam, exhibited profound amnesia, both anterograde and retrograde after implantation. The patient's memory restoration was begun after 6 hours.