Journal of The Korean Dental Society of Anesthesiology (대한치과마취과학회지)

The Korean Dental Society of Anesthsiology (대한치과마취과학회)
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Retro- and Ante-grade Amnesia after Conscious Sedation using Midazolam

Midazolam을 이용한 의식하진정법을 시행한 환자에서 나타난 선행성 및 후행성 기억상실

  • Kim, Yeong-Wook (Department of Oral & Maxillofacial Surgery, LivingWell Dental Hospital) ;
  • Keum, Yoon-Seon (Department of Oral & Maxillofacial Surgery, LivingWell Dental Hospital) ;
  • Mo, Dong-Yub (Department of Oral & Maxillofacial Surgery, LivingWell Dental Hospital) ;
  • Lee, Jang-Yeol (Department of Oral & Maxillofacial Radiology, LivingWell Dental Hospital) ;
  • Kim, Hyoun-Chull (Department of Oral & Maxillofacial Surgery, LivingWell Dental Hospital) ;
  • Lee, Sang-Chul (Department of Oral & Maxillofacial Surgery, LivingWell Dental Hospital)
  • 김영욱 (리빙웰치과병원 구강악안면외과) ;
  • 금윤선 (리빙웰치과병원 구강악안면외과) ;
  • 모동엽 (리빙웰치과병원 구강악안면외과) ;
  • 이장렬 (리빙웰치과병원 구강악안면방사선과) ;
  • 김현철 (리빙웰치과병원 구강악안면외과) ;
  • 이상철 (리빙웰치과병원 구강악안면외과)
  • Received : 2011.09.29
  • Accepted : 2011.12.24
  • Published : 2011.12.31
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Abstract

Midazolam is known to produce sedation as well as amnesia. Many articles reported about anterograde amnesia, but it is rare that articles about retrograde amnesia. The 61-year-old female patient (64 kg, 154 cm, ASA physical status I) was administered 3.02 mg (0.047 mg/kg) of midazolam during 2 hours. The patient's Modified Observer's Assesment of Alertness/Sedation Scale was 4. The patient who had been consciously sedated with midazolam, exhibited profound amnesia, both anterograde and retrograde after implantation. The patient's memory restoration was begun after 6 hours.

Keywords

References

  1. 김기준, 김지영, 이종진, 이기영: Midazolam에 의한 선행성 및 후행성 기억 상실에 대한 flumazenil의 가역 효과. 대한마취과학회지, 2002; 42: 241-4
  2. 이석강: 인체 생리학. 제3판. 서울, 계축문화사. 2004, pp 611, 624-5.
  3. Bernstein DA: Psychology. 3rd ed. Geneva, Houghton Mifflin company. 1994, pp 217, 299, 315, 543, 230, 300.
  4. Chernik DA, Gillings D, Laine H, Hendler J, Silver JM, Davidson AB, et al: Validity and reliability of the Observer's Assessment of Alertness/Sedation Scale: study with intravenous midazolam. J Clin Psychopharmacol 1990; 10: 244-51.
  5. Ghoneim MW, Mewaldt SP: Benzodiazepines and human memory: a review. Anesthesiology 1990; 72: 926-38. https://doi.org/10.1097/00000542-199005000-00024
  6. Khanderia U, Pandit SK: Use of midazolam hydrochloride in anesthesia. Clin Pharmacol 1987; 62: 310- 24.
  7. Koht A, Moss JI: Does midazolam cause retrograde amnesia, and can flumazenil reverse that amnesia? Anesth Analg 1997; 85: 211-2
  8. Lydiard RB: The role of GABA in anxiety disorders. J Clin Psychiatry 2003; 64: 21-7.
  9. Peterson LJ, et al: Principles of oral & maxillofacial surgery. 1st ed. Philadelphia, JB Lippincontt co. 1992, pp 125-31.
  10. Reder LM, Oates JM, Dickison D, Anderson JR, Gyulai F, QuinLan JJ, et al: Retrograde facilitation under midazolam: The role of general and specific interference. Psychon Bull Rev 2007; 14: 261-9. https://doi.org/10.3758/BF03194062
  11. Squire LR, Alvarez, P: Retrograde amnesia and memory consolidation: A neurobiological perspective. Current Opinion in Neurobiology 1995; 5: 169-77. https://doi.org/10.1016/0959-4388(95)80023-9
  12. Takano M, Takano Y, Sato I: The effect of midazolam on the memory during cesarean section and the modulation by flumazenil. Masui 1999; 48: 73-5
  13. Twersky RS, Hartung J, Berger BJ, McClain J, Beaton C: Midazolam enhances anterograde but not retrograde amnesia in pediatric patients. Anesthesiology 1993; 78: 51-5. https://doi.org/10.1097/00000542-199301000-00009
  14. Wixted, JT: The psychology and neuroscience of forgetting. Annual Review of Psychology 2004; 55: 235-9. https://doi.org/10.1146/annurev.psych.55.090902.141555