• Journal of Environmental Health Sciences
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• v.33 no.4
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• pp.306-316
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• 2007

This study have a object to found out the effects of oriental herb medicine, Antaeeum, to dams of rats and their offsprings. The Antaeeum was savaged to female Sprague-Dawley rats at a dose of 5 mg/kg/day for 3 weeks during gestation periods. Dams of rat were sacrificed at 20th day of gestation, and were observed major internal and reproductive organs. Approximately live fetuses in the 20th days of gestation were selected randomly and examined with stereo microscopes. Others offsprings were fixed with 95% ethanol for skeletal examinations. The fixed fetuses were stained with alcian blue and alizarin red S to observe skeletal variations or malformations. Maternal body weight of Antaeeum treated dams have a tendency of increasing compared with control dams. There were no significant difference in internal and reproductive organs of weight or findings. The spleenic organ relative weight of treated dams were decreased compared with the control significaltly (p<0.05). There were no significant changes between two groups in blood chemistry and hematological values. There were no significant changes in number of corpus luteum, implantation, live fetuses and implantation rate, delivery rate, late resorption rate and sex ratio. But in the Antaeeum treated group showed lower early resorption rate than that of the control dams. Fetal body weight and number of fetus a dam at Antaeeum treated group were higher than that of control group. The fetuses of dams treated with Antaeeum didn't induced external malformations. Vertebral and sternal variations were observed in Antaeeum group, but compared with the control, those variations were not significant. The ossification numbers of rib, cervical, thoracic, and lumber were normal. Fetuses treated with Antaeeum to the dams showed no significant difference in the number of caudal vertebra (P>0.01). From these results, it can be concluded that Antaeeum showed no toxicity effects on maternal side especially on body weight, early resorption rate, and number of live fetuses. Also there were no significant changes on maternal organ weights except spleen, hematological data, reproductive organs. Although skeletal variations were examined at vertebra and sternum, this Antaeeum could not induced significant choses in bone malformation.

• Journal of Korean Medical Ki-Gong Academy
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• v.13 no.1
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• pp.36-45
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• 2013

Objective : We studied whether Antaeeum and Saahm Spleen-tonifying acupuncture had effects of prolonging pregnancy in pregnant women with pre-eclampsia. Methods : We have administered Antaeeum and applied Saahm Spleen-tonifying acupuncture for 8 weeks and the patient stopped taking steroids she had taken before. Furthermore, we observed edema, fatigue, albuminuria and hypertension. Results : In consequence of administering Antaeeum and applying Saahm Spleen-tonifying acupuncture for 8 weeks, edema and fatigue were improved and albuminuria and hypertension were not changed significantly. However pregnancy was prolonged from 28 weeks to 36 weeks and the patient could give birth successfully. Conclusions : In conclusion, Antaeeum and Saahm Spleen-tonifying acupuncture have effects of prolonging pregnancy in patients with pre-eclampsia.

• The Journal of Korean Obstetrics and Gynecology
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• v.30 no.3
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• pp.146-157
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• 2017

Objectives: This study was performed to assess the effectiveness of Korean medicinal treatments including Antaeeum-gamibang on posterior neck pain and lower back pain caused by traffic accidents during pregnancy. Methods: Patients were treated by Antaeeum-gamibang, acupuncture and Chuna manual therapy. To measure treatment outcomes, Numerical rating scale (NRS), Oswestry disability index (ODI), Neck disability index (NDI), European Quality of Life-5 Dimensions (EQ-5d), and range of motion (ROM) were used. Results: After treatment, the average NRS of posterior neck pain significantly decreased from $4.20{\pm}1.30$ to $1.80{\pm}0.45$ and the average NRS of lower back pain significantly decreased from $6.40{\pm}1.14$ to $2.20{\pm}0.84$. ODI significantly decreased from $41.42{\pm}17.79$ to $28.29{\pm}14.69$, NDI significantly decreased from $34.93{\pm}9.85$ to $20.27{\pm}8.96$. EQ-5d and ROM improved at all cases. Conclusions: Korean Medicinal treatments including Antaeeum-gamibang may be effective in the treatment of posterior neck pain and lower back pain caused by traffic accidents during pregnancy. However, more case reports and studies are required to identify exactly what treatment is more efficient.

• The Journal of Korean Obstetrics and Gynecology
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• v.27 no.4
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• pp.141-149
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• 2014

Objectives: The purpose of this study is to report the effects of herbal medicine and acupuncture on ovarian hyperstimulation syndrome (OHSS). Methods: A patient who had OHSS with edema and pain of left leg as chief complaints was treated by herbal medicne and acupuncture for 11days. We evaluated the results of treatment by change of symptoms, circumference of left leg, Visual Analogue Scale about left leg pain and walking time. Results: After treatment, symptoms of OHSS were almost improved. Circumference and pain of left leg were reduced and walking time was incresed after treatment. Conclusions: This study suggests that Korean medicine mainly herbal medicine and acupuncture is effective on OHSS.

• The Journal of Korean Obstetrics and Gynecology
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• v.32 no.3
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• pp.73-85
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• 2019

Objectives: The purpose of this study was to analyze efficacy and safety of Korean Medicine treatment for traffic accidents during pregnancy. Methods: We investigated the studies on Korean Medicine treatment for traffic accidents during pregnancy via searching through PUBMED, the Cochrane Library, CNKI, and domestic search engines and a total of 6 studies were selected. Results: The major complaints of traffic accidents during pregnancy were low back pain, neck pain and gastrointestinal symptoms. And there were vaginal bleeding and pruritus vulvae in the complaints. All of the studies were given acupuncture treatment for symptom relief, and chuna, herbal acupuncture and cupping were administered. Herbal medicine was also performed, and the most prescribed herbal medicine was Antaeeum-gamibang. All cases reported as traffic accidents during pregnancy showed a reduction in symptoms, normal pregnancy maintenance and delivery, and no miscarriage were reported. Conclusions: Korean Medicine treatment is an effective and safe treatment option for traffic accidents during pregnancy. Further systematic studies are needed to establish the basis for Korean Medicine treatment for traffic accidents during pregnancy.

• The Journal of Korean Medicine
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• v.21 no.3
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• pp.166-173
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• 2000

Objectives : These experiments were undertaken to evaluate the effect of the administration on Korean herbal medicines, Kyoaekungkue-tang, Bojungykki-tang, Kungso-san, Antae-eum, and Antaegumchul-tang, on the reproductive functions in pregnant mice. Methods : Prepared herbal medicines(Kyoaekungkue-tang, Bojungykki-tang, Kungso-san, Antae-eum, Antaegumchul-tang) were administered to three different pregnant staged mice. We designed 3 experiments as follows; prepared herbal medicine administered from ovulation to embryo implantation (Experiment I), or administered after implantation to fetal organogenesis (Experiment II) and lastly administered from end of organogenesis to parturition (Experiment III). At day 14 of pregnancy, the whole uteri of half of the treated mice were retrieved from the Experiment I and in the Experiment II the implantation and mean weight of the fetuses were examined. The mean numbers of offspring, sex ratio and mean birth weight were examined in the other half of the mice. Results : The results from these studies were summarized as followed; 1. From the experiment I (administered from ovulation to embryo implantation), the no. of implantation between control and herbal medicine treated groups were shown similar results. Litter size after parturition was significantly decreased in the herbal medicine treated groups, except for Antaegumchul-tang. However, the mean weight of offspring after parturition showed a tendency to increase in the three herbal medicine treated groups. 2. From the experiment II (administered after implantation to fetal organogenesis), the implantation rates from the herbal medicine treated groups increased more significantly than that of the control Also, litter size and birth weight in the herbal medicine groups, except Antaeeum, increased more significantly than that of the control group. 3. From the experiment III group (administered after organogenesis to parturition), the mean number of offspring in Kyoaekungkue-tang and Antaegumchul-tang treated groups were significantly increased than that of control However, the litter size of the Kungso-san treated mice was significantly decreased compared with that of the control group. Compared with the control and other herbal treated groups, the mean weight of fetuses after parturition in the Kyoaekungkue-tang and Antaegumchul-tang treated groups increased significantly. Conclusions : From these results, it can be concluded that Antaegumchul-tang showed more beneficial effects on the reproductive functions, implantation, maintenance of pregnancy, litter size and mean weight than other herbs.