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http://dx.doi.org/10.5668/JEHS.2007.33.4.306

The Effects of the Administration on Oriental Medicine, Antaeeum, in the Pregnant Rat and Their Fetuses  

Kim, Chang-Seok (Department of Preventive Medicine, College of Traditional Korean Medicine, SangJi University)
Park, Hae-Mo (Department of Preventive Medicine, College of Traditional Korean Medicine, SangJi University)
Lee, Sun-Dong (Department of Preventive Medicine, College of Traditional Korean Medicine, SangJi University)
Lee, Jang-Woo (Department of Occupational & Environmental Health, Yongin University)
Kim, Pan-Gyi (Department of Occupational & Environmental Health, Yongin University)
Shin, Heon-Tae (Department of Preventive Medicine, College of Traditional Korean Medicine, SangJi University)
Publication Information
Journal of Environmental Health Sciences / v.33, no.4, 2007 , pp. 306-316 More about this Journal
Abstract
This study have a object to found out the effects of oriental herb medicine, Antaeeum, to dams of rats and their offsprings. The Antaeeum was savaged to female Sprague-Dawley rats at a dose of 5 mg/kg/day for 3 weeks during gestation periods. Dams of rat were sacrificed at 20th day of gestation, and were observed major internal and reproductive organs. Approximately live fetuses in the 20th days of gestation were selected randomly and examined with stereo microscopes. Others offsprings were fixed with 95% ethanol for skeletal examinations. The fixed fetuses were stained with alcian blue and alizarin red S to observe skeletal variations or malformations. Maternal body weight of Antaeeum treated dams have a tendency of increasing compared with control dams. There were no significant difference in internal and reproductive organs of weight or findings. The spleenic organ relative weight of treated dams were decreased compared with the control significaltly (p<0.05). There were no significant changes between two groups in blood chemistry and hematological values. There were no significant changes in number of corpus luteum, implantation, live fetuses and implantation rate, delivery rate, late resorption rate and sex ratio. But in the Antaeeum treated group showed lower early resorption rate than that of the control dams. Fetal body weight and number of fetus a dam at Antaeeum treated group were higher than that of control group. The fetuses of dams treated with Antaeeum didn't induced external malformations. Vertebral and sternal variations were observed in Antaeeum group, but compared with the control, those variations were not significant. The ossification numbers of rib, cervical, thoracic, and lumber were normal. Fetuses treated with Antaeeum to the dams showed no significant difference in the number of caudal vertebra (P>0.01). From these results, it can be concluded that Antaeeum showed no toxicity effects on maternal side especially on body weight, early resorption rate, and number of live fetuses. Also there were no significant changes on maternal organ weights except spleen, hematological data, reproductive organs. Although skeletal variations were examined at vertebra and sternum, this Antaeeum could not induced significant choses in bone malformation.
Keywords
Antaeeum; oriental medicine; dams; implantation rate; early resolution rate; late resorption rate; variation; malformation;
Citations & Related Records
Times Cited By KSCI : 1  (Citation Analysis)
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1 朱震亨, 方廣 編註 : 丹溪心法附餘, 서울: 大星文化社, 747-757, 1993
2 Eisenberg, D. M., Davis, Ettoner, S. L., Apples, Wilkeys, Rompay M. V., etc : Trend in Alternative Medicine Use in the United States. 1990-1997. Results of Follow-up National Suney JAMA 280 : 1569-75, 1998
3 정진탁 : 임신중 금기약물에 관한 문헌적 조사. 대한한방부인과학회지, 1(1), 32-39, 1987
4 Hayes, A.W. : Principles and methods of toxicology. 2nd, 3rd eds., Raven Press, New York, 1990
5 Doull, J., Curtis D. Kleassen and Mary O. Andur : Toxicology; The basic science if poisons. Third eds., 1985
6 黃星熹 : A study on the estrogenicity and reproductive toxicity by single or combined treatment of bisphenol A and/or benzyl butyl phthalate during gestation and lactation period in rats. 서울대학교. 2001
7 이학식, 임지훈. SPSS 12.0 매뉴얼. 법문사. 2005
8 조주연, 김인규, 이규형 : 약 환경과 선천성기형 관계에 관한 연구. 대한산부회지, 38(10), 1871-1880, 1995
9 이재성, 장준복, 송병기 : 한약이 임신중 태아에 미치는 영향. 대한한의학회지, 19(2), 17-35, 1998
10 劉完素 : 素問病機氣宜保命集, 서울: 도서출판 정담, 90, 1992
11 김동현, 김남재, 장준복, 송병기 : 한약이 임신중 태아에 미치는 영향(II)- 한약이 돌연변이원성과 염색체이상에 미치는 영향. 대한한의학회지, 20, 321-327, 1999
12 陳目明 : 婦人大全良方, 中國: 人民衛生出版社, 348-357, 1991
13 信, 王林等校註 : 古今醫鑑, 中國: 江西科學技術出版社, 324, 1990
14 武之望 : 濟陰綱目, 大成出版社, 서울, 234-237, 1990
15 허지원, 조정훈, 장준복, 이경섭 : 꽃마을 한방병원에서 임신중 한약을 투여받은 환자 146례에 대한 실태 분석연구. 대한한방부인과학회지, 15(3), 129-138, 2002
16 신용완, 이정은, 이보라, 신경숙, 정진홍, 유동열 : 가미당귀적을 투여한 임신병환자 7례에 대한 임상보고. 대한한방부인과학회지, 16(4), 180-188, 2003
17 何時希 : 本草求眞, 學林出版社, 臺北, 46-48, 89-91, 1985
18 대한산부인과학회 : 부인과학, 서울현대의학서적사, 서울, 73, 1987
19 全國韓醫科大學本草學敎授共編著 : 本草學, 서울 永林社 71, 178, 294, 347, 409, 536, 540, 578-582, 1991
20 신규원, 이선동, 박해모, 전성진, 변진석 : 다용 한약처방투여가 흰쥐의 신장 기능에 미치는 영향. -십전대보탕, 보중익기탕, 오적산 및 육미지황탕을 중심으로-. 대한예방한의학회지, 9(1), 119-133, 2005
21 양영호, 손인숙, 송찬호 : 선천성기형에 대한 임상적 고찰. 대한산부인과학회지, 36(7), 2294-2298, 1993
22 김판기, 황성희, 김대용, 석지현, 권은아 : 임신랫드에 투여한 Butyl Benzyl Phthalate가 차산자에 미치는 영향. 한국환경위생학회지, 26(1), 85-94, 2000
23 張志聰 : 侶山常類辨, 人民衛生出版社, 北京, 83-84, 1983
24 張介賓 : 景岳全書(上冊), 上海科學技術出版社, 上海, 657-658, 1959
25 武之望 : 濟陰綱目, 大成出版社, 서울, 234-237, 1990
26 李 : 原本編註醫學入門, 서울: 南山堂, 717-718, 747, 776-778, 1639-1641, 1991
27 羅元愷 : 實用中義婦科學, 中國: 上海科學技術出版社, 128-129, 1994
28 李時珍 : 本草綱目, 人民衛生出版社, 北京, 883-887, 1977
29 費 中 外 : 藥物與姙娠, 上海人民衛生出版社, 上海, 1-25, 1988
30 張景岳, 羅元愷 点注 : 婦人規, 中國: 廣東科技出版社, 134, 182, 1986
31 김종일 : 선천성기형에 대한 연구. 대한산부인과학회지, 35(12), 1720-1729, 1992
32 허준 : 동의보감, 남산당, 서울, 964, 1204, 1966
33 방형애, 이용욱, 서난주, 장일무 : 한국차 원료에 대한 독성 연구-변이원성 검색. 생약학회지, 21(1), 83-87, 1990
34 송병기 : 한방부인과학, 서울: 행림출판, 375-383, 394, 1991
35 巢元方 : 巢氏諸病源候論, 서울: 대성문화사, 300, 1992
36 羅元愷 主篇 : 中醫婦科學, 中國: 人民衛生出版社. 185-197, 1995
37 의학교육연구원 : 가정의학. 서울:서울대학교출판부, 554, 1996
38 이정석, 이선동 : 한.양약 복용이 간기능에 미치는 영향. 대한예방한의학회지, 8(1), 59-74, 2004
39 PanGyi Kim, NaRae Lee and SeongHee Hwang : The Bisphenol A : A moduator of pregnancy in rats. Korean Journal of Enviromental Health, 29(4), 27-34, 2003
40 巢元方 : 諸病源候論校釋, 人民衛生出版社, 北京, 1143-1152, 1955, 1982
41 唐容川 : 血證論, 上海人民衛生出版社, 上海, 94-95, 1977
42 李容旭, 金判起 : 百鼠母體의 카드뮴中毒이 胎仔 및 胎盤에 미치는 影響. 大韓保健協會誌. 13(1), 25-32, 1987
43 김철원 : 임신중 한약을 투여한 37례의 임상보고. 대한한의학회지, 19(2), 75-85, 1998
44 신현규 : 한약 및 한약제제 관리와 연구개발 정책방향에 관한 연구. 대한한의학회지, 21(2), 14-24, 2000
45 Gren Tamura, Cheryl Gold, Anna Ferro-Luzzi, and Bruce N. Ames. Fecalase - A model for activation of dietary glycosides to mutagens by intestinal flora. Proceedings of the National Academy of USA, 77(8), 4981-4965, 1980
46 한의부인과학 교재편찬위원회. 한의부인과학(하), 도서출판 정담, 서울, 9, 97-98, 109-113, 151-156, 182-187, 2001
47 박귀례, 신재호, 김판기, 이유미, 장성재 : 방사선 조사 인삼이 랫드의 기형유발에 미치는 영향에 관한 연구. Journal of Toxicology and Public Health, 17(1), 27-32, 2001
48 김종일 : 선천성기형에 대한 연구. 대한산부인과학회지, 35(12), 1720-1729, 1992
49 최진주, 전영실, 김종일, 우복희, 강신명 : 선천성기형 10년 6개월 연구. 대한산부인과학회지
50 최진주, 전영실, 김종일, 우복희, 강신명 : 선천성기형 10년 6개월 연구. 대한산부인과학회지, 21(12), 1025-1035, 1978
51 이영순 : 실험동물의학. 서울대학교 출판부. 1989