• Journal of Pharmaceutical Investigation
• /
• v.14 no.2
• /
• pp.70-75
• /
• 1984

The contents of organic acid esters in Angelicae gigantis radix were studied using GC-MS. The results revealed that the concentration of propyl p-hydroxy benzoate was 3.0ppm in the head part, 10.5ppm in the main body and 3. 5ppm in the lateral part.

• YAKHAK HOEJI
• /
• v.44 no.3
• /
• pp.283-292
• /
• 2000

Angelicae gigantis Radix aqua-acupuncture solution (AGRAS) and Angelicae gigantis Radix water-extracted solution (AGRWS) were prepared and tested for their organ toxicities and chemopreventive potentials. The organ-toxicity of AGRAS to male ICR mice was studied by the measurements of glutamic oxaloacetic transaminase (GOT), glutamic pyruvate transaminase (GPT), lactate dehydrogenase (LDH) and alkaline phosphatase (ALP-s) activities after injection of AGRAS for 7 days. The activities of GOT GPT and LDH were decreased, but the activity of ALP-s was not changed with AGRAS. When AGRAS was administered once daily for 10 days before the tumor implantation, AGRAS exerted antitumor activity by inhibiting the growth of Ehrich ascites tumor cells (EATC) in viva. The inductions of quinone reductase (QR), glutathione (GSH) and glutathione S-transferase (GST) and inhibition of polyamine metabolism were tested for the chemopreventive potentials of AGRAS and AGRWS. AGRAS was potent inducer of QR activity in murine hepatoma Hepalclc7 cells. In cultured rat Ac2F cells, AGRAS was also significantly induced QR activity GSH levels were increased about 1.3 fold with AGRAS. In addition the activity of GST was increased about 2.5 fold with AGRAS at the concentration of $0.1{\;}{\times}{\;}$. The effects of AGRAS and AGRWS were tested on the growth of Acanthamoeba castellanii. Proliferation of Acanthamoeba castellanii in a broth medium was inhibited by AGRAS and AGRWS at the concentration of $1{\;}{\times}{\;}and{\;}5{\;}{\times}{\;}$, respectively: These results suggest that AGRAS has chemopreventive potential by inducing QR activity increasing GSH and GST levels and inhibition of polyamine metabolism.

• Journal of Haehwa Medicine
• /
• v.9 no.1
• /
• pp.691-710
• /
• 2000

We came to the conclusion after considering all the information from many kinds of book on herb medicine which is treatment method of "quickening blood and transforming stasis" for external wound. 1. Angelicae sinensis Radix and Angelicae Gigantis Radix are account for 16%(57times) of monarch drug and ministerial drug in all. It means that effect of "quickening blood and transforming stasis" of Angelicae sinensis Radix and Angelicae Gigantis Radix are more excellent than any other herb medicine. 2. In the case of the monarch drug, Angelicae sinensis Radix and Rhizoma Rhei are used at most, treatment method is divided into "expel stasis" and "quickening blood and transforming stasis". 3. In the case of the monarch drug, there are Dolomitum, Eupolyphaga, Dracinis Resina, Crinis Carbonisatus, Acronychiae Ligum, Pini Ramulus etc which have strong treatment effect and pecunliar sort. 4. In the case of the ministerial drug, there are Dracinis Resina, Brassica Rapa, Pyritunm, Liquidambaris Resina etc which are unusual sort. 5. In the order of frequency in use of monarch drug and ministerial drug in nature, it is hot, mean, cold drug. In the order of frequency in use of monarch drug and ministerial drug in flavors, it is sharp, pungent, sweat.

• The Korea Journal of Herbology
• /
• v.26 no.1
• /
• pp.81-85
• /
• 2011

Objective : This study was designed to investigate the effects of Angelicae Gigantis Radix (AGR) on Polycystic Ovary (PCO) induced by Estradiol valerate (EV) in female rats. Methods : We investigated the effects of AGR on Changes in body weights and food and water uptake for 5 weeks. In addition, we examined the effects on ovary weights. Finally, we also observed histopathological changes in PCO rats. Results : Treatment with AGR did not affect body weights, amount of food and water uptake. Administration group of AGR restored body/ovary weight ratio to normal levels, which were lowered by induction of PCO. In histopathological observation, formation of cysts was suppressed in AGR group compared with non-treated control group. Conclusion : These results suggest that AGR can be used for patients with PCO to prevent formation of cystic follicles and malfunction of ovary.

• Journal of Korean Medicine Rehabilitation
• /
• v.28 no.2
• /
• pp.47-60
• /
• 2018

Objectives The objective of this study was to investigate the effect of Anti-condensing on the composition of ChondroT Methods Specimens are divided in 7 groups (Control, ChondroT, Lonicerae Folium (Gumenhwa, GEH), Angelicae Gigantis Radix(Danggui, DG), Phellodendri Cortex(HwangBaek, HB), Osterici Radix(Kanghwal, KH), Clematidis Radix(Weeryungsun, WRS)) Each specimen is subjected to a concentration of 20 %, 10 %, and 5 %, and is administered to collagen and thrombin-stimulated platelets. Results In the anticoagulance effect test, Lonicerae Folium and ChondroT very well. The effect was high in order of Lonicerae Folium-Angelicae Gigantis-Phellodendri Cortex-Osterici Radix and Clematidis Radix. Conclusions ChondroT has anti-condensing effects on blood platelet.

• The Korea Journal of Herbology
• /
• v.38 no.5
• /
• pp.1-7
• /
• 2023

Purpose : To compare the skin damage recovery efficacy of natural Angelicae Gigantis Radix extract (N-AGR) and cultivated A. Gigantis Radix extract (C-AGR). Through this, we confirmed whether the quality standards of herbal medicines recorded in the classic books make a difference in the experimental efficacy using epithelial cells. Methods : The quality standards of medicinal herbs in the classic books and the cultivation and processing conditions of two types of A. gigas were compared. After inducing oxidative stress with H₂O₂, cytoprotective property of N-AGR and C-AGR were evaluated through cell viability. Additionally, after wound formation of epithelial JB6 cells, N-AGR and C-AGR were treated to evaluate wound healing efficacy. Result : The natural A, gigas met the excellent quality standards of the classic books. N-AGR inhibited cell death by oxidative stress induced by H₂O₂, and was superior to C-AGR. Both N-AGR and C-AGR showed dose-dependent wound healing efficacy, but N-AGR was significantly superior to C-AGR. Conclusions : Through the oxidative stress of skin and skin wound healing efficacy experiments using epithelial cells, natural A. gigas showed superior efficacy compared to cultivated A. gigas.

• KSBB Journal
• /
• v.17 no.4
• /
• pp.388-395
• /
• 2002

The growth of enterobacteria, Bifidobacteriurn adolescentis KCTC 3216 was promoted by natural products bearing antioxidative capacity and combined two, three and four kinds of them. B. adolescentis was showed a good growth by Sophorae flos, Phellodendri cofex, Mori cortex radicis, Aurantii nobilis pericarpium, Angelicae gigantis radix, alone, and two mixed combinations were composed of Paeonia japonica and Theae foiium, Epimedii herba and Angelicae gigantis radix, Paeonia japonica and epimedii herba, Atractylodis rhizoma alba and angelicae gigantis radix, and three mixed combinations were oraganized with Theae folium, Paeonia japonica and epimedii herba, Theae folium, Beiamcanda chinensis and Paeonia japonica, Theae foiium, Astragaii radix and Mori cortex radicis, and four mixed combinations were formed with Seiamcanda chinensis, Angelicae gigantis radix, Epimedii herba, Theae folium, and Angeiicae gigantis radix, Epimedii herba, Paeonia japonica, Theae folium, and Epimedii herba, Paeonia japonica, Sophorae flos, Theae folium. The best four mixed combination for the growth of B. adolescentis was mixture of Epimedii herba, Paeonia iaponica, Sophorae flow and Theae foiium, which promoted 2.6 times than that of control, and its antioxidative capacity was also 5.6 times higher, and the ratio of elimination of hydroxyl radical was more than 80% in each dilution rate. As these combinations of natural products will activate some parts of body, they may be applied to pharmaceuitcal applications, functional foods, antiaging tea, also expected to promote useful entero bacterial growth for fermentative beverage bearing multifunction.

• 한국생물공학회:학술대회논문집
• /
• 2000.04a
• /
• pp.596-599
• /
• 2000

30 kinds of natural products were considered for developing natural antioxidants by improved D.O. analyzing method including simple calculation of Area Under Curve. Several natural products such as Cimicifuge Rhizoma, Epimedii Herba, Atractylodis Rhizoma Alba, Acori Graminei Rhizoma, Mori Cortex Radicis, Aurantii Nobilis Pericarpium were bore nearly same antioxidant effects compared to synthetic powerful antioxidant BHT and also expressed powerful antioxidant effect than ${\beta}-carotene$ such as Eucommiae Cortex, Cinnamomi Cortex, Angelicae Gigantis Radix, Lycii Furctus, Acanthopanacis Cortex, Sophorae Radix, Paeoniae Radix, Geranii Herba. Another method of DPPH was performed for searching natural antioxidant from natural product. Sophorae Radix, Puerariae Radix, Aurantii Nobilis Pericarpium, Atractylodis Rhizoma Alba, Acori Graminei Rhizoma, Corni Fructus, Angelicae Gigantis Radix, Paeoniae Radix were carried higher antioxidant capacity than ${\beta}-carotene$ by DPPH method.

• KSBB Journal
• /
• v.18 no.2
• /
• pp.90-93
• /
• 2003

Six heavy metals (lead, copper, cadmium, chromium, mercury and arsenic) were analyzed in 9 oriental medical materials(Paeoniae Radix Alba, Zizyphi Fructus, Cnidii Rhizoma, Rehmanniae Radix Preparata, Angelicae Gigantis Radix, Astragali Radix, Glycyrrhizae Radix, Cinnamomi Cortex Spissus, and Zingiberis Rhizoma Crudus) by inductively coupled plasma atomic emission spectrometry (ICP-AES). The heavy metal contents of Zingberis Rhizoma Crudus and Angelicae Gigantis Radix were 44.0 and 37.3 mg/kg, respectively, which were 1.47 and 1.24 times higher than the guideline set by the Korean Food and Drug Administration (KFDA). Washing with deionized water lowered the heavy metal contents by 20-38%, and reduced levels to below the guidelines set by KFDA.

• Journal of Oriental Neuropsychiatry
• /
• v.17 no.2
• /
• pp.123-132
• /
• 2006

Objective : This study was performed to investigate the prescriptions and herbs about Keongke(驚悸), Cheongchung and fear affection(恐證) related to the anxiety disorder Method : 9 main texts in oriental medicine were selected and investigated for this study. And then the results of research were analyzed. Result : 87 prescriptions and 123 herbs were described in 9 books. Especially Chusaanshinhwan(朱砂安神丸), Ginseng Radix(人蔘), Poria(茯神), and Angelicae Gigantis Radix(當歸) were mainly used. Conclusion : The results suggest that the prescriptions and herbs frequently described about Keongke(驚悸), Cheongchung and fear affection(恐證) might have antianxiety effect.