The Korea Journal of Herbology (대한본초학회지)

The Korea Association of Herbology (대한본초학회)
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Comparison of skin damage recovery between natural and cultivated Angelicae Gigantis Radix

자연산 당귀와 재배 당귀의 피부 손상 회복 효능 비교

  • Sun-Young Hwang (Dept. of Herbology & Herbal Formula Science, College of Korean Medicine, Dongshin University) ;
  • Mee-Hyun Lee (Dept. of Herbology & Herbal Formula Science, College of Korean Medicine, Dongshin University) ;
  • Kwanhwan Wi (Dept. of Herbology & Herbal Formula Science, College of Korean Medicine, Dongshin University) ;
  • Do-Hyun Kim (Dept. of Herbology & Herbal Formula Science, College of Korean Medicine, Dongshin University) ;
  • Soong-in Lee (Dept. of Herbology & Herbal Formula Science, College of Korean Medicine, Dongshin University) ;
  • Jong-Gil Jeong (Dept. of Herbology & Herbal Formula Science, College of Korean Medicine, Dongshin University)
  • 황선영 (동신대학교 한의과대학 본초방제학교실) ;
  • 이미현 (동신대학교 한의과대학 본초방제학교실) ;
  • 위관환 (동신대학교 한의과대학 본초방제학교실) ;
  • 김도현 (동신대학교 한의과대학 본초방제학교실) ;
  • 이숭인 (동신대학교 한의과대학 본초방제학교실) ;
  • 정종길 (동신대학교 한의과대학 본초방제학교실)
  • Received : 2023.07.21
  • Accepted : 2023.09.25
  • Published : 2023.09.30
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Abstract

Purpose : To compare the skin damage recovery efficacy of natural Angelicae Gigantis Radix extract (N-AGR) and cultivated A. Gigantis Radix extract (C-AGR). Through this, we confirmed whether the quality standards of herbal medicines recorded in the classic books make a difference in the experimental efficacy using epithelial cells. Methods : The quality standards of medicinal herbs in the classic books and the cultivation and processing conditions of two types of A. gigas were compared. After inducing oxidative stress with H2O2, cytoprotective property of N-AGR and C-AGR were evaluated through cell viability. Additionally, after wound formation of epithelial JB6 cells, N-AGR and C-AGR were treated to evaluate wound healing efficacy. Result : The natural A, gigas met the excellent quality standards of the classic books. N-AGR inhibited cell death by oxidative stress induced by H2O2, and was superior to C-AGR. Both N-AGR and C-AGR showed dose-dependent wound healing efficacy, but N-AGR was significantly superior to C-AGR. Conclusions : Through the oxidative stress of skin and skin wound healing efficacy experiments using epithelial cells, natural A. gigas showed superior efficacy compared to cultivated A. gigas.

Keywords

Acknowledgement

이 논문은 2021년도 과학기술정보통신부 재원으로 연구개발특구진흥재단의 지원을 받아 수행된 연구입니다(No.2021-DD-UP-0380).

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