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http://dx.doi.org/10.6116/kjh.2011.26.1.081

Effects of Angelicae Gigantis Radix (AGR) on Polycystic Ovary induced by Estradiol Valerate in rats  

Kim, Hyung-Woo (School of Korean medicine, Pusan National University)
Choi, Eu-Gene (School of Korean medicine, Pusan National University)
Chung, Hee-Jin (School of Korean medicine, Pusan National University)
Joung, Young-Min (School of Korean medicine, Pusan National University)
Shin, Dong-Sung (School of Korean medicine, Pusan National University)
Cho, Su-In (School of Korean medicine, Pusan National University)
Publication Information
The Korea Journal of Herbology / v.26, no.1, 2011 , pp. 81-85 More about this Journal
Abstract
Objective : This study was designed to investigate the effects of Angelicae Gigantis Radix (AGR) on Polycystic Ovary (PCO) induced by Estradiol valerate (EV) in female rats. Methods : We investigated the effects of AGR on Changes in body weights and food and water uptake for 5 weeks. In addition, we examined the effects on ovary weights. Finally, we also observed histopathological changes in PCO rats. Results : Treatment with AGR did not affect body weights, amount of food and water uptake. Administration group of AGR restored body/ovary weight ratio to normal levels, which were lowered by induction of PCO. In histopathological observation, formation of cysts was suppressed in AGR group compared with non-treated control group. Conclusion : These results suggest that AGR can be used for patients with PCO to prevent formation of cystic follicles and malfunction of ovary.
Keywords
Angelicae Gigantis Radix; Polycystic Ovary; cystic follicles;
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Times Cited By KSCI : 4  (Citation Analysis)
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