• 한국약용작물학회:학술대회논문집
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• 2009.05a
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• pp.135-136
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• 2009

• 한국약용작물학회:학술대회논문집
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• 2009.05a
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• pp.139-140
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• 2009

• 한국약용작물학회:학술대회논문집
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• 2009.05a
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• pp.329-330
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• 2009

• 한국약용작물학회:학술대회논문집
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• 2009.05a
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• pp.109-110
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• 2009

• Fisheries and Aquatic Sciences
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• v.24 no.10
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• pp.319-329
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• 2021

In the search for antibiotic alternatives from safe and effective medicinal plants against fish pathogenic bacteria, we found that a combined extract (CE) of 1:1 (w/w) ratio of Angelica gigas Nakai roots and aerial parts of Artemisia iwayomogi Kitamura showed antibacterial activity against the fish pathogenic bacteria. By antibacterial activity-guided fractionations and isolations, five compounds were isolated and identified as decursinol angelate (1), decursin (2), xanthotoxin (3), demethylsuberosin (4), and 2,4-dihydroxy-6-methoxyacetophenone (5) through spectroscopic analyses, such as nuclear magnetic resonance (NMR) and mass spectrometry (MS). Among the compounds, 1 and 2 showed the highest antibacterial activities against Streptococcus iniae and Vibrio anguillarum, showing minimum inhibitory concentrations (MICs) of 62.5-250 ㎍/mL. Compounds 3, 4, and 5 were also found to be active, with MICs of 31.25-1,000 ㎍/mL for those strains. Furthermore, active compounds, 1 and 2 in CE were simultaneously quantified using high-performance liquid chromatography-tandem MS (HPLC-MS/MS). The average contents of 1 and 2 in CE was 3.68% and 6.14%, respectively. The established method showed reliable linearity (r² > 0.99), good precision, accuracy, and specificity with intra- and inter-day variations of < 2 % and recoveries of 90.13%-108.57%. These results may be helpful for establishing the chemical profile of CE for its commercialization as an antibiotic alternative in aquaculture.

• Korean Journal of Medicinal Crop Science
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• v.2 no.1
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• pp.20-25
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• 1994

This study was carried out to investigate the effect of temperature and daylength on the bolting of Angelica gigas Nakai for decreasing the rate of bolting.Seedlings were transplanted on early December to the PVC pot(1 /1000) in the greenhouse con­trolled the temperature of 15, 20 and $25^{\circ}C$, and the daylength of 8, 12, and 16hrs. Growth of aerial parts, bolting rate and root characteristics of A. gigas were investigated. Seedlings of A. gigas untreated with low temperature were nomally emerged, bolted and flowered in maturing stage. In this results, it was assumed that A. gigas was low sensitive to low temperature. The early growth stage was good at $20^{\circ}C\;and\;25^{\circ}C$, but the late growth was effective at $15^{\circ}C\;and\;20^{\circ}C$. The bolting rate was the highest at $20^{\circ}C$ while the root weight was the lowest. Although the bolting rate was high at $15^{\circ}C$, the yield was increased by the delay of bolting and flowering stage. The bolting rate was increased in the longer daylength and showed more sensitive to the daylength condition than to the temperature. Thus, A. gigas cultivated in gully field with cool temperature or under the shading light could be reduced could the bolting rate.

• KOREAN JOURNAL OF CROP SCIENCE
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• v.42 no.2
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• pp.196-201
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• 1997

This study was carried out to understand the effect of low temperature treatment and seedling size on growth and bolting in Angeljca gjgas. Bolting rate increased as period of low temperature increased and bolting rate of control was lower than that of low temperature treatment. In low temperature treatment with seedling size, the smaller seedling size, the higher bolting rate. Period from transplanting to bolting was reduced with low temperature treatment extended and large seedling. The plant height, position of bolting leaf and number of developing leaf were decreased with low temperature treatment extended and large seedling, respectively, There was a highly significant negative correlation between bolting rate and number of developed leaves before bolting and number of developed leaves in growth to first bolting but positive correlation in late growth, respectively.

• Natural Product Sciences
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• v.9 no.2
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• pp.73-79
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• 2003

To discover the sources with antioxidative activity in traditional medicines, 100 extracts of Korean medicinal plants were screened for their scavenging effect on peroxynitrite $(ONOO^{-})$ and total reactive oxygen species (ROS). The potency of total ROS scavenging activity was shown in the extracts of 25 plants, and 4 of their species, Macleaya cordata R. Br., Salvia plebeia R. Br., Cassia tora L. and Angelica gigas Nakai, had a greater effect with $IC_{50}$ values of $1.7{\pm}0.36$, $4.3{\pm}1.08$, $4.9{\pm}0.17$ and $5.8{\pm}1.01\;{\mu}g/ml$, respectively, than that of trolox, positive control $(7.61{\pm}0.12\;{\mu}g/ml)$. Another 35 extracts exhibited inhibitory effect of below 50 percent at $100\;{\mu}g/ml$ of sample concentrations on total ROS, while the rest observed total ROS generators rather than scavengers. The peroxynitrite scavenging activities were observed in the greater part of the plants tested. Five of them, Schisandra chinensis Baill, Campsis grandiflora (Thunb.) K. Schum., Cedrela sinensis A. Juss., Pleuropterus multiflorus Turcz. and Veronica linariaefolia Pall represented scavenging activities on peroxynitrite twice as strong with $IC_{50}$ Values of $0.48{\pm}0.10$, $0.59{\pm}0.15$, $0.60{\pm}0.10$, $0.64{\pm}0.10$ and $0.91{\pm}0.23\;{\mu}g/ml$, respectively, as that of penicillamine $(1.72{\pm}0.05\;{\mu}g/ml)$, positive control. Consequently, 25 species of the entire plants tested, exhibited scavenging activities on total ROS and $ONOO^{-}$, Salvia plebeia R. Br., Macleaya cordata R. Br., Cassia tora L. and Angelica gigas Nakai exerted potent scavenging activities on both radicals.

• KOREAN JOURNAL OF CROP SCIENCE
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• v.36 no.3
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• pp.254-258
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• 1991

Experiment was conducted to investigate the effects of size of root crown at transplanting and fertilization on the growth and root yield of Angelica gigas Nakai. Plant height and fresh weight of shoots were increased by fertilizer application, but was not different in emergence rate. Size of root crown at transplanting was also affected the growth of shoot. Plant which had 7.2mm of root crown at transplanting showed highest in plant height and fresh weight of shoots. Growth of root in terms of root length, number of root branches, diameter of root crown, and fresh weight of root was increased by fertilizer application and 5.4mm of root crown at transplanting. Application of fertilizer accelerated the development and growth of node on the stem, which in turn resulted bolting and flowering. Plants which had greater than 7.2mm of root crown at transplanting and application of fertilizer were produced woody roots. Woody roots cannot be used for medicinal purpose. Therefore, yield of roots was highest at transplanting of 3.lmm root crown with fertilizer application.

• Journal of Korean Medical classics
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• v.25 no.1
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• pp.173-196
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• 2012

Object : From the ancient times, the importance of childbirth has been well recognized by Korean Traditional Medicine. Numeral methods have been developed to ease the labor process and keep the mother and child healthy from conception to labor. Bulsusan(佛手散) is one of the main remedies to healthy labor in KTM, both widely known and applied as well. Method : This paper examines the labor theory and practice of KTM focused on Bulsusan which is composed of Angelica gigas Nakai(當歸) and Cnidium officinale MAKINO(川芎). Result : 1. From the ancient times until the Q$\bar{i}$ng period, much attention was placed to the handling of the placenta, as it was conceived as bearing much relation to the health of the mother and her fate, and thus included in the labor process. 2. There was a recognition of the 'birth pulse[離經脈]', an intense change in the pulse that presents itself prior to somatic signs of labor. 3. There were numerous prescriptions that were administered beforehand to ease the process. They are mostly constituted with medicinals that nurture Gi(氣) and stimulate its flow, which in turn makes the fetus firm and reduces the volume, easing the labor process. 4. The medical practice of labor-induction was called 'Choesaeng(催生)'. The prescriptions which functioned as such were mostly constituted with blood medicinals such as Angelica gigas Nakai and Cnidium officinale MAKINO, those which nurture both Gi(氣) and blood, and medicinals that physically lubricate the labor pathway such as honey, oil and Talcum(滑石). Conclusion : Bulsusan can be used in most problems concerning pregnancy and labor, and cases of emergency blood loss due to injury. The term 'bulsu(佛手)' infers to the medical ability of the great doctor who takes care of major blood-loss situations resulting from discharge of dead fetus, cesarean delivery, etc. The prescription name takes after this meaning, as it deals with similar conditions in its effect.