• 대한치과교정학회지
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• 제52권5호
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• pp.313-323
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• 2022

Objective: This study aimed to estimate the clinical effects of different types of bone-anchored maxillary protraction devices by using a network meta-analysis. Methods: We searched seven databases for randomized and controlled clinical trials that compared bone-anchored maxillary protraction with tooth-anchored maxillary protraction interventions or untreated groups up to May 2021. After literature selection, data extraction, and quality assessment, we calculated the mean differences, 95% confidence intervals, and surface under the cumulative ranking scores of eleven indicators. Statistical analysis was performed using R statistical software with the GeMTC package based on the Bayesian framework. Results: Six interventions and 667 patients were involved in 18 studies. In comparison with the tooth-anchored groups, the bone-anchored groups showed significantly more increases in Sella-Nasion-Subspinale (°), Subspinale-Nasion-Supramentale(°) and significantly fewer increases in mandibular plane angle and the labial proclination angle of upper incisors. In comparison with the control group, Sella-Nasion-Supramentale(°) decreased without any statistical significance in all treated groups. IMPA (angle of lower incisors and mandibular plane) decreased in groups with facemasks and increased in other groups. Conclusions: Bone-anchored maxillary protraction can promote greater maxillary forward movement and correct the Class III intermaxillary relationship better, in addition to showing less clockwise rotation of mandible and labial proclination of upper incisors. However, strengthening anchorage could not inhibit mandibular growth better and the lingual inclination of lower incisors caused by the treatment is related to the use of a facemask.

• Structural Engineering and Mechanics
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• 제83권5호
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• pp.627-644
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• 2022

In past major earthquakes (1994 Northridge, 1995 Kobe, Chi-Chi 1999, Kocaeli 1999), significant damages occurred in the liquid storage tanks. The basic failure patterns were observed to be the buckling of the tank wall and uplift of the anchorage system. The damages in the industrial facilities and nuclear power plants have caused the spread of toxic substances to the environment and significant fires. Seismic isolation can be used in liquid storage tanks to decouple the structure and decrease the structural demand in the superstructure in case of ground shaking. Previous studies on the use of seismic isolation systems on liquid storage tanks show that an isolation system reduces the impulsive response but might slightly increase the convective one. There is still a lack of understanding of the seismic response of seismically isolated liquid storage tanks considering the fluid-structure interaction. In this study, one broad tank, one medium tank, and one slender tank are selected and designed. Two- and three-dimensional elastomeric bearings are used as seismic isolation systems. The seismic performance of the tanks is then investigated through nonlinear dynamic time-history analyses. The effectiveness of each seismic isolation system on tanks' performance was investigated. Isolator tension forces, modal analysis results, hydrodynamic stresses, strains, sloshing heights and base shear forces of the tanks are compared. The results show that the total base shear is lower in 3D-isolators compared to 2D-isolators. Even though the tank wall stresses, and strains are slightly higher in 3D-isolators, they are more efficient to prevent the tension problem.

• Computers and Concrete
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• 제29권 6호
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• pp.375-391
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• 2022

This paper examined the impact of the cross-sectional structure on the structural results under different loading conditions of reinforced concrete (RC) members' management limited in Carbon Fiber Reinforced Polymers (CFRP). The mechanical properties of CFRC was investigated, then, totally 32 samples were examined. Test parameters included the cross-sectional shape as square, rectangular and circular with two various aspect rates and loading statues. The loading involved concentrated loading, eccentric loading with a ratio of 0.46 to 0.6 and pure bending. The results of the test revealed that the CFRP increased ductility and load during concentrated processing. A cross sectional shape from 23 to 44 percent was increased in load capacity and from 250 to 350 percent increase in axial deformation in rectangular and circular sections respectively, affecting greatly the accomplishment of load capacity and ductility of the concentrated members. Two Artificial Intelligence Models as Extreme Learning Machine (ELM) and Particle Swarm Optimization (PSO) were used to estimating the tensile and flexural strength of specimen. On the basis of the performance from RMSE and RSQR, C-Shape CFRC was greater tensile and flexural strength than any other FRP composite design. Because of the mechanical anchorage into the matrix, C-shaped CFRCC was noted to have greater fiber-matrix interfacial adhesive strength. However, with the increase of the aspect ratio and fiber volume fraction, the compressive strength of CFRCC was reduced. This possibly was due to the fact that during the blending of each fiber, the volume of air input was increased. In addition, by adding silica fumed to composites, the tensile and flexural strength of CFRCC is greatly improved.

• 수산해양기술연구
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• 제58권3호
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• pp.230-240
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• 2022

In general, a high tension on the anchor and chain is placed when a ship at anchor is subjected to heavy weather. Mariners have to pay attention to whether dragging anchor occurs to keep the safety of the ship at anchorage since it is difficult to maintain the stable motion of ship and it causes collisions with other ships nearby. In this paper, the ship motion against the external forces was shown to obtain the fundamental data about characteristic of holding power due to nature of seabed at anchor, so practical trials were carried out in rocky area and muddy area using a trial ship around coastal area of South Korea. In muddy seabed, holding power showed reasonable tension values depending on the distance from anchor position of continuing swing motions of a ship corresponding to wind force. Meanwhile in rocky seabed, tension values on the chain appeared very high occasionally regardless of the distance from the anchor position and seemed to exceed its holding power to be the breaking strain of the chain although weather was not in a severe condition. Therefore, some of the cables laid on the seabed were presumed to be caught in a crack on the rock. It is assumed that even a small amount of external force may cause the chain to break in a moment in rocky seabed. Additionally, wind and current forces had a somewhat contradictory effect on holding power of the ship between them.

• Biomolecules & Therapeutics
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• 제31권2호
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• pp.200-209
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• 2023

Patients with non-small-cell lung cancer (NSCLC) with epidermal growth factor receptor (EGFR) amplification or sensitive mutations initially respond to the tyrosine kinase inhibitor gefitinib, however, the treatment becomes less effective over time by resistance mechanism including mesenchymal-epithelial transition (MET) overexpression. A therapeutic strategy targeting MET and EGFR may be a means to overcoming resistance to gefitinib. In the present study, we found that picropodophyllotoxin (PPT), derived from the roots of Podophyllum hexandrum, inhibited both EGFR and MET in NSCLC cells. The antitumor efficacy of PPT in gefitinib-resistant NSCLC cells (HCC827GR), was confirmed by suppression of cell proliferation and anchorage-independent colony growth. In the targeting of EGFR and MET, PPT bound with EGFR and MET, ex vivo, and blocked both kinases activity. The binding sites between PPT and EGFR or MET in the computational docking model were predicted at Gly772/Met769 and Arg1086/Tyr1230 of each ATP-binding pocket, respectively. PPT treatment of HCC827GR cells increased the number of annexin V-positive and subG1 cells. PPT also caused G2/M cell-cycle arrest together with related protein regulation. The inhibition of EGFR and MET by PPT treatment led to decreases in the phosphorylation of the downstream-proteins, AKT and ERK. In addition, PPT induced reactive oxygen species (ROS) production and GRP78, CHOP, DR5, and DR4 expression, mitochondrial dysfunction, and regulated involving signal-proteins. Taken together, PPT alleviated gefitinib-resistant NSCLC cell growth and induced apoptosis by reducing EGFR and MET activity. Therefore, our results suggest that PPT can be a promising therapeutic agent for gefitinib-resistant NSCLC.

• 도시과학
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• 제11권2호
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• pp.19-24
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• 2022

Conventional RC beams for crossing small and medium-sized rivers do not have a cross-sectional area, so the floating debris is accumulated and disasters such as damage to bridges occur. To improve this, the PSC method was invented. However, this also had problems such as transverse curvature, increase in dead weight due to cross-sectional shape, and negative moment generated during serialization, so it was necessary to develop a new type of girder. Therefore, it was intended to propose a LIT(Leton Interaction Thrust) girder bridge that is safer and has better performance than the conventional PSC girder with improved section efficiency. Unlike existing girder bridges, the LIT girder has the feature that the change in the strands of the entire girder occurs only in the vertical direction when the first tension is applied because the tendon arrangement is symmetrical by applying the raised portion. In addition, slab continuation generates a secondary moment that is advantageous to the continuous point, effectively controlling the negative moment and preventing the corrosion of the tendon. The dimensions of the cross section were determined, and the arrangement of the strands was designed to conduct structural analysis and detailed analysis. As a result of the structural analysis, the stress of the girder showed results within the allowable compressive stress, and the deflection showed the result within the allowable deflection. showed results. In addition, a detailed analysis was performed to examine the stress distribution around the girder body and the anchorage area and the stress distribution of the embossed portion, and as a result, the stress of the girder body due to the tension force showed a stable level.

• 대한토목학회논문집
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• 제26권5A호
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• pp.881-885
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• 2006

사장교 케이블은 구조적으로 휨강성과 감쇠력이 작아 풍우에 의해 쉽게 유해진동이 발생한다. 이러한 풍우진동을 저감시키기 위한 효과적인 방법으로 부가댐퍼를 장착하여 케이블의 감쇠력을 증가시키는 제어시스템이 널리 사용되어왔다. 그러나 사장교의 장대화로 인해 구조적으로나 미적으로 충분한 감쇠력을 제공할 수 있는 위치에 부가댐퍼를 장착하기 어렵게 되었다. 그러므로 본 논문은 사장교의 미관을 해치지 않으면서 기존의 제어시스템보다 효과적으로 케이블의 진동을 저감시킬 수 있는 새로운 개념의 제어시스템을 제안하였다. 제안된 시스템은 케이블 앵커리지에 적층고무베어링과 같은 유동이 가능한 장치와 내부댐퍼로 구성되었으며, 제어성능평가를 위해 해석모델을 개발하였다. 제안된 시스템의 제어성능 분석을 위해 수치해석을 수행하였으며 기존의 부가 댐퍼시스템과 진동 저감효과를 비교하였다. 제안된 제어시스템은 기존의 부가댐퍼 시스템 보다 효과적으로 진동을 저감시킬 수 있었으며 사장교 케이블의 풍우진동 저감을 위해 효과적인 시스템으로 사료된다.

• Biomolecules & Therapeutics
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• 제31권6호
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• pp.682-691
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• 2023

Cell transformation induced by epidermal growth factor (EGF) and 12-O-tetradecanoylphorbol-13-acetate (TPA) is a critical event in cancer initiation and progression, and understanding the underlying mechanisms is essential for the development of new therapeutic strategies. Licorice extract contains various bioactive compounds, which have been reported to have anticancer and anti-inflammatory effects. This study investigated the cancer preventive efficacy of licochalcone D (LicoD), a chalcone derivative in licorice extract, in EGF and TPA-induced transformed skin keratinocyte cells. LicoD effectively suppressed EGF-induced cell proliferation and anchorage-independent colony growth. EGF and TPA promoted the S phase of cell cycle, while LicoD treatment caused G1 phase arrest and down-regulated cyclin D1 and up-regulated p21 expression associated with the G1 phase. LicoD also induced apoptosis and increased apoptosis-related proteins such as cleaved-caspase-3, cleaved-caspase-7, and Bax (Bcl2-associated X protein). We further investigated the effect of LicoD on the AKT signaling pathway involved in various cellular processes and found decreased p-AKT, p-GSK3β, and p-NFκB expression. Treatment with MK-2206, an AKT pharmacological inhibitor, suppressed EGF-induced cell proliferation and transformed colony growth. In conclusion, this study demonstrated the potential of LicoD as a preventive agent for skin carcinogenesis.

• The Korean Journal of Physiology and Pharmacology
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• 제28권1호
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• pp.21-30
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• 2024

The challenging clinical outcomes associated with advanced cervical cancer underscore the need for a novel therapeutic approach. Monensin, a polyether antibiotic, has recently emerged as a promising candidate with anti-cancer properties. In line with these ongoing efforts, our study presents compelling evidence of monensin's potent efficacy in cervical cancer. Monensin exerts a pronounced inhibitory impact on proliferation and anchorage-independent growth. Additionally, monensin significantly inhibited cervical cancer growth in vivo without causing any discernible toxicity in mice. Mechanism studies show that monensin's anti-cervical cancer activity can be attributed to its capacity to inhibit the Wnt/β-catenin pathway, rather than inducing oxidative stress. Monensin effectively reduces both the levels and activity of β-catenin, and we identify Akt, rather than CK1, as the key player involved in monensin-mediated Wnt/β-catenin inhibition. Rescue studies using Wnt activator and β-catenin-overexpressing cells confirmed that β-catenin inhibition is the mechanism of monensin's action. As expected, cervical cancer cells exhibiting heightened Wnt/β-catenin activity display increased sensitivity to monensin treatment. In conclusion, our findings provide pre-clinical evidence that supports further exploration of monensin's potential for repurposing in cervical cancer therapy, particularly for patients exhibiting aberrant Wnt/β-catenin activation.

• Journal of Periodontal and Implant Science
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• 제53권6호
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• pp.453-466
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• 2023

Purpose: This study aimed to quantify alveolar bone morphology, demonstrate the relationship between tooth angulation and alveolar bone thickness, and introduce a new classification for anterior mandibular teeth related to immediate implant placement (IIP). Methods: Cone-beam computed tomography (CBCT) images of 211 anterior mandibular teeth were analyzed in sagittal slices to measure the thickness of the facial alveolar bone crest (FAB1) and apex (FAB2), and the lingual alveolar bone crest (LAB1) and apex (LAB2). Tooth angulation was classified as 1°-10°, 11°-20°, and >20° according to the tooth's long axis and alveolar bone wall. Spearman correlation coefficients were used to evaluate correlations between the variables. Results: FAB1 and LAB1 were predominantly thin (<1 mm) (84.4% and 73.4%, respectively), with the lateral incisors being thinnest. At the apical level, FAB2 and LAB2 were thick in 99.5% and 99.1% of cases, respectively. Significant differences were documented in FAB2 (P=0.004), LAB1 (P=0.001), and LAB2 (P=0.001) of all mandibular teeth. At all apical levels of the inspected teeth, a significant negative correlation existed between TA and FAB2. Meanwhile, TA showed a significant positive correlation with LAB2 of the lateral incisors and canines. These patterns were then divided into class I (thick facial and lingual alveolar bone), class II (facially inclined teeth) with subtype A (1°-10°) and subtype B (11°-20°), and class III (lingually inclined teeth) with subtype A (1°-10°) and subtype B (11°-20°). Conclusions: Mandibular anterior teeth have predominantly thin facial and lingual crests, making the lingual bone apical thickness crucial for IIP. Although anchorage can be obtained from lingual bone, tooth angulation and tooth types had an impact on IIP planning. Hence, the new classification based on TA and alveolar bone wall may enable rational clinical planning for IIP treatment.