• East Asian Economic Review
• /
• v.20 no.1
• /
• pp.67-90
• /
• 2016

This paper provides an assessment of the potential economic impacts of the Vietnam-Korea free trade agreement on Vietnam, by using general equilibrium modeling. The results show that Vietnam-Korea FTA will increase aggregate welfare for both countries in the long run. The most important gains accrue from better allocation of resources consequent to trade liberalization. All the sectoral differences and changes are consistent with the trade profiles of the two countries, and the long-run results are more pronounced than those of the short-run. In comparison with other ASEAN countries, the CGE analysis suggests that Vietnam's agriculture exports to Korea would especially rise in the long run. However, there will be strong competition in this sector among ASEAN members. Thus, an earlier conclusion of a comprehensive FTA with Korea is expected to be a good strategy for Vietnam, so as to avoid the direct competition with ASEAN members in the future.

• Food Science of Animal Resources
• /
• v.34 no.3
• /
• pp.316-324
• /
• 2014

Milk fat is an important food component, and plays a significant role in the economics, functional nutrition, and chemical properties of dairy products. Dairy products also contain nutritional resources and essential fatty acids (FAs). Because of the increasing demand for dairy products, milk fat is a common target in economic fraud. Specifically, milk fat is often replaced with cheaper or readily available vegetable oils or animal fats. In this study, a method for the discrimination of milk fat was developed, using FAs profiles, and triacylglycerols (TGs) profiles. A total of 11 samples were evaluated: four milk fats (MK), four vegetable oils (VG), two pork lards (PL), and one beef tallow (BT). Gas chromathgraphy analysis were performed, to monitor the FAs content and TGs composition in MK, VG, PL, and BT. The result showed that qualitative determination of the MK of samples adulterated with different vegetable oils and animal fats was possible by a visual comparision of FAs, using C14:0, C16:0, C18:1n9c, C18:0, and C18:2n6c, and of TGs, using C36, C38, C40, C50, C52, and C54 profiles. Overall, the objective of this study was to evaluate the potential of the use of FAs and TGs in the detection of adulterated milk fat, and accordingly characterize the samples by the adulterant oil source, and level of adulteration. Also, based on this preliminary investigation, the usefulness of this approach could be tested for other oils in the future.

• Bulletin of the Korean Chemical Society
• /
• v.28 no.9
• /
• pp.1523-1530
• /
• 2007

The first reduction peak of the cyclic voltammogram (CV) for sulfur reduction in dimethyl sulfoxide has been studied using time resolved Fourier transform electrochemical impedance spectroscopic (FTEIS) analysis of small potential step chronoamperometric currents. The FTEIS analysis results reveal that the impedance signals obtained during short potential steps can be resolved into electron transfer reactions of two different time constants in a high frequency region. The FTEIS method provides snap shots of impedance profiles during an earlier phase of the reaction, leading to time resolved EIS measurements. Our results obtained by the FTEIS analysis are consistent with a series of electron transfer and chemical equilibrium steps of a complex reaction, making up an ECE (electrochemical-chemical-electrochemical) mechanism postulated from the results of computer simulation.

• Asian Pacific Journal of Cancer Prevention
• /
• v.17 no.3
• /
• pp.1571-1576
• /
• 2016

Alteration of the acetylation status of chromatin and other non-histone proteins by HDAC inhibitors has evolved as an excellent epigenetic strategy in treatment of cancers. The present study was sought to identify compounds with positive pharmacological profiles targeting HDAC1. Analogues of Vorinostat synthesized by Cai et al, 2015 formed the test compounds for the present pharmacological evaluation. Hydroxamte analogue 6H showed superior pharmacological profile in comparison to all the compounds in the analogue dataset owing to its better electrostatic interactions and hydrogen bonding patterns. In order to identify compounds with even better high affinity and pharmacological profile than 6H and Vorinostat, virtual screening was performed. A total of 83 compounds similar to Vorinostat and 154 compounds akin to analogue 6H were retrieved. SCHEMBL15675695 (PubCid: 15739209) and AKOS019005527 (PubCid: 80442147) similar to Vorinostat and 6H, were the best docked compounds among the virtually screened compounds. However, in spite of having good affinity, none of the virtually screened compounds had better affinity than that of 6H. In addition SCHEMBL15675695 was predicted to be a carcinogen while AKOS019005527 is Ames toxic. From, our extensive analysis involving binding affinity analysis, ADMET properties predictions and pharmacophoric mappings, we report Vorinostat hydroxamate analogue 6H to be a potential candidate for HDAC inhibition in treatment of cancers through an epigenetic strategy.

• Structural Engineering and Mechanics
• /
• v.62 no.5
• /
• pp.519-535
• /
• 2017

In this article, static analysis of a magneto-electro-elastic (MEE) beam subjected to various thermal loading and boundary conditions has been investigated. Influence of pyroeffects (pyroelectric and pyromagnetic) on the direct quantities (displacements and the potentials) of the MEE beam under different boundary conditions is studied. The finite element (FE) formulation of the MEE beam is developed using the total potential energy principle and the constitutive equations of the MEE material taking into account the coupling between elastic, electric, magnetic and thermal properties. Using the Maxwell electrostatic and electromagnetic relations, variation of stresses, displacements, electric and magnetic potentials along the length of the MEE beam are investigated. Effect of volume fractions, aspect ratio and boundary conditions on the direct quantities in thermal environment has been determined. The present investigation may be useful in design and analysis of magnetoelectroelastic smart structures and sensor applications.

• Journal of the Society of Naval Architects of Korea
• /
• v.41 no.1
• /
• pp.15-22
• /
• 2004

Twin-skeg type stern shapes are recently adopted for very large commercial ships. However it is difficult to apply a CFD system to a hull form having twin-skeg, since grid topology around a twin-skeg type stern is more complicated than that of a conventional single-screw ship, or of an open-shaft type twin-screw ship with center-skeg. In the present study a surface mesh generator and a multi-block field grid generation program have been developed for twin-skeg type stern. Furthermore, multi-block flow solvers are utilized for potential and viscous flow analysis around a twin-skeg type stern The present computational system is applied to a 15,000TEU container ship with twin-skeg to prove the applicability. Wave profiles and wake distribution are calculated using the developed flow analysis tools and the results are compared with towing tank measurements.

• Transactions of the Korean Society of Pressure Vessels and Piping
• /
• v.11 no.2
• /
• pp.61-67
• /
• 2015

3D FEM modeling based on 3D CAD data has been performed to evaluate the efficiency of CP system in a real operating nuclear power plant. The results of it successfully produced sophisticated profiles of electrolytic potential and current distributions in the soil of an interested area. This technology is expected to be a breakthrough for detection technology of damages on buried pipes when it comes into combining with a brand of area potential earth current (APEC) and ground penetrated radar (GPR) technologies. 2D current distribution and 2D current vectors on the earth surface from the APEC survey will be used as boundary conditions with exact 3D geometry data resulting in visualization of locations and extents of corrosion damages on the buried pipes in nuclear power plants.

• Journal of the Institute of Electronics Engineers of Korea CI
• /
• v.42 no.1
• /
• pp.1-7
• /
• 2005

Cluster analysis of microarray data has been often used to find biologically relevant Broups of genes based on their expression levels. Since many functionally related genes tend to be co-expressed, by identifying groups of genes with similar expression profiles, the functionalities of unknown genes can be inferred from those of known genes in the same group. In this Paper we address a novel clustering approach, called seed clustering, and investigate its applicability for microarray data analysis. In the seed clustering method, seed genes are first extracted by computational analysis of their expression profiles and then clusters are generated by taking the seed genes as prototype vectors for target clusters. Since it has strong mathematical foundations, the seed clustering method produces the stable and consistent results in a systematic way. Also, our empirical results indicate that the automatically extracted seed genes are well representative of potential clusters hidden in the data, and that its performance is favorable compared to current approaches.

• BMB Reports
• /
• v.56 no.6
• /
• pp.341-346
• /
• 2023

Acute myocardial infarction (AMI) is a multifaceted syndrome influenced by the functions of various extrinsic and intrinsic pathways and pathological processes, which can be detected in circulation using biomarkers. In this study, we investigated the secretome protein profile of induced-hypertrophy cardiomyocytes to identify next-generation biomarkers for AMI diagnosis and management. Hypertrophy was successfully induced in immortalized human cardiomyocytes (T0445) by 200 nM ET-1 and 1 μM Ang II. The protein profiles of hypertrophied cardiomyocyte secretomes were analyzed by nano-liquid chromatography with tandem mass spectrometry and differentially expressed proteins that have been identified by Ingenuity Pathway Analysis. The levels of 32 proteins increased significantly (>1.4 fold), whereas 17 proteins (<0.5 fold) showed a rapid decrease in expression. Proteomic analysis showed significant upregulation of six 14-3-3 protein isoforms in hypertrophied cardiomyocytes compared to those in control cells. Multi-reaction monitoring results of human plasma samples showed that 14-3-3 protein-zeta levels were significantly elevated in patients with AMI compared to those of healthy controls. These findings elucidated the role of 14-3-3 protein-zeta in cardiac hypertrophy and cardiovascular disorders and demonstrated its potential as a novel biomarker and therapeutic strategy.

• Clinical Nutrition Research
• /
• v.13 no.2
• /
• pp.121-129
• /
• 2024

The prevalence of metabolic syndrome caused by diets containing excessive fatty acids is increasing worldwide. Patients with metabolic syndrome exhibit abnormal lipid profiles, chronic inflammation, increased levels of saturated fatty acids, impaired insulin sensitivity, excessive fat accumulation, and neuropathological issues such as memory deficits. In particular, palmitic acid (PA) in saturated fatty acids aggravates inflammation, insulin resistance, impaired glucose tolerance, and synaptic failure. Recently, adiponectin, brain-derived neurotrophic factor (BDNF), and glucose-like peptide-1 (GLP-1) have been investigated to find therapeutic solutions for metabolic syndrome, with findings suggesting that they are involved in insulin sensitivity, enhanced lipid profiles, increased neuronal survival, and improved synaptic plasticity. We investigated the effects of adiponectin, BDNF, and GLP-1 on neurite outgrowth, length, and complexity in PA-treated primary cortical neurons using Sholl analysis. Our findings demonstrate the therapeutic potential of adiponectin, BDNF, and GLP-1 in enhancing synaptic plasticity within brains affected by metabolic imbalance. We underscore the need for additional research into the mechanisms by which adiponectin, BDNF, and GLP-1 influence neural complexity in brains with metabolic imbalances.