• Progress in Medical Physics
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• v.6 no.2
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• pp.61-70
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• 1995

The picosecond time resolved fluorescence spectra of Hematoporphyrin Derivative (HPD) in both solutions and cancer cell are measured by a time correlated single photon counting system with a synchronously mode locked dye laser. Two exoponential decay components in the fluorescence spectra were observed. The slow decay(6.3 ㎱)and the fast one(350 ㎰)are attributed to be originated from monomers and dimers, respectively. The absorption and fluorescence measurements in steady state also showed the presence of a monomeric and dimeric forms of HPD molecules. The monomer lifetime in the cancer cell was measured to be longer than that in solution, which was expected from the blue shift and narrowing of the absorption spectra for HPD-treated in vitro. The relative amplitude of the fast component was found to be enhanced in cancer cell, strongly indicating the higher affinity of the dimer for the cancer cell.

• The Korean Journal of Physiology and Pharmacology
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• v.16 no.1
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• pp.25-30
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• 2012

Under some pathological conditions as bile flow obstruction or liver diseases with the enterohepatic circulation being disrupted, regurgitation of bile acids into the systemic circulation occurs and the plasma level of bile acids increases. Bile acids in circulation may affect the nervous system. We examined this possibility by studying the effects of bile acids on gating of neuronal (N)-type $Ca^{2+}$ channel that is essential for neurotransmitter release at synapses of the peripheral and central nervous system. N-type $Ca^{2+}$ channel currents were recorded from bullfrog sympathetic neuron under a cell-attached mode using 100 mM $Ba^{2+}$ as a charge carrier. Cholic acid (CA, $10^{-6}M$) that is relatively hydrophilic thus less cytotoxic was included in the pipette solution. CA suppressed the open probability of N-type $Ca^{2+}$ channel, which appeared to be due to an increase in (no activity) sweeps. For example, the proportion of sweep in the presence of CA was ~40% at +40 mV as compared with ~8% in the control recorded without CA. Other single channel properties including slope conductance, single channel current amplitude, open and shut times were not significantly affected by CA being present. The results suggest that CA could modulate N-type $Ca^{2+}$ channel gating at a concentration as low as $10^{-6}M$. Bile acids have been shown to activate nonselective cation conductance and depolarize the cell membrane. Under pathological conditions with increased circulating bile acids, CA suppression of N-type $Ca^{2+}$ channel function may be beneficial against overexcitation of the synapses.

• The Korean Journal of Physiology and Pharmacology
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• v.14 no.6
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• pp.399-405
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• 2010

Gamma-aminobutyric acid (GABA)-ergic inhibition is important in the function of the visual cortex. In a previous study, we reported a developmental increase in $GABA_A$ receptor-mediated inhibition in the rat visual cortex from 3 to 5 weeks of age. Because this developmental increase is crucial to the regulation of the induction of long-term synaptic plasticity, in the present study we investigated in detail the postnatal development of phasic and tonic inhibition. The amplitude of phasic inhibition evoked by electrical stimulation increased during development from 3 to 8 weeks of age, and the peak time and decay kinetics of inhibitory postsynaptic potential (IPSP) and current (IPSC) slowed progressively. Since the membrane time constant decreased during this period, passive membrane properties might not be involved in the kinetic changes of IPSP and IPSC. Tonic inhibition, another mode of $GABA_A$ receptor-mediated inhibition, also increased developmentally and reached a plateau at 5 weeks of age. These results indicate that the time course of the postnatal development of GABAergic inhibition matched well that of the functional maturation of the visual cortex. Thus, the present study provides significant insight into the roles of inhibitory development in the functional maturation of the visual cortical circuits.

• Journal of Advanced Navigation Technology
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• v.8 no.1
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• pp.73-80
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• 2004

In the case of Non-Line-of-Sight (NLOS), common telecommunication systems typically have Rayleigh distributed amplitude characteristics. However measurement result of Ultra Wideband (UWB) Multi-Band Orthogonal Frequency Division Multiplexing (MB-OFDM) system which is proposed as one of candidate standard in IEEE 802. 15. 3a for Wireless Personal Area Network (WPAN) shows that it has independent log normal fading in each cluster as well as in each ray within the cluster. Based on this clustering phenomenon observed, MB-OFDM channel model derived from Saleh-Valenzuela model with a couple of slight modifications. In this paper, channel remodeling for RF frequency hopping in MB-OFDM system is achieved, and performances of MB-OFDM system for each channel mode and data rate are verified using modified channel model.

• Proceedings of the Korean Society of Propulsion Engineers Conference
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• 2006.05a
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• pp.275-278
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• 2006

Systematic experiments in $CH_4/Air$ counterflow diffusion flames diluted with He have been undertaken to study the oscillatory instability in which lateral heat loss could be remarkable at low global strain rate. The oscillatory instability arises for Lewis numbers greater than unity and occurs near extinction condition. The dynamic behaviors of extinction in this configuration can be classified into three modes; growing, harmonic and decaying oscillation mode near extinction. As the global strain rate decreases, the amplitude of the oscillation becomes larger. This is caused by the increase of lateral heat loss which ran be confirmed by the reduction of lateral flame size. Oscillatory edge flame instabilities at low global strain rate are shown to be closely associated with not only Lewis number but also heat loss (radiation and lateral heat loss).

• The Journal of the Acoustical Society of Korea
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• v.9 no.4
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• pp.66-76
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• 1990

In this work, the effect of noise and distortion of a telephone channel on the speech recognition is studied, and methods to improve the recognition rate are proposed. Computer simulation is done using the 100-word test data whichwere made by pronouncing ten times 100-phonetically balanced Korean isolated words in a speaker dependent mode. First, a spectral subtraction method is suggested to improve the noisy speech recognition. Then, the effect of bandwidth limiting and channel distortion is studied. It has been found that bandwidth limiting and amplitude distortion lower the recognition rate significantly, but phase distortion affects little. To reduce the channel effect, we modify the reference pattern according to some training data. When both channel noise and distortion exist, the recognition rate without the proposed method is merely 7.7~26.4%, but the recognition rate with the proposed method is drastically increased to 76.2~92.3%.

• Journal of Korea Multimedia Society
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• v.16 no.10
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• pp.1171-1179
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• 2013

Interactive audio service provide with audio generating and editing functionality according to user's preference. A spatial audio object coding (SAOC) scheme is audio coding technology that can support the interactive audio service with relatively low bit-rate. However, when the SAOC scheme remove the specific one object such as vocal object signal for Karaoke mode, the scheme support poor quality because the removed vocal object remain in the SAOC-decoded background music. Thus, we propose a new SAOC vocal harmonic extranction and elimination technique to improve the background music quality in the Karaoke service. Namely, utilizing the harmonic information of the vocal object, we removed the harmonics of the vocal object remaining in the background music. As harmonic parameters, we utilize the pitch, MVF(maximum voiced frequency), and harmonic amplitude. To evaluate the performance of the proposed scheme, we perform the objective and subjective evaluation. As our experimental results, we can confirm that the background music quality is improved by the proposed scheme comparing with the SAOC scheme.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.30 no.11C
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• pp.1083-1090
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• 2005

This paper presents the design of a video encoder for the device of need TV-OUT function. The designed video encoder satisfies the standard conditions of International Telecommunication Union-Radiocommunication (ITU-R) BT.470. ITU-R BT.470 can be classified as NTSC, PAL or SECAM. NTSC and PAL use Amplitude Modulation (AM) to transmit color difference signals and SECAM uses Frequency Modulation (FM). SECAM must have an antic-cloche filter but the filter recommended by ITU-R BT.470 is not easy to design due to sharpness of the frequency response. So formerly the filter was designed as analog. This paper proposes that the filter is designed as digital and the special quality of the filter is transformed easy to design. And the modulation method is modified to be identical with the result required at standard. The encoder can control power consumption by output mode to apply mobile phone, mobile devices, etc. The proposed encoder is experimentally demonstrated with ALTERA FPGA APEX20KE EP20K1000EBC652-3 device and SAMSUNG LCD-TV.

• Journal of Korean Society of Steel Construction
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• v.13 no.2
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• pp.191-200
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• 2001

This paper presents buckling analysis of the cylindrical shell subjected to axial loads using numerical method. The modeling method, appropriate element type, and number of element are recommended by comparing with analytical solution. Based on the parametric study, buckling stress decreases significantly as the diameter-thickness ratio increases. These results are different from those obtained from buckling analysis of columns. The number of buckling half-wave in circumferential direction decreases as the diameter-height ratio increases. Buckling stress increases 1~2% as the thickness of base plate increases. Therefore the effect of base plate on buckling strength for cylindrical shell can be disregarded. Buckling stress significantly decreases as the amplitude of initial geometric imperfection used for calculating buckling stress is developed and it shows a good agreement with numerical results.

• Journal of the Korean Society for Aeronautical & Space Sciences
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• v.42 no.1
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• pp.29-36
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• 2014

Hybrid rocket displays many different low frequency pressure oscillations during combustion. Thermal lag between solid and gas phase is the primary mechanism to trigger low frequency pressure oscillations of around 10Hz, and Helmholtz or $L^*$ mode also produces other types of low frequency oscillations above 10 Hz which is associated with the change in combustion volume. Since the flow characteristics in hybrid rocket is very similar to those in solid rocket combustion, it is not surprising to observe similar pressure oscillation behaviors. Experimental test shows that combustion pressure suddenly turns into to a big amplitude oscillation around 10Hz then followed by returning to an original pressure level after a short period combustion. Further investigations show that this instability is independent of the change in O/F ratio at all. One of the possible candidates is the vortex shedding dynamics over the backward step in the post combustion chamber. It is required to investigate the low frequency oscillation mechanism in the future study.