• Preventive Nutrition and Food Science
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• 제12권1호
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• pp.16-22
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• 2007

In order to evaluate the hepatoprotective effect of an herb distillate, ie., a mixture of 28 traditional Korean herbs, germanium, tormarine and Gijangsoo (Gijang water), $CCl_4$ was intraperitoneally administered to rats before or after supplementation of the diluted herb distillate (HD) for 2 weeks. Then hepatic xanthine oxidase activity and serum lipid profiles were determined. The experimental groups had higher feed intake than the normal control (NC), but had lower weight gain. Water intake and the amount of feces were not significantly different, but urine was excreted in lower amounts in all the experimental groups compared to the NC. Liver weights in the HD-supplemented groups were lower than that of the distilled water-supplemented groups (DW-groups) after $CCl_4$-administration. Serum ALT activities in all the experimental groups were higher than that of the NC-group. However, the increasing activity of serum ALT in the HD-supplemented groups (HD-groups) was lower than that of the DW-groups. Total serum and LDL-cholesterol levels were higher in all the $CCl_4$-administered groups than in the NC-groups, and serum HDL-cholesterol levels were lower in all the experimental groups compared with the NC-groups. Meanwhile, the increasing rate of total serum and LDL-cholesterol levels and the decreasing rate of HDL-cholesterol in the HD-groups were lower than that of the DW-groups. But, levels of serum TG were similar among all the experimental groups. The activities of hepatic xanthine oxidase (XOD) type O of the $CCl_4$-administered rats showed a significant increase in and an increasing rate of XOD in the HD-groups, which was lower than that of the DW-groups. On the other hand, GST activities in all the experimental groups were significantly decreased, and the decreasing rate was lower in the HD-groups than in the DW-groups. The hepatic contents of GSH and LPO in all the rats were not changed by $CCl_4$ administration. These results suggest that the decreased liver damage in the HD-supplemented groups was due to the inhibition of XOD-type O activity by constituents of HD, as well as by a prevention/inhibition of serum lipid profile changes in $CCl_4$-treated rats. However, further detailed studies are needed to support this hypothesis.

• Current Research on Agriculture and Life Sciences
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• 제31권4호
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• pp.265-271
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• 2013

이 시험은 국내에서 육성된 딸기 5품종에 대한 적정 착과수를 알아보기 위해 수행되었다. 화방 당 착과수를 4~5과, 7~9과 그리고 적과를 하지 않은 방임구를 비교한 결과, 적과를 함으로써 모든 품종의 평균 과중이 증가하였으며, 당도는 높아지고 산도는 낮아져 상품성이 향상되었다. 적과 정도가 강할수록 화경장은 짧아지는 경향이었으나 잎 수, 엽병장, 관부직경 등은 차이가 없었다. 적과를 실시한 후 각 화방의 1번 과중을 조사한 결과, 설향과 매향 품종은 2화방에서부터 뚜렷이 과중이 커졌으며, 대왕과 싼타 품종은 3화방의 1번 과중이 무거워졌다. 옥매 품종은 뚜렷한 경향을 보이지 않았다. 대왕과 매향은 화방 당 4~5과를 남기는 강한 적과를 하는 것이 방임구에 비해 각각 4.3% 및 6.6% 증수되었으며, 싼타, 옥매, 설향 품종은 7~9과를 남기는 가벼운 적과를 하는 것이 방임구에 비해 각각 3.1, 3.5, 9.1% 증수되었다. 결과적으로 각 품종의 개화습성에 맞게 착과 수를 조절함으로써 과실 품질을 향상시키고 수확량을 증대시킬 수 있었다.

• 대한치과보철학회지
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• 제39권2호
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• pp.197-207
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• 2001

Development of new ceramics and esthetic needs of patients increase the use of all ceramic restorations. Fractured teeth often need metal post and core as foundation for final restoration. When all ceramic restorations are planned, metal post and core may lead to compromised esthetics because of opacity and gray color of metal post and core. Many techniques have been proposed to solve this problem such as application of an opaque porcelain to the metal core or all ceramic post and core. This study was performed to evaluate effect on color of Empress 2 crown according to various post systems. Color was evaluated by the CIE $L^*a^*b^*$ systems and measured by spectrophotometer (Model CM-3500, Minolta, Japan). Specimens were divided into 4 groups as follows Group 1 : gold cast post specimen + Empress 2 crown specimen Group 2 : application of an opaque porcelain to gold cast post specimen + Empress 2 crown specimen Group 3 : cosmopost specimen + Empress 2 crown specimen Group 4 : In-ceram post specimen + Empress 2 crown specimen. The results obtained as follows, 1. $L^*$ Values showed that group 2, 3, 4 were higher than group 1 with significant difference and group 2, 3, 4 were not significantly different. 2. $a^*$ Values and $b^*$ values also showed that group 2. 3, 4 were higher than group 1 with significant difference and group 2, 3, 4 were not significantly different. 3. ${\Delta}E^* ab$ Values showed that ${\Delta}E^* ab$ 3 was the highest value and ${\Delta}E^* ab$ 5 was the lowest value.

• 대한수의학회지
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• 제36권1호
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• pp.151-159
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• 1996

This study was carried out to evaluate the effects of all-trans retinoic acid(RA) on the development of cholangiocarcinoma in hamsters. Eighty six female Syrian golden hamsters were divided into four groups. Group I was for the induction of the cholangiocarcinoma, which was infected orally with C sinensis and given dimethylnitrosamine(DMN, 15ppm) in drinking water for 4 weeks. Group II was for evaluating the effect of all-trans RA treatment on the cholangiocarcinogenesis, which was treated the same as group I and orally given RA(1mg/kg, 5 times per week) for 15 weeks. Group III was given only RA hr 15 weeks. Control group IV was given only soybean oil which was solvent for RA treatment. More than 5 heads of hamsters in each group were sacrificed at 4, 7, 11 and 15 weeks after the begining of the experiment. The livers were examined grossly, histopathologically, and immunohistochemically. The results obtained were as follows : 1. Death of animals started from the 11 weeks after the begining of the experiment. One of the total 22 animals(5%) and 7 of the total 24 animals(29%) died in group I and group II, respectively. 2. Proliferation of oval cell was peaked at 11 weeks in group I and at 7 weeks in group II, and decreased gradually after those periods of the time. 3. Cholangiocarcinomas were found in 1 of 6 animals(17%) at 11 weeks and in 4 of 6 animals(67%) at 15 weeks in group I, respectively. But in group II, the cholangiocarcinomas occured in 1 of 5 animals(20%) at 7 weeks, in 7 of 12 animals(58%) at 11 weeks and in 2 of the rest animals(100%) at 15 weeks, respectively. 4. Expression of $\alpha$-fetoprotein(AFP) of the oval cells in the group II showed the same degree of positive reaction at that of group I at 4 weeks. But AFP postive oval cells decreased gradually and AFP negative oval cells(ductlike oval cells) increased gradually. 5. Expression of cytokeratin of the oval cells in group II was shown slightly at 4 weeks and the degree of expression increased moderately from the 7 weeks. But the expression of the oval cells in group I was shown slightly after the 7 weeks. These results suggested that all-trans RA promoted the occurrence and the rate of cholangiocarcinoma by inducing differentiation of small cells and oval cells in the liver of hamsters infected with C sinensis and treated with DMN.

• 혜화의학회지
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• 제8권1호
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• pp.675-687
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• 1999

Gamigungguitang(GMGGT) and GamigungguitangGaNokyong(GMGGTN) are one of the importent prescription that has been used in oriental medicine(dongyyibangjehak) for helling fractured condition. The study was done to evaluate effects of GMGGT and GMGGTN water extract on the tibia fractured rats. The result were obtained as follows : 1. In the change of X-ray, all experimental group was significantly effected than control. 2. In the changes of body weight, all experimental group was decreased than control. 3. In the change of Ca, P and ALP(alkaline phosphatase) on serum, all experimental group was not significant. 4. In the change of bone tissue, all experimental group was was significantly effected than control in callus formation and maturity. From above results GMGGT and GMGGTNBSH were had significant effects on the helling of fractured in rats, so it is expected to clinical application.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• 제28권3호
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• pp.205-215
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• 2002

The purpose of this study was to evaluate the tissue response in various bone grafting materials, especially xenogenous bone materials in vivo, compare of bone formation capacity of various bone grafting materials on rat skull defects and evaluate the effect of Hyaluronic acid on healing of human Demineralized Freezed Dried Bone allogenous graft (DFDBA) materials in rat calvarial defects. 30 Sprague-Dawly rats were divided into 4 groups. $7{\times}7mm$ size bony defect were artificially prepared in the calvaria (both parietal bone) of all 30 rats and follwed group grafting of autogenous bone graft on right side and allogenic DFDBA on left side bone graft (rat DFDB) in 15 control group, but in 15 experimental group, xenograft (human DFDB) on left side, hyaluronic acid treated with xenograft on right side. Sequential sacrifices was performed at 1, 2, 4, 6, 8 weeks of experiment. These specimens were stained with H&E and MT stain, and then histologic analysis under light microscope was carried out. There were inflammatory reaction in all graft material during early stage. Autogenous and Allogenous DFDBA graft group observed inflammatory reaction at 1 week. Xenograft group persistant inflammatory reaction until 4 weeks, but in HA treated xenograft group inflammatory reaction was decreased at 2 weeks. Osteoblastic activity in control group was begun at 2 week, xenograft group was delayed at 6 weeks, however HA treated xenograft group was begun at 4 weeks. At 2 week, mild osteoclastic activity were observed in all xenograft group not in concerned to HA, but there was no difference each group after 4 weeks. There are most activated angiogenesis around graft mateirals in xenograft group at 2 weeks, but in HA treated xenograft group, decreased angiogenesis was observed at same time. Bone formation and bone maturation of xenograft group, there was no difference in HA treatment, was less than control group. Fibrosis around xenograft materials were observed until 6 weeks, there was no difference between xenograft and HA treated groups.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• 제31권4호
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• pp.300-305
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• 2005

Purpose: For the reconstruction of maxillofacial defect created by trauma, infection, or tumor etc, the role of microvascular anastomosis or vessel graft has been increased. Many methods has been tried to increase the success rate of microvascular anastomosis. Various anticoagulants and thrombolytic agents have been used to reduce the failure rate of microvascular anastomosis and avoid re-operation. Many drugs, however, have been used in the limited cases because most of these drugs may cause complications, such as allergy, fever or systemic bleeding. This study was performed to evaluate the influence of the Argatroban on patency and thrombosis in microvascular anastomosis when it is used for local irrigation or general administration. Materials & methods: Eight mature rabbits, weighing 2kg, were used. After exposing both femoral veins, the artificial thrombotic model was made by crushing injury using a smooth needle holder, and the transverse incision were made on femoral vein. The animals were divided into 4 groups according to Argatroban administration methods; control group (n=4), topical irrigation of lumen with saline solution; experimental group 1 (n=4), topical irrigation of lumen with Argatroban saline solution; experimental group 2 (n=4), topical irrigation of lumen with heparin followed by intravenous injection of Argatroban; experimental group 3 (n=4), topical irrigation of lumen with Argatroban followed by IV of Argatroban. Microvascular anastomosis was done with 10-0 Ethilon. The patency was evaluated by empty-and-refill test 30 minutes and 3 days after microanastomosis. The thrombus formation was examined 3 days after microanastomosis by surgical microscope. The histologic findings were also examined. Results: 1. Thirty minutes after microvascular anastomosis, the patency of all experimental groups was better than that of control group, but there was no significant difference among groups. 2. Three days after microvascular anastomosis, the patency of all experimental groups was more improved than that of control group (p<0.05). There was no significant difference among experimental groups. 3. Three days after microvascular anastomosis, the amount of thrombus in all experimental groups was less than that of control group (p<0.05). There was no significant difference among experimental groups. 4. Histologically, a lot of luminal thrombus was observed around sutured area in control group. Few luminal thrombus was observed in all experimental groups. The necrotic changes were observed on the sutured vein wall in all specimens. Conclusion: These results indicate that topical irrigation and/or intravenous administration of Argatroban is effective in improving patency and preventing thrombus formation after microvascular anastomosis.

• Korean Journal of Mathematics
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• 제27권4호
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• pp.969-976
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• 2019

Let ℬ(ℋ) be the algebra of all bounded linear operators on a complex Hilbert space ℋ and 𝒨 ⊆ ℬ(ℋ) be a von Neumann algebra without central abelian projections. Let ξ be a non-zero scalar. In this paper, it is proved that a mapping φ : 𝒨 → ℬ(ℋ) satisfies φ([A, B]^ξ_⁎)= [φ(A), B]^ξ_⁎+[A, φ(B)]^ξ_⁎ for all A, B ∈ 𝒨 if and only if φ is an additive ⁎-derivation and φ(ξA) = ξφ(A) for all A ∈ 𝒨.

• International Journal of Fuzzy Logic and Intelligent Systems
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• 제1권1호
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• pp.119-124
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• 2001

In this pattern recognition on the large volumes of remote sensing satellite images, the inference time is much increased. In the case of the remote sensing data [5] having 4 wavebands, the 778 training patterns are learned. Each land cover pattern is classified by using 159, 900 patterns including the trained patterns. For the fuzzy classification, the 778 fuzzy rules are generated. Each fuzzy rule has 4 fuzzy variables in the condition part. Therefore, high performance parallel fuzzy inference system is needed. In this paper, we propose a novel parallel fuzzy inference system on T3E parallel computer. In this, fuzzy rules are distributed and executed simultaneously. The ONE_To_ALL algorithm is used to broadcast the fuzzy input to the all nodes. The results of the MIN/MAX operations are transferred to the output processor by the ALL_TO_ONE algorithm. By parallel processing of the fuzzy rules, the parallel fuzzy inference algorithm extracts match parallelism and achieves a good speed factor. This system can be used in a large expert system that ha many inference variables in the condition and the consequent part.

• 한국잠사곤충학회지
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• 제20권1호
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• pp.5-10
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• 1978

Kinetin의 엽면살포가 상수의 생장및 생체내 대사에 미치는 영향을 분석 검토하여 얻어진 결과를 요약하면 다음과 같다. 1. 상엽의 생건중, 엽면적. 지조장, 지조경의 증대에 효과가 있었다. 2. 상엽의 엽록소의 함량증대에 효과가 있었다. 3. 상엽의 GOT활성은 촉진시켜 주었으나 GPT활성에는 영향을 주지 않았다. 4. 상엽내 당대사를 촉진시켜 주었다.