• Title/Summary/Keyword: Aging processes

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Inhibitory Activity of Blueberries on UVB-induced Oxidative Stress and Matrix Metalloproteinase Expression in Human Skin Fibroblasts (인간피부 섬유아세포에서 UVB 유도된 산화 스트레스와 기질금속단백질가수분해효소 발현에 블루베리의 저해능)

  • Jang, Young Ah;Kim, Se Gie
    • Journal of Life Science
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    • v.29 no.12
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    • pp.1321-1328
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    • 2019
  • Intermediate-wavelength solar radiation, also known as ultraviolet B (UVB: 290-320 nm) radiation, may cause premature aging and oxidative damage-dependent skin cancer in humans. UVB-induced formation of reactive oxygen species (ROS)-often a consequence of excessive exposure to these rays-could activate matrix metalloproteinases (MMPs) such as MMP-1 and MMP-3. These enzymes break down type I collagen in human fibroblasts. In this study, we assessed the antioxidant and anti-aging effects of ethyl acetate extract of blueberry (EEB). An antioxidant test in blueberries evaluated ROS production using CCD-986sk cells and DPPH assay. In order to evaluate the anti-wrinkle efficacy of blueberries, the MMP-1 production and type 1 procollagen synthesis evaluated and the expression of MMP 1, 3 were tested through Western blot and RT- PCR. EEB exhibited 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity and reduced the production of UVB-induced ROS. Also, EEB inhibited UVB-induced processes associated with photoaging and skin cancer, such as reduction in procollagen production and increase in MMP-1 production. More precisely, EEB (50 ㎍/ml) markedly suppressed mRNA and protein levels of MMP-1 and -3. The anti-aging effects are attributable to the antioxidant activity of EEB. These findings indicate that EEB has a protective effect against UVB-induced aging in human fibroblast cells by regulating the levels of type-1 procollagen, MMP-1, and MMP-3.

electrical Damage of Metallized Film Capacitors (필름 Capacitor의 전기적Damage에 관한 연구)

  • ;Chathan M. Cooke
    • The Transactions of the Korean Institute of Electrical Engineers
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    • v.40 no.6
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    • pp.574-581
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    • 1991
  • Damage in film capacitors has been investigated, using FTIR and ESCA, aiming to elucidate the nature of electrode removal and the possibility of base films to be damaged. Also, tests were conducted to investigate the effect of a long-term thermal aging at elevated temperatures. Unsuccessful clearing or grape-clustering processes can induce a long-term degradation which involves the chemical and morphological changes. Major changes are the oxidation and the decrease in surface crystallinity possibly arising from the corona discharge. An immediate deterioration of BOPP film may occur when the air entrapped between the film layers induces an extensive autocatalytic oxidative degradation. This type of immediate damage may result in a premature failure at an early stage of qualification test. As far as the nature of electrode removal is concerned, a permanent removal of electrode materials was observed in the main erosion area.

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Typical Classification of Rural Area Considering Settlement Environment by Decision Tree Method (정주여건을 고려한 의사결정나무기법 활용 농촌지역 유형화)

  • Bae, Seung-Jong;Kim, Dae-Sik;Eun, Sang-Kyu
    • Journal of The Korean Society of Agricultural Engineers
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    • v.58 no.6
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    • pp.79-92
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    • 2016
  • The objective of this study is to classify the types of rural areas (138 $si{\cdot}gun$) considering settlement environment by Decision Tree Method (CHAID). The CHAID method was used for decision tree algorithm and the seven dependant variables and 5 explanatory variables were selected, respectively. By decision tree method, rural areas were finally classified into six groups through three separate processes. City area, lower area in aging rate and higher area in farmland area ratio was analyzed to be relatively rich rather than other area in the case of settlement environment index. In the future, this study will be able to utilize as a reference to the planning of rural development projects.

Study on the Synthesis and thermal Characteristics of Nano Porous Silica Powder (나노세공 실리카 분말의 합성과 열적 특성에 관한 연구)

  • 김종길;박진구;김호건
    • Journal of Powder Materials
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    • v.9 no.5
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    • pp.365-369
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    • 2002
  • Silica hydrogel was synthesized by the reaction of liquid sodium silicate with sulfuric acid. The condensation polymerization of the synthesized hydrogel was carried out via an aging process under the acidic or alkaline conditions. Nano porous silica with the pore size below 3 nm and surface area of $715m^2/g$, was obtained by the above processes in acidic ranges(pH : 3~5). The pore size and surface area of the silica varied with pH, and in alkaline ranges(pH : 8~10), those were 21 nm and $300m^2/g$ respectively. The characteristics of the silica varied with the thermal treatment which caused the change of surface area, pore volume and pore diameter.

A Study on the Failure Behavior of Carbon Fiber Sheet Reinforced Mortar Using Acoustic Emission Technique (AE를 이용한 탄소섬유시트 강화 모르타르의 파괴거동에 관한 연구)

  • 이진경;이준현;장일영
    • Journal of the Korea Concrete Institute
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    • v.12 no.3
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    • pp.67-75
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    • 2000
  • It was well recognized that the damages associated mainly with the aging of civil infrastructures were one of very serious problems for assurance of safety and reliability. Recently carbon fiber sheet(CFS) has been widely used for reinforcement and rehabilitation of damaged concrete beam. However, the fundamental mechanism of load transfer and its load-resistant for carbon fiber sheet reinforced concrete are not fully understood. In this study, three point bending test has been carried out to understand the damage progress and the micro-failure mechanism of CFS reinforced mortars. For this purpose, four different types of specimens are used, that is, mortar, steel bar reinforced mortar, CFS reinforced mortar, and steel bar and CFS reinforced morter. Acoustic Emission(AE) technique was used to evaluate the characteristics of damage progress and the failure mechanism of specimens. in addition, two-dimensional AE source location was also performed to monitor crack initiation and propagation processes for these specimens.

Histone tail cleavage as a novel epigenetic regulatory mechanism for gene expression

  • Yi, Sun-Ju;Kim, Kyunghwan
    • BMB Reports
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    • v.51 no.5
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    • pp.211-218
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    • 2018
  • Chromatin is an intelligent building block that can express either external or internal needs through structural changes. To date, three methods to change chromatin structure and regulate gene expression have been well-documented: histone modification, histone exchange, and ATP-dependent chromatin remodeling. Recently, a growing body of literature has suggested that histone tail cleavage is related to various cellular processes including stem cell differentiation, osteoclast differentiation, granulocyte differentiation, mammary gland differentiation, viral infection, aging, and yeast sporulation. Although the underlying mechanisms suggesting how histone cleavage affects gene expression in view of chromatin structure are only beginning to be understood, it is clear that this process is a novel transcriptional epigenetic mechanism involving chromatin dynamics. In this review, we describe the functional properties of the known histone tail cleavage with its proteolytic enzymes, discuss how histone cleavage impacts gene expression, and present future directions for this area of study.

Factors Influencing Satellite Cell Activity during Skeletal Muscle Development in Avian and Mammalian Species

  • Nierobisz, Lidia S;Mozdziak, Paul E
    • Asian-Australasian Journal of Animal Sciences
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    • v.21 no.3
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    • pp.456-464
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    • 2008
  • Avian and mammalian skeletal muscles exhibit a remarkable ability to adjust to physiological stressors induced by growth, exercise, injury and disease. The process of muscle recovery following injury and myonuclear accretion during growth is attributed to a small population of satellite cells located beneath the basal lamina of the myofiber. Several metabolic factors contribute to the activation of satellite cells in response to stress mediated by illness, injury or aging. This review will describe the regenerative properties of satellite cells, the processes of satellite cell activation and highlight the potential role of satellite cells in skeletal muscle growth, tissue engineering and meat production.

A Brief review of Aragonite Precipitated Calcium Carbonate (PCC) Synthesis Methods and Its Applications

  • Ramakrishna, Chilakala;Thenepalli, Thriveni;Ahn, Ji Whan
    • Korean Chemical Engineering Research
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    • v.55 no.4
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    • pp.443-455
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    • 2017
  • This article provides an exclusive overview of the synthesized aragonite precipitated calcium carbonate and its applications in various fields. The last decade has seen a steady increase in the number of publications describing the synthesis, characterization and applications of calcium carbonate morphologies. Mainly, two kinds of processes have been developed for the synthesis of aragonite precipitated calcium carbonate under controlled temperature, concentrations and aging, and the final product is single-phase needle-like aragonite precipitated calcium carbonate formed. This review is mainly focused on the history of developed methods for synthesizing aragonite PCC, crystal growth mechanisms and carbonation kinetics. Carbonation is an economic, simple and ecofriendly process. Aragonite PCC is a new kind of functional filler in the paper and plastic industries, nowadays; aragonite PCC synthesis is the most exciting and important industrial application due to numerous attractive properties. This paper describes the aragonite PCC synthetic approaches and discusses some properties and applications.

A study on the On-Line Diagnostic Technique of High Voltage Induction Motor by partial discharge Pattern Analysis (부분방전 패턴분석에 의한 고압유도전동기 무정전 진단기법 연구)

  • Jung, Young-Ill;Lee, Eun-Suk;Kim, Duck-Keun;Lim, Yung-Bae;Kim, Jong-Seo
    • Proceedings of the KIEE Conference
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    • 2002.07c
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    • pp.1685-1687
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    • 2002
  • High voltage(H.V.) induction motors have been applied to various industrial applications. But aging and failure of induction motors are initiated by electrical, mechanical, thermal and chemical processes during manufacturing or in-service. These detects reduce locally the dielectric strength of the insulation. At such defects partial discharges can occur, which cause further degradation of the insulation and reduce the life time of the H.V induction motors. Consequently in this paper, we studied the partial discharge pattern analysis of H.V. induction motor for on-site applications.

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Analysis on the Mechanism of Fluting in the Bending of Low Carbon Steels (저탄소강판을 이용한 굽힘 가공에서 발생하는 꺾임 현상에 대한 발생기구 해석)

  • Park, K.C.;Yoon, J.B.
    • Transactions of Materials Processing
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    • v.16 no.4 s.94
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    • pp.317-322
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    • 2007
  • In order to investigate the cause and condition of fluting in tangential bending of low carbon steel sheet, an analytic analysis, an experiment and a series of finite element analysis for bending process were done. The fluting in bended sheet was related with the yield point elongation of material. Due to the yield point elongation, unstable plastic hinge was occurred in course of bending of elastic perfectly plastic sheet. According to the analysis and computational results, lower yield point elongation than 5% was required to prevent fluting in 0.5-0.6t sheet in $15{\sim}25mm$ radius bending. The tendency of fluting occurrence was reduced as decreasing the radius of bending, increasing thickness of bended sheet, and removing irregularity in sheet and bending processes.