• Journal of Genetic Medicine
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• v.20 no.2
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• pp.39-45
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• 2023

As advanced sequencing technologies continue to uncover an increasing number of variants in genes associated with human genetic diseases, there is a growing demand for systematic approaches to assess the impact of these variants on human development, health, and disease. While in silico analyses have provided valuable insights, it is essential to complement these findings with model organism studies to determine the functional consequences of genetic variants in vivo. Drosophila melanogaster is an excellent genetic model for such functional studies due to its efficient genetic technologies, high gene conservation with humans, accessibility to mutant fly resources, short life cycles, and cost-effectiveness. The traditional GAL4-UAS system, allowing precise control of gene expression through binary regulation, is frequently employed to assess the effects of monoallelic variants. Recombinase medicated cassette exchange or CRISPR-Cas9-mediated GAL4 insertion within coding introns or substitution of gene body with Kozak-Gal4 result in the loss-of-function of the target gene. This GAL4 insertion strategy also enables the expression of reference complementary DNA (cDNA) or cDNA carrying genetic variants under the control of endogenous regulatory cis elements. Furthermore, the CRISPR-Cas9-directed tissue-specific knockout and cDNA rescue system provides the flexibility to investigate candidate variants in a tissue-specific and/or developmental-timing dependent manner. In this review, we will delve into the diverse genetic techniques available in Drosophila and their applications in diagnosing and studying numerous undiagnosed diseases over the past decade.

• The Research Journal of the Costume Culture
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• v.32 no.1
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• pp.17-37
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• 2024

This study examines the rise of the Body Positive Movement on TikTok and its role as a form of online content activism influencing the fashion design and industry. Through a combination of literature review and case study methodology, the study explores the expression techniques and thematic types of Body Positive Movement on TikTok. Reviews of literature, previous studies, online articles, fashion journals, and relevant search terms on TikTok informed a definition of Body Positive Movement and an analysis of its formation and rise. The research findings confirm the impact TikTok content on Body Positive Movement has on the fashion industry in addressing external factors (i.e., 'Appearance', 'Race', 'Aging', 'Physical Disability') and intrinsic factors (i.e., 'Acceptance of Diversity', 'Self-Esteem', 'Rejection of Stereotypes', 'Appropriate Representation', 'Information Provision'). The key external factor , 'Appearance', includes subcategories such as 'Body Shape', 'Body Hair', 'Skin', and 'Facial Features'. TikTok content creators on fashion creatively combine music, emojis, and visual storytelling to exhibit positive self-perception concerning these factors. A significant finding of the study is that short clips predominantly manifesting external factors differentiate into informative or enlightening videos associated with intrinsic factors. The study underscores Body Positive Movement's important influence on the fashion industry from design to presentation.

• Journal of Ocean Engineering and Technology
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• v.12 no.1
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• pp.65-75
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• 1998

The fracture resistance curve is one of most important and design techniques employed in nuclear pressure vessel structures. This study is to evaluate the J-R curve characteristics for the SA508C-3 by the unloading compliance method and load rato analysis. The effect of strain aging for the exponential correlation of the J-R curve in this metal are investigated at room temperature, 20$0^{\circ}C$ and 30$0^{\circ}C$. The load ratio analysis method can evaluate the J-R curve by using the simple tension load-displacement curve only without the repeat of the unloading and loading. Therefore, the analysis by the proposed load ratio method has a merit, in comparison with the unloading compliance method, which can measure the crack length without the precision measurement equipment.

• Journal of the Society of Cosmetic Scientists of Korea
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• v.23 no.3
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• pp.39-47
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• 1997

Retinol as well as RA is well known to have many beneficial effects on aged skin. But the skin irritation potential and unstable condition of the products containing them have been some problems in their cosmetic uses. So, retinol containing gel product was developed for less skin irritancy and more stability in cosmetic products. To examine the clinical effects of retinlo containing product, we used cilnicla non-invasive assessment techniques on 40 volunteers for 6 months maintaining double-blind test conditions. According to our results, the use of retinol containing product improved skin color and hydration level slightly. But there was no statistical differences. There was no erythema reaction compared to the use of RA. Especially, the skin elasticity increased above 20% and skin wrinkles of crows' feet region decreased more than 10%. Besides the instrumental analysis, a large majority of volnteers felt that their skin were improved in the case of wrunkles, elasticity, hydration and color.

• 한국정보디스플레이학회:학술대회논문집
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• 2004.08a
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• pp.629-631
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• 2004

We report on the synthesis and film formation on a variety of small molecules such as $Alq_3$, $Znq_2$, and $Inq_3$, used as light emitting material in organic light emitting diodes (OLEDs) . The organic materials are usually susceptible to environmental aging and photo-oxidation, which influences their viability for commercial utility. Here, we examine the effects of oxygen and light on these organic materials to enhance the efficiency and lifetime of OLEDs. Optical techniques - ellipsometry, photoluminescence and infrared spectroscopies- have been used to study of environmental and light induced effects on 8-hydroxyquinoline derivative metal complex small molecules thin films

• Journal of Mechanical Science and Technology
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• v.18 no.8
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• pp.1368-1374
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• 2004

The remaining life estimation for the aged components in power plants as well as chemical plants are very important because mechanical properties of the components are degraded with in-service exposure time in high temperatures. Since it is difficult to take specimens from the operating components to evaluate mechanical properties of components, nondestructive techniques are needed to evaluate the degradation. In this study, test materials with several different degradation levels were prepared by isothermal aging heat treatment at $630^{\circ}C$. The DC potential drop method and destructive methods such as tensile and fracture toughness were used in order to evaluate the degradation of 1Cr-1Mo-0.25V steels. In this result, we can see that tensile strength and fracture toughness can be calculated from resistivity and it is possible to evaluate material degradation using DC potential drop method, non-destructive method.

• Proceedings of the KIEE Conference
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• 1991.07a
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• pp.281-285
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• 1991

In this paper, response characteristics by applying impulse into transformer windings in order to precaution diagonosis of power electric instrument are studied. A sample oilless transformer, an aging transformer and a good transformer are slected for models. The experimented results show that for testing the windings distortion and impedanced change of transformer the LVI method are suitable. Also, variation characteristic of output waveforms at time and frequency domain in order to efficient analysis is discussed. The results response that waveforms at frequency domain is very higher resolution at time domain.

• Journal of the Korean Institute of Electrical and Electronic Material Engineers
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• v.27 no.5
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• pp.322-327
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• 2014

Internal corrosion of the distribution line can be detected in order to develop techniques of non-destructive inspection methods that operate only on the metal track eddy current diagnosis is possible by applying the technique investigated. Sensor for the production of a finite element method modeled by using an eddy current sensor, a distribution line by using an accelerated aging samples of sodium hydroxide was prepared. Sheathed cables for internal corrosion studies detected using an eddy current sensor is considered to be possible.

• Journal of the Korean Applied Science and Technology
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• v.17 no.3
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• pp.167-173
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• 2000

The process variables for the manufacture of translucent microemulsion prepared with 2-octyl dodecanol, 12-hydroxy stearic acid cholesteryl , POE(40)HCO and 1,3-butandiol were examined initially (primary emulsion) and following aging for three months. The techniques empolyed in this study were particle size, turbidity, interfacial tension and microfluidizer. Particle size analysis and turbidity measurement to evaluate the emulsion stability were used. It was concluded that the process of the emulsification was an important indicator of the stability of the translucent microemulsion. From the particle size and and turbidity measurement of translucent microemulsion, adding the surfactant to the oil phase before the emulsification was found to be the most important factor for the stability of emulsions. We found that interfacial tension of the adding the surfactant to the oil phase is lower than that of the adding the surfactant to aqueous phase. In spite of hydrophilic surfactant, adding the surfactant to aqueous phase produced inferior emulsion to that to oil phase.

• Korean Journal of Materials Research
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• v.7 no.8
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• pp.650-653
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• 1997

In large generators in power plants, stator winding insulations is exposed to a combination of thermal, electrical, mechanical, environmental stresses in service. These combined stresses cause insulation aging which leads to final insulation breakdown. In order to identify the breakdown mechanism, the stator winding insulation materials which are composed of mica-epoxy is analyzed by the component of materials with EDS, SEM techniques. We concluded that the potassium ions of mica are replaced by hydrogen ions at boundary area of mica-epoxy and/or mica-mica. It is proposed that through these phenomena, the conductive layers of potassium ions enable high voltage fields of multiple stresses to create voids and microcracks.