• Title/Summary/Keyword: Aging Diagnosis

Search Result 353, Processing Time 0.026 seconds

Assessment of Mild Cognitive Impairment in Elderly Subjects Using a Fully Automated Brain Segmentation Software

  • Kwon, Chiheon;Kang, Koung Mi;Byun, Min Soo;Yi, Dahyun;Song, Huijin;Lee, Ji Ye;Hwang, Inpyeong;Yoo, Roh-Eul;Yun, Tae Jin;Choi, Seung Hong;Kim, Ji-hoon;Sohn, Chul-Ho;Lee, Dong Young
    • Investigative Magnetic Resonance Imaging
    • /
    • v.25 no.3
    • /
    • pp.164-171
    • /
    • 2021
  • Purpose: Mild cognitive impairment (MCI) is a prodromal stage of Alzheimer's disease (AD). Brain atrophy in this disease spectrum begins in the medial temporal lobe structure, which can be recognized by magnetic resonance imaging. To overcome the unsatisfactory inter-observer reliability of visual evaluation, quantitative brain volumetry has been developed and widely investigated for the diagnosis of MCI and AD. The aim of this study was to assess the prediction accuracy of quantitative brain volumetry using a fully automated segmentation software package, NeuroQuant®, for the diagnosis of MCI. Materials and Methods: A total of 418 subjects from the Korean Brain Aging Study for Early Diagnosis and Prediction of Alzheimer's Disease cohort were included in our study. Each participant was allocated to either a cognitively normal old group (n = 285) or an MCI group (n = 133). Brain volumetric data were obtained from T1-weighted images using the NeuroQuant software package. Logistic regression and receiver operating characteristic (ROC) curve analyses were performed to investigate relevant brain regions and their prediction accuracies. Results: Multivariate logistic regression analysis revealed that normative percentiles of the hippocampus (P < 0.001), amygdala (P = 0.003), frontal lobe (P = 0.049), medial parietal lobe (P = 0.023), and third ventricle (P = 0.012) were independent predictive factors for MCI. In ROC analysis, normative percentiles of the hippocampus and amygdala showed fair accuracies in the diagnosis of MCI (area under the curve: 0.739 and 0.727, respectively). Conclusion: Normative percentiles of the hippocampus and amygdala provided by the fully automated segmentation software could be used for screening MCI with a reasonable post-processing time. This information might help us interpret structural MRI in patients with cognitive impairment.

Current Trend of EV (Electric Vehicle) Waste Battery Diagnosis and Dismantling Technologies and a Suggestion for Future R&D Strategy with Environmental Friendliness (전기차 폐배터리 진단/해체 기술 동향 및 향후 친환경적 개발 전략)

  • Byun, Chaeeun;Seo, Jihyun;Lee, Min kyoung;Keiko, Yamada;Lee, Sang-hun
    • Resources Recycling
    • /
    • v.31 no.4
    • /
    • pp.3-11
    • /
    • 2022
  • Owing to the increasing demand for electric vehicles (EVs), appropriate management of their waste batteries is required urgently for scrapped vehicles or for addressing battery aging. With respect to technological developments, data-driven diagnosis of waste EV batteries and management technologies have drawn increasing attention. Moreover, robot-based automatic dismantling technologies, which are seemingly interesting, require industrial verifications and linkages with future battery-related database systems. Among these, it is critical to develop and disseminate various advanced battery diagnosis and assessment techniques to improve the efficiency and safety/environment of the recirculation of waste batteries. Incorporation of lithium-related chemical substances in the public pollutant release and transfer register (PRTR) database as well as in-depth risk assessment of gas emissions in waste EV battery combustion and their relevant fire safety are some of the necessary steps. Further research and development thus are needed for optimizing the lifecycle management of waste batteries from various aspects related to data-based diagnosis/classification/disassembly processes as well as reuse/recycling and final disposal. The idea here is that the data should contribute to clean design and manufacturing to reduce the environmental burden and facilitate reuse/recycling in future production of EV batteries. Such optimization should also consider the future technological and market trends.

Development of Signal Detection Methods for ECG (Electrocardiogram) based u-Healthcare Systems (심전도기반 u-Healthcare 시스템을 위한 파형추출 방법)

  • Min, Chul-Hong;Kim, Tae-Seon
    • Journal of the Institute of Electronics Engineers of Korea CI
    • /
    • v.46 no.6
    • /
    • pp.18-26
    • /
    • 2009
  • In this paper, we proposed multipurpose signal detection methods for ECG (electrocardiogram) based u-healthcare systems. For ECG based u-healthcare system, QRS signal extraction for cardiovascular disease diagnosis is essential. Also, for security and convenience reasons, it is desirable if u-healthcare system support biometric identification directly from user's bio-signal such as ECG for this case. For this, from Lead II signal, we developed QRS signal detection method and also, we developed signal extraction method for biometric identification using Lead II signal which is relatively robust from signal alteration by aging and diseases. For QRS signal detection capability from Lead II signal, ECG signals from MIT-BIH database are used and it showed 99.36% of accuracy and 99.68% of sensitivity. Also, to show the performance of signal extraction capability for biometric diagnosis purpose, Lead III signals are measured after drinking, smoking, or exercise to consider various monitoring conditions and it showed 99.92% of accuracy and 99.97% of sensitivity.

Partial Discharge Measurement of Power Cables for Nuclear Power Plant (원자력발전소 전력케이블 부분방전 진단 사례)

  • Ha, Che-Wung;Ju, Kwang-Ho;Lim, Woo-Sang
    • The Transactions of The Korean Institute of Electrical Engineers
    • /
    • v.60 no.8
    • /
    • pp.1632-1638
    • /
    • 2011
  • Electric cables are one of the most important components in a nuclear power plant since they provide the power needed to operate electrical equipment. Despite their importance, cables typically receive little attention since they are considered passive, long-lived components that have been very reliable over the years when subjected to the environmental conditions for which they were designed. The operating experience reveals that a defect of the insulator or poor construction causes the initial failure of cable. However, the number of cable failures increase with plant aging, and these cable failures are occurring within the plants' 40-year licensed period. These cable failures have resulted in plant transients, shutdown, loss of safety functions or redundancy, entries into limiting conditions for operation, and challenges for plant operators. Therefore, diagnosis of MV cable installed in NPPs has become one of the most urgent issues in recent years. In accordance with PSR, condition maintenance for cables is also continuously required. Recently, HFPD tests have been widely performed to diagnose cable in the transmission and distribution cable system. However, on-line HFPD wasn't used in the NPPs because of the danger of plant shutdown, measurement sensitivity and application problems, etc. In this paper, HFPD measurement with portable device was performed to evaluate the integrity of the 4.16kV & 13.8kV cable lines. The test results show that HFPD is highly attractive to the diagnosis of MV cables in NPP by high detection sensitivity on-site.

Convergence Comparative Analysis of Young-Old and Old-Old Patients Hospitalized Owing to Injury (손상으로 입원한 전·후기 노인의 융복합 비교분석)

  • Suhn, Mi-Ohk
    • Journal of the Korea Convergence Society
    • /
    • v.11 no.2
    • /
    • pp.75-83
    • /
    • 2020
  • This study aimed to understand the differences in general characteristics, principal diagnosis, injury-related characteristics, and types of transportation accidents between young-old and old-old patients who were hospitalized owing to injury based on data from the Korean National Hospital Discharge In-Depth Injury Surveys. We used a complex sample cross tabulation analysis (chi-square test) and complex sample generalized linear model (t-test). Therefore, the primary focus of healthcare professionals working with the old-old should prevent falls in the home and increase the available medical care, financial aid plans, and psychosocial support for aging. Additionally education on traffic accident prevention and road safety is particularly important for old-old patients.

The Effect of Data 3 on the Utilization of Medical Big Data for Early Detection of Dementia (데이터 3법이 치매 조기 예측을 위한 의료 빅데이터 활용에 미치는 영향 연구)

  • Kim, Hyejin
    • Journal of Digital Convergence
    • /
    • v.18 no.5
    • /
    • pp.305-315
    • /
    • 2020
  • As the incidence and prevalence of dementia increases with our aging population, so does the social burden on our society, which calls for a special emphasis on need for early diagnosis. Thus, efforts are made to prevent dementia and early detection but with current diagnostic measures, these efforts appear futile. As a solution, it is crucial to integrate and standardize healthcare big data and analysis of each index. In order to increase use of large database, the Korea National Assembly passed the Data 3 Act focusing on open-access and sharing of database, but a follow-up legislation is needed a for safer utilization. In this study, we have identified number of foreign of foreign policies through review of prior researches on the topic leading to specific enforcement ordinances tailored to the Data 3 Act for safe access and utilization of database. We also aimed to establish secure process of data collection and disposal as well as governance at the national level to ensure safe utilization of healthcare big data.

A Study on the Health Status and the Needs of Health-related Services of Female Elderly in an Urban-rural Combined City (여성노인의 건강상태와 건강관련서비스 요구)

  • Kang Young Sil;Kim Eun Sim;Gu Mee Ock;Eun Young
    • Journal of Korean Public Health Nursing
    • /
    • v.17 no.1
    • /
    • pp.47-57
    • /
    • 2003
  • The purpose of this study was to investigate health status and health promoting behaviors of female elderly, and their needs for health-related services in an urban-rural combined city. The data were collected from the subjects registered in senior welfare center and senior citizens' clubs. A total of 119 women were participated in the survey. The results of the study are as follows; 1. The subjects perceived their health status relatively unhealthy. Their health promotion behavior score was 10.82 (range 0-17), and more than $60\%$ of them performed well in smoking and drinking control, regular meal. taking breakfast, and maintaining good relationship with others. 2. The most needed service was health screening followed by health risk assessment, disease diagnosis and treatment. 3. The most demanded education was on dementia prevention, followed by exercise, balanced diet, and maintenance of memorial and mental capability. 4. As the health interest and the health responsibility increased, the need for health service increased as well. Likewise, the health education needs increased as the health interest, health responsibility, and health promotion behavior increased. The results show that the health promotion programs for female elderly need to be focused, primarily, on health screening, health risk assessment, medical services for disease diagnosis and treatment, and health consulting and education. And health consulting and education programs should be designed to promote health interest and health responsibility of female elderly, change positively their attitude to aging, and include education on dementia prevention, exercise and nutrition management. Recommendations are discussed.

  • PDF

Deterioration Characteristics and an On-Line Diagnostic Equipment for Surge Protective Devices (서지 보호기의 열화 특성과 온라인 진단장치)

  • Park, Kyoung-Soo;Wang, Guoming;Hwang, Seong-Cheol;Kim, Sun-Jae;Kil, Gyung-Suk
    • Journal of the Korean Institute of Electrical and Electronic Material Engineers
    • /
    • v.29 no.10
    • /
    • pp.635-640
    • /
    • 2016
  • This paper dealt with the deterioration characteristics and an on-line diagnosis equipment for SPDs (surge protective devices). An accelerated aging test was carried out using a $8/20{\mu}s$ standard lightning impulse current to analyze the changes of electrical characteristics and to propose the diagnostic parameters and the criterion for deterioration of ZnO varistor which is the core component of SPDs. Based on the experimental results, an on-line diagnosis equipment for SPD was fabricated, which can measure the total leakage current, reference and clamping voltage. The leakage current measurement circuit was designed using a low-noise amplifier and a clamp type ZCT. A linear controller, the leakage current measurement part and a HVDC were used in the measurement of reference voltage. The measurement circuit of clamping voltage consisted of a surge generator and a coupling circuit. In a calibration process, measurement error of the prototype equipment was less than 3%.

The Characteristics of UV Generation and Aging Materials in According to Surface Discharge (연면방전에 의한 폴리머애자의 자외선 발생과 열화특성)

  • Shong, Kil-Mok;Bang, Sun-Bae;Kim, Chong-Min;Kim, Young-Seok;Jung, Jin-Su
    • The Transactions of The Korean Institute of Electrical Engineers
    • /
    • v.57 no.9
    • /
    • pp.1606-1611
    • /
    • 2008
  • Recently, The diagnosis techniques of electric facilities are developed on live line. This paper describes the discharge characteristics of polymer insulator(EPDM A type). Keeping the facilities in good working order, the goal of this paper will provide the information to enable user to easily judge conditions of facilities on the spot. The performance of polymer insulator is assessed from the KS C IEC 60270 and CEA LWIWG-01(96)(Tracking Wheel Test). As the results, UV generation patterns of polymer insulator grow like a jellyfish shape follow the ramping voltage. Discharging UVs are detected at about 31.25% of breakdown voltage. Just then, dimension of UV image is about $0.84cm^{2}$. The dimension of max. UV image is about $297.4cm^{2}$ at $160kV(V_{bd})$. The position of UV generation due to surface discharge of polymer insulator is the center of insulator in the early, then moved the ground side and the last, UV image moved through the junction part of source side. Surface of aged polymer insulator is cracked and faded due to arc. UV absorption spectrum of polymer insulator are appeared the C-H bond of scissoring vib. at $1014cm^{-1}$ and C=O bond of recombination structure. Also, recombined UV absorption peak such as C-H, N-H, and O-H is detected at the $3321cm^{-1}$. Through the paper, there are inspection data which are the relations between surface discharge of polymer insulator and UV detecting image.

Multimodal Imaging of Sarcopenia using Optical Coherence Tomography and Ultrasound in Rat Model

  • Jeon, Byeong Hwan;Chae, Yu-Gyeong;Hwang, Sang Seok;Kim, Dong Kyu;Oak, Chulho;Park, Eun-Kee;Ahn, Yeh-Chan
    • Journal of the Optical Society of Korea
    • /
    • v.18 no.1
    • /
    • pp.55-59
    • /
    • 2014
  • Sarcopenia, or reduced muscle mass and volume, is due to various factors such as senile change, neuronal degeneration, drug, malignancy, and sepsis. Sarcopenia with the aging process has been evidenced by the decline in muscle mass by 0.5 to 1% per year with 3-5% reduction in muscle strength for 10 years between the ages of 40 and 50, and a 1-2% of decline of mass every year in people aged 60-70. Therefore, early diagnosis and understanding the mechanism of sarcopenia are crucial in the prevention of muscle loss. However, it is still difficult to image changes of muscle microstructure due to a lack of techniques. In this study, we developed an animal model using denervated rats to induce a rapid atrophy in the tibialis anterior (TA) and imaged its structural changes using optical coherence tomography (OCT) along with histologic and ultrasound analyses. Ultrasound showed changes of overall muscle size. Histology revealed that the atrophic TA muscle displayed an increased size variability of muscle fiber and inflammatory changes. Three dimensional OCT imaged the changes of perimysial grid and muscle fiber structure in real time without sacrifice. These observed advantages of multimodal imaging using OCT and ultrasound would provide clinical benefits in the diagnosis of sarcopenia.