• Korean Journal of Culture and Social Issue
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• v.17 no.3
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• pp.343-364
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• 2011

This study investigated the objective and perceived level of economy and its relationship with mother's mental health, parenting behaviors, and problem behaviors in preschoolers. Data drawn from mothers and teachers of 238 preschoolers, ages 3-5, were used. Using the objective and perceived level of economy, subjects were classified into four groups. Individuals categorized as high by objective and perceived level of economy, low by objective and perceived level of economy, high by objective and low by perceived level of economy, and low by objective and high by perceived level of economy were categorized as in-agreement/high group, in-agreement/low group, over-estimator group, and under-estimator group, respectively. To investigate the difference between groups, one-way ANOVAs and post-hoc analyses were used. The results showed that in-agreement/low group and under-estimator group showed greater depression and anxiety than in-agreement/high group and over-estimator group. In addition, in-agreement/high group and over-estimator group showed greater affective parenting behaviors and lower aggressive parenting behaviors than in-agreement/low group and under-estimator group. In terms of internalizing problem behavior by mother, in-agreement/high group and over-estimator group were lower than under-estimator group. In terms of externalizing problem behavior by mother, in-agreement/high group was lower than under-estimator group. However, in terms of internalizing and externalizing problem behavior by teacher, there was no difference between groups. In externalizing problem behavior by teacher, in-agreement/low group was lower than over-estimator group.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• v.16 no.1
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• pp.47-53
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• 2005

Objectives : Few studies have examined the relation between the attachment styles of the primary caregivers and the behavioral problems of their children. This study was performed to identify the impact of the insecure parental attachment patterns on the development of their higher grades elementary school children's psychiatric manifestations and disorders. Methods : 504 higher elementary pupils and their primary caretakers were included in our study. Relationship Questionnaire, Kovacs Children's Depression Inventory, Spielberger's State-Trait Anxiety Inventory for children, and Korean Child Behavior Checklist were applied to them. Results : The grade-school children of the parents who belonged to preoccupied attachment type revealed higher Withdrawn, Anxious/depressed, Social Problems, Attention Problems, Delinquent Problems, Aggressive Problems, Internalizing Problems, Externalizing Problems, Total Behavioral Problems scores than ones of securely attached parents (p<0.01). Internalizing Problems score of preoccupied parents' children was highest, and one of avoidant and secure typed parents' kids followed in order (p=0.004) . More youngsters revealed Total Behavior Problem score high enough to clinically meaningful level in insecure parental attachment style than in secure one (p=0.038). Higher CDI score in insecure parental group was reported than in secure one (p=0.040). Conclusion : Parental insecure attachment can be associated with the development of the behavioral problems and psychiatric illness of their children.

• Journal of the korean academy of Pediatric Dentistry
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• v.30 no.3
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• pp.341-347
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• 2003

Smith-Magenis syndrome (SMS) is a clinically recognizable multiple congenital anomaly and mental retardation syndrome caused by an interstitial deletion of chromosome 17 p11.2. Physical features include short stature, characteristic facial appearance: flattened mid-face, down-turned mouth, prominent and often rosy cheeks; prominent jaw in older children and adults, chronic ear infections, hearing impairment, eye problems, including: strabismus (an eye which turns in or out) and myopia (nearsightedness), hoarse voice, short fingers and toes, heart defects or murmurs, problems related to the urinary system, scoliosis (curvature of the spine), an unusual gait (walking pattern), and decreased sensitivity to pain. Behavioral and developmental characteristics include speech delay and articulation problems, developmental delay, learning disability, mental retardation, hyperactivity, self-injury, including: head banging; hand biting; picking at skin, sores and nails; pulling off finger- and toenails; inserting foreign objects into ears, nose, or other body orifices, explosive outbursts, prolonged tantrums, destructive and aggressive behavior, excitability, arm hugging or hand squeezing when excited. This report is the case of a Korean 3-year-3-month old male with Smith-Magenis syndrome referred from local clinic for the treatment of dental caries. The patient was treated by physical restraint after prophylatic administration of antibiotic(Amoxacillin 50mg/kg).

• Journal of Korean Neurosurgical Society
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• v.30 no.4
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• pp.443-450
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• 2001

Objective : The cyclin-dependent kinase inhibitor $p27^{kip1}$ protein is a negative regulator of the cell cycle, and its degradation is required for entry into the S phase. Loss of $p27^{kip1}$ expression has been reported to be associated with aggressive behavior in a variety of tumors of epithelial and lymphoid origin. However, its association with various astrocytic tumors has not been clearly demonstrated. We studied to investigate the relationship of $p27^{kip1}$ expression with the biological behavior of astrocytic tumors in addition to study on the role of $p27^{kip1}$ in the tumorigenesis of these tumors. Patients and Methods : From 1990 to 1998, a total of 29 astrocytic tumor of all grades obtained by operative resection were included for evaluation. We studied the expression of $p27^{kip1}$ protein immunohistochemical assay in astrocytic tumors and compared the findings with the clinicopathologic parameters. Immunohistochemical staining was performed on formalin-fixed paraffin-embedded sections by the avidin-biotin-peroxidase complex method. According to WHO classification, all cases were divided into astrocytomas(4 cases), anaplastic astrocytomas(9 cases), and glioblastomas(16 cases) by 3 pathologists. Clinical information was obtained from medical records, and others such as location and size of tumors from imaging studies. Results : Mean $p27^{kip1}$ protein labeling indexes(LI, mean${\pm}$standard deviation) of astrocytomas, anaplastic astrocytomas, and glioblastomas were $80.6{\pm}9.1$, $63.6{\pm}21.0$, and $28.9{\pm}18.7$, respectively, and were inversely correlated with grade of glial tumors(p<0.0001). Mean $p27^{kip1}$ protein LI in the recurrent group was lower than that in the nonrecurrent group, but there was no significant difference statistically(p=0.464). Additionally, $p27^{kip1}$ protein expression did not show any significant relationship to other prognostic factors such as age(p=0.1643), tumor size(p=0.8), or location(p=0.8). Conclusion : These results suggested that reduced expression of $p27^{kip1}$ protein may play a important role in the malignant transformation process of astrocytic tumor cells.

• Korean Journal of Human Ecology
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• v.8 no.2
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• pp.255-273
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• 1999

The purpose of this study was to examine the relationship between characteristics of personality and respondent characteristics of Kinetic Family Drawing for young children. The subjects were 170 children(110 boys and 60 girls). The personal interview contained Personality Characteristic Test for young children(In-Sub Song, 1993) and Kinetic Family Drawing Test(Burns and Kaufman, 1982). Results of the test were analyzed by t-test and ANOVA by SAS program. Results are followings. First, chileren's sex and the general tendency of personal characteristic showed significant difference in the emotional personality among 4 personality characteristics. Girls show more positive tendency than boys in moral, physical, appearance and feature which expressed personal feeling and emotion. Also, girls showed more positive tendency than boys in personal characteristic which showed physical ability. Second, Children's sex and individual characteristic in Kinetic Family Drawing respondent characteristic showed significant difference in own's arm length. Also, Using a rare of paper and chapter 1 of the power among the family showed significant difference in styles and symbols. The boys drew lengther arms compared with their height than the girls. The girls were less complicative, anxious, comparative and aggressive for their family. Third, As a result of the study about the relationship between 4 personal characteristics of children and individual's behavior in Kinetic Family Drawing respondent characteristic, the significant difference is showed in academic personality and social personality had higher completion of their father's feature and drew bigger feet. In socal personality, negative behavior than positive children. Fourth, As a result of the study about the relationship between 4 personal characteristics of children and individual's characteristic, the significant difference were found in academic personality, social personality, family personality and emotional personality. Children with negative academic personality drew longer arms than children with positive academic personality, social personality and family personality. Also, Children with negative emotional personality drew more siblings than children with positive emotional personality. Fifth, The academic personality and the social personality had significant difference in the relationship between 4 personal characteristics of children and dynamics. In social personality, normal children were more tendencious to look at the important person with their mother's direction than positive children. Sixth, In terms of the relationship between 4 personal characteristics of children and mode, academic personality and family personality showed significant difference. Children with negative academic personality used more edge of papers than children with positive academic personality and children with positive academic personality and children with negative family personality fold more papers than children with positive family personality. At last, there were no significant difference between 4 personal characteristics of children and styles as well as symbols.

• Journal of The Korean Association of Information Education
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• v.10 no.1
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• pp.107-115
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• 2006

As the use of computers and the Internet become more commonplace, many children are using the Internet. The Internet is rapidly permeating into the daily lives of elementary school students. There are some positive effects of using the Internet: it helps children's studies and communication skills and relives stress. However, some negative effects are arising, such as aggressive behavior caused by Internet games, sleeping disorders, and Internet addiction. The goal of this disquisition was to find out how an upper class of elementary school children are using the Internet and also the degree of their Internet addictions. The effects that Internet addiction had on various aspects, such as on the individual, family, and school were observed. In the individual aspect, self-respect, self-control, awareness of stress, depression, and personal taste were observed. In the aspect of family, communication with parents, the nursing behavior of parents, family functions, friendliness within the family, and the family's emotional support were observed. In the aspect of school, relationships with teachers, relationships with friends, study activities, compliance to rules and participation in events were observed. By analyzing each cause of Internet addiction, this disquisition hopes to help prevent Internet addiction and to support educational guiding about Internet addiction of elementary school children.

• Asian Pacific Journal of Cancer Prevention
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• v.13 no.8
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• pp.3781-3789
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• 2012

Background: Pancreatic cancer is one of the most aggressive tumors with a dismal prognosis. The membrane cytoskeletal crosslinker Ezrin participates in several functions including cell proliferation, adhesion, motility and survival. There is increasing evidence that Ezrin is overexpressed in vast majority of malignant tumors and regulates tumor progression. However, its roles in pancreatic cancer remain elusive. Methods: Three pairs of specific Ezrin siRNAs were designed and synthetized and screened to determine the most efficient one for construction of a hairpin RNA plasmid targeting Ezrin. After transfection into the Panc-1 pancreatic cancer cell line, real-time quantitative PCR and Western blotting were performed to examine the expression of mRNA and protein. The MTT method was applied to examine the proliferation and the drug sensibility to Gemcitabine. Flow cytometry was used to assess the cycle and apoptosis, while capacity for invasion was determined with transwell chambers. Furthermore, we detected phosphorylated-Erk1/2 protein and phosphorylated-Akt protein by Western blotting. Results: Real-time quantitative PCR and Western blotting revealed that Ezrin expression was notably down-regulated at both mRNA and protein levels by RNA interference (P< 0.01). Proliferation was inhibited and drug resistance to gemcitabine was improved (P< 0.05). Flow cytometry showed that the proportion of cells in the G1/G0 phase increased (P< 0.01), and in G2/M and S phases decreased (P< 0.05), with no apparent differences in apoptosis (P> 0.05). The capacity for invasion was markedly reduced (P< 0.01). In addition, down-regulating Ezrin expression had no effect on phosphorylated-Akt protein (P>0.05), but could decrease the level of phosphorylated-Erk1/2 protein (P< 0.05). Conclusions: RNA interference of Ezrin could inhibit its expression in the pancreatic cancer cells line Panc-1, leading to a potent suppression of malignant behavior in vitro. Assessment of potential as a target for pancreatic cancer treatment is clearly warranted.

• Korean Journal of Social Welfare
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• v.57 no.3
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• pp.133-164
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• 2005

This study examined the effects of children's perceived stress of economic strain, resulting family conflict, and stress coping strategies on their adjustment. Dimensions of children's adjustment studied in this research were problem behaviors (aggression, delinquency, withdrawal and anxiety depression) and school adjustment. Interaction effects between children's stress variables and coping strategies on the adjustment were also explored. 1,115 fifth to eighth graders from Chungbuk regions participated in self-administered structured questionnaires. Data were processed with SPSS PC 10.0 statistical package. Results were: First, the level of children's problem behaviors and school adjustment indicated differences according to their academic achievement, gender, and their age. Middle schoolers with rather low grade average reported higher level of aggression, delinquency, withdrawal and that of depression/anxiety. Boys tended to be more prone to external problems while girls to internal problems. Second, stresses originated from children's perceived economic strain and family conflicts showed consistent meaningful explanatory power on adjustment. Boys' adjustment was influenced by stress from economic strain and family conflict while girls by family conflict and academic achievements. The support seeking coping strategy among others was the most popularly employed coping strategy of children followed by aggressive coping strategy. In boys' cases, interaction effects of stress and coping strategies were significant in all of the adjustment variables, the more frequent the use of support seeking coping strategies, the lower the problem behavior, while interaction effect of family conflict stress and support seeking coping strategies played the opposite significant role in girls' cases. Further research efforts are required. Research results suggest; when developing a program facilitating children's adjustment, training on stress coping strategies should be considered as a potent new arena of interest.

• Journal of Korean Neurosurgical Society
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• v.30 no.9
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• pp.1103-1107
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• 2001

Objective : Atypical and malignant meningiomas(AM, MM) are known to be rare and show aggressive behavior. Limited data are available concerning the clinical features, effectiveness of surgical removal and role of radiation therapy with AM, MM. The authors report our experience of AM, MM, with respect to clinical features. Methods : Twenty-four cases of AM and 28 cases of MM, who were operated between 1988 and 1999 were retro-spectively studied review of medical records and radiological findings. These were compared with control group of 24 cases of menigiomas manifestating usual clinical course, which are selected arbitrarily among operative cases between Apr. 1999 and Dec. 1999. Mean follow-up periods were 26(1-91) months for AM and 23(1-62) for MM. Authors analyzed the prognostic factors for survival, and statistical analysis were accomplished by Kaplan-Meier method and log-rank test. Results : Differences of clinical features between control groups and these atypical and malignant meningioma group were not significant. However, the location of MM was frequent in non-basal area(p<0.01). In AM, there were 4 patients of recurrence, and 3 patients of mortality. Among mortality cases, only one patient died of tumor progression, the other patients died of other causes. The survival at 2 year and 5 year in this group were 88% and 74% respectively, and in MM, 11 patients died due to tumor progression and 2 had spinal metastasis. The survival at 2 year and 5 year were 72% and 20%, respectively. For extent of resection, total removal(Simpson grade 1 or 2) was less often achieved in MM compared with AM(50% vs. 83%). Extent of resection of tumor and postoperative radiation therapy did not affect survival in both AM, MM. Conclusions : Clinical behavior of AM showed more benign than that of MM. Prognostic factor for survival is not related extent of resection of tumor and postoperative radiation therapy. However, further investigation with long-term follow-up and additional cases is mandatory.

• Journal of Korean Society of Forest Science
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• v.108 no.4
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• pp.655-662
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• 2019

The aim of the present study was to examine the effects of school forests on the cognition and mental health of elementary school students. Data were obtained through the surveys of sixth graders in an elementary school in Seoul that took part in the School Forest Project run by Korea Post, the Korea Forest Welfare Institute, and the Seoul Metropolitan Office of Education. Students were surveyed before and after the creation of green spaces in their schools, and changes in their environmental sensitivity, attitude toward forests, depression, anxiety, and aggression were analyzed. The findings indicated that the creation of green spaces showed significant effects on the students in terms of encouraging them to strengthen their environmental sensitivity, helping them develop more positive attitudes toward forests, and reducing anxiety and physical aggression, which are the subfactors of aggressive behavior. In other words, creating school forests had positive effects on cognition and mental health, reduced bad behavior, and improved attitudes toward nature in children. The findings of this study are significant in that they reinforce the requirement of school forests by indicating the positive effects of school forests on children's cognition and mental health.