• Biomolecules & Therapeutics
• /
• 제20권6호
• /
• pp.506-512
• /
• 2012

Although pruritus is the critical symptom of atopic dermatitis that profoundly affect the patients' quality of life, controlling and management of prurirtus still remains as unmet needs mainly due to the distinctive multifactorial pathogenesis of pruritus in atopic dermatitis. Based on the distinct feature of atopic dermatitis that psychological state of patients substantially influence on the intensity of pruritus, various psychotropic drugs have been used in clinic to relieve pruritus of atopic dermatitis patients. Only several psychotropic drugs were reported to show real antipruritic effects in atopic dermatitis patients including naltrexone, doxepin, trimipramine, bupropion, tandospirone, paroxetine and fluvoxamine. However, the precise mechanisms of antipruritic effect of these psychotropic drugs are still unclear. In human skin, serotonin receptors and serotonin transporter protein are expressed on skin cells such as keratinocytes, melanocytes, dermal fibroblasts, mast cells, T cells, natural killer cells, langerhans cells, and sensory nerve endings. It is noteworthy that serotonergic drugs, as well as serotonin itself, showed immune-modulating effect. Fenfluramine, fluoxetine and 2, 5-dimethoxy-4-iodoamphetamine significantly decreased lymphocyte proliferation. It is still questionable whether these serotonergic drugs exert the immunosuppressive effects via serotonin receptor or serotonin transporter. All these clinical and experimental reports suggest the possibility that antipruritic effects of selective serotonin reuptake inhibitors in atopic dermatitis patients might be at least partly due to their suppressive effect on T cells. Further studies should be conducted to elucidate the precise mechanism of neuroimmunological interaction in pruritus of atopic dermatitis.

• 한국산업보건학회지
• /
• 제29권4호
• /
• pp.530-540
• /
• 2019

Objectives: The purpose of this study was to identify factors related with demographic and work characteristics that affect musculoskeletal pain and quality of life among personal assistants for people with severe disabilities. Methods: The subjects were recruited among personal assistant for people with severe disabilities who participated in refresher training held in K-si, Gyeonggi-do Province through convenience sampling. Using a survey instrument developed by the authors, subjects responded to questionnaires concerning muscluloskeletal pain and quality of life. The collected data was analyzed using SPSS 21.0. Basically, collected data was analyzed in terms of frequency, t-test or ANOVA and multiple regression analysis. Results: Total years of work experience and subjective physical workload were associated with the number of pain sites and intensity. Additionally, for quality of life, subjective physical workload was related in the regression model. Conclusions: Based on this study, we identified that characteristics of work affected the musculoskeletal pain and quality of life of personal assistants for the severely disabled, and suggested improvement of the working environment, including musculoskeletal pain prevention education programs during the refresher education for assistants to the severely disabled.

• 지질공학
• /
• 제5권2호
• /
• pp.155-165
• /
• 1995

열극암반내의 지하수유동 및 용질이동 해석을 위해서는 추계론적인(Simulation Techique) 3차원 불연속체 모형(Discrete Fracture Model)이 요구된다. Monte Carlo 모의기법(Simulation Techique)에 의해 구성된 추계론적 불연속체모형을 지하 유류저장공동의 기밀성평가를 위한 지하수유동 및 용질이동 모의에 적용하였다. 불연속체모형구성에 영향을 미치는 열극 특성요소는 방향서 및 크기로 분석되었으며, 구성도니 모형(Model)에서의 지하수유동에 영향을 미치는 요소는 투수성 열극밀도로 분석되었다. Particle Tracking 기법을 사용한 불연속체모형의 용질이동 모의에서는 열극의 투수성에 의해 이동경로 및 이동속도에 많은 차이가 관찰되었다. 검증된 추계론적 불연속체모형은 지하 유류저장공동 기밀성평가에 적용이 가능함이 부분적으로 인정되었다.

• 한국식품과학회지
• /
• 제20권4호
• /
• pp.553-557
• /
• 1988

저장습도가 크랙카의 texture 특성에 미치는 영향을 규명하기 위하여 관능검사법과 texturometer를 이용한 기계적 측정법을 병행시켜 실험하였다. 국내산 크랙카 제품을 23%, 31%, 51% 79%의 상대 습도에서 1주와 3주간 저장한 결과 일반적으로 저장습도가 증가함에 따라 texture 특성인 crispness의 감소를 나타냈으며 저장기간은 큰 영향을 주지 못했다. 국내산과 외국산 크랙카를 상대습도 31%와 79%에서 1주와 3주간 저장하면서 texture의 변화를 비교한 결과 제품간에 유의적인 차이를 나타내지 않았다.

• KIEAE Journal
• /
• 제14권3호
• /
• pp.55-63
• /
• 2014

This study selected and analyzed filter media that can be applied in non-point pollution reduction devices aimed at processing the source of pollution on site for road runoff that increases rapidly in rainfall-runoff in order to improve the water quality of urban areas. First, the factors that affect the quality of runoff caused by sources of non-point pollution include physical and social factors such as the usage of land around the area of water collection, type of pavement and movement of cars and people, as well as rainfall characteristics such as frequency, intensity, amount and duration of rainfall. Second, the purification tests of the filter media were processed for pH, BOD, COD and T-P, and the filter media showed to have initial purification effect at that items. However, the filter media showed to be very effective for the processing of SS, T-N, Zn and Cd from the beginning to the end. Third, for filter media, zeolite and vermiculite showed to be effective for processing SS, T-N, Zn and CD constantly, and composite filter media including zeolite showed to have strong processing effects. The authors conclude that this study can be applied to technical areas and policies aimed at reducing non-point pollution in urban areas and can also contribute to allowing eco-friendly management of rainfall as well as improvement of water quality.

• 한국전기전자재료학회:학술대회논문집
• /
• 한국전기전자재료학회 2009년도 춘계학술대회 논문집
• /
• pp.7-8
• /
• 2009

Non-contact critical current measurement apparatus was developed using hall probe which measures the magnetic field distribution across the width of superconducting tape. The hall probe consists of 7 independent hall sensors which lie in a line 600 ${\mu}m$. The difference between maximum and minimum magnetic field in the magnetic filed distribution is a main parameter to determine the critical current. As preliminary research, we calculated the magnetic field intensity at the middle sensor, which is a minimum magnetic field and generated by the circular shielding current modeled by Bean model. We confirmed that there are some parameters that affect on the minimum magnetic field; the distance between superconducting layer and hall sensor, the width of superconducting tape, and the critical current distribution across the width of superconducting tape. Among these parameters, the distance between superconducting layer and hall sensor highly influences on the minimum magnetic field.

• Advances in concrete construction
• /
• 제10권2호
• /
• pp.141-149
• /
• 2020

In the present study, a mechanical model is applied to account the effects of the surrounding viscoelastic media on the buckling behavior of single microfilament within the cell. The model immeasurably associates filament's bending rigidity, neighboring system elasticity, and cytosol viscosity with buckling wavelengths, buckling growth rates and buckling amplitudes of the filament. Cytoskeleton components in living cell bear large compressive force and are responsible in maintaining the cell shape. Actually these filaments are surrounded by viscoelastic media consisting of other filaments network and viscous cytosole within the cell. This surrounding, viscoelastic media affects the buckling behavior of these filaments when external force is applied on these filaments. The obtained results, indicate that the coupling of viscoelastic media with the viscous cytosol greatly affect the buckling behavior of microfilament. The buckling forces increased with the increase in the intensity of surrounding viscoelastic media.

• International Journal of Aerospace System Engineering
• /
• 제2권2호
• /
• pp.19-23
• /
• 2015

This work deals with the study of buckling and post buckling characteristics of laminated composite plates with and without localized regions of damage. The need of a detailed study on Finite Element Analysis of buckling and post buckling of laminated composite structures considering various aspects enhances the interest among researchers. Mathematical formulation is developed for damaged composite plates using a finite element technique based on Inverse Hyperbolic Shear Deformation Theory. This theory satisfies zero transverse shear stresses conditions at the top and bottom surfaces of the plate and provides a non-linear transverse shear stress distribution. Damage modeling is done using an anisotropic damage formulation, which is based on the concept of stiffness change. The structural elements are subjected to in-plane loading. The computer program is developed in MATLAB environment. The numerical results are presented after through validation of developed finite element code. The effect of damage on buckling and post buckling has been carried out for various parameters such as amount of percentage of damaged area, damage intensity, etc. The results show that the presence of internal flaws will significantly affect the buckling characteristics of laminated composite plates. The outcomes and remarks from this work will assist to address some key issues concerning composite structures.

• 설비공학논문집
• /
• 제15권3호
• /
• pp.177-186
• /
• 2003

In the present study, the flow characteristics of developing turbulent flows are investigated at the exit region of a square cross-sectional 180" curved duct with dimensions of 40mm$\times$40mm$\times$4000mm (height $\times$ width $\times$length). Smoke particles produced from mosquito coils were used as seed particles for the LDV measurement. Experiments were carried out to measure axial velocity profiles, shear stress distributions and entrance lengths by using an LDV system and Rotating Machinery Resolver RMR with PHASE software. Experimental results clearly show that the time-averaged Reynolds number does not affect oscillatory flow characteristics because the turbulent components tend to balance the oscillatory components in the fully developed flow region. Also, the velocity profiles are in good agreement with 1/7power law such as the results of steady turbulent flows. The turbulent intensity linearly increases along the walls and is slightly higher, especially in the period of deceleration. On the other hand, the LDV measurements show that shear stress values in slightly higher in the period of deceleration due to the flow characteristics in the exit region. The entrance length where flows become stable appears at the point that is 40 times the length of hydraulic diameter.eter.

• 대한인간공학회지
• /
• 제25권3호
• /
• pp.1-15
• /
• 2006

Loss of postural balance can possibly lead to increased risk of slips and falls in work places. Present study was performed to investigate the effects of noisy environments on postural stability during standing. It is known that a sound is characterized by the frequency and pressure level of the sound. Therefore, effects of the frequency and pressure level on postural stability were of primary concern. Ten male subjects participated in the experiment. Subject's center of pressure(COP) position was collected on a force plate while they were exposed to different frequency and pressure levels of the sound. Measured COP was then converted into the length of postural sway path in both anterior-posterior(AP) and medio-lateral(ML) axis. Results showed that the length of sway path in AP axis was significantly affected by the frequency of sound. The length of sway path was lowest at frequency level of 2000Hz and increased below and above this frequency range. The sound pressure level, however, did not significantly affect the postural sway length in both AP and ML axis. The results imply that industrial workers in noisy environments should be aware that their abilities of postural balance can be disturbed significantly.