• Biomolecules & Therapeutics
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• v.20 no.6
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• pp.506-512
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• 2012

Although pruritus is the critical symptom of atopic dermatitis that profoundly affect the patients' quality of life, controlling and management of prurirtus still remains as unmet needs mainly due to the distinctive multifactorial pathogenesis of pruritus in atopic dermatitis. Based on the distinct feature of atopic dermatitis that psychological state of patients substantially influence on the intensity of pruritus, various psychotropic drugs have been used in clinic to relieve pruritus of atopic dermatitis patients. Only several psychotropic drugs were reported to show real antipruritic effects in atopic dermatitis patients including naltrexone, doxepin, trimipramine, bupropion, tandospirone, paroxetine and fluvoxamine. However, the precise mechanisms of antipruritic effect of these psychotropic drugs are still unclear. In human skin, serotonin receptors and serotonin transporter protein are expressed on skin cells such as keratinocytes, melanocytes, dermal fibroblasts, mast cells, T cells, natural killer cells, langerhans cells, and sensory nerve endings. It is noteworthy that serotonergic drugs, as well as serotonin itself, showed immune-modulating effect. Fenfluramine, fluoxetine and 2, 5-dimethoxy-4-iodoamphetamine significantly decreased lymphocyte proliferation. It is still questionable whether these serotonergic drugs exert the immunosuppressive effects via serotonin receptor or serotonin transporter. All these clinical and experimental reports suggest the possibility that antipruritic effects of selective serotonin reuptake inhibitors in atopic dermatitis patients might be at least partly due to their suppressive effect on T cells. Further studies should be conducted to elucidate the precise mechanism of neuroimmunological interaction in pruritus of atopic dermatitis.

• Journal of Korean Society of Occupational and Environmental Hygiene
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• v.29 no.4
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• pp.530-540
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• 2019

Objectives: The purpose of this study was to identify factors related with demographic and work characteristics that affect musculoskeletal pain and quality of life among personal assistants for people with severe disabilities. Methods: The subjects were recruited among personal assistant for people with severe disabilities who participated in refresher training held in K-si, Gyeonggi-do Province through convenience sampling. Using a survey instrument developed by the authors, subjects responded to questionnaires concerning muscluloskeletal pain and quality of life. The collected data was analyzed using SPSS 21.0. Basically, collected data was analyzed in terms of frequency, t-test or ANOVA and multiple regression analysis. Results: Total years of work experience and subjective physical workload were associated with the number of pain sites and intensity. Additionally, for quality of life, subjective physical workload was related in the regression model. Conclusions: Based on this study, we identified that characteristics of work affected the musculoskeletal pain and quality of life of personal assistants for the severely disabled, and suggested improvement of the working environment, including musculoskeletal pain prevention education programs during the refresher education for assistants to the severely disabled.

• The Journal of Engineering Geology
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• v.5 no.2
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• pp.155-165
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• 1995

Fluid flow studies of fractured rocks require three-dimensional modeling of the fracture system. The stochastic discrete fracture models constructed by Monte Carlo simulation technique were applied to the analysis of groundwater flow and mass transport in fractured rock for the assessment of tightness criteria of underground LPG storage cavern. The parameters that most affect the conceptual discrete fracture modeling proved either fracture orientation or size and on the fract'lre flow interpretation proved conductive fracture intensity. The fracture transmissivity played important role in solute transport in fractured rock simulated by particle tracking approach. It was partly recognized that the calibrated stochastic discrete fracture model can be used for the tightness criteria of underground LPG storage cavern.

• Korean Journal of Food Science and Technology
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• v.20 no.4
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• pp.553-557
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• 1988

To investigate the effect of storage humidity on the textural characteristics of crackers, their crispness and tenderness were measured by sensory and instrumental methods. Domestic cracker samples stored for 1 and 3 weeks at 4 different relative humidities of 23, 31, 51 and 79% showed the decrease in crispness intensity as the humidity increased while storage period did not affect their textural characteristics. When domestic and imported cracker samples were stored for 1 and 3 weeks at relative humidities of 31% and 79%, there was no significant difference in their textural characteristics.

• KIEAE Journal
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• v.14 no.3
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• pp.55-63
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• 2014

This study selected and analyzed filter media that can be applied in non-point pollution reduction devices aimed at processing the source of pollution on site for road runoff that increases rapidly in rainfall-runoff in order to improve the water quality of urban areas. First, the factors that affect the quality of runoff caused by sources of non-point pollution include physical and social factors such as the usage of land around the area of water collection, type of pavement and movement of cars and people, as well as rainfall characteristics such as frequency, intensity, amount and duration of rainfall. Second, the purification tests of the filter media were processed for pH, BOD, COD and T-P, and the filter media showed to have initial purification effect at that items. However, the filter media showed to be very effective for the processing of SS, T-N, Zn and Cd from the beginning to the end. Third, for filter media, zeolite and vermiculite showed to be effective for processing SS, T-N, Zn and CD constantly, and composite filter media including zeolite showed to have strong processing effects. The authors conclude that this study can be applied to technical areas and policies aimed at reducing non-point pollution in urban areas and can also contribute to allowing eco-friendly management of rainfall as well as improvement of water quality.

• Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
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• 2009.05a
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• pp.7-8
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• 2009

Non-contact critical current measurement apparatus was developed using hall probe which measures the magnetic field distribution across the width of superconducting tape. The hall probe consists of 7 independent hall sensors which lie in a line 600 ${\mu}m$. The difference between maximum and minimum magnetic field in the magnetic filed distribution is a main parameter to determine the critical current. As preliminary research, we calculated the magnetic field intensity at the middle sensor, which is a minimum magnetic field and generated by the circular shielding current modeled by Bean model. We confirmed that there are some parameters that affect on the minimum magnetic field; the distance between superconducting layer and hall sensor, the width of superconducting tape, and the critical current distribution across the width of superconducting tape. Among these parameters, the distance between superconducting layer and hall sensor highly influences on the minimum magnetic field.

• Advances in concrete construction
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• v.10 no.2
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• pp.141-149
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• 2020

In the present study, a mechanical model is applied to account the effects of the surrounding viscoelastic media on the buckling behavior of single microfilament within the cell. The model immeasurably associates filament's bending rigidity, neighboring system elasticity, and cytosol viscosity with buckling wavelengths, buckling growth rates and buckling amplitudes of the filament. Cytoskeleton components in living cell bear large compressive force and are responsible in maintaining the cell shape. Actually these filaments are surrounded by viscoelastic media consisting of other filaments network and viscous cytosole within the cell. This surrounding, viscoelastic media affects the buckling behavior of these filaments when external force is applied on these filaments. The obtained results, indicate that the coupling of viscoelastic media with the viscous cytosol greatly affect the buckling behavior of microfilament. The buckling forces increased with the increase in the intensity of surrounding viscoelastic media.

• International Journal of Aerospace System Engineering
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• v.2 no.2
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• pp.19-23
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• 2015

This work deals with the study of buckling and post buckling characteristics of laminated composite plates with and without localized regions of damage. The need of a detailed study on Finite Element Analysis of buckling and post buckling of laminated composite structures considering various aspects enhances the interest among researchers. Mathematical formulation is developed for damaged composite plates using a finite element technique based on Inverse Hyperbolic Shear Deformation Theory. This theory satisfies zero transverse shear stresses conditions at the top and bottom surfaces of the plate and provides a non-linear transverse shear stress distribution. Damage modeling is done using an anisotropic damage formulation, which is based on the concept of stiffness change. The structural elements are subjected to in-plane loading. The computer program is developed in MATLAB environment. The numerical results are presented after through validation of developed finite element code. The effect of damage on buckling and post buckling has been carried out for various parameters such as amount of percentage of damaged area, damage intensity, etc. The results show that the presence of internal flaws will significantly affect the buckling characteristics of laminated composite plates. The outcomes and remarks from this work will assist to address some key issues concerning composite structures.

• Korean Journal of Air-Conditioning and Refrigeration Engineering
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• v.15 no.3
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• pp.177-186
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• 2003

In the present study, the flow characteristics of developing turbulent flows are investigated at the exit region of a square cross-sectional 180" curved duct with dimensions of 40mm$\times$40mm$\times$4000mm (height $\times$ width $\times$length). Smoke particles produced from mosquito coils were used as seed particles for the LDV measurement. Experiments were carried out to measure axial velocity profiles, shear stress distributions and entrance lengths by using an LDV system and Rotating Machinery Resolver RMR with PHASE software. Experimental results clearly show that the time-averaged Reynolds number does not affect oscillatory flow characteristics because the turbulent components tend to balance the oscillatory components in the fully developed flow region. Also, the velocity profiles are in good agreement with 1/7power law such as the results of steady turbulent flows. The turbulent intensity linearly increases along the walls and is slightly higher, especially in the period of deceleration. On the other hand, the LDV measurements show that shear stress values in slightly higher in the period of deceleration due to the flow characteristics in the exit region. The entrance length where flows become stable appears at the point that is 40 times the length of hydraulic diameter.eter.

• Journal of the Ergonomics Society of Korea
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• v.25 no.3
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• pp.1-15
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• 2006

Loss of postural balance can possibly lead to increased risk of slips and falls in work places. Present study was performed to investigate the effects of noisy environments on postural stability during standing. It is known that a sound is characterized by the frequency and pressure level of the sound. Therefore, effects of the frequency and pressure level on postural stability were of primary concern. Ten male subjects participated in the experiment. Subject's center of pressure(COP) position was collected on a force plate while they were exposed to different frequency and pressure levels of the sound. Measured COP was then converted into the length of postural sway path in both anterior-posterior(AP) and medio-lateral(ML) axis. Results showed that the length of sway path in AP axis was significantly affected by the frequency of sound. The length of sway path was lowest at frequency level of 2000Hz and increased below and above this frequency range. The sound pressure level, however, did not significantly affect the postural sway length in both AP and ML axis. The results imply that industrial workers in noisy environments should be aware that their abilities of postural balance can be disturbed significantly.