• Asian Pacific Journal of Cancer Prevention
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• v.15 no.1
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• pp.117-122
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• 2014

Background: Breast cancer is the most common malignancy and the second leading cause of cancer-related death among women in the developed countries. Despite advances in screening, improved local therapies and adjuvant systemic treatments, median survival of metastatic breast cancer patients (MBC) is in the range of 2-3 years at most. We aimed to investigate whether the prognostic factors and therapeutic responses of our Turkish patients are similar to those in the literature. Materials and Methods: We reviewed the medical records of MBC patients who had been treated in our institution between 1999-2009 and analyzed their clinicopathological features and survival outcomes retrospectively Results: A hundred and sixty patients were included. Median age was 47 (23-82), median follow up was 24 (2-186) months. At the time of diagnosis 59% of patients were under the age of 50 and 46% were postmenopausal. The majority (37%) had multiple sites of metastases. Forty percent received endocrine therapy and 40% chemotherapy as first line metastatic treatment. Thirty (20%) patients were treated with molecular targeting agents like trastuzumab, lapatinib and sunitinib, frequently combined with a chemotherapy agent. Five-year overall survival (OS) was 32% and median OS was 38 months for the whole group. Five year progression free survival (PFS) was 10% and median PFS was 10 months. Menopausal status, hormone receptor expression and disease free status had a significant impact on overall survival in the multivariate analysis (p 0.018, p 0.018 and p:0.003, respectively). Conclusions: All our patients were treated with the modern oncologic therapies recommended by the international guidelines. From our data, MBC patients live up to 3-4 years, indicating that further improvement beyond that requires development of new treatment modalities. The survival outcomes of our patients were consistent with the data reported in the literature.

• Journal of KIISE:Computer Systems and Theory
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• v.36 no.3
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• pp.140-148
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• 2009

Recent advances in communication and multimedia technologies make it possible to provide video-on-demand(VOD) services and people can access video servers over the Internet at any time using their electronic devices, such as PDA, mobile phone and digital TV. Each device has different processing capabilities, energy budgets, display sizes and network connectivities. To support such diverse devices, multiple versions of videos are needed to meet users' requests. In general cases, VOD servers cannot store all the versions of videos due to the storage limitation. When a device requests a stored version, the server can send the appropriate version immediately, but when the requested version is not stored, the server first converts some stored version to the requested version, and then sends it to the client. We call this conversion process transcoding. If transcoding occurs frequently in a VOD server, the CPU resource of the server becomes insufficient to response to clients. Thus, to admit as many requests as possible, we need to maximize the CPU availability. In this paper, we propose a new algorithm to select versions from those stored on disk using a branch and bound technique to maximize the CPU availability. We also explore the impact of these storage management policies on streaming to heterogeneous users.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.21 no.8
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• pp.26-35
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• 2020

Tunnel construction is an important part of Korean public construction projects. Although the development of various equipment and technologies has led to advances in tunnel construction methods that are implemented on sites, the cost standards related to such works do not yet reflect the realities of the construction sites. A literature review and site surveys were conducted to suggest reasonable cost standards for tunnel work that reflects the realities of the field. First, each item in the cost standards for tunnel work, as established in the Construction Standard Production Rates, were analyzed. The results were compared with the actual costs implemented on tunnel projects. The key items analyzed included those regarding the work cycle time, such as rock classification, profiling survey, drilling speed, and muck-disposal processing equipment combination, as well as the number of people put to tunneling work. Based on the site survey results, improved estimates regarding the cycle time per one tunnel drilling blast, drilling speed of the machine, muck disposal processing equipment combination, and the number of people put to tunneling work were suggested. This study suggests the cost standards that reflect the realities of tunneling sites. The results are expected to help ensure adequate costs for tunnel construction projects.

• Journal of Korean Neurosurgical Society
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• v.63 no.2
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• pp.137-152
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• 2020

In spite of the developing endovascular era, large (15-25 mm) and giant (>25 mm) wide-neck cerebral aneurysms remained technically challenging. Intracranial flow-diverting stents (FDS) were developed to address these challenges by targeting aneurysm hemodynamics to promote aneurysm occlusion. In 2011, the first FDS approved for use in the United States market. Shortly thereafter, the Pipeline of Uncoilable or Failed Aneurysms (PUFS) study was published demonstrating high efficacy and a similar complication profile to other intracranial stents. The initial FDA instructions for use (IFU) limited its use to patients 22 years old or older with wide-necked large or giant aneurysms of the internal carotid artery (ICA) from the petrous segment to superior hypophyseal artery/ophthalmic segment. Expanded IFU was tested in the Prospective Study on Embolization of Intracranial Aneurysms with PipelineTM Embolization Device (PREMIER) trial. With further post-approval clinical data, the United States FDA expanded the IFU to include patients with small or medium, wide-necked saccular or fusiform aneurysms from the petrous ICA to the ICA terminus. However, IFU is more restrictive in South Korea than in United States. Several systematic reviews and meta-analyses have sought to evaluate the overall efficacy of FDS for the treatment of cerebral aneurysms and consistently identify FDS as an effective technique for the treatment of aneurysms broadly with complication rates similar to other traditional techniques. A growing body of literature has demonstrated high efficacy of FDS for small aneurysms; distal artery aneurysms; non-saccular aneurysms posterior circulation aneurysms and complication rates similar to traditional techniques. In the short interval since the Pipeline Embolization Device was first introduced, FDS has been firmly entrenched as a powerful tool in the endovascular armamentarium. As new FDS are developed, established FDS are refined, and delivery systems are improved the uses for FDS will only expand further. Researchers continue to work to optimize the mechanical characteristics of the FDS themselves, aiming to optimize deploy ability and efficacy. With expanded use for small to medium aneurysms and posterior circulation aneurysms, FDS technology is firmly entrenched as a powerful tool to treat challenging aneurysms, both primarily and as an adjunct to coil embolization. With the aforementioned advances, the ease of FDS deployment will improve and complication rates will be further minimized. This will only further establish FDS deployment as a key strategy in the treatment of cerebral aneurysms.

• Journal of Intelligence and Information Systems
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• v.15 no.4
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• pp.79-98
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• 2009

Web traffic is becoming an important indicator to make inferences about internet companies' future prospects so that traditional firm valuation methods need to be modified to integrate the ideas of web traffic information as a major asset of internet companies. It is because web traffic is a measure of attracting visitors to firm's web site and is the basis for internet companies' marketing expenditure and customer acquisition and retention. Also the web traffic represents the internet companies' technological advances and marketability. The major purpose of this study is to show the relevance of web traffic for valuation of internet companies. For this, we test hypothesis with the firm's web traffic and financial data using the analysis model of Hand(2000a) derived from the log-linear model introduced by Ye and Finn(1999). Test results show that the web traffic, more specifically the number of unique visitors, visits, and page views are all positively related to the firm's value. This implies that the web traffic information should be considered as one of the important non-financial indicator for the internet firm valuation.

• Microbiology and Biotechnology Letters
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• v.45 no.3
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• pp.185-199
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• 2017

Methane, which is emitted from natural and anthropogenic sources, is a representative greenhouse gas for global warming. Methanotrophs are widespread in the environment and play an important role in the biological oxidation of methane via methane monooxygenases (MMOs), key enzymes for methane oxidation with broad substrate specificity. Methanotrophs have attracted attention as multifunctional bacteria with promising applications in biological methane mitigation technology and environmental bioremediation. In this review, we have summarized current knowledge regarding the biodiversity of methanotrophs, catalytic properties of MMOs, and high-cell density cultivation technology. In addition, we have reviewed the recent advances in biological methane mitigation technologies using methanotrophs in field-scale systems as well as in lab-scale bioreactors. We have also surveyed information on the dynamics of the methanotrophic community in biological systems and discussed the various challenges pertaining to methanotroph-related biotechnological innovation, such as identification of suitable methanotrophic strains with better and/or novel metabolic activity, development of high-cell density mass cultivation technology, and the microbial consortium (methanotrophs and non-methanotrophs consortium) design and control technology.

• The Journal of the Korea Contents Association
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• v.17 no.1
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• pp.550-566
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• 2017

Recent advances in wearable devices and quantified-self movement increase the number of personal informatics application that may cause an concern to health industry and user. In this light, the goal of this study is to identify more effective ways of design and evaluation of personal informatics application for self-tracking and delivering health information to users. For this goal, this study conducted areal-world study that processes such that user can assess, be aware of, and self-reflect on their data and behavior activity. In doing so, this study aims to determine the psychological effects of forms of health feedback (comparative vs. non-comparative) and presentation modes (text vs. image) on users' tendencies toward health conservation. Results from a between-subjects experiment revealed that health information in a comparative and textual format was more effective in encouraging health conservation in participants than identical information presented in a non-comparative and image format. In addition, participants' level of health consciousness emerged as a significant predictor. Through this analysis of quantitative data and inferences, this study make a number of contributions to the user affordance research and its methodology of health informatics study and designing personal informatics application that support user's behavior change in various contexts.

• The Journal of the Korea Contents Association
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• v.18 no.3
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• pp.611-625
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• 2018

With innovative advances in wireless communication technology, many researches for extending network lifetime in maximum by using energy harvesting have been actively performed on the area of network resource optimization, QoS-guaranteed transmission, energy-intelligent routing and etc. As known well, it is very hard to guarantee end-to-end network delay due to uncertainty of the amount of harvested energy in multi-hop RF(radio frequency) energy harvesting wireless networks. To minimize end-to-end delay in multi-hop RF energy harvesting networks, this paper proposes an energy efficient routing metric based on interference aware and protocol which takes account of various delays caused by co-channel interference, energy harvesting time and queuing in a relay node. The proposed method maximizes end-to-end throughput by performing avoidance of packet congestion causing load unbalance, reduction of waiting time due to exhaustion of energy and restraint of delay time from co-channel interference. Finally simulation results using ns-3 simulator show that the proposed method outperforms existing methods in respect of throughput, end-to-end delay and energy consumption.

• Journal of Practical Engineering Education
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• v.11 no.2
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• pp.195-206
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• 2019

Accelerated technological advances and the convergence of information and communication technologies have led to changes of career concepts from one of lifetime employment to that of lifetime career. Given the importance of continuous career development for workers these days, systematic supports for workers' career development at the national level is necessary. Accordingly, a conceptual model of career competency mobility map (CCMM) has been proposed to support the development of workers' career competencies. The purpose of this study is to identify key issues that we should consider for real implementation by applying to each stage of the CCMM conceptual model as a case study. Based on the procedure presented in the conceptual model, the research process which includes collecting user information, conducting self-diagnosis of NCS-based job competencies, deriving necessary training competency, offering the guidance of training programs and job information were conducted. The results of the case study showed our participants' scores of competencies required further development and ranged from 1.83 to 4.52. Sequentially, a personalized information profile was offered for competency development, including training, certificates, and job information. Participants stated that the diagnosis results and profiles were meaningful and helped to explore further career development. Based on the results, implications are suggested.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.18 no.3
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• pp.374-380
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• 2017

The Internet of Things (IoT) refers to intelligent technologies and services that connect all things to the internet so they can interactively communicate with people, other things, and other systems. The development of the IoT environment accompanies advances in network protocols applicable to more lightweight and intelligent sensors, and lightweight and diverse environments. The development of those elemental technologies is promoting the rapid progress in smart car environments that provide safety features and user convenience. These developments in smart car services will bring a positive effect, but can also lead to a catastrophe for a person's life if security issues with the services are not resolved. Although smart cars have various features with different types of communications functions to control the vehicles under the existing platforms, insecure features and functions may bring various security threats, such as bypassing authentication, malfunctions through illegitimate control of the vehicle via data forgery, and leaking of private information. In this paper, we look at types of smart car services in the IoT, deriving the security threats from smart car services based on various scenarios, suggesting countermeasures against them, and we finally propose a safe smart car application plan.