• Title/Summary/Keyword: Adhesive force

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Drug Release from Xyloglucan Beads Coated with Eudragit for Oral Drug Delivery

  • Yoo Mi Kyong;Choi Hoo Kyun;Kim Tae Hee;Choi Yun Jaie;Akaike Toshihiro;Shirakawa Mayumi;Cho Chong Su
    • Archives of Pharmacal Research
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    • v.28 no.6
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    • pp.736-742
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    • 2005
  • Xyloglucan (XG), which exhibits thermal sol to gel transition, non-toxicity, and low gelation concentration, is of interest in the development of sustained release carriers for drug delivery. Drug-loaded XG beads were prepared by extruding dropwise a dispersion of indomethacin in aqueous XG solution (2 wt.-$\%$) through a syringe into corn oil. Enteric coating of XG bead was performed using Eudragit L 100 to improve the stability of XG bead in gastrointestinal (GI) track and to achieve gastroresistant drug release. Release behavior of indomethacin from XG beads in vitro was investigated as a function of loading content of drug, pH of release medium, and concentration of coating agent. Adhesive force of XG was also measured using the tensile test. Uniform-sized spherical beads with particle diameters ranging from 692 $\pm$ 30 to 819 $\pm$ 50 $\mu$m were obtained. The effect of drug content on the release of indomethacin from XG beads depended on the medium pH. Release of indomethacin from XG beads was retarded by coating with Eudragit and increased rapidly with the change in medium pH from 1.2 to 7.4. Adhesive force of XG was stronger than that of Carbopol 943 P, a well-known commercial mucoadhesive polymer, in wet state. Results indicate the enteric-coated XG beads may be suitable as a carrier for oral drug delivery of irritant drug in the stomach.

XPS Analysis of PVDF Film Treated by Corona Discharge in Ethyl Methacrylate Vapor Atmosphere (에틸메타크릴레이트 증기 분위기에서 코로나 방전 처리한 PVDF 필름의 XPS 분석)

  • Moon, HuiKwon;Seomoon, Kyu
    • Applied Chemistry for Engineering
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    • v.27 no.6
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    • pp.627-632
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    • 2016
  • Ethyl methacrylate (EMA) monomer coupling onto the polyvinylidene fluoride (PVDF) film surface was attempted to enhance the interfacial adhesive force between PVDF-polyvinyl chloride (PVC) bilayer films via dielectric barrier corona discharge. The interfacial forces were quite enhanced when PVDF films were treated by corona discharge in an EMA 1% atmosphere. The contact angle of PVDF films decreased due to corona treatment. X-ray photoelectron spectroscopy (XPS) analysis showed that the carbon and oxygen content of the PVDF film surface increased with corona discharge while the fluoride content decreased. The curve fitting of XPS $C_{1s}$ peaks revealed that the non-polar C-C bonded carbon and oxygen-bonded carbon increased gradually with corona treatment, while the fluorine-bonded carbon decreased.

Immediate Effects of Low-Dye Taping on the Ankle Motion and Ground Reaction Forces in the Pronated Rear-Foot During Gait

  • Kim, Sung-shin;Chung, Jae-yeop
    • Physical Therapy Korea
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    • v.23 no.1
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    • pp.72-79
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    • 2016
  • Background: Increased foot pronation causes biomedchanical changes at the lower limbs, which may result in musculoskeletal injuries at the proximal joints. Pronation rear-foot leads to plantar fasciitis, Achilles tendonitis, and posterior tibial tendonitis pathologically. According to the recent meta-analysis, They showed that therapeutic adhesive taping is more effective than foot orthoses and motion control footwear, low-Dye (LD) taping has become the most popular method used by physiotherapists. Objects: The purpose of this study was to determine the immediate effects of LD taping results in different ankle motion and ground reaction force (GRF) as before and after applied LD taping on pronated rear-foot during gait. Methods: Twenty-four participants were recruited for this study. The gait data were recorded using an 8-camera motion capture system and two force platforms. At first, the experiments were carried out that participants walked barefoot without LD taping. And then they walked both feet was applied LD taping. Results: The ankle inversion minimum was significantly greater after LD taping than before LD taping (p=.04); however, in the GRF, there were no significant differences in the inversion maximum or total motion of the stance phase (p=.33, p=.07), or in the vertical (p=.33), posterior (p=.22), and lateral (p=.14) peak forces. Conclusion: The application of taping to pronation rear-foot assists in increased ankle inversion.

Debonding forces of three different customized bases of a lingual bracket system

  • Sung, Jang-Won;Kwon, Tae-Yub;Kyung, Hee-Moon
    • The korean journal of orthodontics
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    • v.43 no.5
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    • pp.235-241
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    • 2013
  • Objective: The purpose of this study was to investigate whether extension of the custom base is necessary for enhancement of bond strength, by comparing the debonding forces and residual adhesives of 3 different lingual bracket systems. Methods: A total of 42 extracted upper premolars were randomly divided into 3 groups of 14 each for bonding with brackets having (1) a conventional limited resin custom base; (2) an extended gold alloy custom base: Incognito${TM}$; and (3) an extended resin custom base: KommonBase${TM}$. The bonding area was measured by scanning the bracket bases with a 3-dimensional digital scanner. The debonding force was measured with an Instron universal testing machine, which applied an occlusogingival shear force. Results: The mean debonding forces were 60.83 N (standard deviation [SD] 10.12), 69.29 N (SD 9.59), and 104.35 N (SD17.84) for the limited resin custom base, extended gold alloy custom base, and extended resin custom base, respectively. The debonding force observed with the extended resin custom base was significantly different from that observed with the other bases. In addition, the adhesive remnant index was significantly higher with the extended gold alloy custom base. Conclusions: All 3 custom-base lingual brackets can withstand occlusal and orthodontic forces. We conclude that effective bonding of lingual brackets can be obtained without extension of the custom base.

The Flexible Characteristic of Reversible and Robust Nanohair Fastener

  • Park, Seung-Ho;Yoon, Young-Seok;Lee, Dong-Woo;Lee, Dong-Ik;You, Kyoung-Hwan;Pang, Chang-Hyun;Suh, Kahp-Yang
    • Proceedings of the Korean Vacuum Society Conference
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    • 2011.02a
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    • pp.432-432
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    • 2011
  • Dry adhesion caused by Nanoscale contact comes up to important scientific issue. Herein, we introduce bendable nanohairy locking fastener system with high shear strength and mechanically flexible backing. The polymeric patches like velcro are composed of an array of straight nanohairs with 100 nm diameter and $1{\mu}m$ height. To fabricate high aspect vertical nanohairs, we used UV molding method with appropriately flexible and rigid polyurethane acrylate material on PET substrate. Two identical nanohairy patches are easily merged and locked each other induced by van der Waals force. Because nanohairs can be arrayed with high density ${\sim}4{\times}10^8/cm^2$, we can obtain high shear adhesion force on flat surface (~22 N/$cm^2$). Furthermore, we can obtian nanohairy locking system with maximum shear adhesion ~48 N/$cm^2$ of curved surface due to flexibility of PET substrate. We confirm the tendency that shear adhesion force increases, as radius of curvature increases.

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Development of A New Micro-fabricated AFM Probe for the Measurement of Biomaterials by using the Precision Glass Bead Supply Unit (글래스비드 정밀공급기구에 의한 바이오재료평가용 AFM프로브의 개발)

  • Kweon, H.K.;Lin, J.
    • Journal of the Korean Society of Manufacturing Process Engineers
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    • v.13 no.6
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    • pp.30-36
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    • 2014
  • Many different cells types have been found to be highly sensitive to mechanical force imposed by their surroundings. The cellular response to external mechanical forces has very important effects on numerous biological phenomena. In spite of its importance in biological processes, the cell adhesion force remains difficult to measure quantitatively at the cellular level. In this paper, to enhance quantitative measurements of cell adhesive interactions, a new attaching system and a method in which a glass bead can be attached to an AFM cantilever was designed and fabricated, and the degree of range displacement was controlled in the system. In an experiment, the movement of the stage in the attaching system and the attaching process were measured. The effectiveness of this system was confirmed as well in the experiment. In addition, through a commercial AFM system, the spring constant of the modified AFM probe could be measured.

Measurement of Adhesion Strength for Ceramic Sheet (세라믹 박판의 접착 강도 측정)

  • Huh, Y.H.;Kim, D.I.;Kim, D.J.;Lee, K.;Kim, D.
    • Proceedings of the KSME Conference
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    • 2007.05a
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    • pp.1798-1802
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    • 2007
  • Adhesion strength of single layer ceramic capacitor sheet was measured using a peel testing system developed in this study. The peel test specimens with various dimensions were prepared from the ceramic sheet cast on the PET film. In peel test, the sheet specimen was adhered on the glass jig floating on the liquid media, which was designed to minimize the friction, and the specimen was then pulled up by micro-actuator. During the separation of the sheet from the PET film, peel force was measured. To normalize the testing condition, 3 different widths of the specimen were selected: 5, 10 and 20 mm. was used Furthermore, testing speed effect was investigated in this study. From the resullts using various testing conditions, the standard method for the peel strength testing may be suggested. Based on the testing condition, effect of peel angle on the strength was experimentally examined. It was found that the adhesive strength for the ceramic sheet is nearly identical, irrespective of the specimen width ranged from 5 to 20 mm, while the adhesive strength was increased with increasing testing speed. Furthermore, the strength was shown to be dependent on the peel angle.

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Friction and Wear Behavior of Carbon/Carbon Composites for Aircraft Brake Material (항공기 브레이크 재료용 탄소/탄소 복합재료의 마찰 및 마모 거동)

  • 우성택;윤재륜
    • Tribology and Lubricants
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    • v.9 no.1
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    • pp.62-69
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    • 1993
  • Friction and wear behavior of a carbon/carbon composite material for aircraft brake material was experimentally investigated. Friction and wear test setup was designed and built for the experiment. Friction and wear tests were conducted under various sliding conditions. Friction coefficients were measured and processed by a data acquisition system and amount of wear measured by a balance. Stainless steel disk was used as the counterface material. Temperature was also measured by inserting thermocouple 2.5 mm beneath the sliding surface of the carbon/carbon composite specimen. Wear surfaces were observed by SEM, and analyzed by EDAX. The experimental results showed that sliding speed and normal force did not have significant effects on friction coefficient and wear factor of the composite. Temperature increase just below the surface was not large enough to cause any thermal degradation or oxidation which occurred at higher temperature when tested by TGA. Wear film was generated both on the specimen and on the counterface at relatively low sliding speed but cracks, grooves, and wear debris were observed at high sliding speed. Friction coefficient remained almost constant when the sliding speed or normal load was varied. It is believed that the adhesive and abrasive components contributed mainly to the friction coefficient. Wear behavior at low sliding speed was governed by wear film formation and adhesive wear mechanism. At high speed, fiber orientation, ploughing by counterface asperities, and fiber breakage dominated wear of the carbon/carbon composite.

Development of Solvent-Free Type for UV-Curable Silver Paste (무용제 타입 UV경화형 실버 페이스트 개발)

  • Jang, Min Yong;Nam, Hyun Jin;Nam, Su Yong
    • Journal of the Microelectronics and Packaging Society
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    • v.29 no.2
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    • pp.107-112
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    • 2022
  • In this study, a silver paste capable of UV curing without using any solvent was developed. The viscosity and viscoelasticity of the silver paste developed as a solvent-free type were measured. And after printing the pattern by screen printing, an electrode coating film was formed by UV curing. Conductivity, pencil hardness, and adhesive force of the formed electrode coating film were evaluated. Finally, the curing characteristics of the electrode coating film were evaluated by TGA and FT-IR. Summarizing these results, in terms of conductivity, adhesion, and curing characteristics, it was found that Paste (4), that is, silver paste obtained by mixing 1.2 ㎛ spherical silver powder and 50 nm silver powder at 72:8% had the best physical properties.

A Study on the Effect of Primer Processing Method on the Mechanical Properties of Impact Relief Air Cushion Materials Prepared through Thermal Film Laminating (프라이머 가공 방법이 열융착 필름 라미네이팅으로 제조한 고충격 대응 에어쿠션 소재의 물성에 미치는 영향 연구)

  • Kim, Ji Yeon;Kim, Hun Min;Min, Mun Hong
    • Textile Coloration and Finishing
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    • v.34 no.3
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    • pp.173-184
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    • 2022
  • In this study, the TPU film was laminated on an aramid fabric or circular knits in order to implement an air cushion material that can respond to high impact forces in case of a fall and is easy to expand. To increase the bonding strength between the fabric layer and the film layer, a primer layer was formed in two ways: one for thermally bonding and laminating PET film and two for coating and aging hot melt type PUR adhesive. The tensile strength of the aramid air cushion was 2.5 times higher than that of the circular knits, but the tensile elongation of the aramid air cushion was very low compared to that of the circular knits. The tear strength of the aramid air cushion was about twice or more superior to that of the circular knits, the primer treatment method was good at A, and the peel strength was excellent at method A. The aramid air cushion was the lightest in weight. Summarizing the above results, it was best to combine the air cushion material with aramid woven fabric and primer treatment method A to cope with the high impact force applied when falling.