• Molecules and Cells
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• 제28권5호
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• pp.441-446
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• 2009

During epididymal transit, mammalian sperm acquire selected proteins secreted by the epididymis. We previously showed that a disintegrin and metalloprotease (ADAM) 7 is expressed specifically in the epididymis and transferred to the sperm surface during epididymal transit. Here, we show that mouse ADAM7 secreted to the epididymal lumen is associated with membranous vesicles known as epididymosomes. Furthermore, we found that ADAM7 can be transferred directly from epididymal vesicles to sperm and that it is an integral plasma membrane protein in sperm. Thus, our study provides new information regarding the unique mode of secretion and interaction of ADAM7 during the epididymis-to-sperm transfer process.

• International Journal of Internet, Broadcasting and Communication
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• 제11권4호
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• pp.31-36
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• 2019

Unsupervised neural networks have not caught enough attention until Generative Adversarial Network (GAN) was proposed. By using both the generator and discriminator networks, GAN can extract the main characteristic of the original dataset and produce new data with similarlatent statistics. However, researchers understand fully that training GAN is not easy because of its unstable condition. The discriminator usually performs too good when helping the generator to learn statistics of the training datasets. Thus, the generated data is not compelling. Various research have focused on how to improve the stability and classification accuracy of GAN. However, few studies delve into how to improve the training efficiency and to save training time. In this paper, we propose a novel optimizer, named FAST-ADAM, which integrates the Lookahead to ADAM optimizer to train the generator of a semi-supervised generative adversarial network (SSGAN). We experiment to assess the feasibility and performance of our optimizer using Canadian Institute For Advanced Research - 10 (CIFAR-10) benchmark dataset. From the experiment results, we show that FAST-ADAM can help the generator to reach convergence faster than the original ADAM while maintaining comparable training accuracy results.

• 한국콘텐츠학회논문지
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• 제16권10호
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• pp.608-616
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• 2016

Smith-Waterman(SW) 알고리즘은 DNA 시퀀스 분석에서 중요한 연산 중 하나인 지역 정렬을 처리하는 알고리즘이다. SW 알고리즘은 동적 프로그래밍 방법으로 최적의 결과를 도출할 수 있지만 수행시간이 매우 길다는 문제가 있다. 이를 해결하기 위해서 다수의 노드를 이용한 병렬 분산 처리 기반의 SW 알고리즘이 제안되었다. Apache Spark을 기반으로 하는 병렬 분산 DNA 처리 프레임워크인 ADAM에서도 SW 알고리즘을 병렬로 처리하고 있다. 하지만, ADAM의 SW 알고리즘은 Smith-Waterman 이 동적프로그래밍 기법이라는 특성을 고려하지 않고 있어 최대의 성능을 얻지 못하고 있다. 이 논문에서는 ADAM의 병렬 SW 알고리즘을 개선한다. 제안하는 병렬 SW 기법은 두 단계에 걸쳐 실행된다. 첫 번째 단계에서는 지역정렬 대상인 DNA 시퀀스를 다수의 파티션(partition)으로 분할하고 분할된 각 파티션에 대해서 SW 알고리즘을 병렬로 수행한다. 두 번째 단계에서는 파티션 각각에 대해서 독립적으로 SW를 적용함으로써 발생하는 오류를 보완하는 과정을 역시 병렬로 수행한다. 제안하는 병렬 SW 알고리즘은 ADAM을 기반으로 구현하고 기존 ADAM의 SW와 비교를 통해서 성능을 입증한다. 성능 평가 결과 제안하는 병렬 SW 알고리즘이 기존의 SW에 비해서 2배 이상의 좋은 성능을 내는 것을 확인하였다.

• 한국수자원학회논문집
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• 제56권1호
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• pp.63-74
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• 2023

높은 신뢰도의 댐 유입량 예측은 효율적인 댐 운영을 위해 필요하다. 최근 다층퍼셉트론(Multi Layer Perceptron, MLP)을 활용하여 댐의 유입량을 예측하는 연구들이 진행되었다. 기존 연구들은 MLP의 연산자 중 자료 간의 최적 상관관계를 찾는 optimizer로 경사하강법(Gradient Descent, GD) 기반의 optimizer를 사용하였다. 하지만, GD 기반의 optimizer들은 지역 최적값으로의 수렴 가능성과 저장공간 부재로 인해 예측성능이 저하된다는 단점이 있다. 본 연구는 GD 기반 optimizer 중 Adaptive moments와 Improved Harmony Search (IHS)를 결합한 Adaptive moments combined with Improved Harmony Search (AdamIHS)를 개발하여 GD 기반 optimizer의 단점을 개선하였다. AdamIHS를 사용한 MLP의 학습 및 예측성능을 평가하기 위해 대청댐 유입량을 학습 및 예측하였으며, GD 기반 optimizer를 사용한 MLP의 학습 및 예측성능과 비교하였다. 학습결과를 비교하면, AdamIHS를 사용한 은닉층 5개인 MLP의 Mean Squared Error (MSE) 평균값이 11,577로 가장 낮았다. 예측결과를 비교하면, AdamIHS를 사용한 은닉층 1개인 MLP의 MSE 평균값이 413,262로 가장 낮았다. 본 연구에서 개발된 AdamIHS를 활용하면 다양한 분야에서 향상된 예측성능을 보여줄 수 있을 것이다.

• 대기
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• 제17권1호
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• pp.87-99
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• 2007

Simulation results of Asian Dust Aerosol Model (ADAM) for the period of April 7-9, 2006 were analyzed, comparing with observed PM10 data. ADAM simulated around ten times lower than on-site PM10 concentration in the source regions: Zhurihe, Tongliao, Yushe, Dalian and Huimin. As the result of this low concentration, transported amounts of Asian Dust were under-estimated as well. In order to quantify a forecasting accuracy, Bias and RMSE were calculated. Even though remarkably negative Biases and high RMSEs were observed, ADAM simulation had followed well up the time of dust outbreak and a transported path. However, the emission process to generate dust from source regions requires a great enhancement. The PM10 concentration at the surface reached up to $2,300{\mu}gm^{-3}$ at Baeknyoungdo and Seoul (Mt. Gwanak), up to $1,750{\mu}gm^{-3}$ at KGAWO about 18:00 LST in April 8, respectively; however, ADAM did not simulate the same result on its second peak. It is considered that traveling Asian dust might have been lagged over the Korean peninsula by the blocking of surface high pressure. Moreover, the current RDAPS's 30 km grid resolution (which ADAM adopts as the meteorological input data) might not adequately represent small-scale atmospheric motions below planetary boundary layer.

• Biomolecules & Therapeutics
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• 제21권5호
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• pp.371-380
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• 2013

Doxorubicin is still main drug in chemotherapy with limitation of use due to adverse drug reaction. Increased oxidative stress and alteration of nitric oxide control have been involved in cardiotoxicity of doxorubicin (DOX). A Disintegrin And Metalloproteinase (ADAMs) are transmembrane ectoproteases to regulate cell-cell and cell-matrix interactions, but role in cardiac disease is unclear. The aim of this study was to determine whether DOX activates peroxynitrite and ADAM 10 and thus ADAM and matrix metalloproteinase (MMP) induce cardiac remodeling in DOX-induced cardiomyopathy. Adult male Sprague-Dawley rats were subjected to cardiomyopathy by DOX (6 times of 2.5 mg/kg DOX over 2-weeks), and were randomized as four groups. Then followed by 3, 5, 7, and 14 days after cessation of DOX injection. DOX-injected animals significantly decreased left ventricular fractional shortening compared with control by M-mode echocardiography. The expressions of cardiac nitrotyrosine by immunohistochemistry were significant increased, and persisted for 2 weeks following the last injection. The expression of eNOS was increased by 1.9 times (p<0.05), and iNOS was marked increased in DOX-heart compared with control (p<0.001). Compared to control rats, cardiac ADAM10- and MMP 9- protein expressions increased by 20 times, and active/total MMP 9 proteolytic activity showed increase tendency at day 14 after cessation of DOX injection (n=10, each group). DOX-treated $H_9C_2$ cell showed increased ADAM10 protein expression with dose-dependency (p<0.01) and morphometric changes showed the increase of ventricular interstitial, nonvascular collagen deposition. These data suggest that activation of cardiac peroxynitrite with increased iNOS expression and ADAM 10-dependent MMP 9 expression may be a molecular mechanism that contributes to left ventricular remodeling in DOXinduced cardiomyopathy.

• Molecules and Cells
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• 제24권1호
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• pp.139-147
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• 2007

Although transforming growth factors (TGFs) are implicated in the process of endochondral ossification, which is initiated by the differentiation of mesenchymal cells into chondrocytes, it is not clear how $TGF-{\beta}3$ regulates the chondrogenic differentiation of limb bud mesenchymal cells. Here, differential display polymerase chain reaction (DD-PCR) screening and RT-PCR analysis revealed that transcripts of A Disintegrin And Metalloprotease 10 (ADAM 10) decreased during the chondro-inhibitory action of $TGF-{\beta}3$ on cultured chick leg bud mesenchymal cells. Electroporation of ADAM 10 morpholino antisense oligonucleotides inhibited the ectodomain shedding of delta-1, and cell proliferation and subsequent precartilage condensation, in a manner similar to that caused by $TGF-{\beta}3$. The suppression of mesenchymal cell proliferation induced by $TGF-{\beta}3$ and ADAM 10 morpholino antisense oligonucleotides was reversed by activation of ADAM 10 with phorbol 12-myristate 13-acetate (PMA) or knockdown of Notch-1 with siRNA. Collectively, these data indicate that, in cultured chick leg bud mesenchyme cells, $TGF-{\beta}3$ downregulates ADAM 10 and inhibits cell proliferation and subsequent precartilage condensation by inhibiting the ectodomain shedding of delta-1, and that this results in the activation of Notch signaling.

• BMB Reports
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• 제46권3호
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• pp.139-150
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• 2013

The ADAM and ADAMTS families, also called adamalysins belong to an important group of extracellular matrix proteins. The ADAMs family belong to both the transmembrane and secreted proteins, while ADAMTS family only contains secreted forms. Adamalysins play an important role in the cell phenotype regulation via their activities in signaling pathways, cell adhesion and migration. The human proteome contains 21 ADAM, and 19 ADAMTS proteins, which are involved in extracellular matrix remodeling, shedding of various substrates such as: adhesion ligands, growth factors, their receptors and diverse cytokines. Recent studies provide evidence that adamalysins play a crucial role in colorectal cancer (CRC) etiopathogenesis. It seems possible that adamalysins might be used as CRC prediction markers or potential pharmaceutical targets.

• 한국정보통신학회논문지
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• 제16권9호
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• pp.1977-1982
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• 2012

컴퓨터나 스마트폰 사용자들은 최근에 다양한 소셜 네트워크 서비스가 제공되어 매우 편리하다. 소셜 네트워크 서비스는 사이버 공간에서 사용자가 원하는 멀티미디어 자료들을 저장해 두고 편리하게 이용할 수 있어서 좋다. 하지만, 서비스 사용자가 증가하면서 클라우드 저장소의 공간이 급격하게 증가하고, 서비스 사용자가 사망한 경우에는 빅-테이블이나 상속 문제가 발생하게 된다. 대표적으로 사망자가 남긴 디지털 자산들에 대한 게시, 유포, 보관, 그리고 상속에 관한 문제가 발생할 수 있다. 현재는 디지털 자산을 상속자가 서비스 제공자에게 사망자와 가족관계임을 밝히고, 사실 여부를 확인 받은 후에 디지털 자산에 대한 부분적인 사용, 저장, 그리고 백업만이 가능하다. 그러므로, 우리는 본 논문에서 상속자가 사망자가 남긴 디지털 자산을 쉽고 편리하게, 그리고 안전하게 상속할 수 있도록 하는 ADAM을 제안하고자 한다. ADAM을 사용하면 상속자는 정당한 상속절차를 거쳐서 일반적인 재산과 마찬가지로 디지털 자산에 대해서 자유롭고 편리하게 상속 받을 수 있다.

• 한국수정란이식학회:학술대회논문집
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• 한국수정란이식학회 2003년도 제3회 발생공학 국제심포지움 및 학술대회
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• pp.59-59
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• 2003