• 한국자원식물학회지
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• 제34권4호
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• pp.377-383
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• 2021

이상의 연구 결과로 미루어 볼 때, 산돌배 열매추출물은 대식세포에서 TLR2와 TLR4를 자극하여 MAPKs 신호전달을 활성화하여 NO, iNOS, IL-1𝛽, IL-6 및 TNF-α와 같은 면역증진 인자의 생성을 유도하고, 대식세포의 포식작용을 활성화시키는 것으로 판단된다. 따라서 산돌배 추출물은 대식세포의 활성화를 통해 인체의 면역시스템을 강화할 수 있으므로, 향후 면역 보조제나 면역증진을 위한 기능성 식의약품 개발을 위한 소재로 활용이 가능할 것으로 생각한다.

• 한국자원식물학회:학술대회논문집
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• 한국자원식물학회 2022년도 추계학술대회
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• pp.87-87
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• 2022

Under the COVID-19 pandemic, interest in immune enhancement and anti-obesity is increasing. Thus, in this study, we investigated whether Kadsura japonica fruits (KJF) exhibits immunostimulatory activity and anti-obesity activity. KJF increased the production of immunostimulatory factors and phagocytosis in RAW264.7 cells. Inhibition of TLR2 and TLR4 blocked KJF-mediated production of immunostimulatory factors in RAW264.7 cells. In addition, the inhibition of MAPK and PI3K/AKT signaling pathway reduced KJF-mediated production of immunostimulatory factors, and the activation of MAPK and PI3K/AKT signaling pathway by KJF suppressed the inhibition of TLR2/4. KJF attenuated the lipid accumulation and the protein expression such as CEBPα, PPARγ, perilipin-1, adiponectin, and FABP4 related to the lipid accumulation in 3T3-L1 cells. In addition, KJF inhibited excessive proliferation of 3T3-L1 cells and protein expressions such as β-catenin and cyclin D1 related to cell growth. These findings indicate that KJF may have immunostimulatory activity and anti-obesity activity.

• Journal of Nutrition and Health
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• 제37권5호
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• pp.385-393
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• 2004

This study examined the relations of educational level and life-style behaviors to the obesity. A total of 507 male adults aged 30 - 50 years completed the self-reported questionnaires. Educational level was used for measuring socioeconomic status. Activity at work, leisure-time activity and TV watching were measured for life-style behaviors related to physical activity, and some demographic and family history of disease as well. Subjects were categorized as obese when BMI was equal to or over 25kg/$m^2$, in which 19.7％ resulted obesity. Using multivariate logistic regression, the association between the measured factors and obesity was assessed. The odds ratios (OR) for risk of obesity did not differ with either age or monthly income. Subjects who completed high school (OR = 0.36; 95％ CI = 0.20 - 0.66) or university (OR = 0.34; 95％ CI = 0.16 - 0.71) had lower risk of obesity than those with education below middle school. Those with moderate activity level at work (OR = 0.41; 95％ CI = 0.24 - 0.72) showed lower risk of obesity than in inactive ones. The subjects watching TV more than 3.5 hr/day presented higher risk of obesity (OR = 2.46; 95％ CI = 1.28 - 4.74), compared with those watching TV less than 1.5 hr/day. The higher risk of obesity observed in high level of leisure time activity than in low one was considered due to that physical activity at work and leisure-time might counteract each other. Educational level and activity at work or leisure-time activity or TV watching were jointed and categorized, and then OR for obesity was estimated. The extent of obesity risk at a given level of each work activity or leisure-time activity or TV watching was different depending the educational level, which was significantly high when educational level was below middle school. Educational difference had no effect on activity level at work. However, higher educational attainment increased the leisure activity and reduced TV watching (p＜0.05), indicating that low education tended to contribute to more sedentary life-style. The findings of this study is concluded that low education was related to obesity in adult males, and its relation can partly be explained through acquiring inactive life-style behaviors. Individuals with low education might be more susceptible to the risk factors of obesity.

• Journal of Nutrition and Health
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• 제35권10호
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• pp.1089-1103
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• 2002

The purpose of this study is to identify factors influencing a health-promoting lifestyle among highly educated, married women with or without work outside the home. It is a direct interview, cross-sectional study. Subjects were 250 married, unemployed women and 236 married women employed as teachers. Women who have not graduated college, work only part-time or have no current spouse were excluded. The instruments used were the Health-Promoting Lifestyle Profile (Walker, et al., 1987) and the Habitual Physical Activity Questionnaire (Backe, et al., 1982), The HPLP scores of the employed, married women were significantly lower than those for unemployed respondents. for both groups of respondents, the self-actualization subscale was the highest score and the exercise subscale was the lowest score. The HPLP indicated that exercise is a very weak area. Thus, an increase in exercise time and frequency, especially for highly educated, married women, is suggested. Multiple regression analysis revealed that a health-promoting lifestyle of unemployed, married women was affected by sports activity, leisure-time activity, depression and satisfaction of role allotment. On the other hand, a health-promoting lifestyle of employed, married women was affected by sports activity, leisure-time activity, stress, self-perceived economic status, coffee consumption, husband's help, and maid's help. That is, with more sports activity and leisure-time activity, less depression and more satisfaction of role allotment, unemployed, married women would have higher HPLP scores. Also, with more sports activity and leisure-time activity, less stress, better self-perceived economic status, less coffee consumption, more husband's help and more maid's help, employed, married women would have higher HPLP scores. The results indicate that sports activity and leisure-time activity were the first and the second determinants of health-promoting lifestyle respectively. Therefore, an exercise-centered health-promoting program for highly educated, married women is suggested in the community or workplace. Especially, the program should be designed to be easily approachable for highly educated, employed married women who have more of a role burden compared to unemployed women.

• 성인간호학회지
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• 제28권2호
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• pp.237-245
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• 2016

Purpose: The aim of this study was to examine the effects of an Advanced Practice Nurse (APN)-led self-management program on cardiovascular health status among Korean women at risk of developing or progressing cardiovascular disease. Methods: This pilot study used one-group pre- and post- test experimental design. At health fairs in a community, 30 women who had one or more risk factors for metabolic syndrome were recruited and agreed to participate in the study. A total of 25 women completed the study. The intervention consisted of weekly follow-up calls and self-monitoring diary after an hour of individual counseling regarding risk factors, fast walking, and healthy diet tailored to the participants' needs. Physical activity was assessed with the World Health Organization International Physical Activity Questionnaire and a pedometer. Results: Participants showed statistically significant improvements in blood pressure, body mass index, levels of triglyceride, total cholesterol and low density lipoprotein, numbers of metabolic syndrome factors, and the 10-year CV risk estimate after one month of concentrated intervention. In addition, their physical activity behavior significantly improved after the intervention. Conclusion: This APN-led self-management program targeting modifiable risk factors by offering tailored counseling and concentrated support during the transition might be effective in preventing progression to the cardiovascular disease.

• 농촌계획
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• 제28권2호
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• pp.33-40
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• 2022

The purpose of this study is to review the effect of previous research data with virtual reality-based Physical Activity Therapy Programs(PATPs) in adult on the physical fitness factors. Research articles were retrieved from 2008 to 2021 with the Research Information Sharing Service(RISS) and Pubmed database. The main search terms were 'care', 'therapy', 'healing', 'exercise' or 'physical activity', and 'virtual reality'. The criteria for selecting articles of this study were the originality, duplication, Randomized controlled trial(RCT) experiment and subject. Finally, 18 papers were selected among 318 articles, which were excluded if any of the criteria was not satisfied. Most of papers(15) were conducted in the last 5 years, because of the high interest due to the development of virtual reality implementation technology and COVID-19 pandemic. The participants were mainly patients(8), and the types of diseases were stroke(2). The physical fitness factors were mostly balance ability(7), muscle strength(7), and range of motion(6). All the physical fitness factors were significantly improved after PATPs. However, 11 studies were conducted for less than 4 weeks, including 6 studies were performed a bout of acute exercise. Also, 14 studies did not clearly present the intensity of PATPs. In addition, there were 9 studies, that simply applied games without specialized programs. In conclusion, it seems that virtual reality-based PATPs have a positive effect on physical fitness factors. However, VR-based PATPs should be specialized and developed in order to verify their effectiveness for the further research.

• 종양간호연구
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• 제6권2호
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• pp.143-151
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• 2006

Purpose: This study was to explore the degree of quality of life (QOL) in hospice volunteers and identify related factors Methods: A total of 243 subjects was recruited from eight hospitals of the Catholic University in Korea. Research tool used to measure QOL was questionnaires developed by You-Ja, Ro in 1988. The data obtained was analyzed using the SAS program to compute a t-test, ANOVA, and Stepwise multiple regression. Results: The mean score of QOL was $3.65{\pm}0.39$. The QOL was significantly increased with perceived health status, satisfaction to the hospice volunteer activity, family response on volunteer activity, qualification as a hospice volunteer, and needs of education. Among six domains of QOL, self-esteem had the highest score. Conclusions: It would be necessary for hospice volunteers to provide an program considered health status, satisfaction to the hospice volunteer activity, family response on their activity, qualification as a hospice volunteer, and needs of education to increase their QOL.

• 경영과학
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• 제19권1호
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• pp.179-188
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• 2002

Ventures through technological innovation are increasingly suggested as one of the main engines for economic growth that can help control inflation and black trade balance. The Purpose of this study is to extract the network performance factors for ventures according to ventures life cycle. For the Purpose, the existing studies were examined into start-up company, entrepreneurial firm, smell firms with competitive advantage against large firms, and ventures network activity. And 63 samples from ventures in Korea were taken and analyzed empirically. The analyses and results are (1) the actual conditions of network activity on ventures; (2) the investigation of relationship between network activity and performance of ventures by venture's life cycle through the observations of Korean ventures. From the results, It Is also found that factors such as external environment and a ventures life cycle have been considered as the main influences on the performance of ventures. In addition, limitations and suggestions for further studies are noted.

• 디지털콘텐츠학회 논문지
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• 제11권4호
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• pp.571-578
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• 2010

최근 모바일 기기를 기반으로 수많은 소셜 네트워크 서비스가 확산되고 보급되는 가운데, 위치와 시간을 기반으로 하는 연구들이 증가하고 있다. 그러나 기존 연구들에서는 장소와 시간, 이벤트에 대한 조합적인 질의를 해결하는 것이 주요한 문제가 되었다. 본 연구에서는 소셜 서비스를 위한 시공간 모델링 방안으로 장소와 시간, 이벤트, 사용자의 소셜 액티비티를 통해 Human Activity Graph 모델링 방안과 Quad Relation Factors를 제안하고, 이를 위한 데이터 수집과 분석을 위한 하부 구조를 설계하였다.

• 수면정신생리
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• 제28권2호
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• pp.43-52
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• 2021

Restless Legs Syndrome/Willis-Ekbom Disease (RLS/WED) is a sleep disorder characterized by sensorimotor symptoms such as unpleasant sensations before sleep, akathisia, and periodic limb movements during sleep. It is also closely related to hyperarousal and is often accompanied by insomnia. Although the mechanism is not clear, the understanding of etiology and pathophysiology has greatly expanded through recent advances in genetic and neurobiological research. The most important pathophysiology of RLS/WED is brain iron deficiency. Such iron deficiency in the brain is caused by complex interactions between several genetic factors and various environmental factors, including comorbidities. Iron deficiency in the brain results in dysfunction of several neurotransmitters. A decrease in adenosine activity appears first, followed by an increase in the activity of glutamate and dopamine. A decrease in adenosine activity and an increase in glutamate activity stimulate the brain arousal system, resulting in hyperarousal. In addition, overproduction of dopamine and glutamate leads to dysfunction of the cortical-striatal-thalamic circuit, resulting in symptoms such as akathisia and periodic limb movements during sleep.