• Advances in Traditional Medicine
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• v.9 no.2
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• pp.192-199
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• 2009

Bioactivity-directed isolation has led to the isolation of (-)-ent-costunolide (1) as the major active compound from Hepatostolonophora paucistipula. This compound (1) was determined by spectroscopic data interpretation. This sesquiterpene lactone (1) inhibited the growth of the dermatophytic fungus Trichophyton mentagrophytes ATCC 28185, (4 mm inhibition zone at $15{\mu}g$/disc), cytotoxic activity to murine leukaemia cell lines ATCC CCL 46 P 388D1 ($IC_{50}$ 687 ng/ml, at $0.075{\mu}g$/disk), BSC monkey kidney cell lines (100% of well at $15{\mu}g$/disk) and antiviral activity to Herpes simplex virus (0.25 mg/ml, 100% of well at $7.5{\mu}g$/disk) and Polio virus (0.125 mg/ml, 100% of well at $3.75{\mu}g$/disk). These results suggest that (-)-ent-costunolide (1) has potential antimicrobial and cytotoxic agents.

• YAKHAK HOEJI
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• v.47 no.5
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• pp.331-338
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• 2003

A butyrolactone ester of cefazolin (CFZ-BTL) was synthesized by the esterification of cefazolin (CFZ) with $\alpha$-bromo-${\gamma}$-butyrolactone. The synthesis was confirmed by the spectroscopic analysis. The CFZ-BTL was more lipophilic than the CFZ when assessed by n-octanol/water partition coefficients at various pH. The CFZ-BTL itself did not show any antimicrobial activity in vitro, but after oral administration of CFZ-BTL to rabbits, exerted significant anti-microbial activity in serum samples when measured by the inhibion zone method in nutrient agar plates, due to conversion of CFZ-BTL to an active metabolite, probably CFZ, in the body. The CFZ-BTL was also converted into CFZ as confirmed by in vitro incubation study, with tissue homogenates (liver, blood and intestine) of rabbits. The liver showed the fastest conversion rate, probably via the hydrolysis mechanism. In vivo metabolism of CFZ-BTL to CFZ was also confirmed in vivo serum samples by HPLC. The oral bioavailability of CFZ-BTL in rabbits was 1.6-fold increased when compared to CFZ, resulting from followed by enhanced lipophilicity increased passive absorption in the intestine.

• Proceedings of the KIEE Conference
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• 2003.11c
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• pp.890-893
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• 2003

In this paper, we have designed the fractional-N frequency synthesizer for bluetooth system using 0.35-um CMOS technology and 3.3-V single power supply. The designed synthesizer consist of phase-frequency detector (PFD), charge pump, loop filter, voltage controlled oscillator (VCO), frequency divider, and sigma-delta modulator. A dead zone free PFD is used and a modified charge pump having active cascode transistors is used. A Multi-modulus prescaler having CML D flip-flop is used and VCO having a tuning range from 746 MHz to 2.632 GHz at 3.3 V power supply is used. Total power dissipation is 32 mW and phase noise is -118 dBc/Hz at 1 MHz offset.

• Proceedings of the Korean Society for Noise and Vibration Engineering Conference
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• 2005.11a
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• pp.135-138
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• 2005

On the basis of theoretical studies on the effect of the cylinders attached to semi-infinite screens, the effect of the tangential sound power-transport along the cylindrical top section of noise barriers is studied. Four types of acoustical mechanism between the surface of the cylinder and the adjacent air particles are investigated, namely Z $\rightarrow$ $\infty$, Z $\rightarrow$ pc, Z $\rightarrow$ 0 and actively controlled surface sound field. In active control case the sound power parallel to the surface of the attached cylinder is minimized by means of a secondary sound field, which is generated from a part of the attached cylinder. In each case the change in the acoustical shadow zone was shown and compared. The numerical study shows the possibility of deflecting the incident sound by minimizing the acoustical surface impedance of the upper sections.

• Journal of The Korean Astronomical Society
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• v.33 no.1
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• pp.19-28
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• 2000

In the earlier papers we analyzed the axisymmetric, nonstationary electrodynamics of the central black hole and a surrounding thin accretion disk in an active galactic nucleus. In this paper we analyze the axisymmetric, nonstationary electrodynamics of the black hole magnetosphere in a similar way. In the earlier papers we employed the poloidal component of the plasma velocity which is confined only to the radial direction of the cylindrical coordinate system. In this paper we employ a more general poloidal velocity and get the Grad-Shafranov equation of the force-free magnetosphere of a Kerr black hole. The equation is consistent with the previous ones and is more general in many aspects as it should be. We also show in more general approaches that the angular velocity of the magnetic field lines anchored on the accreting matter tends to become close to that of the black hole at the equatorial zone of the hole.

• Proceedings of the KIPE Conference
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• 2019.07a
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• pp.77-79
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• 2019

Islanding detection is one of the most important issues for the distributed generation (DG) systems connected to the power grid. The conventional passive islanding detection methods inherently have a non-detection zone (NDZ), and active islanding detection methods may deteriorate the power quality of a power system. This paper proposes a novel hybrid islanding detection method based on Digital Lock-In Amplifier with no NDZ by monitoring the harmonics present in the grid. Proposed method detects islanding by passively monitoring the grid voltage harmonics and verify it by injecting small perturbation for only three-line cycles. Unlike FFT for the harmonic extraction, DLA HC have lower computational burden, moreover, DLA can monitor harmonic in real time, whereas, FFT has certain propagation delay. The simulation results are presented to highlight the effectiveness of the proposed technique. In order to prove the performance of the proposed method it is compared with several passive islanding detection methods. The experimental results confirm that the proposed method exhibits outstanding performance as compared to the conventional methods.

• Geomechanics and Engineering
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• v.30 no.4
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• pp.353-362
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• 2022

The seismic failure-prone region in Istanbul has been examined in terms of the segmented pipelines. Although some researchers have suggested that this territory should be left as a green land, many people continue to live in this area. This region is about 9-10 km away from the North Anatolian Fault Line. This fault zone is an active right-lateral strike-slip fault line in Turkey and an earthquake with a magnitude of 7.0-7.5 is expected in the Marmara Sea. Therefore, superstructures and infrastructures are under both land sliding risks and seismic risks in this area. Because there are not any pipeline-fault line intersection points in the region, in this study, it has been focused on the behaviors of the segmented (sewage or stormwater) pipelines subject to earthquake-induced permanent ground deformation and seismic wave propagation. Based on the elastic beam theory some necessary analyses have been carried out and obtained results of this approximation have been examined.

• Korean Journal of Mineralogy and Petrology
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• v.33 no.4
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• pp.349-359
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• 2020

The Ulsan Fault Zone (UFZ) of NNW trend is developed in the Gyeongsang Basin, the southeastern part of the Korean Peninsula, and the Quaternary faults have been found around the UFZ. The faults generally thrust the Bulguksa igneous rocks of Late Cretaceous-Early Tertiary upon the Quaternary deposits or are developed within the Quaternary deposits. They mainly show the reverse-slip sense of top-to-the west movement. The lines connecting the their outcrop sites show a zigzag-form which is similar to the orientation of their fault surfaces which show the various trends, like (W)NW, N-S, (E)NE, ENE trends. The E-W trending dextral strike(-slip) fault is found in the Quaternary deposits of the Singye-ri valley. It cuts the N-S trending reverse fault and are cut by the N-S trending thrust fault again. Two types of at least two times of Quaternary tectonic movements related to the formation of neotectonic fault zone in the Singye-ri valley are considered from such the geometric and kinematic characteristics of Quaternary faults. One is the reverse faulting of N-S trend by the E-W directed 1st compression and associated the strike-slip tear faulting of E-W trend, and then the thrust faulting of N-S trend by the E-W directed 2nd compression. The other is the reverse faulting of N-S trend, and then the dextral strike-slip faulting of E-W trend by the NW-SE directed compression, and then the thrust faulting of N-S trend. In this paper is suggested the development history of Singye-ri neotectonic fault zone on the basis of the various orientations of Quaternary fault surfaces around the UFZ, and the zigzag-form connecting line of their outcrop sites, and the compressive arc-shaped lineaments which convex to the west reported recently in the Yangsan Fault Zone.

• Journal of Practical Agriculture & Fisheries Research
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• v.25 no.1
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• pp.20-35
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• 2023

Chemical preservatives have a good effect on antibacterial activity, but many side effects on the human body have been reported. Recently, the development of natural preservatives that are harmless to the human body and have preservative functions and self-efficacy is active. In addition, in order to increase the absorption rate of natural products by the human body, the method of fermentation using strains is also increasing. Therefore, this study selected varieties that are harmless to the human body and have good antibacterial activity. 1. The yield of origin, thickness and solvent was investigated. Scutellaria baicalensis Georgi was made in China and received a yield of 21.88% from 50% ethyl alcohol extract. Salvia miltiorrhiza Bunge was made in Korea and received a yield of 25.62% from 50% ethyl alcohol extract. Dryopteris crassirhizoma Nakai was made in China and received a yield of 6.50% from 70% ethyl alcohol extract. 2. The solid fermentation with the S. baicalensis and S. miltiorrhiza with B. Subtilis yield gained 24.40%, 39.30%, and D. crassirhizoma obtained 11.10% yield when fermented with L. casei. 3. After the liquid fermentation, a clear zone of 9mm was identified for the S. aureus strain in the S. baicalensis, and the antibacterial activity was not confirmed in S. miltiorrhiza and D. crassirhizoma. 4. When the S. baicalensis was fermented with L. Casei, it showed high antibacterial activity in C. albicans and S. aureus. S. miltiorrhiza showed antibacterial activity in S. aureus when it was solid with S. cerevisiae. When the spectators were solid with L. casei and S. cerevisiae, antibacterial activity was high in E. coli and S. aureus. Overall, the antibacterial activity after fermentation was much higher than when fermented. 5. The change in active ingredients was baicalin 101.57, baicalein 28.26, and wogonin 5.33mg/g in the S. baicalensis that did not ferment solid. When solid fermentation with S. cerevisiae, the content of baicalinin with baicalin 94.31, baicalein 30.41, and wogonin 3.57mg/g was found to have increased. S. miltiorrhiza that was not fermented, salvianolic acid A was 1.82mg/g, and when fermented with S. cerevisiae, it increased to 5.70mg/g. The active ingredients of the spectators were flavaspidic acid AP, flavaspidic acid PB, flavaspidic acid AB, and flavaspidic acid BB.

• Journal of the Korean Geographical Society
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• v.43 no.6
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• pp.775-790
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• 2008

This study shows possibility of active fault, throughout analyzing distributional features of tectonic and fluvial geomorphology and mineral composition of fault fracture clay, at Jinbu fault-line system in Pyeongchang-gun, Gangwon Province. Fault-line valley was formed remarkably in the upper reaches of Odae River and upper reaches of Yeongok River according along Jinbu fault-line. Landforms show rectilineal distribution at right shore slopes of Odae River in Ganpyeong-ri, southern zone of Jinbu fault-line system, related to the tectonic processes, such as triangular facet, kernbut, kerncol and alluvial fan. Fault fracture clay zones were developed at 5 outcrops($jbf1{\sim}5$), located in kerncol. Particularly, jbf1 fault outcrop, developed at granite saprolite, has obvious fault plane and fault clay composed of illite and laumontite. The Jinbu Fault-line along jbf4-2-3-5 may be formed by regional compressive stress, and jbf1 fault may be suggested a tributary fault of the Jinbu fault-line formed before the late Pleistocene. The vertical displacement of the east and west blocks of the Jinbu Fault-line is estimated in $0.024{\sim}0.027m/ka$.