• Environmental Mutagens and Carcinogens
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• v.18 no.1
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• pp.1-8
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• 1998

Chemoprevention refers to the use of non-toxic chemical agents to prevent the neoplastic development by inhibiting, delaying, or reversing a multi-stage carcinogenesis. The primary goal of chemoprevention research is to identify or produce effective agents and strategies for clinical trials for applications to normal or high risk human populations. A large number of compounds have been tested for their possible chemopreventive activities, and it is of interest to note that many of them are naturally occurring substances. Thus, a variety of plant and vegetable constituents, particularly those included in our daily diet, have been found to possess substantial protective properties against experimental carcinogenesis. These substances, collectively known as dietary phytochemicals, exert their chemopreventive effects by influencing specific step(s) of multi-stage carcinogenesis: some inhibit metabolic activation or enhance detoxification of carcinogens, others interfere with covalent interactions between ultimate eloctrophilic carcinogens and the target cell DNA and still others may exert anti-promoting or anti-progressing effects. Mechanism-based interventions by use of safe dietary phytochemicals may provide one of the most practical and promising cancer chemopreventive strategies.

• Korean Institute of Interior Design Journal
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• v.22 no.3
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• pp.205-216
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• 2013

Korean cities need sustainable urban regeneration based on the effective application of space and resource. Especially a sustainable urban regeneration needs the activation of community in the urban underground space as urban development center. The purpose of this study is to propose elements and factors of spatial planning of community in urban underground space for sustainable urban regeneration and to propose the characteristics of spatial planning of community in urban underground space according to strategies of sustainable urban regeneration. The research methods of this study used to conduct research include precedent study reviews and survey. The conclusions of this study are as following; The application of various factors related to spatial planning aspect of communication, supportive cultural facilities, accessibility and nature is needed for creating a sustainable urban regeneration. Especially, in urban underground space, the application of spatial planning for community activation considered strategies of sustainable urban regeneration should be necessary. And introduction of cultural facilities, multi-dimensional pedestrian network for accessibility and natural elements for activating community in urban underground space are needed for making sustainable urban regeneration.

• Clinical and Experimental Pediatrics
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• v.57 no.12
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• pp.505-513
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• 2014

While the survival of extremely premature infants with respiratory distress syndrome has increased due to advanced respiratory care in recent years, necrotizing enterocolitis (NEC) remains the leading cause of neonatal mortality and morbidity. NEC is more prevalent in lower gestational age and lower birth weight groups. It is characterized by various degrees of mucosal or transmural necrosis of the intestine. Its exact pathogenesis remains unclear, but prematurity, enteral feeding, bacterial products, and intestinal ischemia have all been shown to cause activation of the inflammatory cascade, which is known as the final common pathway of intestinal injury. Awareness of the risk factors for NEC; practices to reduce the risk, including early trophic feeding with breast milk and following the established feeding guidelines; and administration of probiotics have been shown to reduce the incidence of NEC. Despite advancements in the knowledge and understanding of the pathophysiology of NEC, there is currently no universal prevention measure for this serious and often fatal disease. Therefore, new potential techniques to detect early biomarkers or factors specific to intestinal inflammation, as well as further strategies to prevent the activation of the inflammatory cascade, which is important for disease progression, should be investigated.

• The Korean Journal of Pain
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• v.22 no.1
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• pp.1-15
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• 2009

Neuropathic pain is often refractory to intervention because of the complex etiology and an incomplete understanding of the mechanisms behind this type of pain. Glial cells, specifically microglia and astrocytes, are powerful modulators of pain and new targets of drug development for neuropathic pain. Glial activation could be the driving force behind chronic pain, maintaining the noxious signal transmission even after the original injury has healed. Glia express chemokine, purinergic, toll-like, glutaminergic and other receptors that enable them to respond to neural signals, and they can modulate neuronal synaptic function and neuronal excitability. Nerve injury upregulates multiple receptors in spinal microglia and astrocytes. Microglia influence neuronal communication by producing inflammatory products at the synapse, as do astrocytes because they completely encapsulate synapses and are in close contact with neuronal somas through gap junctions. Glia are the main source of inflammatory mediators in the central nervous system. New therapeutic strategies for neuropathic pain are emerging such as targeting the glial cells, novel pharmacologic approaches and gene therapy. Drugs targeting microglia and astrocytes, cytokine production, and neural structures including dorsal root ganglion are now under study, as is gene therapy. Isoform-specific inhibition will minimize the side effects produced by blocking all glia with a general inhibitor. Enhancing the anti-inflammatory cytokines could prove more beneficial than administering proinflammatory cytokine antagonists that block glial activation systemically. Research on therapeutic gene transfer to the central nervous system is underway, although obstacles prevent immediate clinical application.

• PNF and Movement
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• v.20 no.2
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• pp.215-222
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• 2022

Purpose: The purpose of this study was to compare the effects of passive scapular upward rotation and posterior tilt and active scapular posterior tilt on the muscle activity of the upper trapezius (UT), lower trapezius (LT), and serratus anterior (SA). Methods: Fifteen healthy subjects performed general arm elevation, arm elevation with passive scapular upward rotation and posterior tilt, and arm elevation with active scapular posterior tilt. For active scapular posterior tilt, the subjects were trained in this movement using visual biofeedback and a motion sensor. During each arm elevation condition, electromyography was used to measure the muscle activity of the UT, LT, and SA. The measured data were analyzed using a one-way repeated ANOVA. Results: LT muscle activity was significantly increased during arm elevation with active scapular posterior tilt compared to both general arm elevation and arm elevation with passive scapular upward rotation and posterior tilt (p < 0.05). SA muscle activity was greater during arm elevation with passive scapular upward rotation and posterior tilt than during general arm elevation (p < 0.05). There was no significant change in UT muscle activity among the tested arm elevation conditions (p > 0.05). Conclusion: Performing arm elevation with active scapular posterior tilt and performing arm elevation with passive scapular upward rotation and posterior tilt may be useful strategies for increasing muscle activation of the LT and SA, respectively.

• Journal of Korea Port Economic Association
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• v.29 no.1
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• pp.215-245
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• 2013

In this world, the interest in the marine leisure-sports, nature friendly oriented, has been increased. The width of leisure activities has became enlarged because of expansion of leisure time and the changes of recognition on the rational management and use of marine resources. Marina ports influence significantly marine leports and this paper reviewed the maria ports status and problems. This Country has strived to develop marina ports in local areas, designing the 1st basic National Plan of Marina Development. We have keen interest in Marina but have no detail strategy and preparation. This paper suggested how marina port shall be developed for the expansion of marine leports and what strategies shall be adopted for the activation of the facilities. After reviewing the previous researches and with the results of questionnaire survey, this paper suggested two types strategies. First on the policy oriented point, it suggested 10 alternatives on the perspectives of development and operation areas. Secondly, it proposed some strategies for the activation of marina ports on the aspects of 4Ps of marketing. This paper theoretically groped the activation schemes with the knowledge and experiences of experts, but it is recommended furthermore some survey on the practical field and user attitude must be progressed.

• Korean Journal of Fisheries and Aquatic Sciences
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• v.49 no.5
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• pp.594-599
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• 2016

Infection with HIV (Human immunodeficiency virus), over time, develops into acquired immunodeficiency syndrome (AIDS). The development of non-toxic and effective anti-HIV drugs is one of the most promising strategies for the treatment of AIDS. In this study, we investigated the anti-HIV-1 activity of gelatin hydrolysates from Alaska pollack skin. Gelatin hydrolysates were prepared using four enzymes (alcalase, flavourzyme, neutrase, and pronase E). Among these, the pronase E gelatin hydrolysate was found to inhibit HIV-1 infection in the human T cell-line MT4. It exhibited inhibitory activity on HIV-1_IIIB-induced cell lysis, reverse transcriptase activity, and viral p24 production at noncytotoxic concentrations. Moreover, it decreased the activation of matrix metalloproteinase-2 (MMP-2) in vitro. Because HIV infection-induced activation of MMP-2 can accelerate collagen resolution and collapse of the immune system, pronase E gelatin hydrolysate might prevent the activation of MMP-2 in cells, resulting in collagen stabilization and immune cell homeostasis consistent with anti-HIV activation. These results suggest that pronase E gelatin hydrolysate could potentially be incorporated into a novel therapeutic agent for HIV/AIDS patients.

• Korean Journal of Construction Engineering and Management
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• v.9 no.1
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• pp.118-125
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• 2008

Recently, the Ministry of Construction and Transportation announced a notice of the legislation related to remove the restriction of construction market activation in advance. he removement is an overwhelming change of the business structure in the Korean construction industry and has a far-reaching influence on general and trade contractors. The purpose of this research was to suggest improvement factors to survive an excessive competition in reinforced concrete market. This research did SWOT analysis to examine the strength, weakness, opportunity and threat of reinforced concrete firm, and established business strategies. The factor analysis was also applied with questionnaire survey to staff in charge of reinforced concrete company. It is expected that the suggested improvement factors can give effective business strategies to reinforced concrete firm. Furthermore, trade contractors having difficulty in a bottleneck in management can get help from the result of this research.

• Journal of Digital Convergence
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• v.11 no.3
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• pp.189-197
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• 2013

Weak competitive Small Business are getting attention for their ability to enhance the brand power and marketing co-brand. Under these circumstances, in this study examined the operational status of the domestic co-branded. Also enable co-branding strategy was proposed. First, learn the various aspects of the concept of co-branding, and looked at the advantages and disadvantages of co-branding. Second, the type of co-branded partner combined, joint venture between companies Union type, a leading company driven and private companies and state agencies co-branded. Looked at the type of advantages and disadvantages of each. Thirdly, we presented the current status of the important co-branded domestic. Fourth, we examined the status of the Small and Medium Business Administration supports a co-branded Examined in detail by year look at the status of support for this type of co-branded Industry Distribution and co-branded interrupted. Finally, the short-term aspects and long-term perspective on the domestic co-brand activation strategy based on these materials are presented. The results of this study is expected to be the foundation of domestic co-branded business in the future to explore the ways to improve the system of government support will help to raise.

• 대한공업교육학회지
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• v.30 no.1
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• pp.19-36
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• 2005

The purpose of this study is to develop the Public Practice Center's teaching-learning model by applying blended learning strategies which is complementary to the expected problems such as expansion of the educational object and diversity of the curriculum to maximize the educational effect and to analyze activation types of the Practical Practice Center to expand the Public Practice Center's function and role by studying the document. Blended Learning Strategies are established in consideration of the following eight (8) factors ; learning environment, learning purpose, learning contents, learning time, learning place, learning type, learning media, type of interaction. It is redesigned and amended to the KEDI's individual confirmation instruction model for skill learning (1975) which is considered to be effective in the filed of education by applying features, educational contents of the Public Practice Center's teaching and merit of Blended Learning Strategies simultaneous. This model is composed of six (6) steps as shown below; 1. Understanding on the purpose and orientation 2. Observation for demonstration of fundamental skill 3. Ex on-line learning 4. Acquirement of element skill 5. Confirmation for acquirement of fundamental skill 6. After on-line learning. Further to this, this model is designed so that the above eight factors will be applied to the students effectively and the merit of e-learning and off-line practice will be mixed to the learner's expectation and satisfaction.