• Parasites, Hosts and Diseases
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• 제60권1호
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• pp.35-38
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• 2022

Cerebral toxoplasmosis is often life-threatening in an immunocompromised patient due to delayed diagnosis and treatment. Several differential diagnoses could be possible only with preoperative brain images of cerebral toxoplasmosis which show multiple rim-enhancing lesions. Due to the rarity of cerebral toxoplasmosis cases in Korea, the diagnosis and treatment are often delayed. This paper concerns a male patient whose cerebral toxoplasmosis was activated 21 years post kidney transplantation. Brain open biopsy was decided to make an exact diagnosis. Cerebral toxoplasmosis was confirmed by immunohistochemistry and PCR analyses of the tissue samples. Although cerebral toxoplasmosis was under control with medication, the patient did not recover clinically and died due to sepsis and recurrent gastrointestinal bleeding.

• 대한응급의학회지
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• 제29권5호
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• pp.437-448
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• 2018

Objective: Acute ischemic stroke (AIS) requires time-dependent reperfusion therapy, and early recognition of AIS is important to patient outcomes. This study was conducted to identify the clinical features and risk factors of AIS patients that are missed during the early stages of diagnosis. Methods: We retrospectively reviewed AIS patients admitted to a hospital through the emergency department. AIS patients were defined as ischemic stroke patients who visited the emergency department within 6 hours of symptom onset. Patients were classified into two groups: an activation group (A group), in which patients were identified as AIS and the stroke team was activated, and a non-activation group (NA group), for whom the stroke team was not activated. Results: The stroke team was activated for 213 of a total of 262 AIS patients (81.3%), while it was not activated for the remaining 49 (18.7%). The NA group was found to be younger, have lower initial National Institutes of Health Stroke Scale scores, lower incidence of previous hypertension, and a greater incidence of cerebellum and cardio-embolic infarcts than the A group. The chief complaints in the A group were traditional stroke symptoms, side weakness (61.0%), and speech disturbance (17.8%), whereas the NA group had non-traditional symptoms, dizziness (32.7%), and decreased levels of consciousness (22.4%). Independent factors associated with missed stroke team activation were nystagmus, nausea/vomiting, dizziness, gait disturbance, and general weakness. Conclusion: A high index of AIS suspicion is required to identify such patients with these findings. Education on focused neurological examinations and the development of clinical decision tools that could differentiate non-stroke and stroke are needed.

• 한국산학기술학회논문지
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• 제18권12호
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• pp.452-458
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• 2017

본 연구에서는 2016년 7월부터 2017년 6월까지 1년 동안 뇌파 측정 신호를 이용한 우울증 진단장치를 개발하였다. 정상인의 경우 좌측 알파파가 우측 알파파에 비해 활성화되는 양상을 보이고, 우울증 환자의 경우 반대로 우측 알파파가 더 활성화된다. 뇌파의 잡음제거와 증폭을 위해 아날로그 회로와 디지털 저역통과필터를 사용하였고, 고속 푸리에 변환을 실시할 때 발생하는 신호의 누수를 제거하기 위해 해밍 창 함수를 적용하였다. 개발한 진단장치의 유효성능을 확인하기 위해 평균연령 24세의 대학교 3, 4학년 학생 20명을 대상으로 뇌파 측정을 실시하였다. 우울증 판독을 하기 위해 좌, 우 알파파의 상대 값을 계산한 결과 최솟값은 66.7, 최댓값은 113.3의 값을 가졌으며, 평균값은 92.2이었다. 또한 20명 중 7명이 90~95 사이에 해당되었고, 우울 점수의 평균 편차가 20가량 높은 사람의 경우 경미한 우울증세의 경향을 보였다. 본 연구 결론을 향후 좌, 우 뇌 비대칭 해소를 통한 우울증 치료기 제작 시 유의미한 자료로 사용할 수 있으며 다수의 우울증 환자에 대한 임상실험이 이루어질 경우 실제적 우울증 진단에 유용하게 적용할 수 있다.

• 전기학회논문지
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• 제57권2호
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• pp.276-285
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• 2008

These days the automobile industry, which has rapidly progressed, has been an indispensable part in social and economic activities as well as its research and development have been activated in response to various needs of consumers and markets. The second and third generation control system, getting count on safety and convenience differently than early circuits, cause the hypertrophy of wire harness. The J/Box(Junction Box), which distributes power and wires, was developed to solve the problem. As vehicles have been better in quantity and intelligence, however, environment-friendly electric apparatus system has continuously increased and ITS(Intelligent Transport System) has been introduced in earnest. In result, wires got complicated and multilateral and also there has been a stronger probability that vehicles are out of order due to various problems including mechanical failure. In this study, ISJB(Intelligent Smart Junction Box) was introduced to solve the problem. The diagnosis system was applied to prevent the overload and short of ISJE. Also, the state of vehicles displayed so that drivers monitor it in motion. Likewise error data are saved in the memory so that such data can be analyzed retrospectively. The busbar was adopted in to the main power terminal and the part of power pattern was coverd by lead. Because ISJB is more sensitive to heat in comparison to the busbar type J/Box. With regard the circuits related with safe, alternative circuits were set up in order that electronic devices may be normally operated even when an error arises. ISJB is expected to improve the safety and quality of vehicles.

• 센서학회지
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• 제28권6호
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• pp.355-359
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• 2019

Exosomes, known as nanoscale extracellular vesicles in the range of 30-150 nm, are known to contain clinically significant information. However, there is still insufficient information on exosomal membrane proteins for cancer diagnosis. In this work, we investigated the characteristics of the membrane proteins of exosomes shed by cultured breast cancer cell lines using a surface plasmon resonance (SPR) spectroscopy and pre-activated alkanethiols modified sensor chips. The antibodies of breast cancer biomarkers such as MCU-16, EpCAM, CD24, ErbB2, and CA19-9 were immobilized on the pre-activated alkanethiols surfaces without any activation steps. The purified exosomes were loaded onto each antibody surface. The affinity rank of the antibody surfaces was decided by the relative capture efficiency factors for the exosomes. In addition, an antibody with a relative capture efficiency close to 100% was tested with exosome concentration levels of 10⁴/µl, 10⁵/µl, and 10⁶/µl for quantitative analysis.

• 보건교육건강증진학회지
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• 제7권1호
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• pp.1-9
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• 1990

This paper discusses a new perspective in health approach and the effect of health life on health status, and suggests some points to be improved in the establishment of health policies hereafter. Today's health problems changed from the acute epidemic diseases caused by simple factor to the multifactorial chronic diseases. Therefore, the health approach tries the holistic health approach, that is, the integrative approach by the interdisciplinary cooperation. With the advent of holistic health and holistic medicine in 1970's, the behavioral medicine was born in 1977, which is the interdisciplinary field concerned with the development and integration of behavioral and biomedical science knowledge and techniques relevent to prevention, diagnosis and treatment. As a means to the reducement of the unnecessary medical utilization and medical expense, the medical self care and self-help movement is well under way in the countries of America, England, and Canada, in which lay persons are encouraged to actively function for themselves to prevent, detect and treat common illnesses and to promote positive health habits through the health activation programs such as The Course for Activated Patients and The Health Activated Person. This study shows that the individual health life gives great positive effect to his health status with the reducement of medical expense. These above facts suggest that the preventive health programs such as health education should be developed and strengthened instead of medical care-oriented health policy.

• 한국물환경학회지
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• 제33권2호
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• pp.140-148
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• 2017

An important factor in determining the design and treatment efficiency of wastewater treatment plants (WWTPs) is the quantity and quality of influent. These detailed and accurate information is essential for process control, diagnosis and operation, as well as the basis in designing the plant, selecting the process and determining the optimal capacity of each bioreactor. Probabilistic models are used to predict the wastewater quantity and quality of WWTPs, which are widely used to improve the design and operation of WWTPs. In this study, the optimal probability distribution of time series influent data was derived for predicting water quantity and quality, and wastewater influent data were generated using the Monte Carlo simulation analysis. In addition, we estimated various alternatives for the improvement of bioreactor operations based on present operation condition using the generated influent data and activated sludge model, and suggested the alternative that can operate the most effectively. Thus, the influent quantity and quality are highly correlated with the actual operation data, so that the actual WWTPs influent characteristics were well reproduced. Using this will improve the operating conditions of WWTPs, and a proposed improvement plan for the current TMS (Tele Monitoring System) effluent quality standards can be made.

• 대한세포병리학회지
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• 제5권1호
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• pp.23-27
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• 1994

Three cases of subacute necrotizing lymphadenitis diagnosed by fine needle aspiration (FNA) of enlarged lymph nodes are reported. The FNA smears contained randomly activated lymphoid cells, necrotic debris and histiocytes. The same patterns were found in subsequently examined excised lymph nodes from these cases. The differential diagnosis of this entity is discussed and the value of preparing FNA cell blocks and accompanying AFB stain with culture is emphasized. FNA may be able to provide a diagnosis in case of this benign disease, therefore avoiding a more traumatic excisional biopsy.

• Journal of Ginseng Research
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• 제47권4호
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• pp.515-523
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• 2023

Background: 20(S)-protopanaxadiol (PPD), one of the main components of ginseng, has anti-inflammatory, anti-estrogenic, and anti-tumor activities. It is known that activated hepatic stellate cells (HSCs) are the primary producers of extracellular matrix (ECM) in the liver, and the Wnt/β-catenin pathway participates in the activation of HSCs. We aimed to explore whether PPD inhibits liver fibrosis is associated with the Wnt/β-catenin pathway inactivation. Methods: The anti-fibrotic roles of PPD were examined both in vitro and in vivo. We also examined the levels of Wnt inhibitory factor 1 (WIF1), DNA methyltransferase 1 (DNMT1) and WIF1 methylation. Results: PPD obviously ameliorated liver fibrosis in carbon tetrachloride (CCl₄)-treated mice and reduced collagen deposition. PPD also suppressed the activation and proliferation of primary HSCs. Notably, PPD inhibited the Wnt/β-catenin pathway, reduced TCF activity, and increased P-β-catenin and GSK-3β levels. Interestingly, WIF1 was found to mediate the inactivation of the Wnt/β-catenin pathway in PPD-treated HSCs. WIF1 silencing suppressed the inhibitory effects of PPD on HSC activation and also restored α-SMA and type I collagen levels. The downregulation of WIF1 expression was associated with the methylation of its promoter. PPD induced WIF1 demethylation and restored WIF1 expression. Further experiments confirmed that DNMT1 overexpression blocked the effects of PPD on WIF1 expression and demethylation and enhanced HSC activation. Conclusion: PPD up-regulates WIF1 levels and impairs Wnt/β-catenin pathway activation via the downregulation of DNMT1-mediated WIF1 methylation, leading to HSC inactivation. Therefore, PPD may be a promising therapeutic drug for patients with liver fibrosis.

• 한국인터넷방송통신학회논문지
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• 제14권4호
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• pp.197-203
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• 2014

발전소의 전력 케이블 시스템에서 발생할 수 있는 사고를 예측하고 방지하는 기술이 필요하다. 사선 상태에 있는 케이블의 동작 특성을 진단하기 위하여 부분방전 및 $tan{\delta}$ 법이 사용되고 있으나, 케이블이 갖고 있는 문제점들을 사전에 발견하기란 쉬운 일이 아니다. 이 논문에서 우리가 연구한 케이블은 (주)서부 발전소에서 설치되어 운전 중인, 발전 운영에 핵심 역할을 하는 6.6kV 고전압 배전 선로이다. 케이블의 온도 및 전류를 측정하고, 이를 바탕으로 절연저항을 측정하기 위한 장치를 개발하였다. 이 장치를 발전소 현장에 시험 설치를 하였고, 동작 중인 케이블의 수명을 평가하기 위한 동작특성의 진단을 성공적으로 마무리 하였다. 진단 데이터를 분석 평가함으로써 단기적으로는 운전 중 6.6kV 케이블 시스템의 고장상태를 파악하는데 활용되며, 장기적으로는 발전소 부하에서의 6.6kV 케이블 시스템의 설치 및 운영에 있어서 원가를 절감하기 위한 노력에 기여하고자 한다.