• 제목/요약/키워드: Aconitum alkaloids

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한국산(韓國産) 부자류(附子類) 생약(生藥)에 관한 연구( IV. ) -진범(Aconitum pseudolaeve var. erectum)의 diterpene alkaloid에 대하여- (Studies on Korean Aconitum Species ( IV ). -Alkaloids of Aconitum pseudolaeve var. erectum-)

  • 정보섭;이현선
    • 생약학회지
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    • 제19권3호
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    • pp.181-187
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    • 1988
  • $Two\;C_{19}-diterpene\;alkaloids$ were isolated from the root of Aconitum psedolaeve var. erectum Nakai, and identified as lycoctonine and septentriodine by UV, IR, MS and NMR data.

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부자류 생약의 성분인 아코니틴과 관련 알칼로이드의 정량 (Determination of Aconitine and Related Alkaloids in Processed Buza)

  • 엄동옥;한상욱;신현덕
    • 약학회지
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    • 제44권2호
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    • pp.135-140
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    • 2000
  • Determination of Aconitum alkaloids in processed Buza (Cho-0, Salted Buza, Moist-heating Buza, Limed Buza), which had been prepared from the raw tubers of Aconitum chiisanenseb(Ranunculaceae), was established using visible spectrophotometry and high-performance liquid chromatography (HPLC) method especially for Aconitine analysis. Aconitum alkloids were reacted with tetra- thiocy-anatocobalt[II] complex ion to form a stable ion pair. The reaction product was insoluble in water but freely soluble in several organic solvents. 1.2-Dichloroethane was the best extracting solvent among the examined solvents. Spectrophotometry of Aconitum alkaloids at nax. 625 was carried out. The HPLC method for aconitine was carried out using Radial PAK-CN column with gradient solvent system by solvent mixture of acetonitrile and phosphate buffer (pH 3.0) at 4$0^{\circ}C$ and 254 nm. Linear relationship was found between absorbance response and concentration of aconitine in range of 0.45 mM~0.9 mM ($r^2$=0.9949) by spectrophotometry and 0.3 mM~1.2mM($r^2$=0.9983) by HPLC method. These methods have been found to be suitable and reproducible for routine analysis of Aconitum alkaloids and its pharmaceutical preparations.

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가는줄돌쩌기 알칼로이드 성분의 분리 및 산화적 특성 (Isolation and Oxidation Characteristics of Alkaloids of Aconitum volubile)

  • 허경희;이정규
    • 생약학회지
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    • 제39권2호
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    • pp.127-134
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    • 2008
  • From the under ground part of Aconitum volubile Pall. (Ranunculaceae),seven nor- or di-terpenoid alkaloids were isolated and identified by NMR spectra and mass spectrum. The alkaloids were three $C_{19}$-norditerpenoid alkaloids such as isotalatizidine, altaconitine and vilmorrianine A, and four $C_{20}$-diterpenoid alkaloids such as 12-epidehydronapelline, 12-epinapelline, songoramine and songorine. Some of the isolated diterpenoid alkaloids were subjected to oxidation reaction with active $MnO_2$ and oxoammonium salt. The results were C-12 oxidation(ketone formation) and N-dealkylation in veatchin-type and decomposition to non-alkaloidal compounds in atisine-type ajaconine.

세잎돌쩌기의 알칼로이드 성분과 함량의 계절적 변화 (Alkaloid Constituents of Aconitum triphyllum NAKAI and their Seasonal Variation)

  • 이진우;박종희;김혜경;이정규
    • 생약학회지
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    • 제35권2호통권137호
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    • pp.128-133
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    • 2004
  • Aconitum triphyllum Nakai, the Korean spontaneous perennial herb, is one of the most important materials of oriental drug Fu-zi(aconite) and has long been used as cardiotonic for arrhythmia, analgesic and antiinflammatory drug in oriental countries. Although the plant is widely used for the preparation of aconite, the composition and amount of the toxic aconitine type alkaloids have not studied so far. As the preliminary study for seasonal variation of major constituents in mother tuber and daughter tuber of the plant, the authors tried to elucidate phytochemical characteristics of $C_{19}-diterpenoid alkaloids by $^{13}C-NMR$ spectra and seasonal variation of the alkaloidal contents by high performance liquid chromatography.

Two New Diterpenoid Alkaloids from Aconitum brachypodum

  • Shen, Yong;Zuo, Ai-Xue;Jiang, Zhi-Yong;Zhang, Xue-Mei;Wang, Hong-Ling;Chen, Ji-Jun
    • Bulletin of the Korean Chemical Society
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    • 제31권11호
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    • pp.3301-3303
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    • 2010
  • Two new diterpenoid alkaloids, N(19)-en-denudatine (1) and N(4)-butanone-flavaconitine (2), were isolated from Aconitum brachypodum Diels.. Their structures were elucidated by comprehensive spectroscopic analyses including UV, IR, MS, 1D- and 2D-NMR.

Alkaloidal Constituents from Aconitum jaluense

  • Shim, Sang-Hee;Kim, Ju-Sun;Kang, Sam-Sik;Son, Kun-Ho;Bae, Ki-Hwan
    • Archives of Pharmacal Research
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    • 제26권9호
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    • pp.709-715
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    • 2003
  • Aconitum jaluense Komar. (Ranunculaceae) is one of the Aconitum plants growing in Korean peninsula. An investigation of the alkaloidal constituents of this species led to the isolation of seven $C_{19}$-norditerpenoid and a $C_{20}$-diterpenoid alkaloid. Three of them have been identified as neoline, mesaconitine, and hypaconitine, which were isolated from this plant collected from Mt. Bultasan in the north part. The other five alkaloids were determined as lipomesaconitine, lipohypaconitine, 15$\alpha$-hydroxyneoline, hokbusine A, and napelline, which have not been found in this plant. Structures of those alkaloids were determined on the basis of their spectral data. It is of interest to note that a comparison of the present work and the previous report showed some differences in the alkaloidal contents.

Two new acylated neoline derivatives from Aconiti Tuber

  • Shim, Sang-Hee;Kim, Ju-Sun;Kang, Sam-Sik
    • 대한약학회:학술대회논문집
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    • 대한약학회 2002년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2
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    • pp.388.1-388.1
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    • 2002
  • Aconiti Tuber (Aconitum spp. tuber, Ranunculaceae) which contains bioactive but toxic alkaloids has been used as analgesic. cardiotonic, diuretic. and stimulant. We have previously reported two new C-19 norditerpenoid alkaloids and five known norditerpenoid alkaloids. Further study has now led to the isolation of two new norditerpenoid alkaloids. 14-O-anisoylneoline and 14-O-veratroylneoline. (omitted)

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Primary Pharmacological and Other Important Findings on the Medicinal Plant "Aconitum Heterophyllum" (Aruna)

  • Paramanick, Debashish;Panday, Ravindra;Shukla, Shiv Shankar;Sharma, Vikash
    • 대한약침학회지
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    • 제20권2호
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    • pp.89-92
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    • 2017
  • Aconitum Heterophyllum (A. Heterophyllum) is an indigenous medicinal plant of India and belongs to the family Ranunculaceae. A. Heterophyllum is known to possess a number of therapeutic effects. For very ancient times, this plant has been used in some formulations in the traditional healing system of India, i.e., Ayurveda. It is reported to have use in treating patients with urinary infections, diarrhea, and inflammation. It also has been used as an expectorant and for the promotion of hepatoprotective activity. The chemical studies of the plant have revealed that various parts of the plant contain alkaloids, carbohydrates, proteins and amino acids, saponins, glycosides, quinones, flavonoids, terpenoids, etc. In the present study, a comprehensive phytochemistry and pharmacognosy, as well as the medicinal properties, of A. Heterophyllum are discussed. Scientific information on the plant was collected from various sources, such as electronic sources (Google scholar, Pubmed) and some old classical text books of Ayurveda and Ethnopharmacology. The study also presents a review of the literature on A. Heterophyllum, as well as the primary pharmacological and other important findings on this medicine. This review article should provide useful information to and be a valuable tool for new researchers who are initiating studies on the plant A. Heterophyllum.