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Isolation and Oxidation Characteristics of Alkaloids of Aconitum volubile  

Heo, Kyong-Hee (College of Pharmacy, Kyungsung University)
Lee, Chung-Kyu (College of Pharmacy, Kyungsung University)
Publication Information
Korean Journal of Pharmacognosy / v.39, no.2, 2008 , pp. 127-134 More about this Journal
Abstract
From the under ground part of Aconitum volubile Pall. (Ranunculaceae),seven nor- or di-terpenoid alkaloids were isolated and identified by NMR spectra and mass spectrum. The alkaloids were three $C_{19}$-norditerpenoid alkaloids such as isotalatizidine, altaconitine and vilmorrianine A, and four $C_{20}$-diterpenoid alkaloids such as 12-epidehydronapelline, 12-epinapelline, songoramine and songorine. Some of the isolated diterpenoid alkaloids were subjected to oxidation reaction with active $MnO_2$ and oxoammonium salt. The results were C-12 oxidation(ketone formation) and N-dealkylation in veatchin-type and decomposition to non-alkaloidal compounds in atisine-type ajaconine.
Keywords
norditerpenoid alkaloid; diterpenoid alkaloid; isotalatizidine; altaconitine; vilmorrianine A; 12-epidehydronapelline; 12-epinapelline; songoramine; songorine; oxidation; active $MnO_2$; oxoammonium salt;
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