Browse > Article

Alkaloid Constituents of Aconitum triphyllum NAKAI and their Seasonal Variation  

Lee, Jin-Woo (College of Pharmacy, Kyungsung University)
Park, Jong-Hee (College of Pharmacy, Pusan National University)
Kim, Hye-Kyung (College of Pharmacy, Kyungsung University)
Lee, Chung-Kyu (College of Pharmacy, Kyungsung University)
Publication Information
Korean Journal of Pharmacognosy / v.35, no.2, 2004 , pp. 128-133 More about this Journal
Abstract
Aconitum triphyllum Nakai, the Korean spontaneous perennial herb, is one of the most important materials of oriental drug Fu-zi(aconite) and has long been used as cardiotonic for arrhythmia, analgesic and antiinflammatory drug in oriental countries. Although the plant is widely used for the preparation of aconite, the composition and amount of the toxic aconitine type alkaloids have not studied so far. As the preliminary study for seasonal variation of major constituents in mother tuber and daughter tuber of the plant, the authors tried to elucidate phytochemical characteristics of $C_{19}-diterpenoid alkaloids by $^{13}C-NMR$ spectra and seasonal variation of the alkaloidal contents by high performance liquid chromatography.
Keywords
Ranunculaceae; Aconitum triphyllum; norditerpene alkaloids; aconitine; chasmanine; hypaconitine; mesaconitine; pseudaconine; vilmorrianine A; seasonal variation;
Citations & Related Records
연도 인용수 순위
  • Reference
1 Nakai, J. (1952) A Synoptical Sketch of Korean Flora, Bull. Nat. Sci. Mus. 31: 1-152
2 정보섭, 김신근, 이형규, 김승한(1984) 한국산 부자류 생약에 대한 연구(I): 노랑투구꽃의 성분연구 및 관련된 부자류의 독성비교, 생약학회지, 15: 108-113
3 정보섭, 이현선(1998) 한국산 부자류 생약에 대한 연구(IV): 진범((A. pseudolaeve var. erectum)의 diterpene alkaloid에 대하여, 생약학회지,19: 181-187
4 이무택, 성환길, 황완균, 김일혁(1997) 지리바꽃 괴경의 알칼로이드, 약학회지, 41: 161-173
5 김호경, 이혜원, 전원경(2002) 초오의 수치방볍에 따른 알칼로이드 함량，생약학회지, 33: 296-300
6 백덕우，박대식，심수일(1976) 한국 Aconitine 자원생약에 대한 연구，생약학회지，7: 241-245
7 Pelletier, S. W., Joshi, B. S., Glinski, J. A., Chokshi, H. P., and Chen, S. (1987) The structures of four new $C_{19}$ diterpenoid alkaloids from Aconitum ' forrestii Stapf, Heterocycles, 25: 365-76   DOI
8 이현선, 정보섭(1989) 한국산 부자류 생약에 대한 연구(V) 진범 지하부의 성분에 대하여, 생약학회지. 20:6-9
9 Pelletier, S. W. (ed., 1991) Alkaloids: Chemical and biological perspectives, 、Vol. 7, 302-308, Springer-Verlag, New York, N.Y, U.S.A
10 木村康一(1979) 新註定國譯本草綱目 第5冊, 586, 春 陽堂書店, 東京.
11 Pelletier, S. W. (ed., 1984) Alkaloids: Chemical and biological perspectives, 、Vol. 2, 214-222, John Wiley & Sons, New York, N.Y, U.S.A
12 김제훈, 오세종, 김일혁, 김기호(1976) Aconitum속 식물의 성분연구(I) 생약학회지, 7: 211-214
13 Yue, J. M., Jun, X., and Chen, Y. Z. (1993) $C_{19}$-diterpenoid alkaloids from Aconitum kongboense, Phytochemistry, 35: 829-832   DOI   ScienceOn
14 Wang, R. and Chen, Y.-Z. (1987) Diterpenoid alkaloids of Aconitum sungpanase, Planta Medica. , 48: 544-546
15 唐漢微撰(1970) 經史證類大觀本草 , 273, 正言出版社, 臺南.
16 Pelletier, S.W. (ed., 1984): Alkaloids: Chemical and biological perspectives, Vol. 2, 393, John Wiley & Sons, New York, N.Y., U.S.A
17 江蘇新醫學院編(1975) 中葯大辭典 上冊, 228, 上海人民 出版社, 上海.
18 이창복(1982) 대한식물도감, 359-365, 향문사, 서울
19 Hanuman, J. B. and Katz, A. (1994) Diterpenoid alkaloids from Ayurvedic processed and unprocessed Aconitum ferox, Phytochemistry, 36: 1527-35   DOI   ScienceOn
20 Purushothaman ， K. K. and Chandrasekharan, S. (1974) Alkaloids of Aconitum ferox, Phytochemisty" 14: 1975-77
21 정보섭, 이현선(1988) 한국산 부자류 생약에 대한 연구(III): 그늘 돌쩌기((Aconitum uchiyamai)의 diterpene alkaloid에 대하여, 생약학회지, 19: 177-180
22 Takayama, H. Ito, M., Koga, M., and Sakai， S. (1981) Structure of ezochasmanine, ezochasmaconitine, anisoezochasmanitine and synthesis of vilmorrianine A, Heterocycles，15: 403-408   DOI
23 Pelletier, S. W., Ying, C. S., Joshi, B. S., and Desai, H. K. (1984) The structures of for.forestine and foresticine, two new $C_{19}$-diterpenoid alkaloids from Aconitum forestii Stapf, J. Nat. Prod., 47: 474-477   DOI