• Korean Journal of Pharmacognosy
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• v.19 no.3
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• pp.181-187
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• 1988

$Two\;C_{19}-diterpene\;alkaloids$ were isolated from the root of Aconitum psedolaeve var. erectum Nakai, and identified as lycoctonine and septentriodine by UV, IR, MS and NMR data.

• YAKHAK HOEJI
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• v.44 no.2
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• pp.135-140
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• 2000

Determination of Aconitum alkaloids in processed Buza (Cho-0, Salted Buza, Moist-heating Buza, Limed Buza), which had been prepared from the raw tubers of Aconitum chiisanenseb(Ranunculaceae), was established using visible spectrophotometry and high-performance liquid chromatography (HPLC) method especially for Aconitine analysis. Aconitum alkloids were reacted with tetra- thiocy-anatocobalt[II] complex ion to form a stable ion pair. The reaction product was insoluble in water but freely soluble in several organic solvents. 1.2-Dichloroethane was the best extracting solvent among the examined solvents. Spectrophotometry of Aconitum alkaloids at nax. 625 was carried out. The HPLC method for aconitine was carried out using Radial PAK-CN column with gradient solvent system by solvent mixture of acetonitrile and phosphate buffer (pH 3.0) at 4$0^{\circ}C$ and 254 nm. Linear relationship was found between absorbance response and concentration of aconitine in range of 0.45 mM~0.9 mM ($r^2$=0.9949) by spectrophotometry and 0.3 mM~1.2mM($r^2$=0.9983) by HPLC method. These methods have been found to be suitable and reproducible for routine analysis of Aconitum alkaloids and its pharmaceutical preparations.

• Korean Journal of Pharmacognosy
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• v.18 no.2
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• pp.103-106
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• 1987

Two diterpene alkaloids were isolated from Aconitum napiforme which is a native plant in Korea, and identified as hypaconitine and mesaconitine by UV, IR, MS and NMR data.

• Korean Journal of Pharmacognosy
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• v.39 no.2
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• pp.127-134
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• 2008

From the under ground part of Aconitum volubile Pall. (Ranunculaceae),seven nor- or di-terpenoid alkaloids were isolated and identified by NMR spectra and mass spectrum. The alkaloids were three $C_{19}$-norditerpenoid alkaloids such as isotalatizidine, altaconitine and vilmorrianine A, and four $C_{20}$-diterpenoid alkaloids such as 12-epidehydronapelline, 12-epinapelline, songoramine and songorine. Some of the isolated diterpenoid alkaloids were subjected to oxidation reaction with active $MnO_2$ and oxoammonium salt. The results were C-12 oxidation(ketone formation) and N-dealkylation in veatchin-type and decomposition to non-alkaloidal compounds in atisine-type ajaconine.

• Korean Journal of Pharmacognosy
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• v.35 no.2 s.137
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• pp.128-133
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• 2004

Aconitum triphyllum Nakai, the Korean spontaneous perennial herb, is one of the most important materials of oriental drug Fu-zi(aconite) and has long been used as cardiotonic for arrhythmia, analgesic and antiinflammatory drug in oriental countries. Although the plant is widely used for the preparation of aconite, the composition and amount of the toxic aconitine type alkaloids have not studied so far. As the preliminary study for seasonal variation of major constituents in mother tuber and daughter tuber of the plant, the authors tried to elucidate phytochemical characteristics of $C_{19}-diterpenoid alkaloids by $^{13}C-NMR$ spectra and seasonal variation of the alkaloidal contents by high performance liquid chromatography.

• Bulletin of the Korean Chemical Society
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• v.31 no.11
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• pp.3301-3303
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• 2010

Two new diterpenoid alkaloids, N(19)-en-denudatine (1) and N(4)-butanone-flavaconitine (2), were isolated from Aconitum brachypodum Diels.. Their structures were elucidated by comprehensive spectroscopic analyses including UV, IR, MS, 1D- and 2D-NMR.

• Archives of Pharmacal Research
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• v.26 no.9
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• pp.709-715
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• 2003

Aconitum jaluense Komar. (Ranunculaceae) is one of the Aconitum plants growing in Korean peninsula. An investigation of the alkaloidal constituents of this species led to the isolation of seven $C_{19}$-norditerpenoid and a $C_{20}$-diterpenoid alkaloid. Three of them have been identified as neoline, mesaconitine, and hypaconitine, which were isolated from this plant collected from Mt. Bultasan in the north part. The other five alkaloids were determined as lipomesaconitine, lipohypaconitine, 15$\alpha$-hydroxyneoline, hokbusine A, and napelline, which have not been found in this plant. Structures of those alkaloids were determined on the basis of their spectral data. It is of interest to note that a comparison of the present work and the previous report showed some differences in the alkaloidal contents.

• Korean Journal of Pharmacognosy
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• v.19 no.3
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• pp.177-180
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• 1988

A diterpene alkaloid and a disaccharide were isolated from root of Aconitum uchiyamai, and identified as mesaconitine and sucrose respectively by UV, IR, MS, and NMR data.

• Proceedings of the PSK Conference
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• 2002.10a
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• pp.388.1-388.1
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• 2002

Aconiti Tuber (Aconitum spp. tuber, Ranunculaceae) which contains bioactive but toxic alkaloids has been used as analgesic. cardiotonic, diuretic. and stimulant. We have previously reported two new C-19 norditerpenoid alkaloids and five known norditerpenoid alkaloids. Further study has now led to the isolation of two new norditerpenoid alkaloids. 14-O-anisoylneoline and 14-O-veratroylneoline. (omitted)

• Journal of Pharmacopuncture
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• v.20 no.2
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• pp.89-92
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• 2017

Aconitum Heterophyllum (A. Heterophyllum) is an indigenous medicinal plant of India and belongs to the family Ranunculaceae. A. Heterophyllum is known to possess a number of therapeutic effects. For very ancient times, this plant has been used in some formulations in the traditional healing system of India, i.e., Ayurveda. It is reported to have use in treating patients with urinary infections, diarrhea, and inflammation. It also has been used as an expectorant and for the promotion of hepatoprotective activity. The chemical studies of the plant have revealed that various parts of the plant contain alkaloids, carbohydrates, proteins and amino acids, saponins, glycosides, quinones, flavonoids, terpenoids, etc. In the present study, a comprehensive phytochemistry and pharmacognosy, as well as the medicinal properties, of A. Heterophyllum are discussed. Scientific information on the plant was collected from various sources, such as electronic sources (Google scholar, Pubmed) and some old classical text books of Ayurveda and Ethnopharmacology. The study also presents a review of the literature on A. Heterophyllum, as well as the primary pharmacological and other important findings on this medicine. This review article should provide useful information to and be a valuable tool for new researchers who are initiating studies on the plant A. Heterophyllum.