• YAKHAK HOEJI
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• v.40 no.4
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• pp.418-421
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• 1996

From the ethanol extract of the whole plant of Aconitum pseudo-laeve var. erectum Nakai, three new aromatic amides, methyl-N-acetyl anthranilate, methyl-N-(3-ethox ycarbonylpropionyl)anthranilate, methyl-N-(3-methoxycarbonylpropionyl) anthranilate were isolated and characterized on the basis of spectral data.

• Archives of Pharmacal Research
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• v.21 no.3
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• pp.344-347
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• 1998

To overcome multidrug resistance (MDR) in cancer chemotherapy, we prepared various plant extracts and searched for a component which is effective for inhibition of MDR. MDR inhibition activity was determined by measuring cytotoxicity to MDR cells using multidrug resistant human fibrocarcinoma KB V20C, which is resistant to 20 nM vincristine and expresses high level of mdr1 gene. Of various plant extracts, the MeOH extract of the root of Aconitum pseudo-laeve var. erectum was found to have potent inhibitory activity on MDR. The bioassayguided fractionation of the MeOH extract of the plant led to the isolation of an alkaloid, lycaconitine, as an active principle. And the $IC_{50}$ of lycaconitne for KB V20C cells was $74\mu{g}$/ml.

• Journal of The Korean Society of Clinical Toxicology
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• v.14 no.1
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• pp.60-65
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• 2016

Aconitum is a genus of various species of flowering plants that belongs to the Family Ranunculaceae. Most Aconitum sp. have extremely toxic alkaloid substances such as aconitine, mesaconitine and hypaconitine. Among these substances, aconitine can cause fatal cardiotoxicity by activating sodium channels followed by calcium channels in myocardial cells. Even though there have been various therapeutic plans suggested comprising antidotes based on diverse case reports and studies, there is no confirmatory treatment protocol for aconite poisoning. Here, we report an aconite poisoning patient who had refractory ventricular tachyarrhythmia that did not respond to intravenous amiodarone therapies even though they were sustained for over 2 hours, but showed successful recovery following intravenous fat emulsions (IFE) therapy.

• Korean Journal of Pharmacognosy
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• v.25 no.4 s.99
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• pp.395-398
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• 1994

A diterpene alkaloid in addition to hypaconitine and mesaconitine was isolated from the tubers of Aconitum napiforme (Ranunculaceae), which is an indigenous plant in Korea. Its structure was elucidated as 8-methoxy 14-benzoyl hypaconine by Physicochemical and spectroscopic data. This compound was isolated from this plant for the first time.

• Korean Journal of Pharmacognosy
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• v.7 no.3
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• pp.211-214
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• 1976

Basic substances were obtained from five Korean Aconitum, A. koreanum, A. chiisanense, A. ciliae, A. pseudoproliferum and unknown Aconitum species and compared TLC patterns of the substances. Soluble substances in ammonia alkali showed 8 spots on TLC, while insoluble substances in ammonia alkali 7 spots. These patterns are all similar in all species used in the investigation.

• Bulletin of the Korean Chemical Society
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• v.31 no.11
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• pp.3301-3303
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• 2010

Two new diterpenoid alkaloids, N(19)-en-denudatine (1) and N(4)-butanone-flavaconitine (2), were isolated from Aconitum brachypodum Diels.. Their structures were elucidated by comprehensive spectroscopic analyses including UV, IR, MS, 1D- and 2D-NMR.

• Korean Journal of Plant Resources
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• v.7 no.1
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• pp.63-66
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• 1994

The experiment was carried out to study the bothanical characteristics of Aconitum charmichaeli Sieb. et Zucc in Korea.The results obtained are summarized as follows ; maximum flowering date was 15 Sep. and plantheight was 65cm, stem diameter was 8.7mm, No. of node was 25 and node of flowering initiation was15th.In flowering, No. of anothers were 52 and No. of flowers were 49.In leaf, length and width was same size, lower leaf size was 2-3 times than upper leaf, lower leafarea was 8.4 times than upper leaf.In tuber, No. of tuber per plant was 8, fresh weight per tuber was 25.4g, total fresh weight per plantwas about 200g.

• Plant Resources
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• v.4 no.1
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• pp.59-64
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• 2001

This study was conducted to clarify the floristic composition and to investigate the landscape structure of habitats of Aconitum pseudo-leave var. erectum. A. pseudo-leave is designated an endemic plant in Korea. Floristic compositions of habitats were mainly composed of Quercus mongolica community. Other elements in this composition were Weigela subsessilis, Corylus sieboldiana and Cornus contioversa. Landscape ecological structure of habitats were defined by soils of mesic, loamy skeletal, slope of more than 60$^{\circ}$, sixty percent of woody coverage at 460-520m above the sea level and 25m away from drainage. Distribution patterns of A. pseudo-leave var. erectum plants in Taejon were presented on the 1km X 1km grid map.

• Korean Journal of Plant Taxonomy
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• v.31 no.4
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• pp.343-358
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• 2001

We have examined the pedicel pubescence and other major morphological characters of 11 putative hybrid populations of Aconitum subgn. Aconitum at Mt. Sobaek to understand their origin. These populations show very complicated patterns of variation in pedicel pubescence ; they contain individuals having pedicels (1) completely glabrous, (2) with few micropapillate curved hairs near the receptacle, (3) moderately pubescent with micropapillate curved hairs from middle to upper portion, (4) sparsely pubescent with a mixture of micropapillate curved hairs and smooth-surfaced spreading glandular hairs near the receptacle, and (5) moderately pubescent with both types of hairs but from middle to upper portion. All five types of individuals co-occur in most populations with varying proportions. These results, in conjunction with evidence from the analysis of other major morphological characters, suggest that the populations at Mt. Sobaek were derived from the multiple hybridization events involving A. kusnezoffii, A. japonicum subsup. napiforme, and A. jaluense subsp. jaluense. In addition, the absence of "typical" forms of these putative parental taxa in Mt. Sobaek area suggests that repeated introgression has probably occurred in these populations.

• Journal of Korean Medicine Rehabilitation
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• v.21 no.2
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• pp.159-170
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• 2011

Objectives : We have studied to know analgesic effects of the combination of Aconitum Cilliare Tuber with honey in the models of peripheral neuropathic pain. Methods : Neuropathic pain model was made by ligating left 5th lumbar spinal nerve. After 3 days, combination of Aconitum Ciliare Tuber and honey extract was administrated each alternate day. Administration was divided three groups, that is NP-OA1(0.06 mg/ml), NP-OA2(0.24 mg/ml), and NO-OA3(0.96 mg/ml). After that, we examined the withdrawl response of neuropathic rats legs by von Frey filament and acetone stimulation. And also we examined c-Fos, glutamic oxaloacetic transaminase(GOT), glutamate-pyruvate transaminase(GPT) and change of weight. Results : Mechanical allodynia in NP-OA1 groups were significantly decreased compared with the control group. Cold allodynia in all experimental groups were no significant differences with the control group. c-Fos protein expression on the central grey, all experimental groups were lower than that of control groups. But, there were no statistically significant differences. Change of weight in all experimental groups were significantly increased compare with the control group. In blood serum GOT in NP-OA1, NP-OA2 groups were significantly decreased compare with the control group. In blood serum GPT in all experimental groups were no significant difference with the control group. Conclusions : We had noticed that the combination of Aconitum Ciliare Tuber and honey decreased mechanical allodynia in the model of neuropathic pain compared with the control group and it has not efficacy in elevation of GOT, GPT and weight loss etc., the element of which becomes damage to liver. This study can be proposed that Aconitum Ciliare with Honey may be applicable to neuropathic pain in clinic. But it is reliability not that cold allodynia and c-Fos expression have effectively to control pain. Therefore we have to follow up about that.