• 한국세라믹학회지
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• 제39권1호
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• pp.21-25
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• 2002

Effect of abnormal grain growth and heat treatment time on the electrical properties of donor-doped semiconductive BaTiO$_3$ceramics was examined. La-doped BaTiO$_3$ceramics was sintered at 134$0^{\circ}C$ for different times from 10 to 600 min in order to change the volume fraction of the abnormal grains in samples. As a result, samples with different volume fraction of abnormal grain growth from 22 to 100% were prepared. The samples were annealed at 120$0^{\circ}C$ for various times. The resistivity of the sam-ples at room and above Curie temperature was examined. The complex impedance measurement as functions of the volume fraction of abnormal grains and annealing time was conducted. Separation of complex impedance semicircle was observed in a sample in which abnormal and fine grains coexist. The results are discussed from a viewpoint of microstructure-property relationship.

• 산업기술연구
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• 제24권A호
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• pp.83-90
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• 2004

Generally, electronic appliances are used on the basis of normal power source supply. The power source inevitably includes the abnormal condition, such as, sudden voltage sagging, power interrupt, and induced noises. As the electronic appliances which include micro-controller-based circuits are being increased recently, the controller circuit sometimes malfunctions by the abnormal condition of the power source. This situation causes serious problems such as hitch of electric appliance, fire and medical instrument glitch, which produces serious situations. In this paper, development of power interrupt tester which is highly suitable for an endurance test device under abnormal power source to microprocessor-based circuits is proposed 89C2051 microcontroller is performed to make power interrupt signal, and software controls peripheral hardwares and built-in functions. Experimental results of this study will offer a good application to electronic appliance maker as a test device of hardware and software debugging use.

• Clinical and Experimental Reproductive Medicine
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• 제41권3호
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• pp.97-107
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• 2014

The placenta is a temporary fetomaternal organ capable of supporting fetal growth and development during pregnancy. In particular, abnormal development and dysfunction of the placenta due to cha nges in the proliferation, differentiation, cell death, and invasion of trophoblasts induce several gynecological diseases as well as abnormal fetal development. Autophagy is a catalytic process that maintains cellular structures by recycling building blocks derived from damaged microorganelles or proteins resulting from digestion in lysosomes. Additionally, autophagy is necessary to maintain homeostasis during cellular growth, development, and differentiation, and to protect cells from nutritional deficiencies or factors related to metabolism inhibition. Induced autophagy by various environmental factors has a dual role: it facilitates cellular survival in normal conditions, but the cascade of cellular death is accelerated by over-activated autophagy. Therefore, cellular death by autophagy has been known as programmed cell death type II. Autophagy causes or inhibits cellular death via the other mechanism, apoptosis, which is programmed cell death type I. Recently, it has been reported that autophagy increases in placenta-related obstetrical diseases such as preeclampsia and intrauterine growth retardation, although the mechanisms are still unclear. In particular, abnormal autophagic mechanisms prevent trophoblast invasion and inhibit trophoblast functions. Therefore, the objectives of this review are to examine the characteristics and functions of autophagy and to investigate the role of autophagy in the placenta and the trophoblast as a regulator of cell death.

• 대한한방부인과학회지
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• 제20권2호
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• pp.176-187
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• 2007

Purpose: Recent studies show that Skin Resistance Variability(SRV) could be related to the functions of Hypothalamus-Pituitary-Ovary(H-P-O) axis. 7-Zone-Diagnostic System is oriental medicine measuring system using SRV. To know the differences of SRV of normal and abnormal menstrual cycle groups, we research the SRV of the two groups. Methods: We measured SRV of two groups that were consist of 126 women who took CP-6000A test in Sangji Oriental Medical Hospital from Mar. 2004 to Feb. 2006. After detection of SRV, we performed correlation analysis by SPSS 12.0. Results: The SRV was measured twice in 7 areas. By the results of 1st trial on Factor AA of the SRV, the patient group's results were lower than normal group's results in all 7 areas. And there were remarkable differences in 1, 2, 3, 4, 5, 7 areas between two groups. By the results of 2nd trial on Factor AA of the SRV, the patient group's results were lower than normal group's results in all 7 areas similar to 1st trial results. And there were remarkable differences in 2, 3 areas between two groups. Conclusion: Comparing normal group with patient group, these results may reflect the relations of abnormal menstrual cycle and H-P-O axis functions. Because patient's results were lower than normal's in all 7 areas. And remarkable different results in 2, 3 areas were repeated by twice trial all. Further study will be needed.

• 정보보호학회논문지
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• 제32권4호
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• pp.647-660
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• 2022

최근 정상 데이터와 일부 비정상 데이터를 보유한 환경에서 딥러닝 기반 준 지도 학습 이상 탐지 기법이 매우 효과적으로 동작함이 알려져 있다. 하지만 사이버 보안 분야와 같이 실제 시스템에 대한 알려지지 않은 공격 등 비정상 데이터 확보가 어려운 환경에서는 비정상 데이터 부족이 발생할 가능성이 있다. 본 논문은 비정상 데이터가 정상 데이터보다 극히 작은 환경에서 준 지도 이상 탐지 기법에 적용 가능한 섭동을 활용한 초구 기반 비정상 데이터 증강 기법인 ADA-PH(Abnormal Data Augmentation Method using Perturbation based on Hypersphere)를 제안한다. ADA-PH는 정상 데이터를 잘 표현할 수 있는 초구의 중심으로부터 상대적으로 먼 거리에 위치한 샘플에 대해 적대적 섭동을 추가함으로써 비정상 데이터를 생성한다. 제안하는 기법은 비정상 데이터가 극소수로 존재하는 네트워크 침입 탐지 데이터셋에 대하여 데이터 증강을 수행하지 않았을 경우보다 평균적으로 23.63% 향상된 AUC가 도출되었고, 다른 증강 기법들과 비교했을 때 가장 높은 AUC가 또한 도출되었다. 또한, 실제 비정상 데이터에 유사한지에 대한 정량적 및 정성적 분석을 수행하였다.

• Molecules and Cells
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• 제46권4호
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• pp.219-230
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• 2023

Down syndrome (DS) is the most common autosomal aneuploidy caused by trisomy of chromosome 21. Previous studies demonstrated that DS affected mitochondrial functions, which may be associated with the abnormal development of the nervous system in patients with DS. Runt-related transcription factor 1 (RUNX1) is an encoding gene located on chromosome 21. It has been reported that RUNX1 may affect cell apoptosis via the mitochondrial pathway. The present study investigated whether RUNX1 plays a critical role in mitochondrial dysfunction in DS and explored the mechanism by which RUNX1 affects mitochondrial functions. Expression of RUNX1 was detected in induced pluripotent stem cells of patients with DS (DS-iPSCs) and normal iPSCs (N-iPSCs), and the mitochondrial functions were investigated in the current study. Subsequently, RUNX1 was overexpressed in N-iPSCs and inhibited in DS-iPSCs. The mitochondrial functions were investigated thoroughly, including reactive oxygen species levels, mitochondrial membrane potential, ATP content, and lysosomal activity. Finally, RNA-sequencing was used to explore the global expression pattern. It was observed that the expression levels of RUNX1 in DS-iPSCs were significantly higher than those in normal controls. Impaired mitochondrial functions were observed in DS-iPSCs. Of note, overexpression of RUNX1 in N-iPSCs resulted in mitochondrial dysfunction, while inhibition of RUNX1 expression could improve the mitochondrial function in DS-iPSCs. Global gene expression analysis indicated that overexpression of RUNX1 may promote the induction of apoptosis in DS-iPSCs by activating the PI3K/Akt signaling pathway. The present findings indicate that abnormal expression of RUNX1 may play a critical role in mitochondrial dysfunction in DS-iPSCs.

• 생물정신의학
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• 제22권2호
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• pp.29-33
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• 2015

The brain maintains homeostasis and normal microenvironment through dynamic interactions of neurons and neuroglial cells to perform the proper information processing and normal cognitive functions. Recent post-mortem investigations and animal model studies demonstrated that the various brain areas such as cerebral cortex, hippocampus and amygdala have abnormalities in neuroglial numbers and functions in subjects with mental illnesses including schizophrenia, dementia and mood disorders like major depression and bipolar disorder. These findings highlight the putative role and involvement of neuroglial cells in mental disorders. Herein I discuss the physiological roles of neuroglial cells such as astrocytes, oligodendrocytes, and microglia in maintaining normal brain functions and their abnormalities in relation to mental disorders. Finally, all these findings could serve as a useful starting point for potential therapeutic concept and drug development to cure unnatural behaviors and abnormal cognitive functions observed in mental disorders.

• 치위생과학회지
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• 제11권3호
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• pp.285-292
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• 2011

본 연구는 치과의원에 내원한 일부 외래환자를 대상으로 측두하악장애 실태와 음식섭취능력을 파악하여 삶의 질을 향상하고자 대전광역시 소재 5개 치과의원에 내원한 외래환자 208명을 대상으로 2010년 1월부터 9월까지 구조화된 설문지를 이용하여 실시하였다. 측두하악장애의 주관적 증상, 악습관 및 이상기능, 음식섭취능력에 대해 조사 분석하여 다음과 같은 결과를 얻었다. 1. 조사대상자의 측두하악장애의 주관적 증상을 보면 악관절 동통 45.7%, 관절잡음 45.2%, 저작 시 동통 41.3%, 개구 시 동통 38.0%, 비저작시 동통 19.7%, 관절탈구 13.0% 순으로 나타났다. 2. 성별에 따른 측두하악장애의 주관적 증상을 보면 관절탈구별로는 남자군 18.0%, 여자군 8.3%로 관절탈구를 보였으며(p=0.038), 저작 시 동통별로는 남자군 49.0%, 여자군 34.3%로 저작 시 동통을 보였으며(p=0.031) 유의하게 높았다. 3. 성별에 따른 악습관 및 이상기능을 보면 이악물기별로는 남성군 35.0%, 여성군 22.2%로 이악물기를 보였으며(p=0.041), 이갈이별로는 남성군 21.0%, 여성군 9.3%로 이갈이를 보였으며(p=0.018) 유의하게 높았다. 4. 연령에 따른 측두하악장애의 주관적 증상을 보면 악관절 동통별로는 21-30세군에서 자주 27.8%, 가끔 25.0%로 52.8%가 악관절 동통을 보였으며(p=0.001) 유의하게 높았다. 5. 연령에 따른 악습관 및 이상기능을 보면 두통여부별로는 31세 이상군에서 48.3%가 두통을 보였으며(p=0.046) 유의하게 높았다. 6. 측두하악장애의 주관적 증상에 따른 음식섭취능력을 보면 관절잡음이 없는 군일수록(p=0.000), 저작시 동통이 없는 군에서(p=0.000), 악관절 동통이 없는 군 일수록(p=0.000) 유의하게 높았다. 7. 악습관 및 이상기능에 따른 음식섭취능력을 보면 이악물기가 없는 군에서(p=0.000), 이갈이가 없는 군에서(p=0.000), 두통이 없는 군에서(p=0.000) 유의하게 높았다. 8. 조사대상자의 측두하악장애에 따른 치료방법을 보면 휴식 30.8%, 물리치료 24.0%, 약물치료 16.4% 순으로 나타났다. 저작 시 동통별로는 저작 시 동통에서 36.0%로 약물치료가, 악관절 동통별로는 악관절 동통에서 자주 52.4%, 가끔 40.5%로 약물치료와 물리치료가 유의하게 높았다(p=0.000). 이상의 연구결과를 종합하여 볼 때 측두하악장애의 복합요인에 대한 관리 조사가 병행되어 치료 및 예방 등에 대한 프로그램의 구축과 음식섭취능력을 높여 삶의 질이 향상되어지도록 신체적, 사회적, 문화적, 심리적인 측면을 고려함과 동시에 개인차가 심하기 때문에 다각적인 후속 연구가 계속 되어져야 할 것으로 사료된다.

• Molecules and Cells
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• 제40권4호
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• pp.243-253
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• 2017

Eukaryotic cilia are organelles that project from the surface of cells to fulfill motility and sensory functions. In vertebrates, the functions of both motile and immotile cilia are critical for embryonic development and adult tissue homeostasis. Importantly, a multitude of human diseases is caused by abnormal cilia biogenesis and functions which rely on the compartmentalization of the cilium and the maintenance of its protein composition. The transition zone (TZ) is a specialized ciliary domain present at the base of the cilium and is part of a gate that controls protein entry and exit from this organelle. The relevance of the TZ is highlighted by the fact that several of its components are coded by ciliopathy genes. Here we review recent developments in the study of TZ proteomes, the mapping of individual components to the TZ structure and the establishment of the TZ as a lipid gate.

• Annals of Clinical Neurophysiology
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• 제13권1호
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• pp.13-20
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• 2011

Neuro-ophthalmological findings are common and occasionally prominent features in movement disorders. Accordingly, careful evaluation of the ocular motor functions may provide valuable information in early detection of the diseases and monitoring of the progression. Furthermore, accurate assessment of the abnormal ocular motor findings aids in understanding the pathophysiology and mechanisms of the movement disorders, and in their differential diagnosis. Ocular motility examination should include bedside evaluation and laboratory recording of the fixational abnormalities, saccades, smooth pursuit, the vestibulo-ocular reflex, optokinetic nystagmus, and vergence eye movements. In this review, we will discuss various ocular motor findings in ataxia and parkinsonian syndromes, and hyperkinetic movement disorders.