• 한국정보통신학회:학술대회논문집
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• 한국정보통신학회 2022년도 춘계학술대회
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• pp.406-409
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• 2022

최근 몇 년 동안, AI 시스템, 블록체인, VR/AR, 3D 프린팅, 로봇 공학, 나노 기술과 같은 기술의 발전은 바로 우리 눈앞에서 건강 관리의 미래를 재편하고 있습니다. 또한, 의료는 소비자의 요구에 초점을 맞춘 예방 중심의 의학으로 패러다임이 전환되었습니다. Covid-19와 같은 전염병의 확산으로 의료 및 치료 시설의 정의가 변경되어 병원의 물리적 환경을 재설계하고 사회적 거리 두기 요구사항을 해결하도록 통신 모델을 조정하고 가상 의료 솔루션을 구현하고 새로운 임상 프로토콜을 수립하기 위한 즉각적인 조치가 필요하게 되었습니다. 전통적으로 의료 시스템의 허브 역할을 해 온 병원은 이러한 환경에 맞서 스스로를 재정립하는 것을 추구하거나 강요당하고 있습니다. 미래의 건강관리는 질병을 치료하는 것뿐만 아니라 건강과 예방에 초점을 맞출 것으로 예상됩니다. 개인화된 진료에서는 장기적인 예방 전략, 원격 모니터링, 조기 진단 및 탐지가 매우 중요합니다. 이러한 현대 기술로 정의되는 스마트 헬스케어에 대한 관심이 높아짐에 따라, 본 연구는 스마트 헬스케어의 정의와 서비스 종류를 조사했습니다. 스마트 병원의 배경과 기술적 측면도 문헌 검토를 통해 탐구했습니다.

• Journal of Yeungnam Medical Science
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• 제24권2호
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• pp.252-261
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• 2007

비만은 서구와 우리나라에서 가장 흔한 영양 관련 질환이며, 유전적, 환경적, 생활습관인자들에 의해 초래된다. 이 연구에서는 성인750명을 대상으로 ${\beta}_3AR$ Trp64Arg, UCP2 -866G/A 유전자 다형성을 PCR-RFLP법으로 조사한 후, 체질량지수와 비교하여 어떤 유전자의 다형성이 비만과 관련 있는지 분석하였다. ${\beta}_3AR$의 Trp64Arg의 다형성 분포는 Arg64Arg의 경우 체질량지수 27이상인 비만인에서만 관찰되었지만, 전체적으로 비만인과 정상인에서 통계적으로 유의한 차이가 없었다. UCP2 -866G/A 다형성의 분포는 G/A의 경우 비만인 에서, A/A의 경우 정상인에서 더 통계적으로 유의하게 높았다(p<0.05). 이상의 결과로부터 ${\beta}_3AR$ Trp64Arg 다형성에 비해 UCP2 -866G/A 다형성이 한국인에서 비만과 비만관련 질병을 예측하는데 더 유용한 것으로 판단된다.

• 한국지하수토양환경학회:학술대회논문집
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• 한국지하수토양환경학회 2003년도 총회 및 춘계학술발표회
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• pp.73-76
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• 2003

SF$_{6}$ (Sulfur Hexafluoride) is a gaseous compound whose use is being greatly increased recently. The compound has a negligible background concentration from natural sources and is stable in most of groundwater environments. Therefore, SF$_{6}$ has potential for a dating tool for young groundwater. It has many advantages over chlorofluorocarbons (CFCs) for groundwater investigation that sampling procedure is much simpler than CFCs and its growth is continued up to at least near future in the atmosphere. However, solubility of SF$^{6}$ is so low that excess air causes large uncertainties in recharge date of groundwater. To compensate the limitation, $N_2$/Ar method can be employed to estimate excess air content. A groundwater study is currently carrying out in Jeju Island using SF$_{6}$ as an environmental tracer, Well waters and spring waters were sampled for SF$_{6}$ and $N_2$/Ar. To establish SF$_{6}$ input history in the study area, air sampling is being conducted in the area near the center of the island on a monthly and weekly basis. Based on the present data, the level of SF$_{6}$ concentration in the atmosphere of the Island is corresponding to the trend of the Northern Hemisphere.

• Journal of Ginseng Research
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• 제40권3호
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• pp.251-259
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• 2016

Background: Estrogen signaling pathways are modulated by exogenous factors. Panax ginseng exerts multiple activities in biological systems and is classified as an adaptogen. Zearalenol is a potent mycoestrogen that may be present in herbs and crops arising from contamination or endophytic association. The goal of this study was to investigate the impact of P. ginseng, zearalenol and estradiol in tests on spermatozoal function. Methods: The affinity of these compounds for estrogen receptor (ER)-alpha and beta ($ER{\alpha}$ and $ER{\beta}$)-was assessed in receptor binding assays. Functional tests on boar spermatozoa motility, movement and kinematic parameters were conducted using a computer-assisted sperm analyzer. Tests for capacitation, acrosome reaction (AR), and chromatin decondensation in spermatozoa were performed using microscopic analysis. Results: Zearalenol-but not estradiol ($E_2$)- or ginseng-treated spermatozoa-decreased the percentage of overall, progressive, and rapid motile cells. Zearalenol also decreased spontaneous AR and increased chromatin decondensation. Ginseng decreased chromatin decondensation in response to calcium ionophore and decreased AR in response to progesterone ($P_4$) and ionophore. Conclusion: Zearalenol has adverse effects on sperm motility and function by targeting multiple signaling cascades, including $P_4$, $E_2$, and calcium pathways. Ginseng protects against chromatin damage and thus may be beneficial to reproductive fitness.

• 전력전자학회논문지
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• 제19권1호
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• pp.41-50
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• 2014

The rising penetration of renewable energy resulted in the development of grid-connected large-scale power plants. Therefore, grid stabilization, which depends on the system-type or grid of each country, plays an important role and has been strengthened by different grid codes. With this background, VDE-AR-N 4105 for photovoltaic (PV) systems connected to the low-voltage grid and the German Association of Energy and Water Industries (BDEW) introduced the medium-voltage grid code for connecting power plants to the grid and they are the most stringent certifications. In this paper, an optimal control strategy scheme for three-phase grid-connected PV system is enhanced with VDE-AR-N 4105 and BDEW grid code, where both active/reactive powers are controlled. Simulation and experimental results of 100kW PV inverter are shown to verify the effectiveness of the proposed implemental control strategy.

• Mass Spectrometry Letters
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• 제3권2호
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• pp.54-57
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• 2012

Mass spectrometric analysis was carried out using multicollector inductively coupled plasma mass spectrometry (MC-ICP-MS) for the precise and accurate determination of the isotope ratios of ultratrace levels of uranium dissolved in 3% $HNO_3$. We used the certified reference material (CRM) 112-A at a trace level of 100 pg/mL for the uranium isotopic measurement. Multiple collectors were utilized for the simultaneous measurement of uranium isotopes to reduce the signal uncertainty due to variations in the ion beam intensity over time. Mass bias correction was applied to the measured U isotopes to improve the precision and accuracy. Furthermore, elemental standard solution with certified values of platinum, iridium, gold, and thallium dissolved in 3% $HNO_3$ were analyzed to investigate the formation rates of the polyatomic ions of $Ir^{40}$ $Ar^+$, $Pt^{40}$ $Ar^+$, $Tl^{40}$ $Ar^+$, $Au^{40}$ $Ar^+$ for the concentration range of 50-400 pg/mL. Those polyatomic ions have mass-to-charge ratios in the 230-245 m/z region that it would contribute to the increase of background intensity of uranium, thorium, plutonium, and americium isotopes. The effect of the polyatomic ion interference on uranium isotope measurement has been estimated.

• 한국컴퓨터정보학회논문지
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• 제20권1호
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• pp.49-62
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• 2015

본 연구에서는 건축정보모델링(Building Information Modeling, BIM) 데이터와 증강현실기술의 결합을 통한 기본적인 형태의 건축설계지원도구의 개발 방법을 제안한다. 본 연구에서 제안하는 시스템은 투명형 디스플레이, Mock-up 모델 및 디지털 건축 모델을 적극적으로 활용하여 다자간 디자인 검증 협업작업을 진행할 수 있는 시스템으로서, 투명형 디스플레이를 증강현실에 이용하기 위한 하드웨어 구성 및 고유한 시스템 프레임의 형태를 제안하고, 사용자의 시점에 맞는 증상현실 영상을 제시하기 위한 캡쳐 이미지의 배경 제거 및 관찰자 시점의 보정에 대해서 설명한다. 그리고 건축분야에서 많이 활용되고 있는 BIM으로 작성된 디지털 건축 모델의 증강현실 활용 가능성에 대하여 검토하였다. 또한 본 논문에서 제작한 2인용의 건축디자인 협업 시스템은 보다 많은 사용자가 작업을 진행할 수 있는 시스템으로 확장이 가능하며, 확장된 디자인평가시스템을 구성하기 위한 설계안에 대해서 제안한다. 이와 같은 증강현실기술을 이용한 건축설계지원도구의 개발을 통해 건축디자인 분야에서 실물 모델 및 BIM 저작툴로 작성된 디지털 모델을 적극적으로 활용하여, 보다 효율적이고 경제적인 건축디자인 검증 작업이 가능할 것으로 생각된다.

• Journal of Ginseng Research
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• 제45권4호
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• pp.519-526
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• 2021

Background: This study aimed to investigate the effect of cold plasma treatment on the improvement of seed germination and surface sterilization of ginseng seeds. Methods: Dehisced ginseng (Panax ginseng) seeds were exposed to dielectric barrier discharge (DBD) plasma operated in argon (Ar) or an argon/oxygen mixture (Ar/O₂), and the resulting germination and surface sterilization were compared with those of an untreated control group. Bacterial and fungal detection assays were performed for plasma-treated ginseng seeds after serial dilution of surface-washed suspensions. The microbial colonies (fungi and bacteria) were classified according to their phenotypical morphologies and identified by molecular analysis. Furthermore, the effect of cold plasma treatment on the in vitro antifungal activity and suppression of Cylindrocarpon destructans in 4-year-old ginseng root discs was investigated. Results: Seeds treated with plasma in Ar or Ar/O₂ exhibited a higher germination rate (%) compared with the untreated controls. Furthermore, the plasma treatment exhibited bactericidal and fungicidal effects on the seed surface, and the latter effect was stronger than the former. In addition, plasma treatment exhibited in vitro antifungal activity against C. destructans and reduced the disease severity (%) of root rot in 4-year-old ginseng root discs. The results demonstrate the stimulatory effect of plasma treatment on seed germination, surface sterilization, and root rot disease suppression in ginseng. Conclusion: The results of this study indicate that the cold plasma treatment can suppress the microbial community on the seed surface root rot in ginseng.

• Journal of Ginseng Research
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• 제46권3호
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• pp.473-480
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• 2022

Background: Benign prostatic hyperplasia (BPH) is a disease characterized by abnormal proliferation of the prostate, which occurs frequently in middle-aged men. In this study, we report the effect of red ginseng oil (KGC11o) on BPH. Methods: The BPH-induced Sprague-Dawley rats were divided into seven groups: control, BPH, KGC11o 25, 50, 100, 200, and finasteride groups. KGC11o and finasteride were administered for 8 weeks. The BPH biomarkers, DHT, 5AR1, and 5AR2, androgen receptor, prostate-specific antigen (PSA), Bax, Bcl-2, and TGF-β were determined in the serum and prostate tissue. The cell viability after KGC11o treatment was determined using BPH-1 cells, and, androgen receptor, Bax, Bcl-2, and TGF-β were confirmed by western blotting. Results: In the in vivo study, administration of KGC11o reduced prostate weight by 18%, suppressed DHT (up to 22%) and 5AR2 (up to 12%) levels from administration of 100 mg/kg KGC11o (P < 0.05). PSA was significantly downregulated dose-dependently from at the concentration of 50 mg/kg KGC11o (P < 0.05). BPH-1 cell viability significantly reduced through the treatment with KGC11o. In vitro and vivo, AR, Bcl-2 TGF-β levels reduced significantly but Bax was increased (P < 0.05). Conclusion: These results suggest that KGC11o may inhibit the development of BPH by significantly reducing the levels of BPH biomarkers via 5ARI, anti-androgenic effect, and anti-proliferation effect, serving as a potential functional food for treating BPH.

• Nutrition Research and Practice
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• 제16권4호
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• pp.419-434
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• 2022

BACKGROUND/OBJECTIVES: Benign prostatic hyperplasia (BPH) is the most common prostate disease and one of the most common chronic diseases caused by aging in men. On the other hand, there has been no research on BPH using Abeliophyllum distichum Nakai (A. distichum). Therefore, this study investigated the effects of A. distichum on BPH. MATERIALS/METHODS: A. distichum leaves were extracted with distilled water, 70% ethanol, and 95% hexane as solvents. Subsequently, the inhibitory effects of each A. distichum extract on androgen receptor (AR) signaling were evaluated in vitro. The testosterone-induced BPH model was then used to confirm the efficacy of A. distichum leaves in 70% ethanol extract (ADLE). RESULTS: ADLE had the strongest inhibitory effect on AR signaling. A comparison of the activity of ADLE by harvest time showed that the leaves of A. distichum harvested in autumn had a superior inhibitory effect on AR signaling to those harvested at other times. In the BPH rat model, the administration of ADLE reduced the prostate size and prostate epithelial cell thickness significantly and inhibited AR signaling. Subsequently, the administration of ADLE also reduced the expression of growth factors, thereby inactivating the PI3K/AKT pathway. CONCLUSIONS: An analysis of the efficacy of ADLE to relieve BPH showed that the ethanol extract grown in autumn exhibited the highest inhibitory ability of the androgen-signaling related factors in vitro. ADLE also inhibited the expression of growth factors by inhibiting the expression of the androgen-signaling related factors in vivo. Overall, ADLE is proposed as a functional food that is effective in preventing BPH.