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http://dx.doi.org/10.4162/nrp.2022.16.4.419

Ameliorative effect of Abeliophyllum distichum Nakai on benign prostatic hyperplasia in vitro and in vivo  

Choi, Young-Jin (Department of Food Science and Nutrition, Dong-A University)
Fan, Meiqi (Division of Food Bioscience, College of Biomedical and Health Sciences, Konkuk University)
Tang, Yujiao (School of Bio-Science and Food Engineering, Changchun University of Science and Technology)
Moon, Sangho (Division of Food Bioscience, College of Biomedical and Health Sciences, Konkuk University)
Lee, Seung-Hyun (Department of Microbiology, School of Medicine, Konkuk University)
Lee, Bokyung (Department of Food Science and Nutrition, Dong-A University)
Bae, Sung Mun (Gyeongnam Agricultural Research and Extension Services)
Lee, Sang Moo (Department of Animal Science, Kyungpook National University)
Kim, Eun-Kyung (Department of Food Science and Nutrition, Dong-A University)
Publication Information
Nutrition Research and Practice / v.16, no.4, 2022 , pp. 419-434 More about this Journal
Abstract
BACKGROUND/OBJECTIVES: Benign prostatic hyperplasia (BPH) is the most common prostate disease and one of the most common chronic diseases caused by aging in men. On the other hand, there has been no research on BPH using Abeliophyllum distichum Nakai (A. distichum). Therefore, this study investigated the effects of A. distichum on BPH. MATERIALS/METHODS: A. distichum leaves were extracted with distilled water, 70% ethanol, and 95% hexane as solvents. Subsequently, the inhibitory effects of each A. distichum extract on androgen receptor (AR) signaling were evaluated in vitro. The testosterone-induced BPH model was then used to confirm the efficacy of A. distichum leaves in 70% ethanol extract (ADLE). RESULTS: ADLE had the strongest inhibitory effect on AR signaling. A comparison of the activity of ADLE by harvest time showed that the leaves of A. distichum harvested in autumn had a superior inhibitory effect on AR signaling to those harvested at other times. In the BPH rat model, the administration of ADLE reduced the prostate size and prostate epithelial cell thickness significantly and inhibited AR signaling. Subsequently, the administration of ADLE also reduced the expression of growth factors, thereby inactivating the PI3K/AKT pathway. CONCLUSIONS: An analysis of the efficacy of ADLE to relieve BPH showed that the ethanol extract grown in autumn exhibited the highest inhibitory ability of the androgen-signaling related factors in vitro. ADLE also inhibited the expression of growth factors by inhibiting the expression of the androgen-signaling related factors in vivo. Overall, ADLE is proposed as a functional food that is effective in preventing BPH.
Keywords
Androgen receptor; dihydrotestosterone; prostatic hyperplasia; cell proliferation;
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Times Cited By KSCI : 2  (Citation Analysis)
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1 Huang Y, Chen H, Zhou X, Wu X, Hu E, Jiang Z. Inhibition effects of chlorogenic acid on benign prostatic hyperplasia in mice. Eur J Pharmacol 2017;809:191-5.   DOI
2 Bisson JF, Hidalgo S, Rozan P, Messaoudi M. Therapeutic effect of ACTICOA powder, a cocoa polyphenolic extract, on experimentally induced prostate hyperplasia in Wistar-Unilever rats. J Med Food 2007;10:628-35.   DOI
3 Olaisen C, Muller R, Nedal A, Otterlei M. PCNA-interacting peptides reduce Akt phosphorylation and TLR-mediated cytokine secretion suggesting a role of PCNA in cellular signaling. Cell Signal 2015;27:1478-87.   DOI
4 Khalaf HA, Jasim RA, Ibrahim IT. Verbascoside-A review of its antitumor activities. Pharmacol Pharm 2021;12:109-26.   DOI
5 Krieg M, Nass R, Tunn S. Effect of aging on endogenous level of 5 alpha-dihydrotestosterone, testosterone, estradiol, and estrone in epithelium and stroma of normal and hyperplastic human prostate. J Clin Endocrinol Metab 1993;77:375-81.   DOI
6 Culig Z, Hobisch A, Cronauer MV, Radmayr C, Trapman J, Hittmair A, Bartsch G, Klocker H. Androgen receptor activation in prostatic tumor cell lines by insulin-like growth factor-I, keratinocyte growth factor, and epidermal growth factor. Cancer Res 1994;54:5474-8.
7 Waga S, Hannon GJ, Beach D, Stillman B. The p21 inhibitor of cyclin-dependent kinases controls DNA replication by interaction with PCNA. Nature 1994;369:574-8.   DOI
8 Hsu YT, Wolter KG, Youle RJ. Cytosol-to-membrane redistribution of Bax and Bcl-XL during apoptosis. Proc Natl Acad Sci U S A 1997;94:3668-72.   DOI
9 Lepor H. Alpha blockers for the treatment of benign prostatic hyperplasia. Rev Urol 2007;9:181-90.
10 Park GH, Park JH, Eo HJ, Song HM, Woo SH, Kim MK, Lee JW, Lee MH, Lee JR, Koo JS, et al. The induction of activating transcription factor 3 (ATF3) contributes to anti-cancer activity of Abeliophyllum distichum Nakai in human colorectal cancer cells. BMC Complement Altern Med 2014;14:487.   DOI
11 McVary KT. A review of combination therapy in patients with benign prostatic hyperplasia. Clin Ther 2007;29:387-98.   DOI
12 Marks LS, Partin AW, Epstein JI, Tyler VE, Simon I, Macairan ML, Chan TL, Dorey FJ, Garris JB, Veltri RW, et al. Effects of a saw palmetto herbal blend in men with symptomatic benign prostatic hyperplasia. J Urol 2000;163:1451-6.   DOI
13 Grino PB, Griffin JE, Wilson JD. Testosterone at high concentrations interacts with the human androgen receptor similarly to dihydrotestosterone. Endocrinology 1990;126:1165-72.   DOI
14 Ueda T, Mawji NR, Bruchovsky N, Sadar MD. Ligand-independent activation of the androgen receptor by interleukin-6 and the role of steroid receptor coactivator-1 in prostate cancer cells. J Biol Chem 2002;277:38087-94.   DOI
15 Andriole G, Bruchovsky N, Chung LW, Matsumoto AM, Rittmaster R, Roehrborn C, Russell D, Tindall D. Dihydrotestosterone and the prostate: the scientific rationale for 5alpha-reductase inhibitors in the treatment of benign prostatic hyperplasia. J Urol 2004;172:1399-403.   DOI
16 Agarwal A, Eryuzlu LN, Cartwright R, Thorlund K, Tammela TL, Guyatt GH, Auvinen A, Tikkinen KA. What is the most bothersome lower urinary tract symptom? Individual- and population-level perspectives for both men and women. Eur Urol 2014;65:1211-7.   DOI
17 Choi YJ, Lee JI, Fan M, Tang Y, Yoon EJ, Ryu YB, Kim EK. Metabolomic analysis of Morus cultivar root extracts and their ameliorative effect on testosterone-induced prostate enlargement in Sprague-Dawley rats. Int J Mol Sci 2020;21:1435.   DOI
18 Miao MS, Wang ZM, Zhang YL, Gao JL. Effects of total flavonoids from bastard speedwell on benign prostatic hyperplasia rats models. Chin J Mod Appl Pharm 2011;28:4-7.
19 Wu Y, Chhipa RR, Zhang H, Ip C. The antiandrogenic effect of finasteride against a mutant androgen receptor. Cancer Biol Ther 2011;11:902-9.   DOI
20 Sheehy CM, Perry PA, Cromwell SL. Dehydration: biological considerations, age-related changes, and risk factors in older adults. Biol Res Nurs 1999;1:30-7.   DOI
21 Nicholson TM, Ricke WA. Androgens and estrogens in benign prostatic hyperplasia: past, present and future. Differentiation 2011;82:184-99.   DOI
22 Vignozzi L, Rastrelli G, Corona G, Gacci M, Forti G, Maggi M. Benign prostatic hyperplasia: a new metabolic disease? J Endocrinol Invest 2014;37:313-22.   DOI
23 Luke MC, Coffey DS. Human androgen receptor binding to the androgen response element of prostate specific antigen. J Androl 1994;15:41-51.
24 Liu RF, Fu G, Li J, Yang YF, Wang XG, Bai PD, Chen YD. Roles of autophagy in androgen-induced benign prostatic hyperplasia in castrated rats. Exp Ther Med 2018;15:2703-10.
25 de la Rosette JJ, Alivizatos G, Madersbacher S, Perachino M, Thomas D, Desgrandchamps F, de Wildt M; European Association of Urology. EAU guidelines on benign prostatic hyperplasia (BPH). Eur Urol 2001;40:256-63.   DOI
26 Baldin V, Lukas J, Marcote MJ, Pagano M, Draetta G. Cyclin D1 is a nuclear protein required for cell cycle progression in G1. Genes Dev 1993;7:812-21.   DOI
27 Martinou JC, Youle RJ. Mitochondria in apoptosis: Bcl-2 family members and mitochondrial dynamics. Dev Cell 2011;21:92-101.   DOI
28 Marzo I, Brenner C, Zamzami N, Jurgensmeier JM, Susin SA, Vieira HL, Prevost MC, Xie Z, Matsuyama S, Reed JC, et al. Bax and adenine nucleotide translocator cooperate in the mitochondrial control of apoptosis. Science 1998;281:2027-31.   DOI
29 Steenkamp V, Gouws MC, Gulumian M, Elgorashi EE, van Staden J. Studies on antibacterial, anti-inflammatory and antioxidant activity of herbal remedies used in the treatment of benign prostatic hyperplasia and prostatitis. J Ethnopharmacol 2006;103:71-5.   DOI
30 Pirozzi L, Sountoulides P, Castellan P, Presicce F, Lombardo R, Romero M, De Nunzio C, Tubaro A, Schips L, Cindolo L. Current pharmacological treatment for male LUTS due to BPH: dutasteride or finasteride? Curr Drug Targets 2015;16:1165-71.   DOI
31 You JH, Lee CH. Analysis on herbaceous communities and flora around Abeliophyllum distichum habitats. Korean J Plant Resour 2005;18:315-24.
32 Aggarwal S, Thareja S, Verma A, Bhardwaj TR, Kumar M. An overview on 5α-reductase inhibitors. Steroids 2010;75:109-53.   DOI
33 Traish AM, Hassani J, Guay AT, Zitzmann M, Hansen ML. Adverse side effects of 5α-reductase inhibitors therapy: persistent diminished libido and erectile dysfunction and depression in a subset of patients. J Sex Med 2011;8:872-84.   DOI
34 Lee TB. Studies on conservation of endemic species Abeliophyllum distichum. J Nat Conserv 1976;12:6-10.
35 Ahn J, Park JH. Effects of Abeliophyllum distichum Nakai flower extracts on antioxidative activities and inhibition of DNA damage. Korean J Plant Res 2013;26:355-61.   DOI
36 Chang SJ, Jeon NB, Park JW, Jang TW, Jeong JB, Park JH. Antioxidant activities and anti-inflammatory effects of fresh and air-dried Abeliophyllum distichum Nakai leaves. Korean J Food Preserv 2018;25:27-35.   DOI
37 Kim EY, Kim JH, Kim M, Park JH, Sohn Y, Jung HS. Abeliophyllum distichum Nakai alleviates postmenopausal osteoporosis in ovariectomized rats and prevents RANKL-induced osteoclastogenesis in vitro. J Ethnopharmacol 2020;257:112828.   DOI
38 Kwon S, Kang H, Kim M, Kim J, Shin H, Kim K. Analysis on the components and safety evaluation of Abeliophyllum distichum Nakai leaves and stems. J Environ Health Sci 2014;40:234-44.   DOI
39 Khoury CK, Bjorkman AD, Dempewolf H, Ramirez-Villegas J, Guarino L, Jarvis A, Rieseberg LH, Struik PC. Increasing homogeneity in global food supplies and the implications for food security. Proc Natl Acad Sci U S A 2014;111:4001-6.   DOI
40 Mustonen S, Ala-Houhala IO, Tammela TL; Long-term renal dysfunction in patients with acute urinary retention. Scand J Urol Nephrol 2001;35:44-8.   DOI
41 Bent S, Kane C, Shinohara K, Neuhaus J, Hudes ES, Goldberg H, Avins AL. Saw palmetto for benign prostatic hyperplasia. N Engl J Med 2006;354:557-66.   DOI
42 Cunha GR, Alarid ET, Turner T, Donjacour AA, Boutin EL, Foster BA. Normal and abnormal development of the male urogenital tract. Role of androgens, mesenchymal-epithelial interactions, and growth factors. J Androl 1992;13:465-75.
43 Nandeesha H. Benign prostatic hyperplasia: dietary and metabolic risk factors. Int Urol Nephrol 2008;40:649-56.   DOI
44 Dai GC, Hu B, Zhang WF, Peng F, Wang R, Liu ZY, Xue BX, Liu JY, Shan YX. Chemical characterization, anti-benign prostatic hyperplasia effect and subchronic toxicity study of total flavonoid extract of Pteris multifida. Food Chem Toxicol 2017;108:524-31.   DOI
45 Li Z, Shen J, Wu WK, Yu X, Liang J, Qiu G, Liu J. Leptin induces cyclin D1 expression and proliferation of human nucleus pulposus cells via JAK/STAT, PI3K/Akt and MEK/ERK pathways. PLoS One 2012;7:e53176.   DOI
46 Vickman RE, Franco OE, Moline DC, Vander Griend DJ, Thumbikat P, Hayward SW. The role of the androgen receptor in prostate development and benign prostatic hyperplasia: a review. Asian J Urol 2020;7:191-202.   DOI
47 Yoo TK, Kim JS, Hyun TK. Polyphenolic composition and anti-melanoma activity of white forsythia (Abeliophyllum distichum nakai) organ extracts. Plants (Basel) 2020;9:757.
48 Kim HW, Yu AR, Kang M, Sung NY, Lee BS, Park SY, Han IJ, Kim DS, Oh SM, Lee YI, et al. Verbascoside-rich Abeliophyllum distichum Nakai leaf extracts prevent LPS-induced preterm birth through inhibiting the expression of proinflammatory cytokines from macrophages and the cell death of trophoblasts induced by TNF-α. Molecules 2020;25:4579.   DOI
49 Eom J, Thomas SS, Sung NY, Kim DS, Cha YS, Kim KA. Abeliophyllum distichum ameliorates high-fat diet-induced obesity in C57BL/6J mice by upregulating the AMPK pathway. Nutrients 2020;12:3320.   DOI
50 Carson C 3rd, Rittmaster R. The role of dihydrotestosterone in benign prostatic hyperplasia. Urology 2003;61:2-7.   DOI