• The Journal of Korean Medicine
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• v.45 no.1
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• pp.165-181
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• 2024

Objectives: This study was aimed to review the global status of adverse event (AE) reports and the characteristics of the reported AEs of plants managed as herbal medicines (HMs) with toxic precautions in Korea. Methods: This is a cross-sectional quantitative study that analyzed information available through VigiAccess, a website that provides summarized statistical information from the WHO's global AE database to the public. VigiAccess was searched in 8 Jan, 2024. Information on the total number of reports, number of reports by year and continent, and the age and gender of patients were obtained, and the types of frequently reported AEs were also reviewed. Results: Data on the status of report submissions were obtained for a total of 9 HMs including Aconitum ciliare, Aconitum carmichaeli, Arisaema japonicum, Pinellia ternata, Euphorbiae Lathyridis, Croton tiglium, Strychni Ignatii, Strychnons nux-vomica, and Linum usitatissimum. The number of reports per HM was from 1 to 137. The most commonly reported type of AEs were gastrointestinal disorders in most of the HMs, followed by neurological disorders. Serious adverse events were reported only in Strychni Ignatii, Strychnons nux-vomica, and Linum usitatissimum, including one case of death. Conclusions: This study shows the status of reported AEs of botanicals considered as HMs with toxic precautions in Korea based on real world data. However, when interpreting the findings of this study, readers should consider the significant limitations of this study mainly because of the characteristics of the data source.

• The Transactions of the Korea Information Processing Society
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• v.6 no.1
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• pp.225-233
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• 1999

One of the reasons that debugging distributed programs is much more difficult than sequential programs is the communication among processes. Even though there are many debuggers constructed on distributed system environment, no available debugger provides an efficient way to debug communication events.. In this paper, we show the way to debug RPC communication, which is regarded as one of the most popular communication protocol in distributed system development. This paper presents the implementation of the RPC event trace function based on the RPC event model, which is proposed to accommodate communication events into debugging objects. Analyzing conventional RPC protocols, we formalized library function calls as corresponding actions to sending and receiving of messages. B recognizing the locations of library calls the debugger can detect all occurrences of communication events, This RPC event trace function is implemented on the on-line distributed debugger UniVIEW system.

• Journal of Korea Water Resources Association
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• v.46 no.3
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• pp.287-299
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• 2013

The objective of this study is to derive and evaluate the drought threshold level based on hydro-meteorological data using historical drought events. After collecting the drought events during 1991 to 2009 year, the observed meteorological data and estimated hydrological component from LSM are used as input for the percentile analysis that is drought analysis data. The drought threshold level that precipitation and runoff of 3 month duration are less than 35%, soil moisture of 2 month duration is less than 35% and evapotranspiration of 3 month duration is more than 65% is derived using ROC analysis that are objective test method. ROC analysis with SPI (3) is performed to evaluate the applicability of threshold level in the domestic. As a result, it can be concluded that the derived drought threshold level show better performance to reflect the historical drought events than SPI (3) and it reasonably explain the spatial drought situation through the spatial analysis.

• Pediatric Infection and Vaccine
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• v.7 no.2
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• pp.183-192
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• 2000

Purpose : Adverse events(AE) associated with vaccination have not been systematically monitored in Korea. But since 1994, several deaths after inactivated mouse brain derived Japanese encephalitis vaccine injection arouse the safety problem of immunization in the public, and a evaluation of vaccination program including the effectiveness and safety problem had been started. We have been using MMR vaccine containing Japanese mumps vaccine strains, which are known to be associated with the high rate of adverse events including aseptic meningitis, for the last decade. Methods : We conducted a prospective study of vaccine adverse events associated with MMR vaccine through a tracking system using telephone calls. We followed up 7,594 cases of MMR vaccinees. Results : Reported adverse events included fever, couvulsion, parotitis, and aseptic meningitis. Nine cases of parotitis and seven cases of aseptic meningitis were recognized during follow up period. The incidence of both parotitis and aeptic meningitis was $85.1/10^5$, for Urabe mumps strain. For Hoshino strain, the incidence of parotitis and aseptic meningitis was $158.0/10^5$ and $94.8/10^5$, respectively. Conclusions : The incidence of adverse events was to be a higher than that of natural infection in Korea and was comparable to the results of studies done in other countries.

• Nuclear Engineering and Technology
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• v.34 no.6
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• pp.596-609
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• 2002

Korea Electric Power Research Institute has developed the in-house safety analysis methodologies for non-LOCA(Loss Of Coolant Accident) events based on codes and methodologies of vendors and Electric Power Research Institute . According to the new methodologies, analyses of system responses and calculation of DNBR(Departure from Nucleate Boiling Ratio) during the transient have been carried out with RETRAN code and a sub-channel analysis code, respectively. However, it takes too much time to calculate DNBR for each case using the two codes to search for the limiting case from sensitivity study. To simplify the search for the limiting case, accordingly, RETRAN code has been modified to roughly calculate DNBR using hot channel modeling. The W-3 correlation is already included in RETRAN as one of the auxiliary DNBR models. However, WRB-1 and WRB-2 correlations required to analyze some Westinghouse type fuels are not considered in RETRAN DNBR models. In this paper, the RETRAN DNBR models using the correlations have been developed and the partial and complete loss of forced reactor coolant flow events have been analyzed for Yonggwang units 1 and 2 with the new methodologies to validate the models. The results of the analyses have been compared with those mentioned in the chapter 15 of the Final Safety Analysis Report.

• The Journal of Pediatrics of Korean Medicine
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• v.35 no.1
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• pp.104-121
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• 2021

Objectives The purpose of this study is to evaluate the efficacy and safety of herbal medication for the treatment of functional abdominal pain in children by analyzing randomized controlled trials conducted in China. Methods Literatures from China National Knowledge Infrastructure published up to 23 November, 2020 were searched. Then they were collected and analyzed by their publication year, demographic information, treatment methods used, duration of illnesses, duration of treatments, follow-up periods, outcome measurement and adverse events. Results A total of 27 studies were selected for the analysis. In all studies, the total efficacy of the herbal medicine treatment group was reported to be higher than that of the control group. The most frequently used medical herb was Root of Glycyrrhiza uralensis Fischer (甘草). The most frequently used classes of herbal medications are Qi regulating medicine (理氣藥), Qi tonics (補氣藥), Aromatic wet medicine (芳香化濕藥), and Digestant (消食藥). The adverse events rate for the herbal medicine treatment group were significantly lower than those in the Western medicine treatment group. Conclusions This study showed that herbal medicine treatment can be effective and safe option for treating pediatric functional abdominal pain. However, additional well-designed clinical studies are needed to solidify the findings.

• The Korean Journal of Ceramics
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• v.6 no.3
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• pp.267-271
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• 2000

The influence of photoexcited nonequilibrium carriers on domain switching and photovoltaic current was investigated in two kinds of poled La-modified PbTiO$_3$ferroelectric ceramics, (Pb$_{0.85}$La$_{0.15}$)TiO$_3$and (Pb$_{0.76}$La$_{0.24}$)TiO$_3$, under illumination in the absence of external electric field. Both photovoltaic current and cumulative AE event counts increased with illumination time. The observed nonsteady-state photovoltaic current could be explained on the basis of the cycles of a series of physical events consisting the establishment of space charge field by photoexcited carriers trapped at the grain boundaries, the photoinduced domain switching, and the increase in the remanent polarization. An analysis of energy distribution of the observed AE signals also revealed that the space charge field in (Pb$_{0.85}$La$_{0.15}$)TiO$_3$allowed both 18$0^{\circ}C$ and 90$^{\circ}$domains to be switched during illumination.

• Journal of the Korean Society for Nondestructive Testing
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• v.23 no.5
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• pp.418-428
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• 2003

Fiber fracture is one of the dominant failure phenomena affecting the total mechanical Performance of the composites. Fiber fracture locations were measured through the conventional optical microscope and the nondestructive acoustic emission (AE) technique and then were compared together as a function of the epoxy matrix modulus and the fiber surface treatment by the electrodeposition method (ED). Interfacial shear strength (IFSS) was measured using tensile fragmentation test in combination of AE method. ED treatment of the fiber surface enlarged the number of fiber fracture locations in comparison to the untreated case. The number of fiber fracture events measured by the AE method was less than optically obtained one. However, fiber fracture locations determined by AE detection corresponded with those by optical observation with small errors. The source location of fiber breaks by AE analysis could be a nondestructive, valuable method to measure interfacial shear strength (IFSS) of matrix in non-, semi- and/or transparent polymer composites.

• Journal of Food Hygiene and Safety
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• v.25 no.3
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• pp.278-280
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• 2010

This study was aimed to develop a novel qualitative multiplex polymerase chain reaction (PCR) for simultaneous detection of genetically modified (GM) soy and maize within a single reaction. The specific primers designed to detect four respective GM events (A2704-12, MON88017, Bt11, and MON863) were included in the tetraplex PCR system. Each of PCR products for four GM events could be distinguished by agarose gel based on their different lengths. The specificity and reproducibility of this multiplex PCR were evaluated. This multiplex PCR consistently amplified only a fragment corresponding to a specific inserted gene in each of the four GM events and also amplified all four of the PCR products in the simulated GM mixture. These results indicate that this multiplex PCR method could be an effective qualitative detection method for screening GM soy and maize in a single reaction.

• Composites Research
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• v.16 no.4
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• pp.74-79
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• 2003

Comparison of interfacial properties and microfailure mechanisms of oxygen-plasma treated poly(p-phenylene-2,6-benzobisoxazole(PBO. Zylon) and poly(p-phenylene terephthalamide)(PPTA, Kevlar) fibers/ epoxy composites were investigated using micromechanical technique and nondestructive acoustic emission(AE). Interfacial shear strength(IFSS) and work of adhesion, Wa of PBO or Kevlar fibers/epoxy composites increased by oxygen-plasma treatment. Plasma-treated Kevlar fiber shooed the maximum critical surface tension and polar term, whereas the untreated PBO fiber showed the minimum value. Microfibril fracture pattern of plasma-treated Kevlar fiber appeared obviously. Based on the propagation of microfibril failure toward core region. the number of AE events for plasma-treated PBO and Kevlar fibers increased significantly. The results oi nondestructive AE were consistent well with microfailure modes by optical observation in microdroplet and two-fiber composites tests.