• Journal of Korea Society of Industrial Information Systems
• /
• v.6 no.1
• /
• pp.24-32
• /
• 2001

This paper proposes an easy method to develop GUI for the campus facility management. In the developing stage of GUI, the most important thing is to apply effective Windows programming techniques and component software supporting techniques. This study shows a GUI developing method using the OLE automation objects and ADO data control. For a case study, the study constructs its GUI which performs map overlaying referencing attribute tables, retrieving by SQL, mapping/displaying of thematic map, and so on.

• The KIPS Transactions:PartD
• /
• v.9D no.5
• /
• pp.945-954
• /
• 2002

Clickstream is the information which demonstrate users' path through web sites. Analysis of clickstream shows how web sites are navigated and used by users. Clickstream of online web sites contains effective information of web marketing and to offers usefully personalized services to users, and helps us understand how users find web sites, what products they see, and what products they purchase. In this paper, we present an extended web log system that add to module of collection of clickstream to understand users' behavior patterns In web sites. This system offers the users clickstream information to database which can then analyze it with ease. Using ADO technology in store of database constructs extended web log server system. The process of making clickstreaming into database can facilitate analysis of various user patterns and generates aggregate profiles to offer personalized web service. In particular, our results indicate that by using the users' clickstream. We can achieve effective personalization of web sites.

• Clinical and Experimental Reproductive Medicine
• /
• v.32 no.4
• /
• pp.293-300
• /
• 2005

연구목적: 단일 유전자 이상에 대한 착상전 유전진단을 성공적으로 시행하기 위해서는 효과적이고 신뢰도가 높은 PCR 방법의 확립이 중요하다. 본 연구에서는 alkaline lysis와 duplex nested PCR 방법을 단일 림프구와 할구의 유전자 분석에 적용하여 그 효용성을 확인하고자 하였다. 재료 및 방법: 단일 유전자의 이상이 확인된 Duchenne muscular dystrophy (DMD), ornithine transcarbamylase (OTC) 결핍증과 epidermolysis bullosa (EB) 가계의 대상자들에서 채취한 단일 림프구와 공여 받은 배아의 할구를 이용하여 각각 PCR, restriction fragment length polymorphism (RFLP)와 direct DNA sequencing 분석을 시행하였다. 이러한 분석에서 유전자 증폭률 (amplification rate)과 두개의 allele 중에서 하나의 allele이 증폭되지 않는 allele drop-out (ADO) 빈도에 대해 살펴보았다. 결 과: 단일 림프구와 할구를 이용한 PCR 방법의 유전자 증폭률은 DMD에서 91.1%와 81.8%, OTC 결핍증에서 96.0%와 78.1%, EB에서 91.3%와 90.0%를 각각 나타냈으며, ADO 빈도는 OTC 결핍증에서 13.3%, EB에서 16.8%로 관찰되었다. 결 론: 본 연구에서 적용한 alkaline lysis와 duplex nested PCR 방법은 단일 유전자에 대한 착상전 유전진단에 성공적으로 적용할 수 있는 방법으로 생각되며, ADO 빈도를 최소화할 수 있는 효율적인 방법의 개발에 대한 지속적인 연구가 필요하다.

• Clinical and Experimental Pediatrics
• /
• v.56 no.4
• /
• pp.176-181
• /
• 2013

Purpose: Apical muscular ventricular septal defects (MVSDs), especially in small infants, can be difficult to manage using surgical and percutaneous closure. An intraoperative perventricular procedure is a good option for closing apical MVSDs in small children with or without associated cardiac anomalies. We evaluated the results of hybrid perventricular closure of apical MVSDs performed using an Amplatzer duct occluder (ADO). Methods: We retrospectively reviewed the medical records of 5 patients who underwent hybrid perventricular closure of MVSDs with ADOs, from March 2006 to May 2011. The median patient age at the time of the procedure was 12 months (range, 25 days to 25 months), and the median body weight was 9.1 kg (range, 4.3 to 15 kg). Two patients had multiple ventricular septal defects (VSDs; additional perimembranous VSD in 1 patient and multiple MVSDs in the other) and 3 patients had associated cardiac anomalies; complete transposition of the great arteries in 1 patient and an atrial septal defect in 2 patients. All the procedures were performed on beating hearts, exception in 1 case. The ADO selected for the aortic side was at least 1 to 2 mm larger than the largest VSD in the left ventricle side. Results: The procedure was successful in all patients and each device was well positioned. During the median follow-up of 2.4 years, a small residual VSD was noted in 2 patients who had multiple VSDs and no leakage was seen in the other 3 patients. Conclusion: Perventricular closure of MVSD with an ADO is a good option for patients with apical MVSD. However, careful manipulation is important, especially in the case of small infants.

• Clinical and Experimental Reproductive Medicine
• /
• v.40 no.4
• /
• pp.163-168
• /
• 2013

Objective: Preimplantation genetic diagnosis (PGD) is an assisted reproductive technique for couples carrying genetic risks. Charcot-Marie-Tooth (CMT) disease is the most common hereditary neuropathy, with a prevalence rate of 1/2,500. In this study, we report on our experience with PGD cycles performed for CMT types 1A and 2F. Methods: Before clinical PGD, we assessed the amplification rate and allele drop-out (ADO) rate of multiplex fluorescent polymerase chain reaction (PCR) followed by fragment analysis or sequencing using single lymphocytes. We performed six cycles of PGD for CMT1A and one cycle for CMT2F. Results: Two duplex and two triplex protocols were developed according to the available markers for each CMT1A couple. Depending on the PCR protocols, the amplification rates and ADO rates ranged from 90.0% to 98.3% and 0.0% to 11.1%, respectively. For CMT2F, the amplification rates and ADO rates were 93.3% and 4.8%, respectively. In case of CMT1A, 60 out of 63 embryos (95.2%) were diagnosed and 13 out of 21 unaffected embryos were transferred in five cycles. Two pregnancies were achieved and three babies were delivered without any complications. In the case of CMT2F, a total of eight embryos were analyzed and diagnosed. Seven embryos were diagnosed as unaffected and four embryos were transferred, resulting in a twin pregnancy. Two healthy babies were delivered. Conclusion: This is the first report of successful pregnancy and delivery after specific PGD for CMT disease in Korea. Our PGD procedure could provide healthy babies to couples with a high risk of transmitting genetic diseases.

• Proceedings of the Optical Society of Korea Conference
• /
• 1998.08a
• /
• pp.98-99
• /
• 1998

In this paper, an acousto-optic defiector9ADO) is used to perform the angular multiplexing without moving parts. The error-correction coding techniques was used to achive low bit-error rates in the experiment. A part of Lena image(64*64) encoded by Reed-Solomon codes were stored and retrieved.

• Journal of the Korea Computer Industry Society
• /
• v.7 no.4
• /
• pp.421-426
• /
• 2006

Because the 3-Tier structure cia share a business logic, the reuse of existing code could be guaranteed Al so tiny and little client application in charge of user interface can he made that it doesn't need plenty of client memory and calculation capability. Catering system that capable of meal material code management autom atic production of requiring quantity, purchase and shipping management menu management, account management was developed for grafting 3-Tire structure technology using database language and ADO(ActiveX Dat a Object). This system improved production in field of school lunch program and saved o(poises. finally, this system is suitable to the service environment of school lunch program and lots of utilizations would be anticipated.

• Bulletin of the Korean Chemical Society
• /
• v.28 no.4
• /
• pp.561-566
• /
• 2007

Adenosine kinase (AK) is a ubiquitous intracellular enzyme, which catalyzes the phosphorylation of adenosine (ADO) to adenosine monophosphate (AMP). AK inhibitors have therapeutic potential as analgesic and antiinflammatory agents. A chemical feature based pharmacophore model has been generated from known AK inhibitors (26 training set compounds) by HypoGen module implemented in CATALYST software. The top ranked hypothesis (Hypo1) contained four features of two hydrogen-bond acceptors (HBA) and two hydrophobic aromatics (Z). Hypo1 was validated by 124 test set molecules with a correlation coefficient of 0.905 between experimental and estimated activity. It was also validated by CatScramble method. Thus, the Hypo1 was exploited for searching new lead compounds over 238,819 chemical compounds in NCI database and then the selected compounds were screened based on restriction estimated activity and Lipinski's rules to evaluate their drug-like properties. Finally we could obtain 72 new lead candidates and the two best compound structures from them were posted.

• Bulletin of the Korean Chemical Society
• /
• v.28 no.6
• /
• pp.941-946
• /
• 2007

Bacillus halodurans O-methyltransferase (BhOMT) is a S-adenosylmethionine (SAM or AdoMet) dependent methyltransferase. Three dimensional structure of the BhOMT bound to S-adenosyl-L-homocysteine (SAH or AdoHcy) has been determined by comparative homology modeling. BhOMT has 40% sequence identity with caffeoyl-CoA 3-O-methyltransferase (CCoAOMT) from alfalfa. Based on x-ray structure of CCoAOMT, three dimensional structure of BhOMT was determined using MODELLER. The substrate binding sites of these two proteins showed slight differences, but these differences were important to characterize the substrate of BhOMT. Automated docking study showed that four flavonoids, quercetin, fisetin, myricetin, and luteolin which have two hydroxyl groups simultaneously at 3'- and 4'-position in the B-ring and structural rigidity of Cring resulting from the double bond characters between C2 and C3, were well docked as ligands of BhOMT. These flavonoids form stable hydrogen bondings with K211, R170, and hydroxyl group at 3'-position in the Bring has stable electrostatic interaction with Ca2+ ion in BhOMT. This study will be helpful to understand the biochemical function of BhOMT as an O-methyltransferase for flavonoids.

• Journal of the Korea Safety Management & Science
• /
• v.24 no.2
• /
• pp.127-134
• /
• 2022

Production management in the automobile parts industry is carried out according to the production plan of the customer, so it is important to prevent shortages in product supply. As the product composition became increasingly complex, the MES System was built for the purpose of efficient production plan management and inventory management, but its utilization is low. This study analyzed the problems of the MES system and sought to improve it. Through previous studies, it was confirmed that the inventory management of the pull approach that actually occurred in the warehouse is more suitable than the push approach based on the forecast of the warehouse for the volatility, complexity, and uncertainty of orders in the auto parts industry. To realize this, we tried distributed MRP by using the ADO function of VBA to link the standard information of the MES system with Excel and change the structure of the BOM table. Through this, it can help increase the accuracy of production planning and realize efficient inventory management, thereby increasing the utilization of the MES system in the auto parts industry and enhancing the competitiveness of the company.