• 한국산업정보학회논문지
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• 제6권1호
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• pp.24-32
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• 2001

본 논문에서는 캠퍼스 시설물 관리를 위한 GUI 개발 방법을 제안하였다. GUI 개발에 있어서는 효율적인 윈도우즈 프로그래밍과 컴포넌트 소프트웨어 제작기술의 적용이 가장 중요하다. 본 연구에서는 OLE 자동화 객체와 ADO 데이터 콘트롤을 사용하여 GUI를 개발하는 방법을 제시하였으며, 사례 연구를 통해 개발한 GUI가 지도중첩, 속성테이블 참조, SQL 질의를 이용한 검색, 주제도의 매핑/디스플레이 기능 등을 수행함을 보였다.

• 정보처리학회논문지D
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• 제9D권5호
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• pp.945-954
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• 2002

인터넷을 통한 비즈니스에 수익 모델에 대한 관심이 높아지면서 방문자별로 개인화된 서비스를 제공하려는 노력이 커지고 있다. 개인화(Personalization)란 고객 한 명을 대상으로 하여 그 고객 한 사람을 위한 정보나 제품을 제공해주는 작업을 말한다. 개인화 서비스를 위해서 전 처리과정인 사용자 프로파일 생성과정이 필요하며, 적극적인 개인화 서비스를 제공하기 위해서는 충분한 고객 데이터가 필요하다. 본 논문에서는 웹사이트 상에서 사용자 행위 패턴을 파악할 수 있는 클릭스트림 정보를 모듈화 하였으며, 이를 이용하여 확장된 웹 로그 시스템을 구현하였다. 클릭스트림 정보를 웹 로그정보에 포함시켜 사용자의 행위 패턴을 파악할 수 있도록 웹 서버 시스템을 설계하고 구현하였다. 그리고 이 웹 서버는 웹사이트로부터 얻은 클릭스트림 정보를 분류하고 저장하여 관리자가 쉽게 분석할 수 있다. 이때 데이터베이스 저장 기술로 OLE DB Provider상에서 수행되는 ADO(ActiveX Data Object)기술을 사용함으로써 확장된 웹 로그 처리 시스템을 설계하였다. 확장된 웹 로그 DB를 패턴분석, 군집분석 등의 마이닝(Mining) 기법을 통하여 맞춤서비스에 대한 사용자 프로파일을 구축할 수 있다.

• Clinical and Experimental Reproductive Medicine
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• 제32권4호
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• pp.293-300
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• 2005

연구목적: 단일 유전자 이상에 대한 착상전 유전진단을 성공적으로 시행하기 위해서는 효과적이고 신뢰도가 높은 PCR 방법의 확립이 중요하다. 본 연구에서는 alkaline lysis와 duplex nested PCR 방법을 단일 림프구와 할구의 유전자 분석에 적용하여 그 효용성을 확인하고자 하였다. 재료 및 방법: 단일 유전자의 이상이 확인된 Duchenne muscular dystrophy (DMD), ornithine transcarbamylase (OTC) 결핍증과 epidermolysis bullosa (EB) 가계의 대상자들에서 채취한 단일 림프구와 공여 받은 배아의 할구를 이용하여 각각 PCR, restriction fragment length polymorphism (RFLP)와 direct DNA sequencing 분석을 시행하였다. 이러한 분석에서 유전자 증폭률 (amplification rate)과 두개의 allele 중에서 하나의 allele이 증폭되지 않는 allele drop-out (ADO) 빈도에 대해 살펴보았다. 결 과: 단일 림프구와 할구를 이용한 PCR 방법의 유전자 증폭률은 DMD에서 91.1%와 81.8%, OTC 결핍증에서 96.0%와 78.1%, EB에서 91.3%와 90.0%를 각각 나타냈으며, ADO 빈도는 OTC 결핍증에서 13.3%, EB에서 16.8%로 관찰되었다. 결 론: 본 연구에서 적용한 alkaline lysis와 duplex nested PCR 방법은 단일 유전자에 대한 착상전 유전진단에 성공적으로 적용할 수 있는 방법으로 생각되며, ADO 빈도를 최소화할 수 있는 효율적인 방법의 개발에 대한 지속적인 연구가 필요하다.

• Clinical and Experimental Pediatrics
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• 제56권4호
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• pp.176-181
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• 2013

Purpose: Apical muscular ventricular septal defects (MVSDs), especially in small infants, can be difficult to manage using surgical and percutaneous closure. An intraoperative perventricular procedure is a good option for closing apical MVSDs in small children with or without associated cardiac anomalies. We evaluated the results of hybrid perventricular closure of apical MVSDs performed using an Amplatzer duct occluder (ADO). Methods: We retrospectively reviewed the medical records of 5 patients who underwent hybrid perventricular closure of MVSDs with ADOs, from March 2006 to May 2011. The median patient age at the time of the procedure was 12 months (range, 25 days to 25 months), and the median body weight was 9.1 kg (range, 4.3 to 15 kg). Two patients had multiple ventricular septal defects (VSDs; additional perimembranous VSD in 1 patient and multiple MVSDs in the other) and 3 patients had associated cardiac anomalies; complete transposition of the great arteries in 1 patient and an atrial septal defect in 2 patients. All the procedures were performed on beating hearts, exception in 1 case. The ADO selected for the aortic side was at least 1 to 2 mm larger than the largest VSD in the left ventricle side. Results: The procedure was successful in all patients and each device was well positioned. During the median follow-up of 2.4 years, a small residual VSD was noted in 2 patients who had multiple VSDs and no leakage was seen in the other 3 patients. Conclusion: Perventricular closure of MVSD with an ADO is a good option for patients with apical MVSD. However, careful manipulation is important, especially in the case of small infants.

• Clinical and Experimental Reproductive Medicine
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• 제40권4호
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• pp.163-168
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• 2013

Objective: Preimplantation genetic diagnosis (PGD) is an assisted reproductive technique for couples carrying genetic risks. Charcot-Marie-Tooth (CMT) disease is the most common hereditary neuropathy, with a prevalence rate of 1/2,500. In this study, we report on our experience with PGD cycles performed for CMT types 1A and 2F. Methods: Before clinical PGD, we assessed the amplification rate and allele drop-out (ADO) rate of multiplex fluorescent polymerase chain reaction (PCR) followed by fragment analysis or sequencing using single lymphocytes. We performed six cycles of PGD for CMT1A and one cycle for CMT2F. Results: Two duplex and two triplex protocols were developed according to the available markers for each CMT1A couple. Depending on the PCR protocols, the amplification rates and ADO rates ranged from 90.0% to 98.3% and 0.0% to 11.1%, respectively. For CMT2F, the amplification rates and ADO rates were 93.3% and 4.8%, respectively. In case of CMT1A, 60 out of 63 embryos (95.2%) were diagnosed and 13 out of 21 unaffected embryos were transferred in five cycles. Two pregnancies were achieved and three babies were delivered without any complications. In the case of CMT2F, a total of eight embryos were analyzed and diagnosed. Seven embryos were diagnosed as unaffected and four embryos were transferred, resulting in a twin pregnancy. Two healthy babies were delivered. Conclusion: This is the first report of successful pregnancy and delivery after specific PGD for CMT disease in Korea. Our PGD procedure could provide healthy babies to couples with a high risk of transmitting genetic diseases.

• International Journal of Knowledge Content Development & Technology
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• 제14권2호
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• pp.81-97
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• 2024

The study investigated computer literacy skills as a determinant of electronic reference sources utilization among selected secondary school students in Ado-Odo Ota Local Government, Ogun State, Nigeria. Four specific objectives with conforming research questions guided the study. Descriptive survey research design was adopted for the study. The population of the study comprises of SSS3 students of the three selected Community Secondary Schools in Ado Odo Ota. A sample size of 150 was used for the study. The instrument for data collection was a self-developed structured questionnaire. Data collected was analyzed using frequency and percentages. Findings of the study revealed that majority of secondary school students were not aware of the availability of electronic reference sources. It also revealed that the level of their computer literacy skills was below average. Majority of them have never used computer before and the few of them that have used computer before used it in their homes, their friend's homes or in the cyber café. It was found that lack of formal training on the use of electronic reference sources, lack of access to computer, lack of awareness of availability of electronic reference sources, lack of funds for internet subscriptions, over dependency on printed reference sources and lack of motivation to use electronic reference sources were the major hindrances to the use of electronic reference sources among secondary school students. It was recommended that the school librarians and teachers should play a role in creating awareness among secondary school students about the availability of online/ electronic reference sources among others.

• 한국광학회:학술대회논문집
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• 한국광학회 1998년도 제15회 광학 및 양자전자 학술발표회 논문집
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• pp.98-99
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• 1998

In this paper, an acousto-optic defiector9ADO) is used to perform the angular multiplexing without moving parts. The error-correction coding techniques was used to achive low bit-error rates in the experiment. A part of Lena image(64*64) encoded by Reed-Solomon codes were stored and retrieved.

• 한국컴퓨터산업학회논문지
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• 제7권4호
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• pp.421-426
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• 2006

3-Tier 구조는 비즈니스 로직을 공유할 수 있으므로 기존의 코드의 재사용성이 보장되며, 사용자 인터페이스만 담당하는 작고 가벼운 클라이언트 어풀리케이션을 만들 수 있기 때문에 클라이언트의 많은 메모리와 계산능력을 필요로 하지 않는다. 본 논문에서는 데이터베이스, 언어 그리고 ADO(ActiveX Data Object) 엔진을 이용하여 3-Tier 구조의 기술을 접목한 식자재 코드관리, 식자재 소요량 자동산출, 식자재 매입/출하 관리, 식단관리, 결산처리 등을 할 수 있는 케이터링 시스템을 개발한다. 이 시스템은 급식 분야에 생산성을 향상시킬 뿐만 아니라 비용 절감을 얻을 수 있다 급식 서비스 업무 환경에 적합한 시스템으로써 많은 활용이 기대 된다.

• Bulletin of the Korean Chemical Society
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• 제28권4호
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• pp.561-566
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• 2007

Adenosine kinase (AK) is a ubiquitous intracellular enzyme, which catalyzes the phosphorylation of adenosine (ADO) to adenosine monophosphate (AMP). AK inhibitors have therapeutic potential as analgesic and antiinflammatory agents. A chemical feature based pharmacophore model has been generated from known AK inhibitors (26 training set compounds) by HypoGen module implemented in CATALYST software. The top ranked hypothesis (Hypo1) contained four features of two hydrogen-bond acceptors (HBA) and two hydrophobic aromatics (Z). Hypo1 was validated by 124 test set molecules with a correlation coefficient of 0.905 between experimental and estimated activity. It was also validated by CatScramble method. Thus, the Hypo1 was exploited for searching new lead compounds over 238,819 chemical compounds in NCI database and then the selected compounds were screened based on restriction estimated activity and Lipinski's rules to evaluate their drug-like properties. Finally we could obtain 72 new lead candidates and the two best compound structures from them were posted.

• Bulletin of the Korean Chemical Society
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• 제28권6호
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• pp.941-946
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• 2007

Bacillus halodurans O-methyltransferase (BhOMT) is a S-adenosylmethionine (SAM or AdoMet) dependent methyltransferase. Three dimensional structure of the BhOMT bound to S-adenosyl-L-homocysteine (SAH or AdoHcy) has been determined by comparative homology modeling. BhOMT has 40% sequence identity with caffeoyl-CoA 3-O-methyltransferase (CCoAOMT) from alfalfa. Based on x-ray structure of CCoAOMT, three dimensional structure of BhOMT was determined using MODELLER. The substrate binding sites of these two proteins showed slight differences, but these differences were important to characterize the substrate of BhOMT. Automated docking study showed that four flavonoids, quercetin, fisetin, myricetin, and luteolin which have two hydroxyl groups simultaneously at 3'- and 4'-position in the B-ring and structural rigidity of Cring resulting from the double bond characters between C2 and C3, were well docked as ligands of BhOMT. These flavonoids form stable hydrogen bondings with K211, R170, and hydroxyl group at 3'-position in the Bring has stable electrostatic interaction with Ca2+ ion in BhOMT. This study will be helpful to understand the biochemical function of BhOMT as an O-methyltransferase for flavonoids.