• 대한한방소아과학회지
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• 제21권2호
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• pp.169-184
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• 2007

Objetives The late research tendency on atopic dermatitis is mainly focused on the experiment of unbalance of cytokine released from T cell subtype. Merhods As there's no experiment with herbal medicine using Hanghaedan(HHD), we isolated and cultured monocytes of atopic dermatitis pateints (AD) peripheral blood, for knowing the influence of HHD on the secretory function of IL-4, IL-5, $IFN-{\gamma}$. Results 1. In AD group, HHD exhibits statistically significant inhibitory effect on IL-4(p<0.05). 2. In AD group, HHD exhibits statistically significant inhibitory effect on IL-5(p<0.05). 3. In AD group, HHD exhibits statistically significant inhibitory effect on $IFN-{\gamma}$ (p<0.01). 4. Sample group comparing with the cytokine concentration rate value of AD patients and that of NAD patients IL-4 of AD patients exhibits statistically significant decrease(p<0.05). 5. In AD group, there is no significant relation between serum IgE and cytokines. 6. In AD group, there is no significant relation between total eosinophil and IL-5. Conclusions Effects of Hanghaedan on the cytokine(IL-4, IL-5, $IFN-{\gamma}$) secretory function of monocytes of atopic dermatitis patients is recognized.

• Journal of Preventive Medicine and Public Health
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• 제42권3호
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• pp.171-176
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• 2009

Objectives : The frequency of visiting clinics in Jejudo for treating atopic dermatitis (AD) has been reported to be higher than that for other counties of Korea. The aim of this work was to estimate the prevalence of AD for the students of the primary, middle and high schools in Jejudo, Korea. Methods : We planned to evaluate about 5,000 students, so classes were randomly selected by random systematic sampling methods. The parents of all the students in the selected classes were asked to respond to a structured questionnaire concerned with the prevalence of AD. Results : The prevalence of AD based on ever being diagnosed by a doctor, on currently being diagnosed by a doctor, on ever being treated for AD by a doctor, on currently being treated for AD by a doctor was 25.57% (95% CI=25.3-25.8), 14.67% (95% CI=14.5-14.9), 21.90% (95% CI=21.6-22.2) and 14.41% (95% CI=14.2-14.6), respectively. Conclusions : On comparing the prevalence of AD, the students in Jejudo had a higher number of recurrence events in spite of their lower number of cases. Further studies are needed to evaluate these aspects of AD.

• 한국조리학회지
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• 제14권1호
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• pp.107-122
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• 2008

The purpose of this study is to analyze the effects of the presenting type of menu labels(regular/descriptive) and knowledge level(high/low) on the advertisement(Ad) comprehension, attitude toward the Ad, attitude toward the brand, purchase intentions. For that reasons, 157 university students who are majoring in food-service management or culinary arts were conveniently selected as sample for $2{\times}2$ factorial design. A final sample of 153 responses were deemed usable and then two-way ANOVA was used for statistical analysis. The findings are as follows. First, there were significant differences between the presenting types of menu labels and communication effects including the Ad comprehension, attitude toward the Ad, attitude toward the brand, purchase intentions. It can be known that descriptive menu labels showed higher communication effects than regular menu labels. Second, there were significant differences between the knowledge levels and communication effects including the Ad comprehension, attitude toward the Ad, and purchase intention but not in attitude toward the brand. It can be known that consumers with relatively high knowledge levels showed higher the Ad comprehension, attitude toward the Ad, purchase intention than consumers with low knowledge levels. The results of this study can be used as data for more effective menu marketing and basic of further empirical study for effectiveness of menu labels.

• Biomolecules & Therapeutics
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• 제30권3호
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• pp.221-231
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• 2022

Adiponectin (Ad), a 30 kDa molecule, is an anti-diabetic adipokine; although derived from adipose tissue, it performs numerous activities in various other tissues. It binds to its own receptors, namely adiponectin receptor 1(AdipoR1), adiponectin receptor 2 (AdipoR2), and T-cadherin (CDH13). Ad plays several roles, especially as a regulator. It modulates lipid and glucose metabolism and promotes insulin sensitivity. This demonstrates that Ad has a robust correlation with fat metabolism. Furthermore, although Ad is not in direct contact with other tissues, including the skin, it can be delivered to them by diffusion or secretion via the endocrine system. Recently it has been reported that Ad can impact skin cell biology, underscoring its potential as a therapeutic biomarker of skin diseases. In the present review, we have discussed the association between skin cell biology and Ad. To elaborate further, we described the involvement of Ad in the biology of various types of cells in the skin, such as keratinocytes, fibroblasts, melanocytes, and immune cells. Additionally, we postulated that Ad could be employed as a therapeutic target to maintain skin homeostasis.

• 한국물환경학회지
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• 제32권3호
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• pp.297-302
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• 2016

Microbial electrochemical technology (MET) has recently been studied to improve the efficiency of a traditional anaerobic digestion (AD). The purpose of this study was to investigate the impact of MET in the system when MET was combined with traditional AD (i.e., AD-MET). Electrodes used in the MET were Cu coated graphite electrodes. They were supplied with a voltage of 0.3 V. AD started to generate methane in 80 days. But AD-MET started to generate methane from the initial operation after the system started. It was observed that AD-MET reached steady state faster and produced higher methane yield than AD. During the steady state, the average daily methane productions in AD and AD-MET were 2.3L/d and 4.9L/d, respectively. Methane yields were 0.07-CH₄/g‧CODre in AD and 0.25L-CH₄/g‧CODre in AD-MET. In AD-MET, the production rates of total volatile fatty acids (TVFAs) and soluble chemical oxygen demand (SCOD) were 0.12 mg TVFAs/mg VS‧d and 0.35 mg SCOD/mg VS‧d, respectively. They were significantly (p < 0.05) higher than those in AD. However, the concentrations of residual TVFAs in both systems were not significantly (p > 0.05) different from each other, confirming that methane conversion in AD-MET was greater than that in AD.

• 한국대기환경학회지
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• 제23권2호
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• pp.169-182
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• 2007

To evaluate the possibly potent role of Asian Dust (AD) on the long range transport of Hg, statistical analyses were carried out using the hourly concentration data of gaseous elemental mercury (Hg) along with relevant environmental parameters. For the purpose of this study, Hg data were collected from Yang-Jae monitoring station in Seoul, Korea during Sept. 1997 to June 2002. During the study period, Hg concentrations in non-AD period ranged from $0.03\;to\;32.70\;ng\;m^{-3}$ with a mean $5.27{\pm}3.06\;ng\;m^{-3}$, while those in AD period from $1.79\;to\;32.60\;ng\;m^{-3}$ with a mean $5.20{\pm}3.06\;ng\;m^{-3}$. The air quality during AD were typically deteriorated by enhanced PM10 mass concentration (by $2{\sim}5$ times) compared to non-AD period, however comparison of the Hg concentration data indicates that they are not critically distinguished between events of AD and non-AD, except for the high minimum level of Hg during AD. The results of correlation and factor analysis also indicated somewhat complex patterns; in the case of AD events, Hg and $SO_{2}$ were assorted concurrently into a same factor. Evidence collected from this study thus suggests that long-range transport of Hg, if occurring, is unlikely to raise statistically Hg concentration levels such as seen during AD event. However, in nighttime of winter season, Hg concentrations are higher during AD (along with PM10 levels) than non-AD period. Although such observations suggest the effect of long range transport on the enhancement of Hg concentrations, more deliberate analysis may be required to track down the effect of such mechanism in relation with various factors including the air mass transport route.

• Toxicological Research
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• 제32권2호
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• pp.149-158
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• 2016

Atopic dermatitis (AD) is a chronic inflammatory skin disease with a complex etiology that encompasses immunologic responses. AD is frequently associated with elevated immunoglobulin (Ig) E levels, and common environmental factors contribute to its pathogenesis. Several recent studies have documented the role of specific lactic acid bacteria in the treatment and prevention of AD in humans and mice. In this study, the efficacy of Duolac ATP, a probiotic preparation, was determined in a mouse model with AD-like skin lesions. Alterations in the cytokine levels and histological staining suggested the alleviation of AD. The in vivo test showed that T helper (Th)2 cytokines, IgE, interleukin (IL)-4, and IL-5, were significantly downregulated, whereas Th1 cytokines, IL-12p40 and interferon (IFN)-${\gamma}$, were upregulated in all groups of mice treated with Duolac ATP compared to that observed in the group of mice treated with 1-chloro-2,4-dinitrobenzene (DNCB) alone. Moreover, the scratch score decreased in all mice treated with Duolac ATP. Staining of the dorsal area of the mice in each group with hematoxylin and eosin and toluidine blue further confirmed the alleviation of AD in mice orally treated with Duolac ATP. These results suggest that Duolac ATP inhibits the development of AD-like skin lesions in NC/Nga mice by suppressing the Th2 cell response and increasing the Th1 cell response. Thus, Duolac ATP is beneficial and effective for the treatment of AD-like skin lesions.

• 한방안이비인후피부과학회지
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• 제32권2호
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• pp.94-106
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• 2019

Objectives : This study was conducted to investigate the effects of Gwakhyangjeonggi-san(GJS) on atopic dermatitis(AD) induced by 2,4-dinitrochlorobenzene(DNCB) in mice. Methods : The mice(Balb/c mice) were divided into three groups; normal Balb/c mice with oil treatment(Sham group), DNCB-induced AD mice(AD group), and GJS treated AD mice(GJS group). GJS group were orally administered GJS daily for 2 weeks. We observed changes of clinical skin severity score, the expression of thymic stromal lymphopoietin(TSLP), interleukin(IL)-4 and tumor necrosis factor(TNF)-${\alpha}$ in skin and mast cell infiltration. Also, serum immunoglobulinE(IgE), IL-4, $TNF-{\alpha}$ and IL-6 were evaluated. Results : The clinical skin severity score of GJS group was decreased compared to AD group. In hematoxylin and eosin staining results, GJS group showed a significant reduction of epithelial skin thickness. In addition, expression of TSLP and mast cell infiltration in skin were also reduced by GJS treatment compared to those of AD group. Thus, we evaluated expression of IL-4, Th2-dependent cytokine, and $TNF-{\alpha}$, pro-inflammatory cytokine in skin. GJS significantly reduced both IL-4 and $TNF-{\alpha}$ compared to AD mice. Moreover, levels of IgE, IL-4, $TNF-{\alpha}$ and IL-6 in plasma also significantly decreased by oral GJS treatment. Conclusion : The present study suggests that GJS can significantly reduced symptoms of AD, therefore it can be a promising candidate for anti-atopic dermatitis treatment.

• 인터넷정보학회논문지
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• 제2권3호
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• pp.9-17
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• 2001

유선망과 기지국을 가지고 있지 않는 이동 노드들로만 구성된 Ad-Hoc 무선망에서는 잦은 호스트의 이동과 토폴로지 변화에 의해 패킷의 손실이 자주 발생한다. 이러한 환경 하에서 요구되는 Ad-Hoc 라우팅 프로토콜에 초점을 둔 많은 연구에서 인터넷 트래픽 성능 분석에 대한 연구가 미진하다. 따라서, 본 논문에서는 AODV 라우팅 프로토콜을 사용하여 Ad-Hoc 무선망의 트래픽을 모의 실험하였으며, 시뮬레이션 평가 요소인 Ad-Hoc 무선망의 크기, 이동하는 노드의 이동 속도를 변화시켜 인터넷 트래픽인 TCP/Reno와 TCP/Sack 성능을 모의 실험을 통해 분석하였다. 모의 실험 결과 TCP/Reno가 TCP/Sack보다 노드의 이동 속도나 노드 수에 다소 민감하다는 것을 알 수 있었다.

• 한국위성정보통신학회논문지
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• 제9권4호
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• pp.20-25
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• 2014

본 논문에서는 멀티콥터의 원활한 주파수 사용과 에너지 충전을 위하여 효율적인 스펙트럼 센싱기술을 제안한다. 제안된 구조는 Ad-hoc network를 기반으로 한 Spectrum sensing의 성능을 향상시키는데 중점을 둔다. 우선 Cooperative Spectrum sensing, Ad-hoc based Spectrum sensing의 기본원리와 단점을 설명한다. 이러한 점을 보완하여 인지 무선 시스템 기반 ad-hoc 네트워크에서도 신호들의 detection probability를 향상시키기 위하여 2차 사용자의 ad-hoc 단말들에게 보다 높은 1차 사용자의 전송 파워를 실어 주기 위한 beamforming 기법을 이용한다. 실험 결과는 신호검출 성능으로 보여주며, 본 논문의 실험결과는 ad-hoc 기반 인지 무선 시스템에 적용 가능하다.