The Journal of Pediatrics of Korean Medicine (대한한방소아과학회지)

The Association of Korean Oriental Pediatrics (대한한방소아과학회)
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Effects of Hanghaedan on the Cytokine Secretory Function of Monocytes of Atopic Dermatitis Patients

항해단(沆瀣丹)이 아토피 피부염 환자 단핵세포의 Cytokine 분비능에 미치는 영향

  • Lee, Jin-Yong (Department of Oriental Medicine Graduate School of Kyung Hee University) ;
  • Kim, Woo-Yeoun (Department of Oriental Medicine Graduate School of Kyung Hee University)
  • 이진용 (경희대학교 대학원 한의학과 소아과학교실) ;
  • 김우연 (경희대학교 대학원 한의학과 소아과학교실)
  • Published : 2007.08.31
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Abstract

Objetives The late research tendency on atopic dermatitis is mainly focused on the experiment of unbalance of cytokine released from T cell subtype. Merhods As there's no experiment with herbal medicine using Hanghaedan(HHD), we isolated and cultured monocytes of atopic dermatitis pateints (AD) peripheral blood, for knowing the influence of HHD on the secretory function of IL-4, IL-5, $IFN-{\gamma}$. Results 1. In AD group, HHD exhibits statistically significant inhibitory effect on IL-4(p<0.05). 2. In AD group, HHD exhibits statistically significant inhibitory effect on IL-5(p<0.05). 3. In AD group, HHD exhibits statistically significant inhibitory effect on $IFN-{\gamma}$ (p<0.01). 4. Sample group comparing with the cytokine concentration rate value of AD patients and that of NAD patients IL-4 of AD patients exhibits statistically significant decrease(p<0.05). 5. In AD group, there is no significant relation between serum IgE and cytokines. 6. In AD group, there is no significant relation between total eosinophil and IL-5. Conclusions Effects of Hanghaedan on the cytokine(IL-4, IL-5, $IFN-{\gamma}$) secretory function of monocytes of atopic dermatitis patients is recognized.

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