• The Journal of the Korea institute of electronic communication sciences
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• v.15 no.6
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• pp.1011-1016
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• 2020

Rapid change in network topology in high-speed VANET(: Vehicular Ad Hoc Network) is an important task for routing protocol design. Selecting the next hop relay node that affects the performance of the routing protocol is a difficult process. The disadvantages of AODV(: Ad Hoc On-Demand Distance Vector) related to VANET are end-to-end delay and packet loss. This paper proposes the AAODV (Advanced AODV) technique to reduce the number of RREQ (: Route Request) and RREP (: Route Reply) messages by modifying the AODV routing protocol and adding direction parameters and 2-step filtering. It can be seen that the proposed AAODV reduces packet loss and minimizes the effect of direction parameters, thereby increasing packet delivery rate and reducing end-to-end delay.

• Journal of Microbiology and Biotechnology
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• v.33 no.6
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• pp.823-830
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• 2023

Lactococcus lactis is a lactic acid bacterium and used in the dairy food industry. The ameliorating effects of Lactobacillus species on atopic dermatitis (AD) have been extensively studied, but the specific effect of L. lactis strains has not yet been investigated. In this study, the efficacy of L. lactis LB 1022, isolated from natural cheese, was evaluated using RAW 264.7, HMC-1 and HaCaT cell lines and an ovalbumin-sensitized AD mouse model. L. lactis LB 1022 exhibited nitric oxide suppression and anti-allergy and anti-inflammatory activity in vitro. Oral administration of L. lactis LB 1022 to AD mice significantly reduced the levels of IgE, mast cells, and eosinophils, and a range of T cell-mediated T helper Th1, Th2, and Th17-type cytokines under interleukin (IL)-10, transforming growth factor-β (TGF-β), thymus and activation-regulated chemokine (TARC), and thymic stromal lymphopoietin (TSLP). In addition, L. lactis LB 1022 treatment increased the concentration of short-chain fatty acids. Overall, L. lactis LB 1022 significantly modulated AD-like symptoms by altering metabolites and the immune response, illustrating its potential as candidate for use in functional food supplements to alleviate AD.

• IEMEK Journal of Embedded Systems and Applications
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• v.19 no.2
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• pp.107-114
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• 2024

Mobile ad hoc networks represent self-configuring networks of mobile devices that communicate without relying on a fixed infrastructure. However, traditional routing protocols in such networks encounter challenges in selecting efficient and reliable routes due to dynamic nature of these networks caused by unpredictable mobility of nodes. This often results in a failure to meet the low-delay and low-energy consumption requirements crucial for such networks. In order to overcome such challenges, our paper introduces a novel multi-objective and adaptive routing scheme based on the Q-learning reinforcement learning algorithm. The proposed routing scheme dynamically adjusts itself based on measured network states, such as traffic congestion and mobility. The proposed approach utilizes Q-learning to select routes in a decentralized manner, considering factors like energy consumption, load balancing, and the selection of stable links. We present a formulation of the multi-objective optimization problem and discuss adaptive adjustments of the Q-learning parameters to handle the dynamic nature of the network. To speed up the learning process, our scheme incorporates informative shaped rewards, providing additional guidance to the learning agents for better solutions. Implemented on the widely-used AODV routing protocol, our proposed approaches demonstrate better performance in terms of energy efficiency and improved message delivery delay, even in highly dynamic network environments, when compared to the traditional AODV. These findings show the potential of leveraging reinforcement learning for efficient routing in ad hoc networks, making the way for future advancements in the field of mobile ad hoc networking.

• Korean Journal of Veterinary Research
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• v.37 no.4
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• pp.863-873
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• 1997

Electrical stimulation and vitamin $AD_3E$ administration have been shown to enhance the repair of biological tissues such as bone, ligament and tendon, The objective of this study were (a) to investgate the therapeutic effects of different levels of electrical stimulation and vitamin $AD_3E$ administration on fracture healing in a rat model and (b) to identify the most effective voltage level. Ninety Sprague-dawley rats were divided into electrical stimulation group and vitamin $AD_3E$ administration group. Electricla stimulation group was divided into four groups on the basis of the level of current delivered. The experimental groups received current (which varied by group), while the controls, with identical electrodes, received no current. In vitamin $AD_3E$ administration group, experimental group was injected 2,500 IU of vitamin A, 1,250 IU of vitamine $D_3$, 1mg of vitamine E intramuscularly. And in control group 0.1ml of saline was injected intramuscularly. After time periods (7-day, 14-day, 21-day for stimulation all rats were tested with combination of biochemical, roentgenologic and histomorphological methods. The results obtained were as follows ; In electrical stimulation groups, serum calcium and inorganic phosphorus level of experimental and control groups showed non specific change within normal physiological ranges. In vitamin $AD_3E$ administration group, serum calcium level of experimental and control groups showed non specific changes within normal physiological ranges, while experimental group showed slightly higher serum inorganic phosphorus level. According to roentgenologic and histomorphological examination, 2V 25Hz electrical stimulation group and vitamine $AD_3E$ administration group showed statistically significant improvements in bone density and ossification reaction until day 14. The terapeutic effect of stimulation on fracture healing was similiar to that of vitamin $AD_3E$ administration. In this study stimulation of 2V 25Hz was the most effective level of electrical stimulation for the healing of fracture of rats.

• Journal of Microbiology and Biotechnology
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• v.29 no.11
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• pp.1693-1706
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• 2019

Atopic dermatitis (AD) is a chronic inflammatory skin disease of mainly infants and children. Currently, the development of safe and effective treatments for AD is urgently required. The present study was conducted to investigate the immunomodulatory effects of yeast-extracted β-1,3/1,6-glucan and/or Lactobacillus plantarum (L. plantarum) LM1004 against AD-like symptoms. To purpose, β-1,3/1,6-glucan and/or L. plantarum LM1004 were orally administered to AD-induced animal models of rat (histamine-induced vasodilation) and mouse (pruritus and contact dermatitis) exhibiting different symptoms of AD. We then investigated the treatment effects on AD-like symptoms, gene expression of immune-related factors, and gut microbiomes. Oral administration of β-1,3/1,6-glucan (0.01 g/kg initial body weight) and/or 2 × 10¹² cells/g L. plantarum LM1004 (0.01 g/kg initial body weight) to AD-induced animal models showed significantly reduced vasodilation in the rat model, and pruritus, edema, and serum histamine in the mouse models (p < 0.05). Interestingly, β-1,3/1,6-glucan and/or L. plantarum LM1004 significantly decreased the mRNA levels of Th2 and Th17 cell transcription factors, while the transcription factors of Th1 and Treg cells, galactin-9, filaggrin increased, which are indicative of enhanced immunomodulation (p < 0.05). Moreover, in rats with no AD induction, the same treatments significantly increased the relative abundance of phylum Bacteroidetes and the genus Bacteroides. Furthermore, bacterial taxa associated with butyrate production such as, Lachnospiraceae and Ruminococcaceae at family, and Roseburia at genus level were increased in the treated groups. These findings suggest that the dietary supplementation of β-1,3/1,6-glucan and/or L. plantarum LM1004 has a great potential for treatment of AD as well as obesity in humans through mechanisms that might involve modulation of host immune systems and gut microbiota.

• Textile Coloration and Finishing
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• v.24 no.3
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• pp.189-195
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• 2012

The purpose of this study was to investigate the possibility of bamboo extract as natural dye having the effect on atopic dermatitis(AD). To investigate the effect of bamboo extract on AD in vivo, we applied bamboo extract to the AD-like skin lesion the backs of atopic of NC/Nga mice, an animal model of AD. NC/Nga mice were challenged with DNCB(2.4-Dinitrochlorbenzene) to develope AD-like skin lesions. The efficacy of bamboo extract in the NC/Nga mice was evaluated by measurement of the skin lesion severity(NC mouse score), the serum IgE level, epidermal thickness changes, and mast cell number. Bamboo extracts improved skin lesions in NC/Nga mice. The serum IgE levels were decreased after treatment with bamboo extract. Histological examinations revealed a decrease in epidermal thickness and mast cell number after treatment with bamboo extract. To conclude, the topical application of bamboo extract suppressed the progression of AD-like skin lesions.

• 한국신재생에너지학회:학술대회논문집
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• 2008.05a
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• pp.202-205
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• 2008

Anaerobic digestion(AD) is the most promising method of treating and recycling of different organic wastes, such as OFMSW, household wastes, animal manure, agro-industrial wastes, industrial organic wastes and sewage sludge. During AD, i.e. degradation in the absence of oxygen, organic material is decomposed by anaerobes forming degestates such as an excellent fertilizer and biogas, a mixture of carbon dioxide and methane. AD has been one of the leading technologies that can make a large contribution to producing renewable energy and to reducing $CO_2$ and other GHG emission, it is becoming a key method for both waste treatment and recovery of a renewable fuel and other valuable co-products. A classification of the basic AD technologies for the production of biogas can be made according to the dry matter of biowaste and digestion temperature, which divide the AD process in wet and dry, mesophilic and thermophilic. The biogas produced from AD plant can be utilized as an alternative energy source, for lighting and cooking in case of small-scale, for CHP and vehicle fuel or fuel in industrials in case of large-scale. This paper provides an overview of the status of biogas production and utilization technologies.

• Biomolecules & Therapeutics
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• v.28 no.2
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• pp.131-136
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• 2020

Hippocampal synaptic dysfunction is a hallmark of Alzheimer's disease (AD). Many agents regulating hippocampal synaptic plasticity show an ameliorative effect on AD pathology, making them potential candidates for AD therapy. In the present study, we investigated spinosin as a regulating agent of synaptic plasticity in AD. Spinosin attenuated amyloid β (Aβ)-induced long-term potentiation (LTP) impairment, and improved plasmin activity and protein level in the hippocampi of 5XFAD mice, a transgenic AD mouse model. Moreover, the effect of spinosin on hippocampal LTP in 5XFAD mice was prevented by 6-aminocaproic acid, a plasmin inhibitor. These results suggest that spinosin improves synaptic function in the AD hippocampus by regulating plasmin activity.

• Journal of Advanced Navigation Technology
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• v.12 no.3
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• pp.233-238
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• 2008

Recently, network component become to follow wireless and mobile network from wired network proposed that many TCP algorithm optimized in variety environment. When TCP was created, however as it was design based on wired link, wireless link made more transmission error than wired link. Transmission errors are more frequent and may be incorrectly regarded as indications of network congestion. In this paper, it conduct how effect congestion control algorithm in Mobile ad-hoc network and compare traffic of TCP-Tahoe, TCP-Reno, TCP-New-Reno and TCP-Vegas in Mobile ad-hoc environment.

• Tunnel and Underground Space
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• v.13 no.4
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• pp.260-269
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• 2003

In order to introduce to engineers the suitable calculation techniques of TBM advance rate (ad.) and ultimately promote to understand the designing process, this study was carried out. We analyzed the 17 bored data of TBM which applied to the roadway and water supply tunnels in Korea. From this analysis, it was able to how that the average utilization is 30.83% md the correlation equation of Ad and TBM´s diameter (D) is Ad(m/month) = 506.05ㆍ $e^{-0.1162}$$\times$D than the correlation coefficient ($R^2$) is 0.76. In the object of the W tunnel of Seoul-Busan highspeed railway, the Ad of TBM 5.0mø was analyzed by the variety of empirical models and upper correlation equation. Average Ad of the empirical models was calculated to be larger than one of the upper equations. But considering only the results of 3.0~5.0mø TBM in the 17 bored data, the average Ad by the models belongs to the similar range of bored data. Therefore, when the reliability and representative of parameters are decreased, a reliability test should be carried out through the comparison a variety of empirical models with the upper correlation equation.