• Journal of The Geomorphological Association of Korea
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• v.26 no.4
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• pp.81-96
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• 2019

The Yeongdeok 53m marine terrace (Y₅₃mT), Y₄₃mT, Y₃₃mT, Y₂₄mT, Y₁₉mT and Y₁₁mT distributed along the Yeongdeok coast, southeastern Korean Peninsula are well compared with the thalassostatic terraces of the high terrace 1 (ℓHT₁ ; 51m of the relative heights from the river floor), high terrace 2 (ℓHT₂ ; 43m), middle terrace 1 (ℓMT₁ ; 32m), middle terrace 2 (ℓMT₂ ; 25m), lower terrace 1 (ℓLT₁ ; 18m) and lower terrace 2 (ℓLT₂ ; 10m) respectively, developed along the lower reaches of the Chucksan-cheon and Obo-cheon rivers, judging from the comparison of paleosols (red soils) between the above marine and thalassostatic terraces. Using the Y₁₉mT of the MIS 5e as the key surface, we propose that the terraces of the Y₅₃mT and ℓHT₁, Y₄₃mT and ℓHT₂, T₃₃mT and ℓMT₁, Y₂₄mT and ℓMT₂, Y₁₉mT and ℓLT₁, and Y₁₁mT and ℓLT₂ have been formed at the MIS 11, 9, 7e and 7a (or 7a), 5e and 5a respectively. The red soils have been developed at the Y₁₉mT and ℓLT₁ and above them, but not on the Y₁₁mT and ℓLT₂ surfaces.

• Journal of the Korean Mathematical Society
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• v.53 no.1
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• pp.73-88
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• 2016

We consider ${\mathcal{T}}_{\infty}(F)$ - the space of all innite upper triangular matrices over a eld F. We give a description of all linear maps that satisfy the property: if rank(x) = 1, then $rank({\phi}(x))=1$ for all $x{\in}{\mathcal{T}}_{\infty}(F)$. Moreover, we characterize all injective linear maps on ${\mathcal{T}}_{\infty}(F)$ such that if rank(x) = k, then $rank({\phi}(x))=k$.

• Asian Pacific Journal of Cancer Prevention
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• v.17 no.11
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• pp.4907-4911
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• 2016

Glioblastoma multiforme (GBM) is the most aggressive of the gliomas, a collection of tumors arising from glia in the central nervous system. Possible associations between the human cytomegalovirus (HCMV) and the JC virus with GBM are now attracting interest. Our present aim was to investigate the prevalence of the two viruses in Iranian patients from Kerman's cities in the south of Iran. In addition, the expression rates of pp65, large T antigen and p53 proteins were assessed and their relation with GBM evaluated using reverse transcription real time PCR (rReal Time PCR). A total of 199 patients with GBM cancer were enrolled, with $mean{\pm}SD$ ages of $50.0{\pm}19.5$ and $50.7{\pm}19.6$ years for males and females, respectively. The P53 rate was dramatically low suggesting an aetiological role,. Large T antigen expression was found in JC positive samples, while the PP65 antigen was observed in patients positive for CMV and JC. HCMV products and JC virus with oncogenic potential may induce the development of various tumors including glioblastomas. The JC virus produces an early gene product, T-antigen, which has the ability to associate with and functionally inactivate well-studied tumor suppressor proteins including p53 and pRB.

• Archives of Pharmacal Research
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• v.27 no.8
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• pp.850-856
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• 2004

Intraneuronal deposition containing $\alpha$-synuclein is implicated in the pathogenesis of synuclein-opathies including Parkinsons disease (PD). Although it has been demonstrated that cytoplas-mic inclusions of wild type $\alpha$-synuclein are observed in the brain of PD patients and that $\alpha$-synuclein mutations such as A30P and A53T accelerate aggregate formation, the exact mech-anism by which $\alpha$-synuclein forms insoluble aggregates is still controversial. In the present study, to understand the possible involvement of tissue transglutaminase (tTG) in aggregate formation of $\alpha$-synuclein, SH-SY5Y cell lines stably expressing wild type or mutant (A30P or A53T) $\alpha$-synuclein were created and aggregate formation of $\alpha$-synuclein was observed upon activation of tTG. The data demonstrated that $\alpha$-synuclein negligibly interacted with tTG and that activation of tTG did not result in the aggregate formation of $\alpha$-synuclein in SH-SY5Y cells overexpressing either wild type or mutant $\alpha$-synuclein. In addition, $\alpha$-synuclein was not modi-fied by activated tTG in situ. These data suggest that tTG is unlikely to be a contributing factor to the formation of aggregates of $\alpha$-synuclein in a stable cell model.

• Natural Product Sciences
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• v.13 no.2
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• pp.123-127
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• 2007

We investigated effect of small black soybean fraction (SBSF) T cell-mediated responses for tumor surveillance and proliferation in leukemia cells in vitro. Each SBSF butanol fraction (SBSFBu) and SBSF chloroform fraction (SBSFCh) was administered p.o. once a day far 21 days in BALB/c mice and then levels of serum cytokines and subpopulation of lymphocytes were measured. Moreover, SBSF fraction was treated into the cultured various cell lines for proliferation in leukemia cell lines, NO production by RAW264.7 cells, and expression of p53 gene in U937 leukemia cells. These results showed that SBSFBu increased levels of serum IL-4but not IL-2 and IFN-${\gamma}$, and increased expression of CD4$^+$ T cells and CD8$^+$ T cells in splenocytes in vivo, while SBSFCh increased levels of serum IL-2 and IFN-${\gamma}$ but decreased IL-4, and increased CD8$^+$ T cells but not CD4$^+$ T cells. Moreover, both of SBSFBu and SBSFCh inhibited proliferation of HL60, U937, and L1210 leukemia cell lines in a dose-dependent manner, up-regulated NO production by RAW264.7 cells in a dose-dependent manner, and enhanced expression of p53 gene in U937 leukemia cells. Our findings indicate that SBSFBu and SBSFCh may enhance T cell-dependent immune responses, and that both of SBSFBu and SBSFCh may inhibit proliferation of leukemia cells by up-regulation of NO production and expression of p53 gene.

• Journal of Korea Society of Digital Industry and Information Management
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• v.10 no.3
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• pp.297-310
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• 2014

The objective of this research is to evaluate the web standard as well as web compatibility of English homepage of tourist information manage local government. Thru this research, effective information and service can be provided to increasing foreign visitors and compatibility of English homepage can be strengthened. SortSite, a web compatibility measurement tool and UNICORN, a web standard measurement tool were utilized for this research. Chrome, Internet Explorer, Firefox, Safari and Opera were targeted for evaluating web compatibility and observance rate of Markup grammar and CSS grammar was checked for evaluating web standard. Research result showed that 46.7% of Chrome version ${\leq}34$ and 35 didn't observe the web compatibility while 95.6%, 53.3%, 53.3%, 53.3% and 55.6% of Internet Explorer version in order of 7.0, 8.0, 9.0, 10.0 and 11.0 didn't observe the web compatibility. Concerning Firefox, 75.6% and 48.9% of version in order of ${\leq}6.0$ and 7.0 didn't observe the web compatibility and 37.8% of Opera version ${\leq}12.17$ and ${\leq}21$ didn't observe the web compatibility. Regarding the web standard, 80% of English homepage didn't observe Markup grammar and 60% of them didn't observe CSS grammar. Therefore, urgent improvement of web compatibility and web standard is required.

• Elastomers and Composites
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• v.53 no.2
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• pp.52-56
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• 2018

The present study examines the transformation of dynamic DSC data into the equivalent isothermal data for the formation kinetics of a polyurethane elastomer. The reaction of 2'-dichloro-4,4'-methylenedianiline (MOCA) with a PTMG/TDI-based isocyanate prepolymer was evaluated. DSC measurement was performed in the dynamic scanning mode with several different heating rates to obtain the reaction thermograms. Then, the data was transformed into the isothermal data through a procedure based on Ozawa analysis. The main feature of this procedure was the transformation of $({\alpha}-T)_{\beta}$ curves from dynamic DSC into $({\alpha}-t)_T$ curves using the isoconversional $(t-T)_{\alpha}$ diagram. Validity was discussed for the relationship between the dynamic DSC data and the transformed isothermal results.

• The Korean Journal of Physiology and Pharmacology
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• v.24 no.3
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• pp.203-212
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• 2020

Promyelocytic leukemia (PML) gene, through alternative splicing of its C-terminal region, generates several PML isoforms that interact with specific partners and perform distinct functions. The PML protein is a tumor suppressor that plays an important role by interacting with various proteins. Herein, we investigated the effect of the PML isoforms on oncostatin M (OSM)-induced signal transducer and activator of transcription-3 (STAT-3) transcriptional activity. PML influenced OSM-induced STAT-3 activity in a cell type-specific manner, which was dependent on the p53 status of the cells but regardless of PML isoform. Interestingly, overexpression of PML exerted opposite effects on OSM-induced STAT-3 activity in p53 wild-type and mutant cells. Specifically, overexpression of PML in the cell lines bearing wild-type p53 (NIH3T3 and U87-MG cells) decreased OSM-induced STAT-3 transcriptional activity, whereas overexpression of PML increased OSM-induced STAT-3 transcriptional activity in mutant p53-bearing cell lines (HEK293T and U251-MG cells). When wild-type p53 cells were co-transfected with PML-IV and R273H-p53 mutant, OSM-mediated STAT-3 transcriptional activity was significantly enhanced, compared to that of cells which were transfected with PML-IV alone; however, when cells bearing mutant p53 were co-transfected with PML-IV and wild-type p53, OSM-induced STAT-3 transcriptional activity was significantly decreased, compared to that of transfected cells with PML-IV alone. In conclusion, PML acts together with wild-type or mutant p53 and influences OSM-mediated STAT-3 activity in a negative or positive manner, resulting in the aberrant activation of STAT-3 in cancer cells bearing mutant p53 probably might occur through the interaction of mutant p53 with PML.

• Bulletin of the Korean Mathematical Society
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• v.53 no.2
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• pp.365-371
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• 2016

Let f be a transcendental meromorphic function in the complex plane $\mathbb{C}$, and a be a nonzero constant. We give a quantitative estimate of the characteristic function T(r, f) in terms of $N(r,1/(f^2(f^{\prime})^n-a))$, which states as following inequality, for positive integers $n{\geq}2$, $$T(r,f){\leq}\(3+{\frac{6}{n-1}}\)N\(r,{\frac{1}{af^2(f^{\prime})^n-1}}\)+S(r,f)$$.

• Clinical and Experimental Pediatrics
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• v.53 no.2
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• pp.136-145
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• 2010

Natural killer T (NKT) cell is a special type of T lymphocytes that has both receptor of natural killer (NK) cell (NK1.1, CD161c) and T cell (TCR) and express a conserved or invariant T cell receptor called $V{\alpha}14J{\alpha}18$ in mice or Va24 in humans. Invariant NKT (iNKT) cell recognizes lipid antigen presented by CD1d molecules. Marine-sponge-derived glycolipid, ${\alpha}-galactosylceremide$ (${\alpha}-GalCer$), binds CD1d at the cell surface of antigen-presenting cells and is presented to iNKT cells. Within hours, iNKT cells become activated and start to secrete Interleukin-4 and $interferon-{\gamma}$. NKT cell prevents autoimmune diseases, such as type 1 diabetes, experimental allergic encephalomyelitis, systemic lupus erythematous, inflammatory colitis, and Graves' thyroiditis, by activation with ${\alpha}-GalCer$. In addition, NKT cell is associated with infectious diseases by mycobacteria, leshmania, and virus. Moreover NKT cell is associated with asthma, especially CD4+ iNKT cells. In this review, I will discuss the characteristics of NKT cell and the association with inflammatory diseases, especially asthma.