• 대기
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• 제29권3호
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• pp.241-255
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• 2019

Bias correction (BC) and quality control (QC) are essential steps for the proper use of satellite observations in data assimilation (DA) system. BC should be calculated over quality controlled observation. And also QC should be performed for bias corrected observation. In the Korea Institute of Atmospheric Prediction Systems (KIAPS) Package for Observation Processing (KPOP), we adopted an adaptive BC method that calculates the BC coefficients with background at the analysis time rather than using static BC coefficients. In this study, we have developed an iterative QC-BC method for Advanced Microwave Sounding Unit-A (AMSU-A) to reduce the negative feedback from the interaction between BC and QC. The new iterative QC-BC is evaluated in the KIAPS 3-dimensional variational (3DVAR) DA cycle for January 2016. The iterative QC-BC method for AMSU-A shows globally significant benefits for error reduction of the temperature. The positive impacts for the temperature were predominant at latitudes of $30^{\circ}{\sim}90^{\circ}$ of both hemispheres. Moreover, the background warm bias across the troposphere is decreased. Even though AMSU-A is mainly designed for atmospheric temperature sounding, the improvement of AMSU-A pre-processing module has a positive impact on the wind component over latitudes of $30^{\circ}S$ near upper-troposphere, respectively. Consequently, the 3-day-forecast-accuracy is improved about 1% for temperature and zonal wind in the troposphere.

• 한국육종학회지
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• 제43권5호
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• pp.360-367
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• 2011

Beta-carotene producing transformants were produced in the background of 'Nagdongbyeo', a Japonica rice cultivar. Introgression of the carotenoid locus in the transformant, PAC4-2 into the elite cultivar 'Ilpumbyeo' was started. To initiate a backcrossing program, we surveyed 220 SSR markers and found that 38% of them were polymorphic between 'Ilpumbyeo' as a recurrent parent and the PAC4-2 as a recipient parent. The selection strategy comprising foreground and background selection was employed. First, foreground selection was practiced in $BC_1$, $BC_2$, and $BC_3$ generations using the transgene specific PCR-based marker in addition to visual scoring of the seed color. Marker-based background selection combined with phenotypic selection was employed from $BC_3F_2$ to $BC_3F_4$ generations. Blast search indicated that the transgene PAC4-2 was located between SSR markers, RM6 and RM482. 240 $BC_3F_3$ and 63 $BC_3F_4$ lines were evaluated for four agronomic traits including days to heading. Most of the lines were similar to Ilpumbyeo in agronomic traits evaluated. The percentage of PAC4-2 genome ranged from 4% to 21% with a mean of 12.5%, which was higher than the expected for an unselected $BC_3$ backcross population. This could be explained by the fact that two genes for beta-carotene and the stripe virus resistance were targeted in this study. We selected 10 representative $BC_3F_5$ lines from 63 $BC_3F_4$ lines based on agronomic traits and carotenoids content. The selection strategy would be appropriate for the introgression of beta-carotene gene in a breeding program.

• 한국산업보건학회지
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• 제27권4호
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• pp.313-323
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• 2017

Objectives: This study aimed to assess exposure to black carbon(BC) among forklift operators and to identify environmental and occupational factors influencing their BC exposure. Methods: We studied a total of 23 forklift operators from six workplaces manufacturing paper boxes. A daily BC exposure assessment was conducted during working hours from January to April 2017. A micro-aethalometer was used to monitor daily BC exposure, and information on work activities was also obtained through a time-activity diary(TAD) and interviews. BC exposure records were classified into four categories influencing BC exposure level: working environment, workplace, forklift operation, and job characteristics. Analysis of variance(ANOVA) was used to compare average BC exposure levels among the four categories and the relationships between potential factors and BC exposure were analyzed using a multiple linear regression model. Results: The operators' daily exposure was $12.9{\mu}g/m^3$(N=9,148, $GM=7.5{\mu}g/m^3$) with a range: $0.001-811.4{\mu}g/m^3$. The operators were exposed to significantly higher levels when they operate a forklift in a room ${\leq}20,000m^3$($AM=12.3{\mu}g/m^3$), in indoor workplaces($AM=16.3{\mu}g/m^3$), when they operate a forklift manufactured before 2006 ($AM=13.2{\mu}g/m^3$), a forklift with a loading limit of four-tons($AM=27.1{\mu}g/m^3$), with a roll and bale type clamp($AM=17.1{\mu}g/m^3$), and with no particulate filter($AM=15.7{\mu}g/m^3$). Conclusions: Occupational factors including temperature, smoking, season, daytime, room volume($m^3$), location of operating, and manufacturing era and model of forklift influenced the BC exposure of forklift operators. The results of this study can be used to minimize the BC exposure of forklift operators.

• 미생물학회지
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• 제42권1호
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• pp.67-72
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• 2006

클로닝된 Bacillus circulans ATCC21367 유래 cellulolytic xylanase 유전자(bglBC2)의 염기서열을 결정 분석하였다. 본 유전자는 1,224 bp의 407개 아미노산을 암호하는 open reading frame (ORF)으로 구성되어 있었으며 염기서열로부터 산출된 유전자의 분자량은 45 kDa으로 효소의 SDS-PAGE로부터 측정된 분자량과 일치하였다. ATG 개시 코돈의 9bp 위쪽에 Shine-Dalgarno (SD) 서열로 추정되는 5'-AAAGGAG-3' 서열이 확인되었고 그 상단에 promoter로 추정되는 -35 서열(TTTACA)과 -10 서열(TATACT)이 위치하고 있었으며, 이는 B. subtilis promoter consensus sequence와 유사하였다. 한편, 이 효소의 아미노산 서열은 이미 보고된 B. circulans KSM-N257의 alkaline $endo-\beta-1,4-glucanase$와는 97%, B. circulans WL-12의 $endo-\beta-1,3-1,4-glucanase$와는 75%, Bacillus sp. KSM-330의 $endo-\beta-1,4-glucanase$ (cellulase)와는 45%의 유사성을 나타내었다. 또한 bglBCS 염기서 열의 정보를 GenBank에 등록하였으며 등록번호는 Ar269256이다.

• 한국미생물·생명공학회지
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• 제46권2호
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• pp.120-126
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• 2018

환경친화적으로 항균성이 부여된 상처치료용 BC 드레싱을 개발하기 위한 기초연구로서, 은 이온에 대해 내성이 있으면서 은 나노입자를 생합성할 수 있는 초산균을 분리 및 동정하였다. 나아가 실험균주에 의한 BC 생산 조건을 조사하였다. 부패된 포도껍질로부터 분리된 G7 균주는 0.1 mM $AgNO_3$ 존재 하에서 생육할 수 있었으며, 16S rRNA 유전자의 염기서열 분석에 의거하여 Acetobacter intermdius로 동정되었다. 탄소원으로 2% glucose, 질소원으로 2% yeast extract, 보조탄소원으로 0.115% acetic acid가 함유된 배지에서 BC 생산량이 최대였다. 최적배지에서 생성된 BC의 구조적 특성을 FT-IR 및 XRD를 사용하여 조사한 결과, 생성된 BC는 전형적인 천연 cellulose와 동일한 cellulose I인 것으로 확인되었다. G7 균주를 0.1 mM $AgNO_3$ 가 함유된 최적 배지에서 배양한 결과, 배양액의 색깔이 적갈색으로 변하였으며, 이것은 은 나노입자가 생성되었음을 의미한다. 은 나노입자의 합성유무를 UV-Vis 스펙트럼 분석에 의하여 확인한 바, 425 nm에서 은 나노입자의 고유한 흡수스펙트럼이 관찰되었다. 또한, 생성된 BC를 주사전자현미경으로 관찰한 결과, 표면과 기공에 은 나노입자가 생성되어 있음을 재확인하였다.

• 한국생물공학회:학술대회논문집
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• 한국생물공학회 2002년도 생물공학의 동향 (X)
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• pp.465-468
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• 2002

부패한 사과로부터 bacterial cellulose (BC)를 생산할 수 있는 균주를 분리한 후 배양조건에 따른 BC의 생산량을 조사한 결과 BC의 생산량은 진탕배양한 경우가 정치배양한 경우보다 약 1.5배 높았다. BC의 생산량을 높이고자 mutagen으로 UV와 cylcloheximide를 사용함으로써 BC 생산량을 약 3배 증가시킬 수 있었다.. 미생물에 의해 생성된 BC는 종이나 펄프와는 달리 pectin, 납, 유지, 단백질, 무기질 등의 불순물을 함유하지 않는 filter paper와 성질이 유사한 것으로 나타났다.

• Asian Pacific Journal of Cancer Prevention
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• 제13권1호
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• pp.139-146
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• 2012

Obese postmenopausal women increase their risk of developing breast cancer (BC), in particular if they display an android-type pattern of adiposity, which is also associated to increased risks of diabetes mellitus, hypertension and cardiovascular disease. In order to explore the associations among anthropometry (body mass index, body composition, somatotype), some specific items of medical history (diabetes, hypertension, dislypidemias, hyperuricemia) and the risk of BC in Uruguayan women, a case-control study was carried out between 2004-2009 at our Oncology Unit. 912 women of ages between 23-69 years (367 new BC cases and 545 non hospitalized, age-matched controls with a normal mammography) were interviewed. Twenty body measurements were taken in order to calculate body composition and somatotype. Patients were queried on socio-demographics, reproductive history, family history of cancer, a brief food frequency questionnaire and on personal history of diabetes, dislypidemias, hyperuricemia, hypertension and gallbladder stones. Uni- and multivariate analyses were done, generating odds ratios (ORs) as an expression of relative risks. A personal history of diabetes was positively associated to BC risk (OR=1.64, 95% CI 1.00-2.69), being higher among postmenopausal women (OR=1.92, 95% CI 1.04-3.52). The risks of BC for diabetes in postmenopausal women with overweight combined with dislypidemia (OR=9.33, 95% CI 2.10-41.5) and high fat/muscle ratio (OR=7.81, 95% CI 2.01-30.3) were significantly high. As a conclusion, a personal history of diabetes and overweight was strongly associated to BC. The studied sample had a subset of high-risk of BC featured by postmenopausal overweight and diabetic women, who also had a personal history of hypertension and/or dyslipidemia. The present results could contribute to define new high risk groups and individuals for primary as well as for secondary prevention, since this pattern linked to the metabolic syndrome is usually not considered for BC prevention.

• Asian Pacific Journal of Cancer Prevention
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• 제17권sup3호
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• pp.81-85
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• 2016

Globally, the burden of breast cancer (BC) continues to increase. BC related lymphedema (BCRL) is currently non curable and as a life time risk it affects at least 25% of BC patients. Knowing more about BCRL and appropriate control of its modifiable risk factors can improve quality of life (QOL) of the affected patients. In this case control study to detect factors, 400 women with BCRL (as the case group) and 283 patients with BC without lymphedema (as the control group) that were referred to Shiraz University of Medical Sciences affiliated BC clinic center were assessed. The data were analyzed in SPSS. The mean age of the case group was $52.3{\pm}11.0years$ and of the control group was $50.1{\pm}10.9years$. In patients with BCRL, 203(50.7%) had left (Lt) side BC and in non- lymphedema group 151 (53.3%) had Lt side BC. Out of all BCRL patients, 204 (51%) had lymphedema in all parts of their affected upper extremities, 100 (25%) had swelling in the arm and forearm and 23 (5.7%) had edema in both the upper extremity and trunk. Edema, heaviness, concern about changing body image, pain and paresthesia were the most common signs/symptoms among patients with BCRL. In BCRL patients, the difference of circumference between the affected upper limb and non-affected limb was $4.4{\pm}2.5cm$ and the difference in volume displacement was $528.7{\pm}374.4milliliters$. Multiple variable analysis showed that moderate to severe activity (OR; odds ratio =14, 95% CI :2.6-73.3), invasiveness of BC (OR =13.7, 95% CI :7.3-25.6), modified radical mastectomy (OR=4.3, 95% CI :2.3-7.9), BMI =>25 (OR=4.2, 95% CI :2-8.7), radiotherapy (OR=3.9, 95% CI :1.8-8.2), past history of limb damage (OR=1.7, 95% CI :0.9-3.1) and the number of excised lymph nodes (OR=1.06, 95% CI :1.02-1.09) were the significant predictors of lymphedema in women with BC. Modifiable risk factors of BCRL such as non-guided moderate to severe physical activity, high BMI and trauma to the limb should be controlled as early as possible in BC patients to prevent development of BCRL and improve QOL of these patients.

• ETRI Journal
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• 제34권4호
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• pp.518-526
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• 2012

This paper proposes LC voltage-controlled oscillator (VCO) phase-locked loop (PLL) and ring-VCO PLL topologies with low-phase noise. Differential control loops are used for the PLL locking through a symmetrical transformer-resonator or bilaterally controlled varactor pair. A differential compensation mechanism suppresses out-band spurious tones. The prototypes of the proposed PLL are implemented in a CMOS 65-nm or 45-nm process. The measured results of the LC-VCO PLL show operation frequencies of 3.5 GHz to 5.6 GHz, a phase noise of -118 dBc/Hz at a 1 MHz offset, and a spur rejection of 66 dBc, while dissipating 3.2 mA at a 1 V supply. The ring-VCO PLL shows a phase noise of -95 dBc/Hz at a 1 MHz offset, operation frequencies of 1.2 GHz to 2.04 GHz, and a spur rejection of 59 dBc, while dissipating 5.4 mA at a 1.1 V supply.

• 한국대기환경학회지
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• 제34권5호
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• pp.727-734
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• 2018

In this study, real-time absorption coefficients of carbonaceous species in $PM_{2.5}$ was observed using a dual-spot 7-wavelength Aethalometer between November 1, 2016 and December 31, 2017 at an urban site of Gwangju. In addition, 24-hr integrated $PM_{2.5}$ samples were simultaneously collected at the same site and analyzed for organic carbon and elemental carbon (OC and EC) using the thermal-optical transmittance protocol. A main objective of this study was to estimate mass absorption cross section (MAC) values of black carbon (BC) particles at the study site using the linear regression between aethalometer-based absorption coefficient and filter-based EC concentration. BC particles observed at 880 nm is mainly emitted from combustion of fossil fuels, and their concentration is typically reported as equivalent BC concentration (eBC). eBC concentration calculated using MAC value of $7.77m^2/g$ at wavelength of 880 nm, which was proposed by a manufacturer, ranged from 0.3 to $7.4{\mu}g/m^3$ with an average value of $1.9{\pm}1.2{\mu}g/m^3$, accounting for 7.3% (1.5~20.9%) of $PM_{2.5}$. The relationship between aerosol absorption coefficients at 880 nm and EC concentrations provided BC MAC value of $15.2m^2/g$, ranging from 11.4 to $16.2m^2/g$. The eBC concentrations calculated using the estimated MAC of $15.2m^2/g$ were significantly lower than those reported originally from aethalometer, and ranged from 0.2 to $3.8{\mu}g/m^3$, with an average of $1.0{\pm}0.6{\mu}g/m^3$, accounting for 3.7% of $PM_{2.5}$ (0.8~10.7%). Result from this study suggests that if the MAC value recommended by the manufacturer is applied to calculate the equivalent BC concentration and radiative forcing due to BC absorption, they would result in significant errors, implying investigation of an unique MAC value of BC particles at a study site.