• Title/Summary/Keyword: A/H1N1

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Identification of Reassortant Pandemic H1N1 Influenza Virus in Korean Pigs

  • Han, Jae-Yeon;Park, Sung-Jun;Kim, Hye-Kwon;Rho, Se-Mi;Nguyen, Giap Van;Song, Dae-Sub;Kang, Bo-Kyu;Moon, Hyung-Jun;Yeom, Min-Joo;Park, Bong-Kyun
    • Journal of Microbiology and Biotechnology
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    • v.22 no.5
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    • pp.699-707
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    • 2012
  • Since the 2009 pandemic human H1N1 influenza A virus emerged in April 2009, novel reassortant strains have been identified throughout the world. This paper describes the detection and isolation of reassortant strains associated with human pandemic influenza H1N1 and swine influenza H1N2 (SIV) viruses in swine populations in South Korea. Two influenza H1N2 reassortants were detected, and subtyped by PCR. The strains were isolated using Madin-Darby canine kidney (MDCK) cells, and genetically characterized by phylogenetic analysis for genetic diversity. They consisted of human, avian, and swine virus genes that were originated from the 2009 pandemic H1N1 virus and a neuraminidase (NA) gene from H1N2 SIV previously isolated in North America. This identification of reassortment events in swine farms raises concern that reassortant strains may continuously circulate within swine populations, calling for the further study and surveillance of pandemic H1N1 among swine.

BLOCK THNSOR PRODUCT

  • Lee, Sa-Ge
    • Communications of the Korean Mathematical Society
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    • v.10 no.1
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    • pp.109-113
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    • 1995
  • For a Hilbert space H, let L(H) denote the algebra of all bounded operators on H. For an $n \in N$, it is well known that any element $T \in L(\oplus^n H)$ is expressed as an $n \times n$ matrix each of whose entries lies in L(H) so that T is written as $$ (1) T = (T_{ij}), i, j = 1, 2, ..., n, T_{ij} \in L(H), $$ where $\oplus^n H$ is the direct sum Hilbert space of n copies of H.

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ON UNBOUNDED SUBNOMAL OPERATORS

  • Jin, Kyung-Hee
    • Bulletin of the Korean Mathematical Society
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    • v.30 no.1
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    • pp.65-70
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    • 1993
  • In this paper we will extend some notions of bounded linear operators to some unbounded linear operators. Let H be a complex separable Hilbert space and let B(H) denote the algebra of bounded linear operators. A closed densely defind linear operator S in H, with domain domS, is called subnormal if there is a Hilbert space K containing H and a normal operator N in K(i.e., $N^{*}$N=N $N^*/)such that domS .subeq. domN and Sf=Nf for f .mem. domS. we will show that the Radjavi and Rosenthal theorem holds for some unbounded subnormal operators; if $S_{1}$ and $S_{2}$ are unbounded subnormal operators on H with dom $S_{1}$= dom $S^{*}$$_{1}$ and dom $S_{2}$=dom $S^{*}$$_{2}$ and A .mem. B(H) is injective, has dense range and $S_{1}$A .coneq. A $S^{*}$$_{2}$, then $S_{1}$ and $S_{2}$ are normal and $S_{1}$.iden. $S^{*}$$_{2}$.2}$.X>.

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Studies on the Molybdenum Complexes with Tetradentate Schiff Base Ligand (I). N,N'-bis (Salicylaldehyde)-ethylene Diimine (네자리 Schiff Base 리간드의 몰리브덴착물에 관한 연구 (제1보))

  • Jo, Gi Hyeong
    • Journal of the Korean Chemical Society
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    • v.18 no.4
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    • pp.267-271
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    • 1974
  • The tetradentate schiff base, N,N'-bis(salicylaldehyde)-ethylene diimine has been reacted with a series of Mo(IV), Mo(V), Mo(IV), and Mo(III) oxidation states to form new Complexes; $[MoO_2(C_{16}H_{14}O_2N_2)], (MoO(C_{16}H_{14}O_2N_2)]_2O, (Mo(SCN)(C_{16}H_{14}O_2N_2)]_2O, and (Mo(H_2O)(C_{16}H_{14}O_2N_2)]_2O.$ These complexes have hexa coordinated configurations and the mole ratio of these ions to the ligand was 1:1. These complexes have been identified by visible spectra, infrared specra, T.G.A., D.T.A., and elemental analysis.

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Sero-epidemiology and genetic characterization of swine influenza virus (돼지 인플루엔자 바이러스의 혈청학적 역학조사 및 유전학적 분석)

  • Lyoo, Young-soo;Kim, Lomi
    • Korean Journal of Veterinary Research
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    • v.38 no.1
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    • pp.53-63
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    • 1998
  • Total of 1085 swine sera (1996-1997) from nation-wide were tested for the presence of antibodies to influenza A virus. Fifty nine percent of the tested sera showed seropositive by HI test. Positive sera consisted of 24--- of H3, 15--- of H1, and 20--- of the sample had both antibodies, respectively. Sera collected from various region represented 7~27--- seropositivity to H1N1, 15~25--- to H3N2, respectively. Swine influenza field isolate from nasal swab was characterized antigenically and genetically to elucidate its relatedness with other known strains of influenza A virus. The study was focused on the HA gene which is related to pathogenecity and antigenic variability of the influenza virus. By RT-PCR using influenza A/H1N1 specific primers, influenza virus H1N1 specific DNA fragment was amplified from A/Swine/Iowa/15/30(H1N1), US field isolate but not in H3N2 strain. PCR products were sequenced by dideoxy chain termination method to determine nucleotide homology with other strains of influenza A virus. The US field isolate and A/Swine/Indiana/1726/88 strain had 97--- of nucleotide homology and 98--- of amino acid homology. Based on the results obtained from this experiment, the field isolate was genetically related to A/Swine/Indiana/1726/88 and had higher homology with A/Swine/Indiana/1726/88 than with classical swine influenza virus, A/Swine/Iowa/15/30. The field isolate had no amino acid changes at the antigenic site compare to that of the A/Swine/Indiana/1726/88. The proteolytic enzyme cleavage site between HA1 and HA2 had no alteration and the amino acid arginine was intact. There is no evidence has been found that the field isolate has genetic shift or genetic drift which might altered antigenic determinant.

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Synthesis and Antibacterial Activity of New Tetrazole Derivatives (새로운 Tetrazole유도체의 합성과 항균활성)

  • Mulwad, V.V.;Pawar, Rupesh B;Chaskar, Atul C
    • Journal of the Korean Chemical Society
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    • v.52 no.3
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    • pp.249-256
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    • 2008
  • 3-Acetyl/Formyl 4-hydroxy-2H(1)-benzopyran-2-one on treatment with malonitrile and ethyl cyanoacetate yielded 1,1-dicyano-2-[4/-hydroxy-2/H(1)-benzopyran-2/-one-3/-yl] ethene/propene 2a-h and ethyl-2-cyano-3-[4/-hydroxy-2/H (1)-benzopyran-2/-one-3/-yl] propenoate/butenoate 3a-h respectively. The 1,3 dipolar reaction of 2a-h with NaN3 gave the tetrazole derivative 4a-h. 3a-h on cyclization with PPA gave 3-cyano-2H,5H-pyrano [3, 2-c] benzopyran-2,5-diones 5a-h which on 1,3 dipolar reaction with NaN3 to gave 3-(1/H-tetrazol-5/-yl)-2H,5H-pyrano[3, 2-c] benzopyran-2,5-diones 6a-h. The structures of the compounds have been established on the basis of the spectral and analytical data. All the compounds were screened for their antimicrobial activities and have been found to exhibited significant antibacterial activities. Compounds 2h and 4h showed the activity 50g/mL.

ON THE IDEAL CLASS GROUPS OF ℤp-EXTENSIONS OVER REAL ABELIAN FIELDS

  • Kim, Jae Moon;Ryu, Ja Do
    • Korean Journal of Mathematics
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    • v.7 no.2
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    • pp.227-233
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    • 1999
  • Let $k$ be a real abelian field and $k_{\infty}={\bigcup}_{n{\geq}0}k_n$ be its $\mathbb{Z}_p$-extension for an odd prime $p$. For each $n{\geq}0$, we denote the class number of $k_n$ by $h_n$. The following is a well known theorem: Theorem. Suppose $p$ remains inert in $k$ and the prime ideal of $k$ above $p$ totally ramifies in $k_{\infty}$. Then $p{\nmid}h_0$ if and only if $p{\nmid}h_n$ for all $n{\geq}0$. The aim of this paper is to generalize above theorem: Theorem 1. Suppose $H^1(G_n,E_n){\simeq}(\mathbb{Z}/p^n\mathbb{Z})^l$, where $l$ is the number of prime ideals of $k$ above $p$. Then $p{\nmid}h_0$ if and only if $p{\nmid}h_n$. Theorem 2. Let $k$ be a real quadratic field. Suppose that $H^1(G_1,E_1){\simeq}(\mathbb{Z}/p\mathbb{Z})^l$. Then $p{\nmid}h_0$ if and only if $p{\nmid}h_n$ for all $n{\geq}0$.

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Characterization and Outbreak Pattern of Isolated Influenzavirus in Busan, 2000-2002 Years. (최근 3년 부산지역에서 분리한 인플루엔자바이러스의 특성 및 발생 양상)

  • 정명주;조경순
    • Microbiology and Biotechnology Letters
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    • v.31 no.4
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    • pp.329-333
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    • 2003
  • Influenzavirus were isolated from patients with acute respiratory infections in Busan during 2000-2002 and characterized their antigenic properties. In 2000, 39 viruses were isolated and they were identified as Influenzavirus. Among the isolated influenzavirus, 23 were A type influenzavirus and 16 were B type influenzavirus. As a result of antigenic characterization, the influenzavirus were determined to A/Sydney/05/97 (H3N2)-like, A/Beijing/262/95 (H1N1)-like, and B/Harbin/07/94-like virus. In 2001, 56 viruses were isolated and all of the viruses were identified as influenzavirus. They were A/Panama/2007/99 (H3N2)-like and A/Newcaledonia/20/99 (H1N1)-like virus In 2002, 114 Influenzaviruses were isolated. Among the isolated influenzavirus, 83 were A type influenzaviruses, and 31 were B type influenzaviruses. They were A/Panama/2007/99 (H3N2)-like, A/Newcaledonia/20/99 (H1N1)-like and B/Beijing/243/97, B/Honkong/22/2001, B/Sichuam/379/99-like virus when determined their antigenic properties. These results may be useful for the establishment of reliable epidemic data.

Clinical characteristics and outcomes among pediatric patients hospitalized with pandemic influenza A/H1N1 2009 infection

  • Lee, Eun;Seo, Ju-Hee;Kim, Hyung-Young;Na, Shin;Kim, Sung-Han;Kwon, Ji-Won;Kim, Byoung-Ju;Hong, Soo-Jong
    • Clinical and Experimental Pediatrics
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    • v.54 no.8
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    • pp.329-334
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    • 2011
  • Purpose: The purpose of this article is to describe the clinical and epidemiologic features and outcomes among children hospitalized with pandemic influenza A/H1N1 2009 infection. Methods: We retrospectively reviewed the charts of hospitalized pediatric patients (<18 years) diagnosed with pandemic influenza A/H1N1 2009 infection by reverse-transcriptase polymerase chain reaction at a tertiary hospital in Seoul, Korea, between September 2009 and February 2010. Results: A total of 72 children were hospitalized with pandemic influenza A/H1N1 2009 infection (median age, 6.0 years; range, 2 months to 18 years). A total of 40% had at least 1 underlying medical condition, including asthma (17%), malignancies (19%), and heart diseases (17%). Of the 72 patients, 54 (76%) children admitted with H1N1 infection showed radiographic alterations compatible with pneumonia. There was no significant difference in pre-existing conditions between pandemic influenza A/H1N1 infected patients with or without pneumonia. Children with pandemic influenza A/H1N1 pneumonia were more likely to have a lower lymphocyte ratio (P=0.02), higher platelet count (P=0.02), and higher level of serum glucose (P=0.003), and more commonly presented with dyspnea than did those without pneumonia (P=0.04). Conclusions: No significant differences in age, sex, or presence of preexisting conditions were found between children hospitalized with pandemic influenza A/H1N1 H1N1 influenza infection with pneumonia and those without pneumonia. Higher leukocyte count, higher glucose level, and a lower lymphocyte ratio were associated with the development of pandemic A/H1N1 2009 influenza pneumonia.

ON HARMONIC CONVOLUTIONS INVOLVING A VERTICAL STRIP MAPPING

  • Kumar, Raj;Gupta, Sushma;Singh, Sukhjit;Dorff, Michael
    • Bulletin of the Korean Mathematical Society
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    • v.52 no.1
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    • pp.105-123
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    • 2015
  • Let $f_{\beta}=h_{\beta}+\bar{g}_{\beta}$ and $F_a=H_a+\bar{G}_a$ be harmonic mappings obtained by shearing of analytic mappings $h_{\beta}+g_{\beta}=1/(2isin{\beta})log\((1+ze^{i{\beta}})/(1+ze^{-i{\beta}})\)$, 0 < ${\beta}$ < ${\pi}$ and $H_a+G_a=z/(1-z)$, respectively. Kumar et al. [7] conjectured that if ${\omega}(z)=e^{i{\theta}}z^n({\theta}{\in}\mathbb{R},n{\in}\mathbb{N})$ and ${\omega}_a(z)=(a-z)/(1-az)$, $a{\in}(-1,1)$ are dilatations of $f_{\beta}$ and $F_a$, respectively, then $F_a\tilde{\ast}f_{\beta}{\in}S^0_H$ and is convex in the direction of the real axis, provided $a{\in}[(n-2)/(n+2),1)$. They claimed to have verified the result for n = 1, 2, 3 and 4 only. In the present paper, we settle the above conjecture, in the affirmative, for ${\beta}={\pi}/2$ and for all $n{\in}\mathbb{N}$.