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Novel Nucleotide Variations, Haplotypes Structure and Associations with Growth Related Traits of Goat AT Motif-Binding Factor (ATBF1) Gene

  • Zhang, Xiaoyan;Wu, Xianfeng;Jia, Wenchao;Pan, Chuanying;Li, Xiangcheng;Lei, Chuzhao;Chen, Hong;Lan, Xianyong
    • Asian-Australasian Journal of Animal Sciences
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    • v.28 no.10
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    • pp.1394-1406
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    • 2015
  • The AT motif-binding factor (ATBF1) not only interacts with protein inhibitor of activated signal transducer and activator of transcription 3 (STAT3) (PIAS3) to suppress STAT3 signaling regulating embryo early development and cell differentiation, but is required for early activation of the pituitary specific transcription factor 1 (Pit1) gene (also known as POU1F1) critically affecting mammalian growth and development. The goal of this study was to detect novel nucleotide variations and haplotypes structure of the ATBF1 gene, as well as to test their associations with growth-related traits in goats. Herein, a total of seven novel single nucleotide polymorphisms (SNPs) (SNP 1-7) within this gene were found in two well-known Chinese native goat breeds. Haplotypes structure analysis demonstrated that there were four haplotypes in Hainan black goat while seventeen haplotypes in Xinong Saanen dairy goat, and both breeds only shared one haplotype (hap1). Association testing revealed that the SNP2, SNP5, SNP6, and SNP7 loci were also found to significantly associate with growth-related traits in goats, respectively. Moreover, one diplotype in Xinong Saanen dairy goats significantly linked to growth related traits. These preliminary findings not only would extend the spectrum of genetic variations of the goat ATBF1 gene, but also would contribute to implementing marker-assisted selection in genetics and breeding in goats.

Methodology effects on determining the energy concentration and the apparent total tract digestibility of components in diets fed to growing pigs

  • Huang, Chengfei;Li, Ping;Ma, Xiaokang;Jaworski, Neil William;Stein, Hans-Henrik;Lai, Changhua;Zhao, Jinbiao;Zhang, Shuai
    • Asian-Australasian Journal of Animal Sciences
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    • v.31 no.8
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    • pp.1315-1324
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    • 2018
  • Objective: An experiment was conducted to investigate the effects of different diet formulations: F1 (Two complicated basal diets containing different crude protein levels plus tested feedstuff) vs F2 (A simple corn soybean meal [SBM] basal diet plus tested feedstuff) combined with total collection (TC) or chromic oxide ($Cr_2O_3$) marker or acid-insoluble ash (AIA) marker method, and freeze-dry or oven-dry (OD) technique on estimation of nutrient digestibility in diets fed to growing pigs. Methods: In F1, twelve barrows were allocated to two $6{\times}4$ Youden Squares. The treatment diets included a high protein basal (HPB) diet, a low protein basal (LPB) diet, a corn diet and a wheat bran (WB) diet formulated based on the HPB diet, and a SBM diet and a rapeseed meal (RSM) diet formulated based on the LPB diet. In F2, eight barrows were allocated to two $4{\times}4$ Latin Squares. The treatment diets included a corn basal diet, a SBM basal diet formulated based on the corn diet, and a WB diet and a RSM diet formulated based on the SBM diet. Results: Concentration of digestible (DE) and metabolizable energy (ME), and the apparent total tract digestibility of gross energy, ash, neutral detergent fibre, and acid detergent fibre determined by $Cr_2O_3$ marker method were greater than those determined by TC and AIA marker methods in HPB, LPB, and RSM diets formulated by F1 and in corn diet formulated by F2 (p<0.05). The DE values in WB and both DE and ME values in SBM and RSM estimated using F1 were greater than those estimated using F2 (p<0.05). Conclusion: From the accuracy aspect, the AIA marker or TC method combined with OD technique is recommended for determining the energy concentration and nutrient digestibility of components in diets fed to growing pigs.

Preparation of Al Cathode for OLED by Sputtering Method (스퍼터링법을 이용한 OLED용 Al 음전극 제작)

  • Keum, Min-Jong;Kim, Kyung-Hwan
    • Journal of the Korean Institute of Electrical and Electronic Material Engineers
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    • v.18 no.8
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    • pp.729-733
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    • 2005
  • Al electrode for OLED was deposited by FTS (Facing Targets Sputtering) system which can deposit thin films with low substrate damage. The Al thin films were deposited on the cell (LiF/EML/HTL/Bottom electrode) as a function of working gas such as Ar or Ar+kr mixed gas. Also Al thin films were prepared with working gas pressure (1, 6 mTorr). The film thickness and I-V curve of Al/cell were measured and evaluated. In the results, when Al thin films were deposited using pure Ar gas, the turn-on voltage of Al/cell was about 11 V. And using the Ar:Kr($75\%:25\%$) mixed gas, the turn-on voltage of Al/cell decreased to about 7 V.

CLOSED CONVEX SPACELIKE HYPERSURFACES IN LOCALLY SYMMETRIC LORENTZ SPACES

  • Sun, Zhongyang
    • Bulletin of the Korean Mathematical Society
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    • v.54 no.6
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    • pp.2001-2011
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    • 2017
  • In 1997, H. Li [12] proposed a conjecture: if $M^n(n{\geqslant}3)$ is a complete spacelike hypersurface in de Sitter space $S^{n+1}_1(1)$ with constant normalized scalar curvature R satisfying $\frac{n-2}{n}{\leqslant}R{\leqslant}1$, then is $M^n$ totally umbilical? Recently, F. E. C. Camargo et al. ([5]) partially proved the conjecture. In this paper, from a different viewpoint, we study closed convex spacelike hypersurface $M^n$ in locally symmetric Lorentz space $L^{n+1}_1$ and also prove that $M^n$ is totally umbilical if the square of length of second fundamental form of the closed convex spacelike hypersurface $M^n$ is constant, i.e., Theorem 1. On the other hand, we obtain that if the sectional curvature of the closed convex spacelike hypersurface $M^n$ in locally symmetric Lorentz space $L^{n+1}_1$ satisfies $K(M^n)$ > 0, then $M^n$ is totally umbilical, i.e., Theorem 2.

Improvement of Luminance Properties of Blue OLEO using $SnDP(HPB)_2$ (Sn-complexes를 이용한 OLED의 발광 특성 향상에 관한 연구)

  • Kim, Dong-Eun;Choi, Gyu-Chae;Kwon, Young-Soo
    • Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
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    • 2008.04c
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    • pp.121-122
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    • 2008
  • Blue emitting materials have been explored by various researchers. However, blue-emitting materials with high luminous efficiency, good color purity, and thermal stability are still much desired. In this study, we synthesized a new blue luminescent material, $SnDP(HPB)_2$ which is low molecular compound and thermal stability. The PL spectrum of $SnDP(HPB)_2$ was observed blue at the wavelength of 447nm. The ionization potential(IP) and the electron affinity(EA) of $SnDP(HPB)_2$ was measured to be 6.7 eV and 3.0 eV, respectively. The fundamental structure of the OLED was ITO/NPB/$SnDP(HPB)_2/Alq_3$/LiF/Al. As a Result, we obtained to enhance the performance of blue OLED.

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선형가속기 출력 점검에 사용하는 열형광선량계의 에너지 의존도 평가

  • Park, Seong-Ho;Gang, Se-Gwon;Jo, Byeong-Cheol;Lee, Byeong-Cheol;Kim, Gwi-Ya;Jeong, Hui-Gyo
    • Proceedings of the Korean Society of Medical Physics Conference
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    • 2004.11a
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    • pp.33-35
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    • 2004
  • 방사선치료를 위한 고에너지 광자선의 품질관리를 위해 사용하는 TLD의 광자선 선질에 대한 에너지 의존도를 몬테카를로 모사법을 사용하여 평가하였다. IAEA 선량보증사업에 이용되는 LiF TLD 및 홀더를 EGS4기반의 사용자 코드인 DOSIMETER 와 MCNP4C 몬테카를로 코드를 사용하여 기하학구조를 구성하고, Co, 4, 6,10 밑 15 MV 광자선을 시뮬레이션하였다. DOSIMETER계산 결과를 통해 TLD의 에너지 보정인자가 실험 데이터와 일치함을 확인할 수 있었으며, 이와 별도로 캡슐에 의한 교란량도 무시할 수 없음을 발견하였다.

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Selection and Antifungal Activity of Antagonistic Bacterium Pseudomonas sp. 2112 against Red-Pepper Rotting Phytophthora capsici (생물방제균 Pseduomonas fluorescens 2112의 선발과 고추역병균에 대한 항진균성 길항작용)

  • 이은탁;김상달
    • Microbiology and Biotechnology Letters
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    • v.28 no.6
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    • pp.334-340
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    • 2000
  • In order to select multifunctional powerful antagonistic biocontrol agent against red-pepper rotting fungi Phytophthora capsici, we isolated an indigenous antagonistic bacterium which produces antifungal substances and siderophores from a local soil of Kyongju, Korea. The isolated strain was identified as Pseudomonas fluorescens biotype F. The antibiotic produced from P. fluorescens 2112 inhibited hyphae growth and the zoospore germination of Phytophthora capsici. The favorable carbon, nitrogen source and salts for the production of antibiotic from P. fluorescens 2112 were glycerol, beef extract and LiCi at 1.0%, 0.5% and 5 mM, respectively. And antagonistic activity of P. fluorescens 2112 was confirmed against P. capsici in vivo.

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Color Nanotube Field Emission Displays for HDTV

  • Dean, K.A.;Coll, B.F.;Dinsmore, A.;Howard, E.;Hupp, M.;Johnson, S.V.;Johnson, M.R.;Jordan, D.C.;Li, H.;Marshbanks, L.;McMurtry, T.;Tisinger, L.Hilt;Wieck, S.;Baker, J.;Dauksher, W. J.;Smith, S.M.;Wei, Y.;Weston, D.;Young, S.R.;Jaskie, J.E.
    • 한국정보디스플레이학회:학술대회논문집
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    • 2005.07b
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    • pp.1003-1007
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    • 2005
  • We demonstrate color video displays driven by carbon nanotube electron field emitters. These nanotubes are incorporated into the device by selective growth using low temperature chemical vapor deposition. The device structure is simple and inexpensive to fabricate, and a 45 V switching voltage enables the use of low cost driver electronics. The prototype units are sealed 4.6” diagonal displays with 726 um pixels. They represent a piece of a 42” diagonal 1280x720 high definition television. The carbon nanotube growth process is performed as the last processing step and creates nanotubes ready for field emission. No activation post-processing steps are required, so chemical and particulate contamination is not introduced. Control of the nanotube dimension, orientation, and spatial distribution during growth enables uniform, highquality, color video performance.

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Pharmacologic evalution of some anti-cancer plants in China and its clinical use of traditional Chinese medicine

  • Kim, Soo-Cheol;Lee, Sang-Sae;Li, Jong-Il
    • Plant Resources
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    • v.4 no.2
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    • pp.85-91
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    • 2001
  • Many plant species are used in China in tradtional medicine for the prevention and treatment of cancer. This paper presents some of these species with defals on other pharmacologic evaluation and its tradional Chinese meditional uses. The known bioaktivities and some chemical constituents of each of the species given. Information on bioactivities of each species resulting from tests on experimental animals are given. Many of the known chemical constituents of each species are given. Various species of plants elective for various types. In this meeting I will present on some antitumor of the plants which are as follows ; (1) Akebia trifoliata(Thunb.)Koidz. ((2) Panax notoginseng (Burk.) F, H, Chen ., (3)Ziziphus jujuba Mill., (4)coriotus versicolor(Fr.) Quel., (5) Trich osanthes kirilowii Maxim., (6) Ficus carica Linnaeus., (7) Acanthopanax senticosus(Rupr. et Maxim.)Harms.,(5) Hibiscus mutabilis Linnaeus.,(9) Arctium lappa Linnaeus., (11) Agrimonia pilose Ledebour and (12) Hedyotis diffusa Willd.

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SUPPRESSION BY CHLOROPHYLL, BUT PROMOTION BY CHLOROPHYLLIN, OF COLON CARCINOGENESIS IN THE FISHER 344 RAT

  • Blum, Carmen A.;Xu, Meirong;Orner, Gayle A.;Diaz, G.Daria;Li, Qingjie;Bailey, George S.;Dashwood, Roderick H.
    • Proceedings of the Korean Society of Toxicology Conference
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    • 2001.10b
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    • pp.5-6
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    • 2001
  • The carcinogens 2-arnioo-3-methylimidazo[4,5-f]quinoline (IQ) and 1,2-dimethylhydrazine (DMH) induce colon tumors in the Fisher 344 rat that contain mutations in Ctnnb1, the gene for b-catenin, but the pattern of mutation differs from that found in human colon cancers. in both species, mutations affect the glycogen synthase kinase 3$\beta$ (GSK-3$\beta$) consensus region of $\beta$-catenin, but whereas they directly substitute critical Ser/Thr phosphorylation sites in human colon cancers, the majority of mutations cluster around Ser$^{33}$ in the rat tumors.(omitted)

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