• 대한방사선기술학회지:방사선기술과학
• /
• 제41권4호
• /
• pp.321-327
• /
• 2018

The purpose of this study is to compare PET imaging performance with Fluorine-18 ($^{18}F$) and Gallium-68 ($^{68}Ga$) for influence of physical properties of PET tracer. Measurement were performed on a Siemens Biograph mCT64 PET/CT scanner using NEMA IEC body phantom and Flangeless Esser PET phantom containing filled with $^{18}F$ and $^{68}Ga$. Emission scan duration(ESD) was set to 1, 2, 3, 4 and 5min/bed for $^{68}Ga$ and 1min/bed for $^{18}F$. The PET image were evaluated in terms of contrast, spatial resolution. Under same condition, The percentage of contrast recovery measured in the phantom ranged from 16.88% to 72.56% for $^{68}Ga$ and from 27.51% to 74.43% for $^{18}F$ and The FWHM value to evaluate spatial resolution was 10.96 mm for $^{68}Ga$ and 9.19 mm for $^{18}F$. For this study, $^{18}F$ produces better image contrast and spatial resolution than $^{68}Ga$ due to higher positron yield and lower positron energy ($^{18}F$: 96.86%, 633.5 keV, $^{68}Ga$: 88.9%, 1899 keV), The physical properties of PET tracer effect on the PET image. $^{68}Ga$ image applying ESD of 3, 4, 5min/bed were showed similar to $^{18}F$ image with ESD of 1min/bed. This study suggests that increasing ESD for acquiring $^{68}Ga$ PET image seem to be similar to $^{18}F$ image.

• Genomics & Informatics
• /
• 제2권2호
• /
• pp.75-80
• /
• 2004

In a variety of animal species, the perinatal exposure of experimental animals to the 2,3,7,8-tetrachlorodibenzo­p-dioxin (TCDD) leads to the immune dysfunction, which is more severe and persistent than that caused by adult exposure. We report here the changes of gene expression and the identification of the marker-genes representing the dioxin exposure. The expressions of the transcripts were analyzed using the 11 K oligonucleotide­microarray from the bone marrow cells of male C57BL/6J mice after an intraperitoneal injection of $1{\mu}g$ TCDD/kg body weight at various time intervals: gestational 6.5 day(G6.5), 13.5 day(G13.5), 18.5 day(G18.5), and postnatal 3 (P3W)and 6 week (P6W). The type of self-organizing maps(SOM) representing the specific exposure dioxin could be identified as follows; G6.5D(C14), G13.5D(C0, C5, C10, C18), G18.5D(7): P3W(C2, C21), and P6W(C4, C15, C20). The candidate marker-genes were restricted to the transcripts, which could be consistently expressed greater than $\pm$2-fold in three experiments. The resulting candidates were 85 genes, the characteristics of that were involved in cell physiology and cell functions such as cell proliferation and immune function. We identified the biomarker-genes for dioxin exposure: smc -like 2 from SOM C14 for the dioxin exposure at G6.5D, focal adhesion kinase and 6 other genes from C0, and protein tyrosine phosphatase 4a2 and 3 other genes from C5 for G13.5D, platelet factor 4 from C7 for G18.5D, fos from C2 for P3W.

• 한국방사선학회논문지
• /
• 제5권6호
• /
• pp.363-367
• /
• 2011

일반적으로 중년여성의 골다공증은 저체중에서 발생률이 높은 것으로 보고되었으나 비만인 경우에도 발생할 수 있다. 따라서 본 연구의 목적은 골밀도 검사에서 골다공증으로 진단받은 중년여성 120명을 대상으로 골다공증과 체질량지수의 상관관계를 비교하고자 하였다. 체질량지수가 18.5 미만을 저체중, 18.5 ~ 22.9를 정상, 23.0 ~ 24.9를 과체중, 25.0 ~ 29.9를 비만, 30.0 이상인 경우를 고도비만으로 하였다. 연구 결과 대상자의 체질량지수 분포는 저체중이 2명(1.7%), 정상이 18명(15.0%), 과체중이 19명(15.8%), 비만이 75명(62.5%), 고도비만이 6명(5.0%) 이었다. 또한 체질량지수와 골다공증의 상관관계는 체질량지수가 정상인 경우 18명 중 13명(72.2%)이 골다공증이었으며 과체중의 경우 19명 중 14명(73.7%), 비만의 경우 75명 중 63명(84%), 고도비만의 경우 6명 중 5명(83.3%)로 나타나 체질량지수가 비만인 경우에서 골다공증 발생률이 높았다. 결론적으로 중년여성의 골다공증은 체질량지수가 비만일수록 골다공증 환자가 많다는 것을 알 수 있었으며 대부분 골감소증보다는 골다공증이 높게 나타남을 알 수 있었다.

• 동아시아식생활학회지
• /
• 제4권1호
• /
• pp.57-70
• /
• 1994

The present study was carried out in normal and atherosclerotic New Zealand white(NZW) rabbits, to evaluate the effect of dietary supplementation with Korean pinenut oil, on the total fatty acid composition of red blood cell membranes. Erythrocyte fatty acids of chain lengths ranging fro 12 : 0 to 22 : 6$\omega$3 were identified. In study I, palmitic acid(16 : 0) was found to be the main erythrocyte membranes fatty acid, followed in turn by stearic(18 : 0), oleic(18 : 1), and linoleic acids(18 : 2$\omega$6). There was a large increase in the proportion of 20 : 4$\omega$6 in 10% pinenut oil group on days 40 and 80(compared with control), although the increase was not statistically significant. Most erythrocyte fatty acids were less affected by the types or levels of oils supplemented for periods fo 40 and 80days. In study II,at the end of the dietary treatment, the levels of 12 : 0, 14 : 0, 15 : 0 and 18 : 0 were significantly decreased in the 5% soybean oil/cholesterol group, whereas those of 12 : 0, 14 : 0 and 18 : 0 were significantly decreased, but that of 18 : 2$\omega$6 was significantly increased in the 10% soybean oil/cholesterol group, compared to the cholesterol group. No significant differences in fatty acid composition were seen between the pinenut oil/cholesterol group, whereas the 10% soybean oil/cholesterol group had significantly elevated 18 : 2$\omega$6, compared to the cholesterol group. The proportion of 18 : 4$\omega$6 was significantly raised in the 5% soybean oil/cholesterol and 5% pinenut oil/cholesterol group, and the content of 16 : 1$\omega$7 was significantly lowered in the 5% and 10% soybean/cholesterol groups, compared to the cholesterol group at 10 weeks supplementation. In studies I,II and III, the total proportions of saturated fatty acids were not significantly affected by the types of levels of oils supplemented throughout the study period.

• 한국식품영양과학회지
• /
• 제34권1호
• /
• pp.81-86
• /
• 2005

메밀종자와 메밀나물의 영양성분 및 유용성분을 비교 분석하여, 식품개발 소재로서 메밀나물의 이용성을 증대시키는 기초자료로 삼고자 하였다. 메밀종자를 7일간 발아시켜 메밀나물을 수확한 후, 동결건조하여 분석용 시료로 사용하였다. 건물량 기준으로 메밀나물의 조단백, 조지방, 회분함량은 각각 20.8, 1.3 그리고 2.6%이었다. 메밀나물의 주된 아미노산은 glutamic acid(2,764 mg/100 g)와 aspartic acid(1,698 mg/100 g)이었다. 발아를 통해 tryptophan이 약 1.9배, alanine과 tyrosine이 약 1.8배, histidine이 약 1.7배정도 증가하는 것으로 나타났다. 메밀나물의 주된 지방산은 iinoleic acid(45.9%)와 oleic acid(18.4%)이었다. 메밀종자가 발아되어 메밀나물로 성장하는 가운데 stearic acid(18:0)가 21%, oleic acid(18:1)가 약 50% 감소된 반면 linoleic acid(18:2)와 linolenic acid(18:3)가 각각 1.3배,5.4배 증가하는 현상을 나타내었다 메밀나물의 칼슘함량은 152.0 mg/100 g, 아연 9.9 mg/100 g, 마그네슘 485.0 mg/100 g, 철분 5.4 mg/100 g이었다. 메밀나물의 비타민 A, C and E 함량은 건물량 기준으로 각각 1,180 IU/100 g, 203 mg/100 g 그리고 32.1 mg/100 g이었다. 특히 $\alpha$-tocopherol 함량은 메밀종자에 비해 27.5배나 높았다. 메밀나물의 rutin 함량은 343.67 mg/100 g로 메밀종자보다 약 18배 많은 것으로 나타났다.

• 동아시아식생활학회지
• /
• 제5권2호
• /
• pp.39-48
• /
• 1995

The effects of storage containers and storage temperatures on Kimchi quality were investigated. The results were summarized as follows : 1. Pabix, poly ethylene-back+plastic container, tupper-ware were much better than crock, stainless steel, and plastic container in keeping a Kimchi. However, there was no significant differences between containers in the sensory test for Kimchi. 2. Kimchi stored at 18$\pm$2$^{\circ}C$ was the most delicious, which revealed pH 4.30, acidity 0.45-0.50%, and salt concentration 3.10wt% in the 4th days after storage whereas sensory score for Kimchi quality was very low in the 12th days after storage. 3. pH in Kimchi stored at 5$^{\circ}C$ after fermentation at 18$\pm$2$^{\circ}C$ was slowly decreased as compared to the Kimchi stored at 18$\pm$2$^{\circ}C$, but texture score of Kimchi stored at -5$^{\circ}C$ or -8$0^{\circ}C$ after fermentation at 18$\pm$2$^{\circ}C$, but texture score of Kimchi stored at -5$^{\circ}C$ or -8$0^{\circ}C$ were compared to that of the Kimchi stored at 18$\pm$2$^{\circ}C$ after fermentation. 5. In the group of Kimchi stored at 1$0^{\circ}C$, immediately after picking it took 48days until the best conditions which were pH 4.30 and acidity 0.45-0.50% were matched. 6. The most promising method in keeping good taste and good quality of Kimchi was to store Kimchi at 5$^{\circ}C$ after 4days fermentation at 18$\pm$2$^{\circ}C$. And, for long period preservation of Kimchi, it took would be effective to store at -8$0^{\circ}C$ after fermentation at 18$\pm$2$^{\circ}C$.

• The Plant Pathology Journal
• /
• 제35권3호
• /
• pp.234-242
• /
• 2019

Thirty-four strains of bacteria were isolated from Phellodendron amurense. Using Nectria haematococca as an indicator strain, the best strain, B18, was obtained by the growth rate method. The morphological, physiological and biochemical characteristics of strain B18 and its 16S DNA gene sequence were identified, and the biocontrol effect of strain B18 was assessed in pot and field tests, as well as in a field-control test. Drilling methods were used to determine the antibacterial activity of metabolites from strain B18 and their effects on the growth of pathogen mycelia and spores. The best bacteriostatic rate was 85.4%. B18 can hydrolyse starch and oxidize glucose but does not produce gas; a positive result was obtained in a gelatine liquefaction test. According to 16S DNA gene sequencing, strain B18 is Bacillus methylotrophicus (GenBank accession number: MG457759). The results of pot and field-control trials showed 98% disease control when inoculating $10^8cfu/ml$ of the strain. The disease control effect of the B18 culture liquid (concentrations of $10^8$, $2{\times}10^6$, $10^6$, $5{\times}10^5$ and $2.5{\times}10^5cfu/ml$) in the field-control test was higher than 80%, and the cure rate of the original delivery solution was 96%. Therefore, in the practical forestry production, a $2.5{\times}10^5cfu/ml$ culture liquidshould be applied in advance to achieve good control effects.

• 한국안광학회지
• /
• 제18권3호
• /
• pp.241-246
• /
• 2013

목적: 본 연구에서는 프리폼 누진렌즈와 일반 누진렌즈를 착용 하였을 때 원거리 대비감도에 미치는 영향을 비교 분석 하였다. 방법: 안질환이 없는 성인 20명을 대상으로 원거리 대비감도 검사를 실시하였고 5단계의 공간 주파수를 갖는 F.A.C.T.(Stereo Optical, USA)를 이용하였다. 우안, 좌안, 양안 순서로 프리폼 누진렌즈와 일반누진렌즈 대비감도를 측정하였다. 결과: 우안/좌안/양안 대비감도 검사 값이 A(1.5 cpd) 공간주파수에서는 일반 누진렌즈에 비교하여 프리폼 누진렌즈가 16%/17%/11%, B(3 cpd) 공간주파수에서는 11%/5%/5%, C(6 cpd) 공간주파수에서는 6%/6%/9%, D(12 cpd) 공간주파수에서는 19%/16%/13%, E(18 cpd) 공간주파수에서는 4%/3%/18% 높았다. 결론: 원거리 대비감도의 모든 공간주파수 영역에서 프리폼 누진렌즈가 일반 누진렌즈보다 측정값이 높게 측정되었다.

• 대한화학회지
• /
• 제32권1호
• /
• pp.71-78
• /
• 1988

20,21,24,25-Tetranitrodibenzo-18-crown-6에 알코올성 염기를 가하여 친핵성 치환반응을 유도하면 crown ether 화합물을 이루는 polyether 고리가 끊어져서 주생성물로 2,4,5-trialkoxynitrobenzene 유도체, 4,5-dialkoxy-1,2-dinitrobenzene 유도체 그리고 crown ether 고리가 부분적으로 끊어져 생긴 bis[(alkoxynitrophenoxy)ethyl]ether 유도체가 부생성물로 얻어졌다. 이가 알코올성 염기에서는 polyether 고리가 끊어진 생성물과 분자내 치환반응이 다시 진행되어 고리축소 현상이 일어나 12-crown-4의 유도체를 얻게 되거나 출발물질이 도로 생성되었다. 이상의 실험은 다양한 알코올의 농도에서 염기의 종류를 달리하여 그 선택성을 알아보았다.

• 한국재료학회지
• /
• 제15권12호
• /
• pp.765-772
• /
• 2005

PAS(Plasma Activated Sintering) process was tried to apply for the fabrication of BMG(Bulk Metallic Glasses) of $Ni_{57}Zr_{20}Ti_{18}Si_5}\;and\;Ni_{57}Zr_{20}Ti_{18}Si_3Sn_2$ from the as-atomized amorphous powder. Compressive strength for the BMG(bulk Metallic Glasses) of $Ni_{57}Zr_{20}Ti_{18}Si_5$ were lower than those of BMG rods produced by warm extrusion ,or copper mold casting method. Microstructural examination by optical microcope, SEM ana EDS showed that oxidation had occurred during PASintering. In order to prevent the powder from the oxidation during PASintering, Ni coating for $Ni_{57}Zr_{20}Ti_{18}Si_5$ amorphous powder by electroless-plating method was performed. Microstructural examination for Ni coated layers after PASintering indicated that the Ni coating had been so effective to prevent powder from oxidation during PASintering. Sintering behaviors of $Ni_{57}Zr_{20}Ti_{18}Si_3Sn_2$ represent the same as those of $Ni_{57}Zr_{20}Ti_{18}Si_5$.