• Title/Summary/Keyword: 4-META

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Predictors of Mortality in Patients with COVID-19: A Systematic Review and Meta-analysis (코로나바이러스감염증-19 (COVID-19) 환자들의 사망관련 인자에 대한 연구: 체계적 문헌고찰 및 메타분석)

  • Kim, Woorim;Han, Ji Min;Lee, Kyung Eun
    • Korean Journal of Clinical Pharmacy
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    • v.30 no.3
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    • pp.169-176
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    • 2020
  • Background: Most meta-analyses of risk factors for severe or critical outcomes in patients with COVID-19 only included studies conducted in China and this causes difficulties in generalization. Therefore, this study aimed to systematically evaluate the risk factors in patients with COVID-19 from various countries. Methods: PubMed, Embase, and Web of Science were searched for studies published on the mortality risk in patients with COVID-19 from January 1 to May 7, 2020. Pooled estimates were calculated as odds ratio (OR) with 95% confidence interval (CI) using the random-effects model. Results: We analyzed data from seven studies involving 26,542 patients in total in this systematic review and meta-analysis. Among the patients, 2,337 deaths were recorded (8.8%). Elderly patients and males showed significantly higher mortality rates than young patients and females; the OR values were 3.6 (95% CI 2.5-5.1) and 1.2 (95% CI 1.0-1.3), respectively. Among comorbidities, hypertension (OR 2.3, 95% CI 1.1-4.6), diabetes (OR 2.2, 95% CI 1.2-3.9), cardiovascular disease (OR 3.1, 95% CI 1.5-6.3), chronic obstructive pulmonary disease (OR 4.4, 95% CI 1.7-11.5), and chronic kidney disease (OR 4.2, 95% CI 2.0-8.6) were significantly associated with increased mortalities. Conclusion: This meta-analysis, involving a huge global sample, employed a systematic method for synthesizing quantitative results of studies on the risk factors for mortality in patients with COVID-19. It is helpful for clinicians to identify patients with poor prognosis and improve the allocation of health resources to patients who need them most.

A Meta-Analysis on Effects of Infant's Sociality Development in Forest Experience Activities (숲 체험 활동이 유아의 사회성 발달의 효과에 관한 메타분석)

  • Chan-Woo Kim;Duk-Byeong Park
    • Journal of Agricultural Extension & Community Development
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    • v.29 no.4
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    • pp.225-250
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    • 2022
  • This study aims to examine the effects of infant's social development forest experience activities through meta-analysis. The final nine studies(total of 165 in the experimental group and 159 in the control group) were selected as a method of systematic review. Meta-analysis on overall effect size estimation, chi-square test, significance analysis, publication bias analysis, and subgroup analysis was performed using the R program. The overall effect size of 9 studies was 1.59, indicating a large effect size. As a result of subgroup analysis of the sub-factors of sociality, autonomy showed the largest effect size at 1.47, the adjusted effect size of cooperation was 1.34, the effect size adjusted for peer interaction was 1.29, and the adjusted effect size for perspective-taking ability was 0.97. All were found to have a statistically significant effect. To analyze the moderating effect, a meta-regression analysis was conducted on the participation period(4, 5~6, 7~8weeks), the number of sessions(6~10, 11~15, 16~20), the frequency per week(1, 2, 5), and the participation time(40, 60, 90, 120, 150min), but there was no statistical difference. Although not statistically significant, the effect size was larger when the participation period was 4 weeks, the number of sessions was 16 to 20, the frequency was 2 times per week, and the participation time was 40 minutes. This results can be usefully utilized by policy makers and forest commentators related to the vitalization of forest education through forest experience activities.

Relationship Between Exposure to Air Pollutants and Aggravation of Childhood Asthma : A Meta-Analysis (메타분석을 적용한 대기오염과 소아 천식 관련 입원의 상관성 평가 연구)

  • Cho, Yong-Sung;Kim, Ho;Lee, Jong-Tae;Hyun, Youn-Joo;Kim, Yoon-Shin
    • Journal of Korean Society for Atmospheric Environment
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    • v.17 no.5
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    • pp.425-437
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    • 2001
  • This study is based on the uses meta-analysis methodology to examine the statistical consistency and importance of random variation among results of epidemiologic studies between air pollutants exposure and childhood asthma. Studies for this meta-analysis were conducted by reviewing previous results and by asking researcher active in this field for recommendations. Overall, 10 cases of air pollutants exposures and childhood asthma were reviewed. A variety of statistical methods for meta-analysis have been used to assess the combined effects, to identify heterogeneity, and to provide a single summary risk estimate based on a set of simiar epidemiologic studies. In this study, classification of exposure metircs on air environmental epidemiologic studies are reported for (1) aggravation of childhood asthma by a 50 ppb increase SO$_2$(6 individual studies); (2) aggravation of childhood asthma by a 50 ppb increase NO$_2$(5 individual studies); (3) aggravation of childhood asthma by a 50 ppb increase $O_3$(7 individual studies); (4) aggravation of childhood asthma by a 10$\mu\textrm{g}$/m$^3$increase PM$_{10}$ (4 individual studies); (5) aggravation of childhood asthma by a 1 ppm increase CO (2 individual studies); and (6) comparison of results between a Korean study results and this meta-analytic study. Results of this study indicated that an inverse-variance weighted pooling of the hospital admission risk at a 1ppm increment of CO levels was 1.12% (95% CI : 1.01 ~ 1.24). The hospital admission risk was estimated to increase 5% (95% CI : 1.02~1.08), 6%(95% CI : 1.04~1.09), and 5% (95% CI : 1.02~1.09) with each 50ppb increase of SO$_2$, NO$_2$, and $O_3$, respectively. In addition, our results lead to a small but significant elevation in risk of 2% (RR = 1.02, 95% CI = 1.01~1.04) with each 10$\mu\textrm{g}$/m$^3$increase of PM$_{10}$ among 4 individual studies. We found a small elevation in risk of childhood asthma, and pooled results of 10 epidemiologic studies of childhood asthma using increase a cut-off-point levels of air pollutants showed a few pieces of evidence. The results of this meta-analysis suggested that air pollution associated with an increased incidence of childhood asthma. According to this study, relationship between exposure to air pollutants and childhood asthma in Korea seem to be high than results of this meta-analysis.sis.

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A Quality Assessment of Meta-Analyses Research in Social Work (국내 사회복지 관련 메타분석 연구의 질 평가)

  • Cho, Mi-Kyoung;Kim, Hee-Young
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.17 no.10
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    • pp.158-167
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    • 2016
  • This study was conducted to evaluate the quality of meta-analysis of social work in South Korea using the Assessment of Multiple Systematic Review (AMSTAR). Electronic databases including the Korean Studies Information Service System (KISS), DBpia, and RISS4U were searched for 'meta-analysis', 'social work', and 'social welfare' from 2000 to December 2015, and 42 meta-analysis studies were included. Data were analyzed using descriptive statistics, t-tests, and ANOVA. The mean score for AMSTAR evaluation was $4.766{\pm}1.66$, while 19 studies (45.2%) were classified at the low-quality level, and 22 (52.4%) were at the moderate-quality level. The scores of quality assessment were analyzed by publication year, participants, number of studies included, number of DB, reporting study quality, extraction diagram and topics. The findings indicated that the following changes should be implemented to improve the quality and reliability of meta-analysis results in social work research: 1) common reporting guidelines should be provided for the social work field, 2) quality analyses of each study should be conducted to achieve a high level of evidence of effectiveness of social work interventions, 3) the characteristics of the included studies should be provided, and 4) a consensus and procedure based on at least two independent data extractors should be reported.

THE RHEOLOGY OF THE SOFT LINER WITH 4-META

  • Park, Hyun-Joo;Kim, Chang-Whe
    • The Journal of Korean Academy of Prosthodontics
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    • v.40 no.3
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    • pp.269-274
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    • 2002
  • statement of problem The viscoelastic property is the most important and peculiar characteristics of soft liners. But the authorized standard is not certainly established than other dental materials. purpose of study This study is aimed to compare the initial flow of gelation of the modified soft liner with 4-META with that of PMMA soft liners using dynamic method and evaluate the clinical acceptance of the trial materials. materials and method This study consists of 3 groups with the given % of 4-META powder in the Coe soft liquid; 0%, 5%, 10% Each group was tested for 10 times to record the change of G′values during 3 hours. the gelation time was recorded by the oscillating rheometer with parallel plate with 1 rad/sec. results As the results of this study, the gelation time of modified soft liner was elongated by 5 to 6 minutes. conclusion The mean gelation time of modified soft liner could be within the range of clinically acceptable.

Review of Meta-analysis Research on Exercise in South Korea (국내 운동 관련 메타분석 논문의 질 평가)

  • Song, Youngshin;Gang, Moonhee;Kim, Sun-Ae;Shin, In-Soo
    • Journal of Korean Academy of Nursing
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    • v.44 no.5
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    • pp.459-470
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    • 2014
  • Purpose: The purpose of this study was to evaluate the quality of meta-analysis regarding exercise using Assessment of Multiple Systematic Reviews (AMSTAR) as well as to compare effect size according to outcomes. Methods: Electronic databases including the Korean Studies Information Service System (KISS), the National Assembly Library and the DBpia, HAKJISAand RISS4U for the dates 1990 to January 2014 were searched for 'meta-analysis' and 'exercise' in the fields of medical, nursing, physical therapy and physical exercise in Korea. AMSTAR was scored for quality assessment of the 33 articles included in the study. Data were analyzed using descriptive statistics, t-test, ANOVA and ${\chi}^2$-test. Results: The mean score for AMSTAR evaluations was 4.18 (SD=1.78) and about 67% were classified at the low-quality level and 30% at the moderate-quality level. The scores of quality were statistically different by field of research, number of participants, number of databases, financial support and approval by IRB. The effect size that presented in individual studies were different by type of exercise in the applied intervention. Conclusion: This critical appraisal of meta-analysis published in various field that focused on exercise indicates that a guideline such as the PRISMA checklist should be strongly recommended for optimum reporting of meta-analysis across research fields.

An Exploratory Meta Analysis of Library Economic Valuation Studies (도서관의 경제적 가치측정 연구의 탐색적 메타분석)

  • Chung, Hye-Kyung;Ko, Young-Man;Shim, Won-Sik;Pyo, Soon-Hee
    • Journal of the Korean Society for Library and Information Science
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    • v.43 no.4
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    • pp.117-137
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    • 2009
  • This study aims to grasp how to understand the difference in return on investment (ROI) or the cost-benefit ratio in forty-two domestic and overseas studies of library valuation, using a meta-analytical review method. Meta-analysis, a quantitative analysis on the findings of previous studies, was conducted to gather the general findings and lessons from prior empirical research. The results of meta-regression analysis indicate that the pattern of findings is consistent with our expectations regarding the effect of benefit scope and per capita GDP included in the ROI figure. This study appears to be the first meta-analytical review conducted on library valuations and the findings provide strong implications for the policy-making process.

The Effects of Science Classes Using Abductive Strategies Applied to Elementary School Students on Scientific Concept Understanding and Meta-cognition (귀추전략 과학수업이 초등학생의 과학적 개념 이해와 초인지에 미치는 영향)

  • KIM, Hee-Yeon;KANG, Beodeul;YOO, Pyoung-Kil
    • Journal of Fisheries and Marine Sciences Education
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    • v.28 no.4
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    • pp.1133-1142
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    • 2016
  • The purpose of this study was to verify the effects of science classes using abductive strategies on the scientific concept understanding and meta-cognition. The subjects included two classes of sixth graders from K Elementary School in B Metropolitan City and they divided into two groups. Research group was composed of 21 students(10 boys, 11 girls) and comparative group was composed of 21 students(11 boys, 10 girls). In order to achieve aims of this study, proper contents to apply abductive strategies were selected from the first semester science curriculum for sixth graders. Also five-steps study papers were designed to elicit abductive reasoning. While the research group received 20 times of reframed science lessons using abductive strategies, the comparative group received common science lessons according to the teachers' manual. The results of this study are as follows. First, science classes using abductive strategies were effective for the scientific concept understanding. Also there were statistically significant differences between the research group and the comparative group in overall science sub-domain. In the process of hypothesis formulating, students tried to find out scientific causes thoroughly to present the optimal explanation and they concentrated on the analysis of each scientific concept. It is thought that this process contributed to better understanding in scientific concepts. Second, science classes using abductive strategies were effective for improving meta-cognition. There were statistically significant differences between the two groups and especially in monitoring that is one of sub-factors of meta-cognition. It indicates that hypothesis formulating process gave positive effect on meta-cognition by stimulating critical thinking and manifesting elaboration.

Study on Meta-cognition, Self-efficiency, Clinical competence of nursing students (간호대학생의 메타인지, 자기효능감, 임상수행능력의 융복합적 영향)

  • Chin, Eun Young;Lee, Myung In;Kim, Yoon Lee
    • Journal of Digital Convergence
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    • v.15 no.4
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    • pp.317-326
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    • 2017
  • This study examined the influence of meta-cognition, self-efficiency and clinical competence in nursing students. A convenience sample of 153 subjects were recruited from fourth year nursing students, and the survey was conducted from September 1st to 30th 2015. The data were collected by questionnaires and analyzed SPSS/Win 18.0 program, using descriptive statistics, Pearson's correlation coefficient, t-test, one-way ANOVA and hierarchical regression. Significant positive correlation among the meta-cognition, self-efficiency and clinical competence were found. The regression model explained 27% of the clinical competence. The meta-cognition and self-efficiency for the nursing students were factors influencing clinical competence. Therefor, it is necessary develop an educational program to improve the meta-cognition and self-efficiency of nursing students.

A Study on the Hypoglycemic Effect and Safety of Combined-Therapy of Baekhogainsam-tang and Hypoglycemic Agent for Type 2 Diabetes Mellitus Patients without Complications: A Systematic Review and Meta-Analysis (합병증을 동반하지 않은 2형 당뇨병 환자에 대한 백호가인삼탕과 혈당강하제 병행치료의 혈당 강하 효과 및 안전성 연구 : 체계적 문헌 고찰과 메타분석)

  • Shin, Jae-ik;Baek, Ji-soo;Shin, Seon-mi;Cho, Chung-sik
    • The Journal of Internal Korean Medicine
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    • v.42 no.4
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    • pp.672-686
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    • 2021
  • Objectives: The purpose of this study is to assess the efficacy and safety of Baekhogainsam-tang for type 2 diabetes without complications by systemic review and meta-analysis of randomized controlled trials (RCTs). Methods: For a systematic review and meta-analysis, we set a key question in accordance with PICOT-SD. We searched the following up to March 31. 2021: PubMed, EMBASE, The Cochrane Library, CNKI, CiNii, KISS, KMBASE, OASIS, and ScienceON. A meta-analysis was conducted by synthesizing the results, including fasting plasma glucose level, postprandial 2-hour plasma glucose level, and Glycated Hemoglobin (HbA1c). Results: A total of five trials are included in this systemic review. The treatment group (Baekhogainsam-tang plus conventional treatment) showed more statistically significant effect than did the control group (conventional treatment only) in fasting plasma glucose level, postprandial 2-hour plasma glucose level, and glycated hemoglobin (HbA1c). Conclusions: Baekhogainsam-tang showed statistically significant effects in hypoglycemic effect and in improving insulin resistance. However, the number of studies included in the meta-analysis was insufficient, and the BIT used in the included studies was not standardized. This topic requires further attention and more clinical research.